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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms b...

    Authors: Jing Guo, Kiyotoshi Satoh, Sho Tabata, Masaru Mori, Masaru Tomita and Tomoyoshi Soga

    Citation: BMC Cancer 2021 21:174

    Content type: Research article

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  2. Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island. Human and animal studies have shown that colib...

    Authors: Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt and Manuela M. Santos

    Citation: BMC Cancer 2021 21:172

    Content type: Research article

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  3. Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the mo...

    Authors: Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang and Jinquan Cui

    Citation: BMC Cancer 2021 21:163

    Content type: Research article

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  4. Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior...

    Authors: Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata and Kiyoko Kato

    Citation: BMC Cancer 2021 21:156

    Content type: Research article

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  5. p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC). Extracel...

    Authors: Eid S. Alshammari, Amjad A. Aljagthmi, Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia and Weiwen Long

    Citation: BMC Cancer 2021 21:155

    Content type: Research article

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  6. Cholangiocarcinoma is a common malignant tumor of digestive system. LncRNA metallothionein 1 J, pseudogene (MT1JP) has been reported to play tumor-suppressing roles in multiple cancers. However, its effect on ...

    Authors: Wei Zhao, Jing Zhao, Xiao Guo, Yujie Feng, Bingyuan Zhang and Lantian Tian

    Citation: BMC Cancer 2021 21:142

    Content type: Research article

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  7. Prostate cancers frequently metastasize to bone, where the best microenvironment for distant colonization is provided. Since osteotropic metastasis of prostate cancer is a critical determinant of patients’ sur...

    Authors: Bongjun Kim, Suhan Jung, Haemin Kim, Jun-Oh Kwon, Min-Kyoung Song, Min Kyung Kim, Hyung Joon Kim and Hong-Hee Kim

    Citation: BMC Cancer 2021 21:137

    Content type: Research article

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  8. The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy.

    Authors: Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley and Peter R. Shepherd

    Citation: BMC Cancer 2021 21:136

    Content type: Research article

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  9. Prostate cancer is one of the most common malignant cancers with the second highest global rate of mortality in men. During the early stages of disease progression, tumour growth is local and androgen-dependen...

    Authors: Kristen A. Marcellus, Tara E. Crawford Parks, Shekoufeh Almasi and Bernard J. Jasmin

    Citation: BMC Cancer 2021 21:120

    Content type: Research article

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  10. Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin.

    Authors: Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer and Virna D. Leaner

    Citation: BMC Cancer 2021 21:106

    Content type: Research article

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  11. Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor ...

    Authors: Atene Ito, Shunsuke Kagawa, Shuichi Sakamoto, Kazuya Kuwada, Hiroki Kajioka, Masashi Yoshimoto, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa and Toshiyoshi Fujiwara

    Citation: BMC Cancer 2021 21:102

    Content type: Research article

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  12. Long intergenic non-coding RNAs (lincRNAs) are capable of regulating several tumours, while competitive endogenous RNA (ceRNA) networks are of great significance in revealing the biological mechanism of tumour...

    Authors: Guangdong Liu, Danian Liu, Jingjing Huang, Jianxin Li, Chuang Wang, Guangyao Liu, Shiqiang Ge and Haidong Gong

    Citation: BMC Cancer 2021 21:98

    Content type: Research article

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  13. Recent years, survival rates of human with high-risk acute myeloid leukaemia (AML) have not raised substantially. This research aimed to investigate the role of 4′-O-Methylbroussochalcone B, for the treatment ...

    Authors: Ziying Liu, Changshui Wang, Yali Wang, Lei Wang, Yueyuan Zhang and Genquan Yan

    Citation: BMC Cancer 2021 21:91

    Content type: Research article

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  14. Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to ...

    Authors: Jonathan Guihurt Santiago, Neikelyn Burgos-Tirado, Daniella Dorta Lafontaine, José C. Mendoza Sierra, Roberto Herrera Camacho, Clara M. Vecchini Rodríguez, Vanessa Morales-Tirado and Jacqueline Flores-Otero

    Citation: BMC Cancer 2021 21:53

    Content type: Research article

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  15. Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r...

    Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida

    Citation: BMC Cancer 2021 21:48

    Content type: Research article

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  16. lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has b...

    Authors: Gwan Woo Ku, Yujin Kang, Seong-Lan Yu, Joonghoon Park, Sejin Park, In Beom Jeong, Min Woong Kang, Ji Woong Son and Jaeku Kang

    Citation: BMC Cancer 2021 21:44

    Content type: Research article

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  17. Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG)...

    Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu and He Huang

    Citation: BMC Cancer 2021 21:36

    Content type: Research article

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  18. Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extr...

    Authors: Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang and Zhi-Hui Deng

    Citation: BMC Cancer 2021 21:33

    Content type: Research article

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  19. Aberrant expression of P-cadherin has been reported in various cancers, and has been attracting attention as a target for cancer treatment. Ovarian cancer, the leading cause of death among gynecologic malignan...

    Authors: Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku and Hiroshi Fujiwara

    Citation: BMC Cancer 2021 21:32

    Content type: Research article

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  20. The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth ...

    Authors: Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang and Ming Shi

    Citation: BMC Cancer 2021 21:24

    Content type: Research article

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  21. MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aim...

    Authors: Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia and Hong Zhang

    Citation: BMC Cancer 2021 21:2

    Content type: Research article

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  22. Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vasc...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:1215

    Content type: Research article

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  23. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer and John R. Henley

    Citation: BMC Cancer 2020 20:1213

    Content type: Research article

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  24. The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. ...

    Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma and P. M. A. Sloot

    Citation: BMC Cancer 2020 20:1201

    Content type: Research article

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  25. Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggests that targeting circular RNAs (circRNAs) is an effective strategy to increase cisplatin-...

    Authors: Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang and Xiaojiang Sun

    Citation: BMC Cancer 2020 20:1190

    Content type: Research article

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  26. Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, epidermal growth factor recep...

    Authors: Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu and Jun Chen

    Citation: BMC Cancer 2020 20:1189

    Content type: Research article

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  27. Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. H...

    Authors: Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom and Jung-Ae Kim

    Citation: BMC Cancer 2020 20:1180

    Content type: Research article

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  28. Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    Authors: A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider and C. Gorzelanny

    Citation: BMC Cancer 2020 20:1178

    Content type: Research article

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  29. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

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  30. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

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  31. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang

    Citation: BMC Cancer 2020 20:1152

    Content type: Research article

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  32. All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated i...

    Authors: Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov and Dora Visnjic

    Citation: BMC Cancer 2020 20:1090

    Content type: Research article

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  33. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson

    Citation: BMC Cancer 2020 20:1085

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1196

  34. Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide ...

    Authors: Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez and Susana del Toro-Arreola

    Citation: BMC Cancer 2020 20:1083

    Content type: Research article

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  35. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to...

    Authors: Alexander Ring, Pushpinder Kaur and Julie E. Lang

    Citation: BMC Cancer 2020 20:1076

    Content type: Research article

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  36. Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. How...

    Authors: Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He and Chengfeng Wang

    Citation: BMC Cancer 2020 20:1065

    Content type: Research article

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  37. Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechan...

    Authors: Tao Na, Kehua Zhang and Bao-Zhu Yuan

    Citation: BMC Cancer 2020 20:1064

    Content type: Research article

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  38. This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and p...

    Authors: Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang and Xiaoping Chen

    Citation: BMC Cancer 2020 20:1047

    Content type: Research article

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  39. Breast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The ...

    Authors: Changran Wei and Xiangqi Li

    Citation: BMC Cancer 2020 20:1042

    Content type: Research article

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  40. Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are inco...

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber

    Citation: BMC Cancer 2020 20:1039

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1127

  41. Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elu...

    Authors: Jianbing Liu, Yunfeng Li, Xihua Chen, Xiangbo Xu, Haoqi Zhao, Shufang Wang, Jianqing Hao, Bin He, Shuyan Liu and Jiedong Wang

    Citation: BMC Cancer 2020 20:1029

    Content type: Research article

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  42. Prostate cancer (PCa) is one of the most common types of cancer in men. In the course of the development and progression of this disease, abnormal expression of miR-203 is usually accompanied. However, its rol...

    Authors: Yang Meng, Xiaoyan Hu, Shasha Li, Xinyi Zeng, Lei Qiu, Mingtian Wei, Ziqing Wang and Junhong Han

    Citation: BMC Cancer 2020 20:1028

    Content type: Research article

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  43. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo

    Citation: BMC Cancer 2020 20:1019

    Content type: Research article

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  44. Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be us...

    Authors: Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh

    Citation: BMC Cancer 2020 20:1016

    Content type: Technical advance

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