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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Tumour growth and metastatic infiltration are favoured by several components of the tumour microenvironment. Bone marrow-derived multipotent mesenchymal stromal cells (MSC) are known to contribute to the tumou...

    Authors: Pascal-David Johann, Martin Vaegler, Friederike Gieseke, Philippa Mang, Sorin Armeanu-Ebinger, Torsten Kluba, Rupert Handgretinger and Ingo Müller

    Citation: BMC Cancer 2010 10:501

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  2. Content type: Research article

    An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. In endometrial adenocarcinoma F-prostanoid (FP) receptor expression is ...

    Authors: Margaret C Keightley, Kurt J Sales and Henry N Jabbour

    Citation: BMC Cancer 2010 10:488

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  3. Content type: Research article

    17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Lukas H Margaritis and Gerassimos E Voutsinas

    Citation: BMC Cancer 2010 10:481

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  4. Content type: Research article

    Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation...

    Authors: Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley and Dean A Fennell

    Citation: BMC Cancer 2010 10:380

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  5. Content type: Research article

    Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phe...

    Authors: Helen J Knowles, Karl-Ludwig Schaefer, Uta Dirksen and Nicholas A Athanasou

    Citation: BMC Cancer 2010 10:372

    Published on: