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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-g...

    Authors: Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto and Masatsugu Moriyama

    Citation: BMC Cancer 2011 11:523

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  2. Content type: Research article

    Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal c...

    Authors: Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren and Jennifer S Isaacs

    Citation: BMC Cancer 2011 11:520

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  3. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor ubiquitously expressed in different cell types. STAT3 plays an essential role in cell survival, proliferation, an...

    Authors: Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang and Xiang-Ling Meng

    Citation: BMC Cancer 2011 11:506

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  4. Content type: Research article

    Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malign...

    Authors: Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy and Andrew M Chan

    Citation: BMC Cancer 2011 11:490

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  5. Content type: Research article

    Targeting the ubiquitin-proteasome pathway is a promising approach for anticancer strategies. Recently, we found Bik accumulation in cancer cell lines after they were treated with bortezomib. However, recent e...

    Authors: Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He and Hongbo Zhu

    Citation: BMC Cancer 2011 11:485

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  6. Content type: Research article

    FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF s...

    Authors: Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin and Vincent J Gnanapragasam

    Citation: BMC Cancer 2011 11:484

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  7. Content type: Research article

    Targeted therapies are becoming an essential part of breast cancer treatment and agents targeting the type I insulin-like growth factor receptor (IGF-IR) are currently being investigated in clinical trials. On...

    Authors: Craig I Campbell and Roger A Moorehead

    Citation: BMC Cancer 2011 11:480

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  8. Content type: Research article

    Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicab...

    Authors: Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar and Simon P Langdon

    Citation: BMC Cancer 2011 11:476

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  9. Content type: Research article

    The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional com...

    Authors: Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio and Angélica Figueroa

    Citation: BMC Cancer 2011 11:474

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  10. Content type: Research article

    The evolutionary dynamics between interacting heterogeneous cell types are fundamental properties of neoplastic progression but can be difficult to measure and quantify. Cancers are heterogeneous mixtures of m...

    Authors: Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner and Carlo C Maley

    Citation: BMC Cancer 2011 11:461

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  11. Content type: Research article

    HDGF is a growth factor which is overexpressed in a wide range of tumors. Importantly, expression levels were identified as a prognostic marker in some types of cancer such as melanoma.

    Authors: Angela Sedlmaier, Nicolas Wernert, Rainer Gallitzendörfer, Mekky M Abouzied, Volkmar Gieselmann and Sebastian Franken

    Citation: BMC Cancer 2011 11:457

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  12. Content type: Research article

    Nck1 and Nck2 adaptor proteins are involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response. Overexpression of Nck1 in fibroblasts has been shown to be o...

    Authors: Mélissa Labelle-Côté, Julie Dusseault, Salma Ismaïl, Aude Picard-Cloutier, Peter M Siegel and Louise Larose

    Citation: BMC Cancer 2011 11:443

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  13. Content type: Research article

    Hepatocyte Nuclear Factor 1α (HNF1α) is an atypical homeodomain-containing transcription factor that transactivates liver-specific genes including albumin, α-1-antitrypsin and α- and β-fibrinogen. Biallelic in...

    Authors: Laura Pelletier, Sandra Rebouissou, Danijela Vignjevic, Paulette Bioulac-Sage and Jessica Zucman-Rossi

    Citation: BMC Cancer 2011 11:427

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  14. Content type: Research article

    Our previous studies have identified that miR-125b was overexpressed in type II endometrial carcinoma (EC) cells compared with type I using microRNAs microarray. Although recent studies have shown the importan...

    Authors: Feizhou Jiang, Te Liu, Yinyan He, Qin Yan, Xiaoyue Chen, Hui Wang and Xiaoping Wan

    Citation: BMC Cancer 2011 11:425

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  15. Content type: Research article

    Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear. We have examined signalling pathwa...

    Authors: Kristin M Müller, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Mona Dawood, Olav Dajani, Thoralf Christoffersen and Dagny L Sandnes

    Citation: BMC Cancer 2011 11:421

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  16. Content type: Research article

    Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown...

    Authors: Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn and Göran Landberg

    Citation: BMC Cancer 2011 11:417

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  17. Content type: Research article

    Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra ce...

    Authors: Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli and Malka Cohen-Armon

    Citation: BMC Cancer 2011 11:412

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  18. Content type: Research article

    The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information o...

    Authors: Enke Baldini, Yannick Arlot-Bonnemains, Salvatore Sorrenti, Caterina Mian, Maria R Pelizzo, Enrico De Antoni, Silvio Palermo, Stefania Morrone, Susi Barollo, Angela Nesca, Costanzo G Moretti, Massimino D'Armiento and Salvatore Ulisse

    Citation: BMC Cancer 2011 11:411

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  19. Content type: Research article

    14-3-3 proteins are a family of highly conserved proteins that are involved in a wide range of cellular processes. Recent evidence indicates that some of these proteins have oncogenic activity and that they ma...

    Authors: Vijayababu M Radhakrishnan, Charles W Putnam, Wenqing Qi and Jesse D Martinez

    Citation: BMC Cancer 2011 11:378

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  20. Content type: Research article

    Epidemiological evidence suggests that moderately elevated levels of circulating insulin-like growth factor-I (IGF-I) are associated with increased risk of breast cancer in women. How circulating IGF-I may pro...

    Authors: Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu and Adrian V Lee

    Citation: BMC Cancer 2011 11:377

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  21. Content type: Research article

    Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous stu...

    Authors: Sudhakar Chintharlapalli, Sabitha Papineni, Ping Lei, Satya Pathi and Stephen Safe

    Citation: BMC Cancer 2011 11:371

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  22. Content type: Research article

    Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth of various malignancies. A common inflammatory condition in humans is autoimmune arth...

    Authors: Lopamudra Das Roy, Sriparna Ghosh, Latha B Pathangey, Teresa L Tinder, Helen E Gruber and Pinku Mukherjee

    Citation: BMC Cancer 2011 11:365

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  23. Content type: Research article

    The fusion protein VEGF121/rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects. We have previously shown that VEGF12...

    Authors: Khalid A Mohamedali, Sophia Ran, Candelaria Gomez-Manzano, Latha Ramdas, Jing Xu, Sehoon Kim, Lawrence H Cheung, Walter N Hittelman, Wei Zhang, Johannes Waltenberger, Philip E Thorpe and Michael G Rosenblum

    Citation: BMC Cancer 2011 11:358

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  24. Content type: Research article

    Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a rol...

    Authors: Benedicte Stavik, Grethe Skretting, Hans-Christian Aasheim, Mari Tinholt, Lillian Zernichow, Marit Sletten, Per Morten Sandset and Nina Iversen

    Citation: BMC Cancer 2011 11:357

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  25. Content type: Research article

    Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to hypoxia. It is essential for angiogenesis and is associated with tumor progression and overexpression of HIF-1α has b...

    Authors: Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar and Kalpana S Joshi

    Citation: BMC Cancer 2011 11:338

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  26. Content type: Research article

    A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and meta...

    Authors: Ju-Hee Kang, Ki-Hoon Song, Kyung-Chae Jeong, Sunshin Kim, Changsun Choi, Chang Hoon Lee and Seung Hyun Oh

    Citation: BMC Cancer 2011 11:334

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  27. Content type: Research article

    5-allyl-7-gen-difluoromethoxychrysin (AFMC) is a novel synthetic analogue of chrysin that has been reported to inhibit proliferation in various cancer cell lines. Tumor necrosis factor-related apoptosis-induci...

    Authors: Zhao-Hui Xie, Mei-Fang Quan, Fei Liu, Jian-Guo Cao and Jian-Song Zhang

    Citation: BMC Cancer 2011 11:322

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  28. Content type: Research article

    Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose res...

    Authors: Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach and Johannes Rieger

    Citation: BMC Cancer 2011 11:315

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  29. Content type: Research article

    E7080 is an orally active multi-targeted kinase inhibitor whose targets include vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor...

    Authors: Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod and Valerie G Brunton

    Citation: BMC Cancer 2011 11:309

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  30. Content type: Research article

    Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies, including brain tumors. In human brain cancer, especially...

    Authors: Rita Ferla, Maria Bonomi, Laszlo Otvos Jr and Eva Surmacz

    Citation: BMC Cancer 2011 11:303

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  31. Content type: Research article

    Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target ...

    Authors: Virginie Follin-Arbelet, Peter O Hofgaard, Harald Hauglin, Soheil Naderi, Anders Sundan, Rune Blomhoff, Bjarne Bogen and Heidi K Blomhoff

    Citation: BMC Cancer 2011 11:301

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  32. Content type: Research article

    Emmprin, a glycoprotein containing two Ig domains, is enriched on tumor cell surfaces and stimulates matrix metalloproteinase (MMP) production by adjacent stromal cells. Its first Ig domain (ECI) contains the ...

    Authors: Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki and Kazuki Nabeshima

    Citation: BMC Cancer 2011 11:300

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  33. Content type: Research article

    Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effe...

    Authors: Fabiana A Serrano, Alisson L Matsuo, Priscila T Monteforte, Alexandre Bechara, Soraya S Smaili, Débora P Santana, Tiago Rodrigues, Felipe V Pereira, Luis S Silva, Joel Machado Jr, Edson L Santos, João B Pesquero, Rafael M Martins, Luiz R Travassos, Antonio CF Caires and Elaine G Rodrigues

    Citation: BMC Cancer 2011 11:296

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  34. Content type: Research article

    Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors ...

    Authors: Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric R Paquet, Roscoe Klinck, François A Auger and Jacques Huot

    Citation: BMC Cancer 2011 11:285

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  35. Content type: Research article

    Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin level...

    Authors: Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka and Hisataka Moriwaki

    Citation: BMC Cancer 2011 11:281

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  36. Content type: Research article

    Recently we reported that activation of Epac1, an exchange protein activated by cAMP, increases melanoma cell migration via Ca 2+ release from the endoplasmic reticulum (ER). G-protein βγ subunits (Gβγ) are known...

    Authors: Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos and Kousaku Iwatsubo

    Citation: BMC Cancer 2011 11:256

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  37. Content type: Research article

    The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The r...

    Authors: Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao and Wenchao Liu

    Citation: BMC Cancer 2011 11:251

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  38. Content type: Research article

    The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regu...

    Authors: Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo and Olufunmilayo I Olopade

    Citation: BMC Cancer 2011 11:246

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  39. Content type: Research article

    Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively pr...

    Authors: Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman and Jonathan D Cheng

    Citation: BMC Cancer 2011 11:245

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  40. Content type: Research article

    Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis. ...

    Authors: Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger and Martin Hagedorn

    Citation: BMC Cancer 2011 11:241

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  41. Content type: Research article

    Tumor cells adapt to endoplasmic reticulum (ER) stress through a set of conserved intracellular pathways, as part of a process termed the unfolded protein response (UPR). The expression of UPR genes/proteins c...

    Authors: Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler and Maurizio Zanetti

    Citation: BMC Cancer 2011 11:229

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  42. Content type: Research article

    LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non...

    Authors: Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu and Yongming Luo

    Citation: BMC Cancer 2011 11:227

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  43. Content type: Research article

    Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein. Genistein may inhibit cancer progression by inducing apoptosis or i...

    Authors: Wentao Qi, Christopher R Weber, Kaarin Wasland and Suzana D Savkovic

    Citation: BMC Cancer 2011 11:219

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  44. Content type: Research article

    Heparin affin regulatory peptide (HARP), also called pleiotrophin, is a heparin-binding, secreted factor that is overexpressed in several tumours and associated to tumour growth, angiogenesis and metastasis. T...

    Authors: Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty and Jean Delbé

    Citation: BMC Cancer 2011 11:212

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  45. Content type: Research article

    Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis...

    Authors: Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev and Ola Myklebost

    Citation: BMC Cancer 2011 11:211

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