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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER), cytokeratin 5/6 positivity and basal-like features of breast c...

    Authors: Nina Gran Egeland, Kristin Jonsdottir, Miriam Ragle Aure, Kristine Sahlberg, Vessela N. Kristensen, Deirdre Cronin-Fenton, Ivar Skaland, Einar Gudlaugsson, Jan P. A. Baak and Emiel A. M. Janssen

    Citation: BMC Cancer 2020 20:377

    Content type: Research article

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  2. The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast ca...

    Authors: So-Hyun Yoon, Hoe Suk Kim, Ryong Nam Kim, So-Youn Jung, Bok Sil Hong, Eun Ji Kang, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh and Wonshik Han

    Citation: BMC Cancer 2020 20:375

    Content type: Research article

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  3. The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet i...

    Authors: Shika Hanif Malgundkar, Ikram Burney, Mansour Al Moundhri, Moza Al Kalbani, Ritu Lakhtakia, Aikou Okamoto and Yahya Tamimi

    Citation: BMC Cancer 2020 20:374

    Content type: Research article

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  4. Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets H...

    Authors: Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed, Tessa Davis, Thomas E. Yankeelov and Anna G. Sorace

    Citation: BMC Cancer 2020 20:359

    Content type: Research article

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  5. Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathw...

    Authors: K. Harpelunde Poulsen, J. E. Nielsen, B. Grønkær Toft, U. N. Joensen, L. J. Rasmussen, M. Blomberg Jensen, R. T. Mitchell, A. Juul, E. Rajpert-De Meyts and A. Jørgensen

    Citation: BMC Cancer 2020 20:349

    Content type: Research article

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  6. The enrichment of cancer stem cell-like cells (CSCs) has been considered to be responsible for tumor progression after an initial response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ...

    Authors: Wenxiu Yao, Liyang Wang, Huan Huang, Xin Li, Pinjia Wang, Kun Mi, Jia Cheng, Huifen Liu, Cuirong Gu, Lingxiao Huang and Jianming Huang

    Citation: BMC Cancer 2020 20:315

    Content type: Research article

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  7. Persistent infection with high-risk Human Papillomavirus (HPVs) is associated with the development of cervical cancer. The transforming capacity of these viruses relies on the cooperative action of the E6 and ...

    Authors: María Paula Dizanzo, Federico Marziali, Clarisse Brunet Avalos, Marina Bugnon Valdano, Santiago Leiva, Ana Laura Cavatorta and Daniela Gardiol

    Citation: BMC Cancer 2020 20:293

    Content type: Research article

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  8. Solute Carrier Family 6 Member 1 (SLC6A1) has been identified as a cancer-promoting gene in various human cancers, such as clear cell renal cell carcinoma and ovarian cancer. However, its roles in prostate can...

    Authors: Chaojiang Chen, Zhiduan Cai, Yangjia Zhuo, Ming Xi, Zhuoyuan Lin, Funeng Jiang, Zezhen Liu, Yueping Wan, Yu Zheng, Jianxin Li, Xing Zhou, Jianguo Zhu and Weide Zhong

    Citation: BMC Cancer 2020 20:289

    Content type: Research article

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  9. Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for the majority of the skin-cancer-related deaths. Despite great development and evolution have been made in surgery, ra...

    Authors: Fei Liu, Lanting Hu, Yi Pei, Ke Zheng, Wei Wang, Shenglong Li, Enduo Qiu, Guanning Shang, Jiaming Zhang and Xiaojing Zhang

    Citation: BMC Cancer 2020 20:258

    Content type: Research article

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  10. This study was designed to investigate the clinicopathologic features of pulmonary blastomatoid carcinosarcoma and explore the genomic profiles of epithelial and mesenchymal components in this tumor.

    Authors: Jikai Zhao, Chan Xiang, Ruiying Zhao, Ping Guo, Jingjing Zheng, Han Han-Zhang, Keke Yu, Jie Zhang and Yuchen Han

    Citation: BMC Cancer 2020 20:248

    Content type: Research article

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  11. Treatment resistance is a major clinical challenge of diffuse large B-cell lymphoma (DLBCL) where approximately 40% of the patients have refractory disease or relapse. Since DLBCL is characterized by great cli...

    Authors: Hanne Due, Rasmus Froberg Brøndum, Ken H. Young, Martin Bøgsted and Karen Dybkær

    Citation: BMC Cancer 2020 20:237

    Content type: Research article

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  12. Colorectal cancer (CRC) is the most common cancer and a leading cause of death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and development in CRC. Elastin (ELN) is a component of ECM p...

    Authors: Jinzhi Li, Xiaoyue Xu, Yanyan Jiang, Nicole G. Hansbro, Philip M. Hansbro, Jincheng Xu and Gang Liu

    Citation: BMC Cancer 2020 20:217

    Content type: Research article

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  13. Na+/H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety of intracellular signal pathways. NHERF1 was able to enhance the effects of chemo-drugs i...

    Authors: Fenglian Yang, Mu Hu, Siyuan Chang, Jing Huang, Yang Si, Jinghui Wang, Shan Cheng and Wen G. Jiang

    Citation: BMC Cancer 2020 20:202

    Content type: Research article

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  14. The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative brea...

    Authors: Guoxuan Gao, Zihan Wang, Xiang Qu and Zhongtao Zhang

    Citation: BMC Cancer 2020 20:179

    Content type: Research article

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  15. Aberrant JAK/STAT activation has been detected in many types of human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to direct transcriptional regulation of target genes by phosp...

    Authors: Pranabananda Dutta, Lin Zhang, Huijun Zhang, Qin Peng, Phillippe R. Montgrain, Yingxiao Wang, Yuanlin Song, Jinghong Li and Willis X. Li

    Citation: BMC Cancer 2020 20:145

    Content type: Research article

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  16. Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly an...

    Authors: Tadashi Sasagawa, Atsushi Jinno-Oue, Takeshi Nagamatsu, Kazuki Morita, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Tomoyuki Fujii and Masabumi Shibuya

    Citation: BMC Cancer 2020 20:112

    Content type: Research article

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  17. TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pa...

    Authors: Lixian Oh, Pierre Hainaut, Sandrine Blanchet and Hany Ariffin

    Citation: BMC Cancer 2020 20:110

    Content type: Research article

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  18. Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral sq...

    Authors: Deyu Liu, Xinchun Jian, Pu Xu, Rong Zhu and Yuan Wang

    Citation: BMC Cancer 2020 20:107

    Content type: Research article

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  19. Overexpression of FAT1 gene and its oncogenic effects have been reported in several cancers. Previously, we have documented upregulation of FAT1 gene in glioblastoma (GBM) tumors which was found to increase th...

    Authors: Chitrangda Srivastava, Khushboo Irshad, Yakhlesh Gupta, Chitra Sarkar, Ashish Suri, Parthaprasad Chattopadhyay, Subrata Sinha and Kunzang Chosdol

    Citation: BMC Cancer 2020 20:62

    Content type: Research article

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  20. Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly block HR activity; but most patients even...

    Authors: Afshan F. Nawas, Mohammed Kanchwala, Shayna E. Thomas-Jardin, Haley Dahl, Kelly Daescu, Monica Bautista, Vanessa Anunobi, Ally Wong, Rachel Meade, Ragini Mistry, Nisha Ghatwai, Felix Bayerl, Chao Xing and Nikki A. Delk

    Citation: BMC Cancer 2020 20:46

    Content type: Research article

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  21. Matrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression patter...

    Authors: Shuo Yuan, Li-song Lin, Rui-Huan Gan, Li Huang, Xiao-ting Wu, Yong Zhao, Bo-hua Su, Dali Zheng and You-Guang Lu

    Citation: BMC Cancer 2020 20:33

    Content type: Research article

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  22. Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated...

    Authors: Ji-Gang Zhang, He-Ming Zhou, Xue Zhang, Wan Mu, Juan-Ni Hu, Gao-Lin Liu and Qin Li

    Citation: BMC Cancer 2020 20:32

    Content type: Research article

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  23. Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportun...

    Authors: Xia Liao, Ge Song, Zihan Xu, Yang Bu, Fan Chang, Fengan Jia, Xuelian Xiao, Xuejiao Ren, Mei Zhang and Qingan Jia

    Citation: BMC Cancer 2020 20:31

    Content type: Research article

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  24. Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by...

    Authors: Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu and Ping Ya Zhu

    Citation: BMC Cancer 2020 20:28

    Content type: Research article

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  25. Ewing sarcoma is a malignancy of primitive cells, possibly of mesenchymal origin. It is probable that genetic perturbations other than EWS-FLI1 cooperate with it to produce the tumor. Sequencing studies identifie...

    Authors: Marc El Beaino, Jiayong Liu, Amanda R. Wasylishen, Rasoul Pourebrahim, Agata Migut, Bryan J. Bessellieu, Ke Huang and Patrick P. Lin

    Citation: BMC Cancer 2020 20:3

    Content type: Research article

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  26. Cell adhesion-mediated drug resistance (CAM-DR) is a major clinical problem that prevents successful treatment of multiple myeloma (MM). In particular, the expression levels of integrin β1 and its sub-cellular...

    Authors: Yuejiao Huang, Xianting Huang, Chun Cheng, Xiaohong Xu, Hong Liu, Xiaojing Yang, Li Yao, Zongmei Ding, Jie Tang, Song He and Yuchan Wang

    Citation: BMC Cancer 2019 19:1269

    Content type: Research article

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  27. Invasive mammary carcinomas that spontaneously develop in female cats are associated with high mortality, and resemble the most aggressive human breast cancers, especially triple-negative breast cancer (TNBC)....

    Authors: Elie Dagher, Violette Royer, Paul Buchet, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen

    Citation: BMC Cancer 2019 19:1267

    Content type: Research article

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  28. The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metasta...

    Authors: Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li and Xin Lu

    Citation: BMC Cancer 2019 19:1266

    Content type: Research article

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  29. Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism un...

    Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu and Ziming Dong

    Citation: BMC Cancer 2019 19:1264

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:43

  30. Nimotuzumab (NTZ) is an anti-EGFR monoclonal antibody. However,the effect of targeted drugs combined with induction therapy in locally advanced nasopharyngeal carcinoma remains unclear. The aim of this study i...

    Authors: Ying Lu, Dagui Chen, Jinhui Liang, Jianquan Gao, Zhanxiong Luo, Rensheng Wang, Wenqi Liu, Changjie Huang, Xuejian Ning, Meilian Liu and Haixin Huang

    Citation: BMC Cancer 2019 19:1262

    Content type: Research article

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  31. Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, n...

    Authors: Tugba Kizilboga, Emine Arzu Baskale, Jale Yildiz, Izzet Mehmet Akcay, Ebru Zemheri, Nisan Denizce Can, Can Ozden, Salih Demir, Fikret Ezberci and Gizem Dinler-Doganay

    Citation: BMC Cancer 2019 19:1254

    Content type: Research article

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  32. Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state an...

    Authors: Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, Apurvi R. Patel, David W. Lee, Vijay Gokhale, Laurence H. Hurley, Robert J. Arceci, Cynthia Wetmore and David O. Azorsa

    Citation: BMC Cancer 2019 19:1251

    Content type: Research article

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  33. Cell cycle analysis is important for cancer research. However, available methodologies have drawbacks including limited categorisation and reliance on fixation, staining or transformation. Multispectral analys...

    Authors: Jared M. Campbell, Abbas Habibalahi, Saabah Mahbub, Martin Gosnell, Ayad G. Anwer, Sharon Paton, Stan Gronthos and Ewa Goldys

    Citation: BMC Cancer 2019 19:1242

    Content type: Research article

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  34. Tumor angiogenesis is vital for tumor growth. Recent evidence indicated that bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to tumor sites and exert critical effects on tumor growth through dir...

    Authors: Chao Sun, Xingliang Dai, Dongliang Zhao, Haiyang Wang, Xiaoci Rong, Qiang Huang and Qing Lan

    Citation: BMC Cancer 2019 19:1240

    Content type: Research article

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  35. Colorectal cancer (CRC) is still a leading cause of death worldwide. Recent studies have pointed to an important role of microRNAs in carcinogenesis. Several microRNAs are described as aberrantly expressed in ...

    Authors: Danuta Sastre, João Baiochi, Ildercilio Mota de Souza Lima, Felipe Canto de Souza, Amanda Cristina Corveloni, Carolina Hassib Thomé, Vitor Marcel Faça, Josiane Lilian dos Santos Schiavinato, Dimas Tadeu Covas and Rodrigo Alexandre Panepucci

    Citation: BMC Cancer 2019 19:1239

    Content type: Research article

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  36. The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellu...

    Authors: Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten and Smrati Bhadauria

    Citation: BMC Cancer 2019 19:1236

    Content type: Research article

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  37. Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have es...

    Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An

    Citation: BMC Cancer 2019 19:1224

    Content type: Research article

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  38. Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invas...

    Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle and Claire M. Wells

    Citation: BMC Cancer 2019 19:1214

    Content type: Research article

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  39. Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and ot...

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:1211

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2019 19:1255

  40. Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression. However...

    Authors: Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning and Qingan Jia

    Citation: BMC Cancer 2019 19:1192

    Content type: Research article

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  41. The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...

    Authors: Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1183

    Content type: Research article

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  42. Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis i...

    Authors: Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi and Mingang Hao

    Citation: BMC Cancer 2019 19:1180

    Content type: Research article

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  43. Luminal B cancers show much worse outcomes compared to luminal A. This present study aims to screen key lncRNAs and mRNAs correlated with luminal-B breast cancer.

    Authors: Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei and Ying-Ying Liu

    Citation: BMC Cancer 2019 19:1171

    Content type: Research article

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