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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most i...

    Authors: Liyong Zhang, Zhihong Li, Yehai Liu, Shuping Xu, Manuj Tandon, Brittany Appelboom, Courtney R. LaValle, Simion I. Chiosea, Lin Wang, Malabika Sen, Vivian W. Y. Lui, Jennifer R. Grandis and Q. Jane Wang

    Citation: BMC Cancer 2018 18:1107

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  2. Content type: Research article

    Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes. Although abnormalities in cytokine signaling are common in MPN, the pathophysiology of atypical MPN stil...

    Authors: Pierre-Yves Dumas, Olivier Mansier, Valerie Prouzet-Mauleon, Junji Koya, Arnaud Villacreces, Philippe Brunet de la Grange, Damien Luque Paz, Audrey Bidet, Jean-Max Pasquet, Vincent Praloran, Franck Salin, Mineo Kurokawa, François-Xavier Mahon, Bruno Cardinaud and Eric Lippert

    Citation: BMC Cancer 2018 18:1098

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  3. Content type: Research article

    To investigate the influence of fibroblast activation protein alpha (FAP) derived from cancer-associated fibroblasts (CAFs), as well as potential mechanism of epithelial mesenchymal transition (EMT), on gastri...

    Authors: Jiuyang Liu, Chaoqun Huang, Chunwei Peng, Fei Xu, Yan Li, Yonemura Yutaka, Bin Xiong and Xiaojun Yang

    Citation: BMC Cancer 2018 18:1099

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  4. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...

    Authors: Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi and Xin Chen

    Citation: BMC Cancer 2018 18:1093

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  5. Content type: Research article

    microRNAs (miRNAs) stably exist in circulating blood and are encapsulated in extracellular vesicles such as exosomes. The aims of this study were to identify which exosomal miRNAs are highly produced from epit...

    Authors: Akihiko Yoshimura, Kenjiro Sawada, Koji Nakamura, Yasuto Kinose, Erika Nakatsuka, Masaki Kobayashi, Mayuko Miyamoto, Kyoso Ishida, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi and Tadashi Kimura

    Citation: BMC Cancer 2018 18:1065

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  6. Content type: Review

    For decades, retinoids and their synthetic derivatives have been well established anticancer treatments due to their ability to regulate cell growth and induce cell differentiation and apoptosis. Many studies ...

    Authors: Viera Dobrotkova, Petr Chlapek, Pavel Mazanek, Jaroslav Sterba and Renata Veselska

    Citation: BMC Cancer 2018 18:1059

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  7. Content type: Research article

    Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. Nonetheless, the prognostic relevance of HER3...

    Authors: Satu Luhtala, Synnöve Staff, Anne Kallioniemi, Minna Tanner and Jorma Isola

    Citation: BMC Cancer 2018 18:1045

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  8. Content type: Research article

    New approaches for the prevention of colon cancer perseveres an essential necessity. Though, resistance to existing chemo-preventive drugs is moderately predominant in colon carcinogenesis. Taxifolin (dihydroq...

    Authors: Suhail Razak, Tayyaba Afsar, Asad Ullah, Ali Almajwal, Musaed Alkholief, Aws Alshamsan and Sarwat Jahan

    Citation: BMC Cancer 2018 18:1043

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  9. Content type: Research article

    Remodeling of Ca2+ signaling is an important step in cancer progression, and altered expression of members of the Ca2+ signaling toolkit including the plasma membrane Ca2+ ATPases (PMCA proteins encoded by ATP2B ...

    Authors: Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi and Rita Padányi

    Citation: BMC Cancer 2018 18:1029

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  10. Content type: Research article

    It was demonstrated that long non-coding RNAs occupied an important position in tumor pathogenesis and progression. We have previously found that the metastasis-associated lung adenocarcinoma transcript 1 (MAL...

    Authors: Meng Zhuo, Cuncun Yuan, Ting Han, Jiujie Cui, Feng Jiao and Liwei Wang

    Citation: BMC Cancer 2018 18:1032

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  11. Content type: Research article

    The dismal prognosis of patients with glioblastoma (GBM) is attributed to a rare subset of cancer stem cells that display characteristics of tumor initiation, growth, and resistance to aggressive treatment inv...

    Authors: Brian Tung, Ding Ma, Shuyan Wang, Olutobi Oyinlade, John Laterra, Mingyao Ying, Sheng-Qing Lv, Shuang Wei and Shuli Xia

    Citation: BMC Cancer 2018 18:1025

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  12. Content type: Research article

    NDRG2 is identified as a tumor suppressor gene in many tumors, and functions in cell proliferation, differentiation and apoptosis. Recent data indicate that NDRG2 expression is up-regulated by TP53. Moreover, pro...

    Authors: Yu-Qiong Yang, Tian Tian, Hua-Yuan Zhu, Jin-Hua Liang, Wei Wu, Jia-Zhu Wu, Yi Xia, Li Wang, Lei Fan, Jian-Yong Li and Wei Xu

    Citation: BMC Cancer 2018 18:1009

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  13. Content type: Research article

    Prostate cancer-related morbidity is associated with its preferential spread to the bone. Although the molecular interactions between the bone microenvironment and cancer cells have been researched extensively...

    Authors: Haider Mussawy, Lennart Viezens, Malte Schroeder, Svenja Hettenhausen, Jördis Sündermann, Jasmin Wellbrock, Kai Kossow and Christian Schaefer

    Citation: BMC Cancer 2018 18:979

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  14. Content type: Research article

    Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with auto...

    Authors: Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang and Yingyu Nan

    Citation: BMC Cancer 2018 18:984

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  15. Content type: Research article

    In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytop...

    Authors: Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck

    Citation: BMC Cancer 2018 18:981

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  16. Content type: Research article

    Fibronectin (FN) is a high-molecular-weight glycoprotein component of the extracellular matrix involved in cell adhesion, migration, metastasis, proliferation and differentiation, as well as embryogenesis, wou...

    Authors: Jiefei Xiao, Weilin Yang, Bo Xu, Haoshuai Zhu, Jianyong Zou, Chunhua Su, Jian Rong, Tao Wang and Zhenguang Chen

    Citation: BMC Cancer 2018 18:976

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  17. Content type: Research article

    The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis in some cancers. However, the expression and...

    Authors: Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Thang Pham Quoc, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Fumi Kawakami, Jose A Karam, Kanishka Sircar, Akio Matsubara and Wataru Yasui

    Citation: BMC Cancer 2018 18:952

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  18. Content type: Research article

    Cancer stem cells (CSC) are characterized by deregulated self-renewal, tumorigenicity, metastatic potential, aberrant stemness signaling pathways, resistance to conventional therapy, and the ability to give ri...

    Authors: Gabriele Davide Bigoni-Ordóñez, Elizabeth Ortiz-Sánchez, Pedro Rosendo-Chalma, Heriberto A Valencia-González, Carmen Aceves and Alejandro García-Carrancá

    Citation: BMC Cancer 2018 18:928

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  19. Content type: Research article

    Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) w...

    Authors: Deyu Huang, Chunhua Bi, Qingxi Zhao, Xueli Ding, Cheng Bian, Hui Wang, Ting Wang and Hua Liu

    Citation: BMC Cancer 2018 18:919

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  20. Content type: Research article

    Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellu...

    Authors: Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen

    Citation: BMC Cancer 2018 18:901

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  21. Content type: Research article

    Adipose-tissue stem cells (ASCs) are subject of intensive research since their successful use in regenerative therapy. The drawback of ASCs is that they may serve as stroma for cancer cells and assist tumor pr...

    Authors: Roberta Fajka-Boja, Annamária Marton, Anna Tóth, Péter Blazsó, Vilmos Tubak, Balázs Bálint, István Nagy, Zoltán Hegedűs, Csaba Vizler and Robert L. Katona

    Citation: BMC Cancer 2018 18:872

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  22. Content type: Research article

    The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cance...

    Authors: Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin and Cheok Soon Lee

    Citation: BMC Cancer 2018 18:869

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  23. Content type: Research article

    Gastric cancer (GC) is one of the most common malignant diseases with high morbidity and mortality, especially in Asian countries. During the GC developing progress, TIPE2, a member of TNF-alpha induced protei...

    Authors: Wenming Liu, Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Wei Huang, Dongyan Shen and Zhongquan Qi

    Citation: BMC Cancer 2018 18:857

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  24. Content type: Research article

    It has been shown that the expression of potassium channel tetramerization domain containing 12 (KCTD12) as a regulator of GABAB receptor signaling is reversely associated with gastrointestinal stromal tumors....

    Authors: Mohammad Reza Abbaszadegan, Negin Taghehchian, Liping Li, Azadeh Aarabi and Meysam Moghbeli

    Citation: BMC Cancer 2018 18:853

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  25. Content type: Research article

    Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of ...

    Authors: Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova and Miroslava Matuskova

    Citation: BMC Cancer 2018 18:848

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  26. Content type: Research article

    Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% w...

    Authors: Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen and Olli Kallioniemi

    Citation: BMC Cancer 2018 18:850

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  27. Content type: Debate

    Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have als...

    Authors: Zikang Zhang, Qing Xie, Dongmei He, Yuan Ling, Yuchao Li, Jiangbin Li and Hua Zhang

    Citation: BMC Cancer 2018 18:834

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  28. Content type: Research article

    Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, ...

    Authors: Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han and Guo-Hui Fu

    Citation: BMC Cancer 2018 18:824

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  29. Content type: Research article

    The present study aimed to investigate the role of blood supply in early tumorigenesis in colorectal cancer. We leveraged the renin angiotensin system (RAS) to alter colonic blood supply and determine the effe...

    Authors: Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K. Roy, John Hart, Marc Bissonnette, Vani Konda and Vadim Backman

    Citation: BMC Cancer 2018 18:814

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  30. Content type: Research article

    Breast cancer is the most common malignancy in women worldwide. Although the endocrine therapy that targets estrogen receptor α (ERα) signaling has been well established as an effective adjuvant treatment for ...

    Authors: Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt and Olga Kovalchuk

    Citation: BMC Cancer 2018 18:817

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  31. Content type: Research article

    Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a cr...

    Authors: Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang and Zhi-Hong Jiang

    Citation: BMC Cancer 2018 18:799

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  32. Content type: Research article

    CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expressio...

    Authors: Ning Li, Minghong Chen, Yansha Cao, Hua Li, Jinping Zhao, Zhenhua Zhai, Fu Ren and Keyan Li

    Citation: BMC Cancer 2018 18:793

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  33. Content type: Research article

    Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms ...

    Authors: Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew Anderson, Snorri Thorgeirsson, Itzhak Avital and Udo Rudloff

    Citation: BMC Cancer 2018 18:772

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  34. Content type: Research article

    Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum. Loss of one copy of chromosome 18 is the most frequent observ...

    Authors: Elham Barazeghi, Surendra Prabhawa, Olov Norlén, Per Hellman, Peter Stålberg and Gunnar Westin

    Citation: BMC Cancer 2018 18:764

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  35. Content type: Research article

    Bladder cancer often recurs due to incomplete elimination of the cancer stem cells (CSCs). Therefore, new strategies targeting bladder CSCs are needed and the aim of this study was to investigate the effect of...

    Authors: Yongtong Zhu, Yao Zhou, Xuan Zhou, Yangchun Guo, Daxiong Huang, Jialin Zhang, Chunyan Wang and Longmei Cai

    Citation: BMC Cancer 2018 18:763

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  36. Content type: Research article

    The Zc3h8 gene encodes a protein with three zinc finger motifs in the C-terminal region. The protein has been identified as a component of the Little Elongation Complex, involved in transcription of small nuclear...

    Authors: John A. Schmidt, Keith G. Danielson, Emily R. Duffner, Sara G. Radecki, Gerard T. Walker, Amber Shelton, Tianjiao Wang and Janice E. Knepper

    Citation: BMC Cancer 2018 18:759

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  37. Content type: Research article

    We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identifi...

    Authors: Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull and Irene L. Andrulis

    Citation: BMC Cancer 2018 18:750

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  38. Content type: Research article

    Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to in...

    Authors: Ke Jiang, Cuiping Song, Lingkai Kong, Lulu Hu, Guibin Lin, Tian Ye, Gang Yao, Yupeng Wang, Haibo Chen, Wei Cheng, Martin P. Barr, Quentin Liu, Guirong Zhang, Chan Ding and Songshu Meng

    Citation: BMC Cancer 2018 18:746

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  39. Content type: Research article

    The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...

    Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval

    Citation: BMC Cancer 2018 18:728

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  40. Content type: Research article

    LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.

    Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen

    Citation: BMC Cancer 2018 18:722

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  41. Content type: Research article

    Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...

    Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim

    Citation: BMC Cancer 2018 18:716

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  42. Content type: Research article

    HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...

    Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez

    Citation: BMC Cancer 2018 18:709

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  43. Content type: Research article

    Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...

    Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang

    Citation: BMC Cancer 2018 18:710

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  44. Content type: Research article

    Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen ...

    Authors: Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy and Sandip K. Mishra

    Citation: BMC Cancer 2018 18:690

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  45. Content type: Research article

    The neuronal intermediate filament alpha-internexin (α-internexin) is a cytoskeleton protein which is involved in the tumor initiation and progression. In this study, we examined the expression and prognosis v...

    Authors: Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen and Jie Chen

    Citation: BMC Cancer 2018 18:691

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  46. Content type: Research article

    Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of express...

    Authors: Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón and Luis M. Quirós

    Citation: BMC Cancer 2018 18:687

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