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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative brea...

    Authors: Guoxuan Gao, Zihan Wang, Xiang Qu and Zhongtao Zhang

    Citation: BMC Cancer 2020 20:179

    Content type: Research article

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  2. Aberrant JAK/STAT activation has been detected in many types of human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to direct transcriptional regulation of target genes by phosp...

    Authors: Pranabananda Dutta, Lin Zhang, Huijun Zhang, Qin Peng, Phillippe R. Montgrain, Yingxiao Wang, Yuanlin Song, Jinghong Li and Willis X. Li

    Citation: BMC Cancer 2020 20:145

    Content type: Research article

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  3. Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly an...

    Authors: Tadashi Sasagawa, Atsushi Jinno-Oue, Takeshi Nagamatsu, Kazuki Morita, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Tomoyuki Fujii and Masabumi Shibuya

    Citation: BMC Cancer 2020 20:112

    Content type: Research article

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  4. TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pa...

    Authors: Lixian Oh, Pierre Hainaut, Sandrine Blanchet and Hany Ariffin

    Citation: BMC Cancer 2020 20:110

    Content type: Research article

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  5. Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral sq...

    Authors: Deyu Liu, Xinchun Jian, Pu Xu, Rong Zhu and Yuan Wang

    Citation: BMC Cancer 2020 20:107

    Content type: Research article

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  6. Overexpression of FAT1 gene and its oncogenic effects have been reported in several cancers. Previously, we have documented upregulation of FAT1 gene in glioblastoma (GBM) tumors which was found to increase th...

    Authors: Chitrangda Srivastava, Khushboo Irshad, Yakhlesh Gupta, Chitra Sarkar, Ashish Suri, Parthaprasad Chattopadhyay, Subrata Sinha and Kunzang Chosdol

    Citation: BMC Cancer 2020 20:62

    Content type: Research article

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  7. Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly block HR activity; but most patients even...

    Authors: Afshan F. Nawas, Mohammed Kanchwala, Shayna E. Thomas-Jardin, Haley Dahl, Kelly Daescu, Monica Bautista, Vanessa Anunobi, Ally Wong, Rachel Meade, Ragini Mistry, Nisha Ghatwai, Felix Bayerl, Chao Xing and Nikki A. Delk

    Citation: BMC Cancer 2020 20:46

    Content type: Research article

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  8. Matrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression patter...

    Authors: Shuo Yuan, Li-song Lin, Rui-Huan Gan, Li Huang, Xiao-ting Wu, Yong Zhao, Bo-hua Su, Dali Zheng and You-Guang Lu

    Citation: BMC Cancer 2020 20:33

    Content type: Research article

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  9. Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated...

    Authors: Ji-Gang Zhang, He-Ming Zhou, Xue Zhang, Wan Mu, Juan-Ni Hu, Gao-Lin Liu and Qin Li

    Citation: BMC Cancer 2020 20:32

    Content type: Research article

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  10. Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportun...

    Authors: Xia Liao, Ge Song, Zihan Xu, Yang Bu, Fan Chang, Fengan Jia, Xuelian Xiao, Xuejiao Ren, Mei Zhang and Qingan Jia

    Citation: BMC Cancer 2020 20:31

    Content type: Research article

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  11. Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by...

    Authors: Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu and Ping Ya Zhu

    Citation: BMC Cancer 2020 20:28

    Content type: Research article

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  12. Ewing sarcoma is a malignancy of primitive cells, possibly of mesenchymal origin. It is probable that genetic perturbations other than EWS-FLI1 cooperate with it to produce the tumor. Sequencing studies identifie...

    Authors: Marc El Beaino, Jiayong Liu, Amanda R. Wasylishen, Rasoul Pourebrahim, Agata Migut, Bryan J. Bessellieu, Ke Huang and Patrick P. Lin

    Citation: BMC Cancer 2020 20:3

    Content type: Research article

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  13. Cell adhesion-mediated drug resistance (CAM-DR) is a major clinical problem that prevents successful treatment of multiple myeloma (MM). In particular, the expression levels of integrin β1 and its sub-cellular...

    Authors: Yuejiao Huang, Xianting Huang, Chun Cheng, Xiaohong Xu, Hong Liu, Xiaojing Yang, Li Yao, Zongmei Ding, Jie Tang, Song He and Yuchan Wang

    Citation: BMC Cancer 2019 19:1269

    Content type: Research article

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  14. Invasive mammary carcinomas that spontaneously develop in female cats are associated with high mortality, and resemble the most aggressive human breast cancers, especially triple-negative breast cancer (TNBC)....

    Authors: Elie Dagher, Violette Royer, Paul Buchet, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen

    Citation: BMC Cancer 2019 19:1267

    Content type: Research article

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  15. The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metasta...

    Authors: Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li and Xin Lu

    Citation: BMC Cancer 2019 19:1266

    Content type: Research article

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  16. Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism un...

    Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu and Ziming Dong

    Citation: BMC Cancer 2019 19:1264

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:43

  17. Nimotuzumab (NTZ) is an anti-EGFR monoclonal antibody. However,the effect of targeted drugs combined with induction therapy in locally advanced nasopharyngeal carcinoma remains unclear. The aim of this study i...

    Authors: Ying Lu, Dagui Chen, Jinhui Liang, Jianquan Gao, Zhanxiong Luo, Rensheng Wang, Wenqi Liu, Changjie Huang, Xuejian Ning, Meilian Liu and Haixin Huang

    Citation: BMC Cancer 2019 19:1262

    Content type: Research article

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  18. Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, n...

    Authors: Tugba Kizilboga, Emine Arzu Baskale, Jale Yildiz, Izzet Mehmet Akcay, Ebru Zemheri, Nisan Denizce Can, Can Ozden, Salih Demir, Fikret Ezberci and Gizem Dinler-Doganay

    Citation: BMC Cancer 2019 19:1254

    Content type: Research article

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  19. Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state an...

    Authors: Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, Apurvi R. Patel, David W. Lee, Vijay Gokhale, Laurence H. Hurley, Robert J. Arceci, Cynthia Wetmore and David O. Azorsa

    Citation: BMC Cancer 2019 19:1251

    Content type: Research article

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  20. Cell cycle analysis is important for cancer research. However, available methodologies have drawbacks including limited categorisation and reliance on fixation, staining or transformation. Multispectral analys...

    Authors: Jared M. Campbell, Abbas Habibalahi, Saabah Mahbub, Martin Gosnell, Ayad G. Anwer, Sharon Paton, Stan Gronthos and Ewa Goldys

    Citation: BMC Cancer 2019 19:1242

    Content type: Research article

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  21. Tumor angiogenesis is vital for tumor growth. Recent evidence indicated that bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to tumor sites and exert critical effects on tumor growth through dir...

    Authors: Chao Sun, Xingliang Dai, Dongliang Zhao, Haiyang Wang, Xiaoci Rong, Qiang Huang and Qing Lan

    Citation: BMC Cancer 2019 19:1240

    Content type: Research article

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  22. Colorectal cancer (CRC) is still a leading cause of death worldwide. Recent studies have pointed to an important role of microRNAs in carcinogenesis. Several microRNAs are described as aberrantly expressed in ...

    Authors: Danuta Sastre, João Baiochi, Ildercilio Mota de Souza Lima, Felipe Canto de Souza, Amanda Cristina Corveloni, Carolina Hassib Thomé, Vitor Marcel Faça, Josiane Lilian dos Santos Schiavinato, Dimas Tadeu Covas and Rodrigo Alexandre Panepucci

    Citation: BMC Cancer 2019 19:1239

    Content type: Research article

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  23. The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellu...

    Authors: Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten and Smrati Bhadauria

    Citation: BMC Cancer 2019 19:1236

    Content type: Research article

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  24. Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have es...

    Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An

    Citation: BMC Cancer 2019 19:1224

    Content type: Research article

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  25. Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invas...

    Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle and Claire M. Wells

    Citation: BMC Cancer 2019 19:1214

    Content type: Research article

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  26. Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and ot...

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:1211

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2019 19:1255

  27. Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression. However...

    Authors: Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning and Qingan Jia

    Citation: BMC Cancer 2019 19:1192

    Content type: Research article

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  28. The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...

    Authors: Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1183

    Content type: Research article

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  29. While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Authors: Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm and Claudia R. Ball

    Citation: BMC Cancer 2019 19:1181

    Content type: Research article

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  30. Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis i...

    Authors: Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi and Mingang Hao

    Citation: BMC Cancer 2019 19:1180

    Content type: Research article

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  31. Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one ...

    Authors: Wilson Eduardo Furlan Matos Alves, Murilo Bonatelli, Rozany Dufloth, Lígia Maria Kerr, Guilherme Freire Angotti Carrara, Ricardo Filipe Alves da Costa, Cristovam Scapulatempo-Neto, Daniel Tiezzi, René Aloísio da Costa Vieira and Céline Pinheiro

    Citation: BMC Cancer 2019 19:1173

    Content type: Research article

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  32. Luminal B cancers show much worse outcomes compared to luminal A. This present study aims to screen key lncRNAs and mRNAs correlated with luminal-B breast cancer.

    Authors: Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei and Ying-Ying Liu

    Citation: BMC Cancer 2019 19:1171

    Content type: Research article

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  33. Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not...

    Authors: Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui and Yongjun Mao

    Citation: BMC Cancer 2019 19:1160

    Content type: Research article

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  34. Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a t...

    Authors: Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu and Dingqun Bai

    Citation: BMC Cancer 2019 19:1159

    Content type: Research article

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  35. Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TO...

    Authors: Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen and Irina Gromova

    Citation: BMC Cancer 2019 19:1158

    Content type: Research article

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  36. Chronic stress is well known to promote tumor progression, however, little is known whether chronic stress-mediated regulation of osteoblasts contributes to the migration and invasion of metastatic cancer cells.

    Authors: Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu and Fan Deng

    Citation: BMC Cancer 2019 19:1142

    Content type: Research article

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  37. Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

    Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2019 19:1137

    Content type: Research article

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  38. Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4), which fail to differentiate to pre-spermatogonia (POU...

    Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell

    Citation: BMC Cancer 2019 19:1124

    Content type: Research article

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  39. Osteosarcoma (OS) is a malignancy of the bone that has no clearly identified prognostic factors for diagnosis. In this study, we evaluated the regulatory role of long non-coding RNA (lncRNA) ANCR on the migrat...

    Authors: Bo Liu, Hongyan Zhao, Lili Zhang and Xuefeng Shi

    Citation: BMC Cancer 2019 19:1112

    Content type: Research article

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  40. Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often...

    Authors: Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri and Eric W.-F. Lam

    Citation: BMC Cancer 2019 19:1106

    Content type: Research article

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  41. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu

    Citation: BMC Cancer 2019 19:1094

    Content type: Research article

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  42. Conflicting results have been reported on the influence of carbohydrates in breast cancer.

    Authors: Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1076

    Content type: Research article

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  43. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen

    Citation: BMC Cancer 2019 19:1075

    Content type: Research article

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  44. DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional g...

    Authors: Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi and Yueying Wang

    Citation: BMC Cancer 2019 19:1072

    Content type: Research article

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