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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it i...

    Authors: Yingjie Chen, Zhipeng Yang, Yingxue Wang, Juandong Wang and Chuanxin Wang

    Citation: BMC Cancer 2019 19:651

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  2. Content type: Research article

    DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA plo...

    Authors: Jing Xu, Ruolin Zhu, Lulu Fan, Shangqing Ge, Wei Wei, Xiaoqiu Li, Liangshan Da, Zhenya Jia, Zhiyan Zhao, Jie Ning, Jie Da, Wanren Peng, Kangsheng Gu and Guoping Sun

    Citation: BMC Cancer 2019 19:650

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  3. Content type: Research article

    Recently, long non-coding RNAs (lncRNAs) were considered as important gene expression regulators involving various biological processes. In this study, we explored the role of lncRNAs in the pathogenesis of ra...

    Authors: Ju-Mei Zhou, Rong Liang, Su-Yu Zhu, Hui Wang, Min Zou, Wei-Jing Zou and Shao-Lin Nie

    Citation: BMC Cancer 2019 19:647

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  4. Content type: Research article

    Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...

    Authors: Bin Liu, Xiaojie Huang, Yifang Li, Weiguo Liao, Mingyi Li, Yi Liu, Rongrong He, Du Feng, Runzhi Zhu and Hiroshi Kurihara

    Citation: BMC Cancer 2019 19:645

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  5. Content type: Research article

    Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...

    Authors: Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung and Wei-Qun Ding

    Citation: BMC Cancer 2019 19:642

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  6. Content type: Research article

    Globally, the incidence and mortality rates of gastric cancer are high, and its poor prognosis is closely related to tumor recurrence and metastasis. Therefore, the molecular mechanisms associated with the mig...

    Authors: Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi and Wensheng Qiu

    Citation: BMC Cancer 2019 19:630

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  7. Content type: Research article

    Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with g...

    Authors: Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio and Eugenio Zoni

    Citation: BMC Cancer 2019 19:627

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  8. Content type: Research article

    Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian...

    Authors: Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham and Yong Li

    Citation: BMC Cancer 2019 19:618

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  9. Content type: Research article

    Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need for understanding the molecular mechanism underlying the...

    Authors: Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo and Yiyan Lei

    Citation: BMC Cancer 2019 19:609

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  10. Content type: Research article

    The prognosis of bladder urothelial carcinoma (BLCA) varies greatly among patients, and conventional pathological predictors are generally inadequate and often inaccurate to predict the heterogeneous behavior ...

    Authors: Shuxiong Zeng, Anwei Liu, Lihe Dai, Xiaowen Yu, Zhensheng Zhang, Qiao Xiong, Jun Yang, Fei Liu, Jinshan Xu, Yongping Xue, Yinghao Sun and Chuanliang Xu

    Citation: BMC Cancer 2019 19:604

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  11. Content type: Research article

    NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development is remarkabl...

    Authors: Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx and Frans van Roy

    Citation: BMC Cancer 2019 19:598

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  12. Content type: Research article

    S100A8 and S100A9, two heterodimer-forming members of the S100 family, aberrantly express in a variety of cancer types. However, little is known about the mechanism that regulates S100A8/S100A9 co-expression i...

    Authors: Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He and Xueyuan Xiao

    Citation: BMC Cancer 2019 19:597

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  13. Content type: Research article

    Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate c...

    Authors: Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke and Ivar P. Gladhaug

    Citation: BMC Cancer 2019 19:596

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  14. Content type: Research article

    Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is ...

    Authors: Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao and Xiaofei Chen

    Citation: BMC Cancer 2019 19:585

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  15. Content type: Research article

    In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian c...

    Authors: Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula and Hanna Sallinen

    Citation: BMC Cancer 2019 19:584

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  16. Content type: Research article

    By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms.

    Authors: Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer and Jin-Xiong She

    Citation: BMC Cancer 2019 19:581

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  17. Content type: Research article

    Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remai...

    Authors: Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang and Yueming Sun

    Citation: BMC Cancer 2019 19:576

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  18. Content type: Research article

    Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of c...

    Authors: Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii and Joel A. Malek

    Citation: BMC Cancer 2019 19:565

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  19. Content type: Research article

    Over-expression of cyclooxygenase (COX)-2 promotes breast cancer progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined gene expression and microRNA microarray analyses of e...

    Authors: Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess and Peeyush K. Lala

    Citation: BMC Cancer 2019 19:561

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  20. Content type: Research article

    Sorting Nexin 27 (SNX27) belongs to a family of sortin nexins and possesses a unique binding domain at the C-terminus which mediates protein-protein interaction in intracellular trafficking, membrane remodelin...

    Authors: Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia and Jun Sun

    Citation: BMC Cancer 2019 19:555

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  21. Content type: Research article

    Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). How...

    Authors: Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi and Masamichi Mineshita

    Citation: BMC Cancer 2019 19:546

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  22. Content type: Research article

    The multi-functional BMCC1 (BCH motif-containing molecule at the carboxyl terminal region 1)/PRUNE2 plays a clear role in suppression of tumor activity. In the patients with neuroblastoma (NB), reduced express...

    Authors: Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara and Yasutoshi Tatsumi

    Citation: BMC Cancer 2019 19:542

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  23. Content type: Research article

    Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the mechanisms behind this effect are still unclear. Here we show that aerobic exercise in the form of chronic endurance tra...

    Authors: Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter and John Foley

    Citation: BMC Cancer 2019 19:536

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  24. Content type: Research article

    Homeobox A5 (HOXA5), a member of the HOX family, plays an important role in tumor development and morphogenesis, although opposite effects on tumorigenesis have been observed, depending on the tissue type. In ...

    Authors: Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan and Kensei Nishida

    Citation: BMC Cancer 2019 19:532

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  25. Content type: Research article

    Gastric cancer (GC) is one of the most common human cancers with the high rate of recurrence, metastasis and mortality. Aberrantly expressed microRNAs (miRNAs) are associated with invasion and metastasis in va...

    Authors: Yun Li, Xiaoli Yan, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin and Xu Lin

    Citation: BMC Cancer 2019 19:505

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  26. Content type: Technical advance

    Every biological experiment requires a choice of throughput balanced against physiological relevance. Most primary drug screens neglect critical parameters such as microenvironmental conditions, cell-cell hete...

    Authors: Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu and Erik S. Welf

    Citation: BMC Cancer 2019 19:502

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  27. Content type: Research article

    Cancer cells modify the balance between fatty acid (FA) synthesis and uptake under metabolic stress, induced by oxygen/nutrient deprivation. These modifications were shown to alter the levels of individual tri...

    Authors: Jan Lisec, Carsten Jaeger, Rida Rashid, Rimsha Munir and Nousheen Zaidi

    Citation: BMC Cancer 2019 19:501

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  28. Content type: Research article

    Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, whic...

    Authors: Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu and Yi Zhang

    Citation: BMC Cancer 2019 19:499

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  29. Content type: Research article

    Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known rol...

    Authors: Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson and Stephen P. Ethier

    Citation: BMC Cancer 2019 19:491

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  30. Content type: Research article

    Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expressio...

    Authors: Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro and Rosa Noguera

    Citation: BMC Cancer 2019 19:479

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  31. Content type: Research article

    Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in sev...

    Authors: Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka…

    Citation: BMC Cancer 2019 19:455

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  32. Content type: Research article

    Major vault protein (MVP) is the major component of vault, a eukaryotic organelle involved in multiple cellular processes, and is important in multiple cellular processes and diseases including the drug resist...

    Authors: Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben and Qi Chen

    Citation: BMC Cancer 2019 19:454

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  33. Content type: Research article

    Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We f...

    Authors: Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang and Shiguang Zhao

    Citation: BMC Cancer 2019 19:441

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  34. Content type: Research article

    Palliative pemetrexed-based chemotherapy remains a standard of care treatment for the majority of patients with advanced non-squamous non-small-cell lung cancer (NSCLC). Currently, no predictive markers for pe...

    Authors: S. Visser, J. Hou, K. Bezemer, L. L. de Vogel, J. P. J. J. Hegmans, B. H. Stricker, S. Philipsen and J. G. J. V. Aerts

    Citation: BMC Cancer 2019 19:440

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  35. Content type: Research article

    Dendritic cells (DCs) alter their role from being immunostimulatory to immunosuppressive at advanced stages of tumor progression, but the influence of cancer stem cells (CSCs) and their secreted factors on gen...

    Authors: Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che and Eiichi Gohda

    Citation: BMC Cancer 2019 19:439

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  36. Content type: Research article

    The SK-PN-DW cell line was established in 1979 and is commercially available. Despite the use of this cell line as an in vitro model for functional and therapeutic studies of malignant primitive neuroectoderma...

    Authors: Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu and Feng Wang

    Citation: BMC Cancer 2019 19:412

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  37. Content type: Research article

    CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, th...

    Authors: Isabelle Matte, Perrine Garde-Granger, Paul Bessette and Alain Piché

    Citation: BMC Cancer 2019 19:406

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  38. Content type: Research article

    Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. While these 3D-culture initiatives are already o...

    Authors: Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf and Mathias Hafner

    Citation: BMC Cancer 2019 19:402

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  39. Content type: Research article

    Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor ...

    Authors: Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen and Hongyu Yang

    Citation: BMC Cancer 2019 19:400

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  40. Content type: Research article

    The liver microenvironment plays a key role in the progression and metastasis of hepatocellular carcinoma (HCC). Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastati...

    Authors: Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv and Qingan Jia

    Citation: BMC Cancer 2019 19:395

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  41. Content type: Research article

    Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC...

    Authors: Jin-Yun Li, Wen-Xiao Huang, Xiao Zhou, Jie Chen and Zan Li

    Citation: BMC Cancer 2019 19:391

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  42. Content type: Research article

    Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the ...

    Authors: Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao and Yi Wang

    Citation: BMC Cancer 2019 19:381

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  43. Content type: Research article

    Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...

    Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa

    Citation: BMC Cancer 2019 19:356

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  44. Content type: Research article

    Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit

    Citation: BMC Cancer 2019 19:346

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  45. Content type: Research article

    Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

    Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen

    Citation: BMC Cancer 2019 19:343

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  46. Content type: Research article

    Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the...

    Authors: Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin and Fa-Quan Lin

    Citation: BMC Cancer 2019 19:314

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  47. Content type: Research article

    The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer c...

    Authors: Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori and Martin Buess

    Citation: BMC Cancer 2019 19:312

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