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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Secreted protein acidic and rich in cysteine (SPARC), a calcium-binding matricellular glycoprotein, is implicated in the progressions of some cancers. However, no information has been available to date regardi...

    Authors: Jie Chen, Dehuan Shi, Xiaoyan Liu, Shuang Fang, Jie Zhang and Yueran Zhao

    Citation: BMC Cancer 2012 12:464

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  2. Content type: Research article

    Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs.

    Authors: Elisabetta Lambertini, Andrea Lolli, Federica Vezzali, Letizia Penolazzi, Roberto Gambari and Roberta Piva

    Citation: BMC Cancer 2012 12:445

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  3. Content type: Research article

    Exosomes are nanovesicles secreted by tumour cells which have roles in paracrine signalling during tumour progression, including tumour-stromal interactions, activation of proliferative pathways and bestowing ...

    Authors: Hamish W King, Michael Z Michael and Jonathan M Gleadle

    Citation: BMC Cancer 2012 12:421

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  4. Content type: Research article

    Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical in...

    Authors: Anne-Laure Papa, Sudipta Basu, Poulomi Sengupta, Deboshri Banerjee, Shiladitya Sengupta and Rania Harfouche

    Citation: BMC Cancer 2012 12:419

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  5. Content type: Research article

    Recent studies suggest the potential benefits of statins as anti-cancer agents. Mechanisms by which statins induce apoptosis in cancer cells are not clear. We previously showed that simvastatin inhibit prostat...

    Authors: Anna Goc, Samith T Kochuparambil, Belal Al-Husein, Ahmad Al-Azayzih, Shuaib Mohammad and Payaningal R Somanath

    Citation: BMC Cancer 2012 12:409

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  6. Content type: Research article

    The prognosis of human glioma is poor, and the highly invasive nature of the disease represents a major impediment to current therapeutic modalities. The oncoprotein B-cell-specific Moloney murine leukemia vir...

    Authors: Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li and Mengfeng Li

    Citation: BMC Cancer 2012 12:406

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  7. Content type: Research article

    The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models...

    Authors: Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin and Roger J Daly

    Citation: BMC Cancer 2012 12:395

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  8. Content type: Research article

    Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify n...

    Authors: Lionel Flamant, Edith Roegiers, Michael Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay and Carine Michiels

    Citation: BMC Cancer 2012 12:391

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  9. Content type: Research article

    Cell line models have proven to be effective tools to investigate a variety of ovarian cancer features. Due to the limited number of cell lines, particularly of the serous subtype, the heterogeneity of the dis...

    Authors: Isabelle J Létourneau, Michael CJ Quinn, Lu-Lin Wang, Lise Portelance, Katia Y Caceres, Louis Cyr, Nathalie Delvoye, Liliane Meunier, Manon de Ladurantaye, Zhen Shen, Suzanna L Arcand, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson

    Citation: BMC Cancer 2012 12:379

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  10. Content type: Research article

    MicroRNAs (miRNAs) and their role during tumor development have been studied in great detail during the last decade, albeit their expression pattern and regulation during normal development are however not so ...

    Authors: Jelena Põlajeva, Fredrik J Swartling, Yiwen Jiang, Umashankar Singh, Kristian Pietras, Lene Uhrbom, Bengt Westermark and Pernilla Roswall

    Citation: BMC Cancer 2012 12:378

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  11. Content type: Research article

    Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. In pre-clinical research aiming at the identifi...

    Authors: Jolieke G van Oosterwijk, Danielle de Jong, Maayke AJH van Ruler, Pancras CW Hogendoorn, PD Sander Dijkstra, Carla SP van Rijswijk, Isidro Machado, Antonio Llombart-Bosch, Karoly Szuhai and Judith VMG Bovée

    Citation: BMC Cancer 2012 12:375

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  12. Content type: Research article

    The identification of circulating tumour cells (CTCs) in peripheral blood is a useful approach to estimate prognosis, monitor disease progression, and measure treatment effects in various malignancies. However...

    Authors: Hiroaki Ito, Haruhiro Inoue, Norimasa Sando, Satoshi Kimura, Keigo Gohda, Jun Sato, Katsuhiro Murakami, Shun Ito, Noriko Odaka, Hitoshi Satodate and Shin-ei Kudo

    Citation: BMC Cancer 2012 12:346

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  13. Content type: Research article

    Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cell motility. Snail transcription factor is a zinc finger protein that is increased...

    Authors: Corey L Neal, Veronica Henderson, Bethany N Smith, Danielle McKeithen, Tisheeka Graham, Baohan T Vo and Valerie A Odero-Marah

    Citation: BMC Cancer 2012 12:336

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  14. Content type: Research article

    Cell division cycle associated 3 (CDCA3), part of the Skp1-cullin-F-box (SCF) ubiquitin ligase, refers to a trigger of mitotic entry and mediates destruction of the mitosis inhibitory kinase. Little is known a...

    Authors: Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa and Hiroki Bukawa

    Citation: BMC Cancer 2012 12:321

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  15. Content type: Research article

    Multiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an ...

    Authors: Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg and Helena Jernberg Wiklund

    Citation: BMC Cancer 2012 12:318

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  16. Content type: Research article

    ZIC1, a vital transcription factor with zinc finger domains, has been implicated in the process of neural development. We previously showed that ZIC1 may function as a tumour suppressor in gastrointestinal can...

    Authors: Jing Zhong, Shujie Chen, Meng Xue, Qin Du, Jianting Cai, Hongchuan Jin, Jianmin Si and Liangjing Wang

    Citation: BMC Cancer 2012 12:290

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  17. Content type: Research article

    Transglutaminase 2 (TG2) and its phosphorylation have been consistently found to be upregulated in a number of cancer cell types. At the molecular level, TG2 has been associated with the activation of nuclear ...

    Authors: Yi Wang, Sudharsana R Ande and Suresh Mishra

    Citation: BMC Cancer 2012 12:277

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  18. Content type: Research article

    A candidate oncogene GIG47, previously known as a neudesin with a neurotrophic activity, was identified by applying the differential expression analysis method.

    Authors: Kyou-Hoon Han, Si-Hyung Lee, Seon-Ah Ha, Hyun Kee Kim, CheWook Lee, Do-Hyoung Kim, Kee Hwan Gong, JinAh Yoo, Sanghee Kim and Jin Woo Kim

    Citation: BMC Cancer 2012 12:274

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  19. Content type: Research article

    Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma defined by the presence of chromosomal translocations involving the ALK tyrosine kinase gene. These translocati...

    Authors: Joel D Pearson, Zubair Mohammed, Julinor T C Bacani, Raymond Lai and Robert J Ingham

    Citation: BMC Cancer 2012 12:229

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  20. Content type: Research article

    Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER...

    Authors: Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Rouba Ali-Fehmi, Judith Abrams, Ze Zheng, Kezhong Zhang, Stephen Ethier and Zeng-Quan Yang

    Citation: BMC Cancer 2012 12:225

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  21. Content type: Technical advance

    Numerous transgenic models have been generated to study breast cancer. However, despite many advantages, traditional transgenic models for breast cancer are also burdened with difficulties in early detection a...

    Authors: Agnieszka M Zagozdzon, Patrick O’Leary, John J Callanan, John Crown, William M Gallagher and Radoslaw Zagozdzon

    Citation: BMC Cancer 2012 12:209

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  22. Content type: Research article

    The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our gr...

    Authors: Hannah Mak, Alexandra Naba, Sonal Varma, Colleen Schick, Andrew Day, Sandip K SenGupta, Monique Arpin and Bruce E Elliott

    Citation: BMC Cancer 2012 12:82

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  23. Content type: Research article

    BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only...

    Authors: Stephanie Bacopulos, Yutaka Amemiya, Wenyi Yang, Judit Zubovits, Angelika Burger, Martin Yaffe and Arun K Seth

    Citation: BMC Cancer 2012 12:63

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  24. Content type: Research article

    Cancer-initiating cells (CICs) are proposed to be responsible for the generation of metastasis and resistance to therapy. Accumulating evidences indicates CICs are found among different human cancers and cell ...

    Authors: Jacqueline López, Adela Poitevin, Veverly Mendoza-Martínez, Carlos Pérez-Plasencia and Alejandro García-Carrancá

    Citation: BMC Cancer 2012 12:48

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  25. Content type: Research article

    Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary developme...

    Authors: Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane and Lisa A Porter

    Citation: BMC Cancer 2012 12:45

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  26. Content type: Research article

    Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor assoc...

    Authors: Anne-Katrine Bonde, Verena Tischler, Sushil Kumar, Alex Soltermann and Reto A Schwendener

    Citation: BMC Cancer 2012 12:35

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  27. Content type: Research article

    Fascin is a globular actin cross-linking protein, which plays a major role in forming parallel actin bundles in cell protrusions and is found to be associated with tumor cell invasion and metastasis in various...

    Authors: Hunain Alam, Amruta V Bhate, Prakash Gangadaran, Sharda S Sawant, Shimul Salot, Lalit Sehgal, Prerana P Dange, Devendra A Chaukar, Anil K D'cruz, Sadhna Kannanl, Rajiv Gude, Shubhada Kane, Sorab N Dalal and Milind M Vaidya

    Citation: BMC Cancer 2012 12:32

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  28. Content type: Research article

    The study of breast cancer metastasis depends on the use of established breast cancer cell lines that do not accurately represent the heterogeneity and complexity of human breast tumors. A tumor model was deve...

    Authors: Carolyn G Marsden, Mary Jo Wright, Latonya Carrier, Krzysztof Moroz, Radhika Pochampally and Brian G Rowan

    Citation: BMC Cancer 2012 12:10

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  29. Content type: Research article

    Ezrin is highly expressed in skin cancer and promotes tumor metastasis. Ezrin serves as a promising target for anti-metastasis therapy. The aim of this study is to determine if the flavonoid bacailein inhibits...

    Authors: Bin Wu, Ji Li, Damao Huang, Weiwei Wang, Yu Chen, Youxiang Liao, Xiaowei Tang, Hongfu Xie and Faqing Tang

    Citation: BMC Cancer 2011 11:527

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  30. Content type: Research article

    The Anaplastic Lymphoma Kinase (ALK) is an orphan receptor tyrosine kinase, which undergoes post-translational N-linked glycosylation. The catalytic domain of ALK was originally identified in the t(2;5) transl...

    Authors: Federica Del Grosso, Marilena De Mariano, Lorena Passoni, Roberto Luksch, Gian Paolo Tonini and Luca Longo

    Citation: BMC Cancer 2011 11:525

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  31. Content type: Research article

    Expression of neuronal elements has been identified in various glial tumors, and glioblastomas (GBMs) with neuronal differentiation patterns have reportedly been associated with longer survival. However, the n...

    Authors: Tao Yan, Kai Ove Skaftnesmo, Lina Leiss, Linda Sleire, Jian Wang, Xingang Li and Per Øyvind Enger

    Citation: BMC Cancer 2011 11:524

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  32. Content type: Research article

    Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-g...

    Authors: Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto and Masatsugu Moriyama

    Citation: BMC Cancer 2011 11:523

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  33. Content type: Research article

    Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal c...

    Authors: Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren and Jennifer S Isaacs

    Citation: BMC Cancer 2011 11:520

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  34. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor ubiquitously expressed in different cell types. STAT3 plays an essential role in cell survival, proliferation, an...

    Authors: Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang and Xiang-Ling Meng

    Citation: BMC Cancer 2011 11:506

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  35. Content type: Research article

    Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malign...

    Authors: Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy and Andrew M Chan

    Citation: BMC Cancer 2011 11:490

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  36. Content type: Research article

    Targeting the ubiquitin-proteasome pathway is a promising approach for anticancer strategies. Recently, we found Bik accumulation in cancer cell lines after they were treated with bortezomib. However, recent e...

    Authors: Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He and Hongbo Zhu

    Citation: BMC Cancer 2011 11:485

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  37. Content type: Research article

    FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF s...

    Authors: Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin and Vincent J Gnanapragasam

    Citation: BMC Cancer 2011 11:484

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  38. Content type: Research article

    Targeted therapies are becoming an essential part of breast cancer treatment and agents targeting the type I insulin-like growth factor receptor (IGF-IR) are currently being investigated in clinical trials. On...

    Authors: Craig I Campbell and Roger A Moorehead

    Citation: BMC Cancer 2011 11:480

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  39. Content type: Research article

    Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicab...

    Authors: Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar and Simon P Langdon

    Citation: BMC Cancer 2011 11:476

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  40. Content type: Research article

    The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional com...

    Authors: Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio and Angélica Figueroa

    Citation: BMC Cancer 2011 11:474

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  41. Content type: Research article

    The evolutionary dynamics between interacting heterogeneous cell types are fundamental properties of neoplastic progression but can be difficult to measure and quantify. Cancers are heterogeneous mixtures of m...

    Authors: Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner and Carlo C Maley

    Citation: BMC Cancer 2011 11:461

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  42. Content type: Research article

    HDGF is a growth factor which is overexpressed in a wide range of tumors. Importantly, expression levels were identified as a prognostic marker in some types of cancer such as melanoma.

    Authors: Angela Sedlmaier, Nicolas Wernert, Rainer Gallitzendörfer, Mekky M Abouzied, Volkmar Gieselmann and Sebastian Franken

    Citation: BMC Cancer 2011 11:457

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  43. Content type: Research article

    Nck1 and Nck2 adaptor proteins are involved in signaling pathways mediating proliferation, cytoskeleton organization and integrated stress response. Overexpression of Nck1 in fibroblasts has been shown to be o...

    Authors: Mélissa Labelle-Côté, Julie Dusseault, Salma Ismaïl, Aude Picard-Cloutier, Peter M Siegel and Louise Larose

    Citation: BMC Cancer 2011 11:443

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  44. Content type: Research article

    Hepatocyte Nuclear Factor 1α (HNF1α) is an atypical homeodomain-containing transcription factor that transactivates liver-specific genes including albumin, α-1-antitrypsin and α- and β-fibrinogen. Biallelic in...

    Authors: Laura Pelletier, Sandra Rebouissou, Danijela Vignjevic, Paulette Bioulac-Sage and Jessica Zucman-Rossi

    Citation: BMC Cancer 2011 11:427

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  45. Content type: Research article

    Our previous studies have identified that miR-125b was overexpressed in type II endometrial carcinoma (EC) cells compared with type I using microRNAs microarray. Although recent studies have shown the importan...

    Authors: Feizhou Jiang, Te Liu, Yinyan He, Qin Yan, Xiaoyue Chen, Hui Wang and Xiaoping Wan

    Citation: BMC Cancer 2011 11:425

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  46. Content type: Research article

    Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear. We have examined signalling pathwa...

    Authors: Kristin M Müller, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Mona Dawood, Olav Dajani, Thoralf Christoffersen and Dagny L Sandnes

    Citation: BMC Cancer 2011 11:421

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  47. Content type: Research article

    Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown...

    Authors: Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn and Göran Landberg

    Citation: BMC Cancer 2011 11:417

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  48. Content type: Research article

    Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra ce...

    Authors: Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli and Malka Cohen-Armon

    Citation: BMC Cancer 2011 11:412

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