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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors ...

    Authors: Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric R Paquet, Roscoe Klinck, François A Auger and Jacques Huot

    Citation: BMC Cancer 2011 11:285

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  2. Content type: Research article

    Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin level...

    Authors: Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka and Hisataka Moriwaki

    Citation: BMC Cancer 2011 11:281

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  3. Content type: Research article

    Recently we reported that activation of Epac1, an exchange protein activated by cAMP, increases melanoma cell migration via Ca 2+ release from the endoplasmic reticulum (ER). G-protein βγ subunits (Gβγ) are known...

    Authors: Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos and Kousaku Iwatsubo

    Citation: BMC Cancer 2011 11:256

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  4. Content type: Research article

    The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The r...

    Authors: Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao and Wenchao Liu

    Citation: BMC Cancer 2011 11:251

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  5. Content type: Research article

    The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regu...

    Authors: Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo and Olufunmilayo I Olopade

    Citation: BMC Cancer 2011 11:246

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  6. Content type: Research article

    Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively pr...

    Authors: Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman and Jonathan D Cheng

    Citation: BMC Cancer 2011 11:245

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  7. Content type: Research article

    Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis. ...

    Authors: Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger and Martin Hagedorn

    Citation: BMC Cancer 2011 11:241

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  8. Content type: Research article

    Tumor cells adapt to endoplasmic reticulum (ER) stress through a set of conserved intracellular pathways, as part of a process termed the unfolded protein response (UPR). The expression of UPR genes/proteins c...

    Authors: Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler and Maurizio Zanetti

    Citation: BMC Cancer 2011 11:229

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  9. Content type: Research article

    LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non...

    Authors: Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu and Yongming Luo

    Citation: BMC Cancer 2011 11:227

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  10. Content type: Research article

    Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein. Genistein may inhibit cancer progression by inducing apoptosis or i...

    Authors: Wentao Qi, Christopher R Weber, Kaarin Wasland and Suzana D Savkovic

    Citation: BMC Cancer 2011 11:219

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  11. Content type: Research article

    Heparin affin regulatory peptide (HARP), also called pleiotrophin, is a heparin-binding, secreted factor that is overexpressed in several tumours and associated to tumour growth, angiogenesis and metastasis. T...

    Authors: Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty and Jean Delbé

    Citation: BMC Cancer 2011 11:212

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  12. Content type: Research article

    Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis...

    Authors: Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev and Ola Myklebost

    Citation: BMC Cancer 2011 11:211

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  13. Content type: Research article

    Mifepristone (MF) has been largely used in reproductive medicine due to its capacity to modulate the progesterone receptor (PR). The study of MF has been expanded to the field of oncology; yet it remains uncle...

    Authors: Chelsea R Tieszen, Alicia A Goyeneche, BreeAnn N Brandhagen, Casey T Ortbahn and Carlos M Telleria

    Citation: BMC Cancer 2011 11:207

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  14. Content type: Research article

    Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within the 3q26 region. Functional study has demonstrated the oncog...

    Authors: Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael SY Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu and Xin-Yuan Guan

    Citation: BMC Cancer 2011 11:199

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  15. Content type: Research article

    HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficien...

    Authors: Monika Golinska, Helen Troy, Yuen-Li Chung, Paul M McSheehy, Manuel Mayr, Xiaoke Yin, Lucy Ly, Kaye J Williams, Rachel E Airley, Adrian L Harris, John Latigo, Meg Perumal, Eric O Aboagye, David Perrett, Marion Stubbs and John R Griffiths

    Citation: BMC Cancer 2011 11:198

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  16. Content type: Research article

    Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence sugge...

    Authors: Zhengyu Fang, Wantong Yao, Yi Xiong, Jiana Li, Li Liu, Lei Shi, Wei Zhang, Chao Zhang, Liping Nie and Jun Wan

    Citation: BMC Cancer 2011 11:195

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  17. Content type: Research article

    Treatment of invasive breast cancer has an alarmingly high rate of failure because effective targets have not been identified. One potential target is mitochondrial generated reactive oxygen species (ROS) beca...

    Authors: Jorming Goh, Linda Enns, Soroosh Fatemie, Heather Hopkins, John Morton, Christina Pettan-Brewer and Warren Ladiges

    Citation: BMC Cancer 2011 11:191

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  18. Content type: Research article

    Glioblastoma (GBM) is a highly aggressive malignant primary brain tumor, characterized by rapid growth, diffuse infiltration of cells into both adjacent and remote brain regions, and a generalized resistance t...

    Authors: Barbara C Merk, Jennifer L Owens, Maria-Beatriz S Lopes, Corinne M Silva and Isa M Hussaini

    Citation: BMC Cancer 2011 11:184

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  19. Content type: Research article

    β-Elemene, a compound found in an herb used in traditional Chinese medicine, has shown promising anti-cancer effects against a broad spectrum of tumors. The mechanism by which β-elemene kills cells remains unc...

    Authors: Jing Liu, Ye Zhang, Jinglei Qu, Ling Xu, Kezuo Hou, Jingdong Zhang, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2011 11:183

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  20. Content type: Research article

    Stat3 is a cytokine- and growth factor-inducible transcription factor that regulates cell motility, migration, and invasion under normal and pathological situations, making it a promising target for cancer the...

    Authors: Zanobia A Syed, Weihong Yin, Kendall Hughes, Jennifer N Gill, Runhua Shi and John L Clifford

    Citation: BMC Cancer 2011 11:180

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  21. Content type: Research article

    Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii, which exhibits significant antitumor activity in different cancer models in vitro and in vivo; however, the lac...

    Authors: Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du and Xiaodan Yu

    Citation: BMC Cancer 2011 11:170

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  22. Content type: Research article

    Stromal fibroblasts participate in the development of a permissive environment for tumor growth, yet molecular pathways to therapeutically target fibroblasts are poorly defined. CD248, also known as endosialin...

    Authors: Margarida Maia, Astrid DeVriese, Tom Janssens, Michaël Moons, Rik J Lories, Jan Tavernier and Edward M Conway

    Citation: BMC Cancer 2011 11:162

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  23. Content type: Research article

    Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected lumina...

    Authors: Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker and Frank Entschladen

    Citation: BMC Cancer 2011 11:158

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  24. Content type: Research article

    NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet, it is not clear how they play their protective role. PGE2 is generally shown as the only target of the NSAIDs anticancerous...

    Authors: Lisenn Lalier, François Pedelaborde, Christophe Braud, Jean Menanteau, François M Vallette and Christophe Olivier

    Citation: BMC Cancer 2011 11:153

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  25. Content type: Research article

    Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of mu...

    Authors: Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson and Rafat A Siddiqui

    Citation: BMC Cancer 2011 11:149

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  26. Content type: Research article

    Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effe...

    Authors: Seung Joon Lee, Candice Krauthauser, Victoria Maduskuie, Paul T Fawcett, James M Olson and Sigrid A Rajasekaran

    Citation: BMC Cancer 2011 11:144

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  27. Content type: Research article

    Medulloblastoma is a highly malignant pediatric brain tumor that requires surgery, whole brain and spine irradiation, and intense chemotherapy for treatment. A more sophisticated understanding of the pathophys...

    Authors: Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard and Harald Sontheimer

    Citation: BMC Cancer 2011 11:136

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  28. Content type: Research article

    The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine ...

    Authors: Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman and Adit Ben-Baruch

    Citation: BMC Cancer 2011 11:130

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  29. Content type: Research article

    We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced exp...

    Authors: Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell and Cheryl A London

    Citation: BMC Cancer 2011 11:125

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  30. Content type: Research article

    Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C™), and other...

    Authors: Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally and Donald T Yapp

    Citation: BMC Cancer 2011 11:124

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  31. Content type: Research article

    Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mecha...

    Authors: Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin and Øystein Rekdal

    Citation: BMC Cancer 2011 11:116

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  32. Content type: Research article

    Gastric cancer is the second most common cause of global cancer-related mortality. Although dedifferentiation predicts poor prognosis in gastric cancer, the molecular mechanism underlying dedifferentiation, wh...

    Authors: Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu and Qinlong Gu

    Citation: BMC Cancer 2011 11:109

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  33. Content type: Research article

    It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs. The current study was designed to investigate whether resv...

    Authors: Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan and Hua-Qin Wang

    Citation: BMC Cancer 2011 11:99

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  34. Content type: Research article

    The purpose of this study was to assess the expression levels for TβRI, TβRII, and TβRIII in epithelial layers of oral premalignant lesions (oral leukoplakia, OLK) and oral squamous cell carcinoma (OSCC), as w...

    Authors: Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao and Hongmei Zhou

    Citation: BMC Cancer 2011 11:88

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  35. Content type: Research article

    Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT.

    Authors: Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa and Veli-Matti Kosma

    Citation: BMC Cancer 2011 11:73

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  36. Content type: Research article

    Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular p...

    Authors: Yi Zhang, Rachel M Gonzalez and Richard C Zangar

    Citation: BMC Cancer 2011 11:69

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  37. Content type: Research article

    Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the con...

    Authors: Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen and Jens Overgaard

    Citation: BMC Cancer 2011 11:63

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  38. Content type: Research article

    Transforming growth factor (TGF)-β plays a dual role during mammary gland development and tumorigenesis and has been shown to stimulate epithelial-mesenchymal transition (EMT) as well as cellular migration. Th...

    Authors: Kelly J Gauger, Kerry L Chenausky, Molly E Murray and Sallie S Schneider

    Citation: BMC Cancer 2011 11:59

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  39. Content type: Research article

    Histone modifications in tumorigenesis are increasingly recognized as important epigenetic factors leading to cancer. Increased phosphorylation levels of histone H3 as a result of aurora B and pMSK1 overexpres...

    Authors: Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu and Jan-Gowth Chang

    Citation: BMC Cancer 2011 11:58

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  40. Content type: Research article

    This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC.

    Authors: Yang Yuan, Zhi-Yong Zeng, Xiao-Hong Liu, De-Jun Gong, Jing Tao, He-Zhong Cheng and Sheng-Dong Huang

    Citation: BMC Cancer 2011 11:57

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  41. Content type: Research article

    Mammary carcinomas have been associated with a high-fat diet, and the rate of breast cancer in overweight post-menopausal women is up to 50% higher than in their normal-weight counterparts. Epidemiological stu...

    Authors: Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel Gerstein, Theodoros Tsakiridis and Gurmit Singh

    Citation: BMC Cancer 2011 11:56

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  42. Content type: Research article

    Adeno-associated virus-2 (AAV-2)-mediated gene therapy is quite suitable for local or regional application in head and neck cancer squamous cell carcinoma (HNSCC). However, its low transduction efficiency has ...

    Authors: Minghong Jiang, Zheng Liu, Yang Xiang, Hong Ma, Shilian Liu, Yanxin Liu and Dexian Zheng

    Citation: BMC Cancer 2011 11:54

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  43. Content type: Research article

    The esophageal carcinoma related gene 4 (ECRG4) was initially identified and cloned from human normal esophageal epithelium in our laboratory (GenBank accession no.AF325503). ECRG4 has been described as a nove...

    Authors: Lin-wei Li, Yuan-yuan Li, Xiao-yan Li, Chun-peng Zhang, Yun Zhou and Shih-Hsin Lu

    Citation: BMC Cancer 2011 11:52

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  44. Content type: Research article

    NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring ...

    Authors: Gayle Bennett, Denise Sadlier, Peter P Doran, Padraic MacMathuna and David W Murray

    Citation: BMC Cancer 2011 11:50

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  45. Content type: Research article

    Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for prolifera...

    Authors: Junlin Li and Binhua P Zhou

    Citation: BMC Cancer 2011 11:49

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