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BMC Cancer

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited du...

    Authors: Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya and Mototsugu Oya

    Citation: BMC Cancer 2018 18:113

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  2. Content type: Technical advance

    The poor prognosis for glioblastoma patients is caused by the diffuse infiltrative growth pattern of the tumor. Therefore, the molecular and cellular processes underlying cell migration continue to be a major ...

    Authors: Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel and Heike Peterziel

    Citation: BMC Cancer 2018 18:103

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  3. Content type: Research article

    In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the cr...

    Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati and Sushanta K. Banerjee

    Citation: BMC Cancer 2018 18:99

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  4. Content type: Research article

    FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative rol...

    Authors: Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário and Humberto Miguel Garay-Malpartida

    Citation: BMC Cancer 2018 18:90

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  5. Content type: Research article

    One of the major challenges in soft tissue sarcomas is to identify factors that predict metastasis. AZGP1 is a potential biomarker of cancer progression, but its value in soft tissue sarcomas remains unknown. ...

    Authors: Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li and Jiafu Ji

    Citation: BMC Cancer 2018 18:89

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  6. Content type: Research article

    Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial–mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a i...

    Authors: San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:74

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  7. Content type: Research article

    RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not be...

    Authors: Jeffrey J. Heard, Ivy Phung, Mark I. Potes and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2018 18:69

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  8. Content type: Research article

    The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression...

    Authors: Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest and Deborah Bell-Pedersen

    Citation: BMC Cancer 2018 18:43

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  9. Content type: Research article

    Around the world, cervical cancer is the fourth most common cancer among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers and therapeutic approaches, resp...

    Authors: Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu and Qing H. Meng

    Citation: BMC Cancer 2018 18:61

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  10. Content type: Research article

    Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatmen...

    Authors: Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram and Gopal C. Kundu

    Citation: BMC Cancer 2018 18:52

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  11. Content type: Research article

    Moesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through transductional signals sent to actin filaments by glycoproteins, such as podopla...

    Authors: Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski and Denise Tostes Oliveira

    Citation: BMC Cancer 2018 18:53

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  12. Content type: Research article

    Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex. The aim of this study was t...

    Authors: Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi and Mounir Trimeche

    Citation: BMC Cancer 2018 18:49

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  13. Content type: Research article

    Exosomes, small-membrane vesicles, are secreted by cells and include several types of proteins and nucleic acids. Exosomes transfer cellular information derived from donor cells and are involved in various phy...

    Authors: Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami and Yoshiyuki Rikitake

    Citation: BMC Cancer 2018 18:47

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  14. Content type: Research article

    Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activati...

    Authors: Haiyan Song and Yuxiang Zhang

    Citation: BMC Cancer 2018 18:36

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  15. Content type: Research article

    Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to ...

    Authors: Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li and Yang-Sook Chun

    Citation: BMC Cancer 2018 18:30

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  16. Content type: Research article

    The Grainyhead-like (GRHL) transcription factors have been linked to many different types of cancer. However, no previous study has attempted to investigate potential correlations in expression of different GRHL ...

    Authors: Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski and Tomasz Wilanowski

    Citation: BMC Cancer 2018 18:23

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  17. Content type: Research article

    Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B parti...

    Authors: Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang

    Citation: BMC Cancer 2018 18:27

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