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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a cr...

    Authors: Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang and Zhi-Hong Jiang

    Citation: BMC Cancer 2018 18:799

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  2. Content type: Research article

    CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expressio...

    Authors: Ning Li, Minghong Chen, Yansha Cao, Hua Li, Jinping Zhao, Zhenhua Zhai, Fu Ren and Keyan Li

    Citation: BMC Cancer 2018 18:793

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  3. Content type: Research article

    Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms ...

    Authors: Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew Anderson, Snorri Thorgeirsson, Itzhak Avital and Udo Rudloff

    Citation: BMC Cancer 2018 18:772

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  4. Content type: Research article

    Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum. Loss of one copy of chromosome 18 is the most frequent observ...

    Authors: Elham Barazeghi, Surendra Prabhawa, Olov Norlén, Per Hellman, Peter Stålberg and Gunnar Westin

    Citation: BMC Cancer 2018 18:764

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  5. Content type: Research article

    Bladder cancer often recurs due to incomplete elimination of the cancer stem cells (CSCs). Therefore, new strategies targeting bladder CSCs are needed and the aim of this study was to investigate the effect of...

    Authors: Yongtong Zhu, Yao Zhou, Xuan Zhou, Yangchun Guo, Daxiong Huang, Jialin Zhang, Chunyan Wang and Longmei Cai

    Citation: BMC Cancer 2018 18:763

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  6. Content type: Research article

    The Zc3h8 gene encodes a protein with three zinc finger motifs in the C-terminal region. The protein has been identified as a component of the Little Elongation Complex, involved in transcription of small nuclear...

    Authors: John A. Schmidt, Keith G. Danielson, Emily R. Duffner, Sara G. Radecki, Gerard T. Walker, Amber Shelton, Tianjiao Wang and Janice E. Knepper

    Citation: BMC Cancer 2018 18:759

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  7. Content type: Research article

    We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identifi...

    Authors: Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull and Irene L. Andrulis

    Citation: BMC Cancer 2018 18:750

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  8. Content type: Research article

    Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to in...

    Authors: Ke Jiang, Cuiping Song, Lingkai Kong, Lulu Hu, Guibin Lin, Tian Ye, Gang Yao, Yupeng Wang, Haibo Chen, Wei Cheng, Martin P. Barr, Quentin Liu, Guirong Zhang, Chan Ding and Songshu Meng

    Citation: BMC Cancer 2018 18:746

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  9. Content type: Research article

    The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...

    Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval

    Citation: BMC Cancer 2018 18:728

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  10. Content type: Research article

    LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.

    Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen

    Citation: BMC Cancer 2018 18:722

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  11. Content type: Research article

    Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...

    Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim

    Citation: BMC Cancer 2018 18:716

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  12. Content type: Research article

    HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...

    Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez

    Citation: BMC Cancer 2018 18:709

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  13. Content type: Research article

    Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...

    Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang

    Citation: BMC Cancer 2018 18:710

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  14. Content type: Research article

    Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen ...

    Authors: Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy and Sandip K. Mishra

    Citation: BMC Cancer 2018 18:690

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  15. Content type: Research article

    The neuronal intermediate filament alpha-internexin (α-internexin) is a cytoskeleton protein which is involved in the tumor initiation and progression. In this study, we examined the expression and prognosis v...

    Authors: Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen and Jie Chen

    Citation: BMC Cancer 2018 18:691

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  16. Content type: Research article

    Progesterone receptor (PR) is expressed from a single gene as two isoforms, PRA and PRB. In normal breast human tissue, PRA and PRB are expressed in equimolar ratios, but isoform ratio is altered during malign...

    Authors: María José Carlini, María Sol Recouvreux, Marina Simian and Maria Aparecida Nagai

    Citation: BMC Cancer 2018 18:682

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  17. Content type: Research article

    Uterine serous carcinoma (USC) is a rare but aggressive subtype of endometrial carcinoma. Large-scale comprehensive efforts have resulted in an improved molecular understanding of its pathogenesis, and the p53...

    Authors: Katharina Bischof, Stian Knappskog, Ingunn Stefansson, Emmet Martin McCormack, Jone Trovik, Henrica Maria Johanna Werner, Kathrine Woie, Bjorn Tore Gjertsen and Line Bjorge

    Citation: BMC Cancer 2018 18:684

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  18. Content type: Research article

    Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of express...

    Authors: Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón and Luis M. Quirós

    Citation: BMC Cancer 2018 18:687

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  19. Content type: Research article

    KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcrip...

    Authors: Beth K. Neilsen, Binita Chakraborty, Jamie L. McCall, Danielle E. Frodyma, Richard L. Sleightholm, Kurt W. Fisher and Robert E. Lewis

    Citation: BMC Cancer 2018 18:673

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  20. Content type: Research article

    Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heteroge...

    Authors: Hannah Harrison, Henry J. Pegg, Jamie Thompson, Christian Bates and Paul Shore

    Citation: BMC Cancer 2018 18:674

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  21. Content type: Research article

    The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signal...

    Authors: Justin Zonneville, Alfiya Safina, Alexander M. Truskinovsky, Carlos L. Arteaga and Andrei V. Bakin

    Citation: BMC Cancer 2018 18:670

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  22. Content type: Research article

    Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, ...

    Authors: Yuan Li, Yang Du, Ting Sun, Huadan Xue, Zhengyu Jin and Jie Tian

    Citation: BMC Cancer 2018 18:669

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  23. Content type: Research article

    Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related deaths worldwide. Despite new technologies in diagnosis and treatment, the incidence and mortality ...

    Authors: Hongying Liu, Xieqi Wang, Bing Feng, Lipeng Tang, Weiping Li, Xirun Zheng, Ying Liu, Yan Peng, Guangjuan Zheng and Qinglian He

    Citation: BMC Cancer 2018 18:661

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  24. Content type: Research article

    Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the conte...

    Authors: Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini and Sanna Pasonen-Seppänen

    Citation: BMC Cancer 2018 18:664

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  25. Content type: Research article

    Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations of cells, one of them, known as cancer stem cells, being attributed many important properties ...

    Authors: Z. Kozovska, A. Patsalias, V. Bajzik, E. Durinikova, L. Demkova, S. Jargasova, B. Smolkova, J. Plava, L. Kucerova and M. Matuskova

    Citation: BMC Cancer 2018 18:656

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  26. Content type: Research article

    In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene. Nevertheless, its molecular role and clinical effects remains unknown in bladder cancer.

    Authors: Yang Liu, Han Wang, Jianhua Zhong, Chenglong Wu, Gang Yang, Yuantang Zhong, Jinghua Zhang and Aifa Tang

    Citation: BMC Cancer 2018 18:642

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  27. Content type: Research article

    Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular c...

    Authors: Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O. Michie, Alistair R. W. Williams, Tzyvia Rye, Charlie Gourley and Simon P. Langdon

    Citation: BMC Cancer 2018 18:636

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  28. Content type: Research article

    It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. ...

    Authors: Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang and Wai-Lun Law

    Citation: BMC Cancer 2018 18:621

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  29. Content type: Technical advance

    Metastasis is a complex process which is difficult to study and model. Experimental ingenuity is therefore essential when seeking to elucidate the biological mechanisms involved.

    Authors: Shirley Jean Keeton, Jean Marie Delalande, Mark Cranfield, Alan Burns and Philip Richard Dash

    Citation: BMC Cancer 2018 18:622

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  30. Content type: Research article

    Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor positive BC patient’s response to anti-hormone therapy. Estrogen receptors (ERs) play an important role in breast cancer progressio...

    Authors: B. Madhu Krishna, Sanjib Chaudhary, Dipti Ranjan Mishra, Sanoj K. Naik, S. Suklabaidya, A. K. Adhya and Sandip K. Mishra

    Citation: BMC Cancer 2018 18:607

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  31. Content type: Research article

    Activation of c-Met, a receptor tyrosine kinase, induces radiation therapy resistance in non-small cell lung cancer (NSCLC). The activated residual of c-Met is located in lipid rafts (Duhon et al. Mol Carcinog...

    Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Cheng Sun, Yusi Liang, Jinyang Yu and Huawei Zou

    Citation: BMC Cancer 2018 18:611

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  32. Content type: Research article

    Cancer remains one of the leading causes of death around the world, where incidence and mortality rates are at a constant increase. Tumourigenic cells are characteristically seen to over-express the 37 kDa/67 ...

    Authors: Leila Vania, Thalia M. Rebelo, Eloise Ferreira and Stefan F. T. Weiss

    Citation: BMC Cancer 2018 18:602

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  33. Content type: Research article

    Lung adenocarcinoma is the most common type of lung cancer and one of the most lethal and prevalent cancers. Aberrant glycosylation was common and essential in tumorigenesis, with fucosylation as one of the mo...

    Authors: Xing Wei, Kun Zhang, Haifeng Qin, Jinlong Zhu, Qiaoxi Qin, Yang Yu and Hong Wang

    Citation: BMC Cancer 2018 18:600

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  34. Content type: Research article

    Glioma is the most common primary brain tumor in adults with a poor prognosis. As a member of ARF subfamily GTPase, ARL2 plays a key role in regulating the dynamics of microtubules and mitochondrial functions....

    Authors: Yulin Wang, Gefei Guan, Wen Cheng, Yang Jiang, Fengping Shan, Anhua Wu, Peng Cheng and Zongze Guo

    Citation: BMC Cancer 2018 18:599

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  35. Content type: Research article

    Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several s...

    Authors: Carrie D. House, Valentina Grajales, Michelle Ozaki, Elizabeth Jordan, Helmae Wubneh, Danielle C. Kimble, Jana M. James, Marianne K. Kim and Christina M. Annunziata

    Citation: BMC Cancer 2018 18:595

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  36. Content type: Research article

    Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controvers...

    Authors: Jan Breza Jr, Andrea Soltysova, Sona Hudecova, Adela Penesova, Ivan Szadvari, Petr Babula, Barbora Chovancova, Lubomira Lencesova, Ondrej Pos, Jan Breza, Karol Ondrias and Olga Krizanova

    Citation: BMC Cancer 2018 18:591

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  37. Content type: Research article

    The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprisin...

    Authors: Mohammed I. Khan, Anna A. Sobocińska, Klaudia K. Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M. Czarnecka and Cezary Szczylik

    Citation: BMC Cancer 2018 18:583

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  38. Content type: Research article

    Carbonic anhydrase related proteins (CARPs) VIII, X and XI functionally differ from the other carbonic anhydrase (CA) enzymes. Structurally, they lack the zinc binding residues, which are important for enzyme ...

    Authors: Sini L. Karjalainen, Hannu K. Haapasalo, Ashok Aspatwar, Harlan Barker, Seppo Parkkila and Joonas A. Haapasalo

    Citation: BMC Cancer 2018 18:584

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  39. Content type: Research article

    Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote tumor metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), a monomeric compound ...

    Authors: Honglin Li, Nan Huang, Weikang Zhu, Jianchun Wu, Xiaohui Yang, Wenjing Teng, Jianhui Tian, Zhihong Fang, Yingbin Luo, Min Chen and Yan Li

    Citation: BMC Cancer 2018 18:579

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  40. Content type: Research article

    Lung cancer remains the top contributor to cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been reported to participate in normal development and tumorigenesis. LncRNA nuclear enriched ...

    Authors: Wu Zhou, Xing Chen, Qinghua Hu, Xuliang Chen, Yingji Chen and Lingjin Huang

    Citation: BMC Cancer 2018 18:580

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  41. Content type: Research article

    A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression an...

    Authors: Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang and Guanzhen Yu

    Citation: BMC Cancer 2018 18:570

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  42. Content type: Research article

    Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were re...

    Authors: Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan and Anna Karlsson

    Citation: BMC Cancer 2018 18:559

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  43. Content type: Research article

    Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives t...

    Authors: T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou and H. J. Knowles

    Citation: BMC Cancer 2018 18:536

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  44. Content type: Research article

    SETDB1 is a histone H3K9 methyltransferase, which plays a significant role in the occurrence and progression of tumors. Previous studies have confirmed that T-lymphom invasion and metastasis gene (Tiam1) is a ...

    Authors: Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen and Yi Ding

    Citation: BMC Cancer 2018 18:539

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