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BMC Cancer

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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    The role of Spalt-like gene-2 (SALL2) in tumorigenesis remains incompletely elucidated. This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.

    Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang

    Citation: BMC Cancer 2017 17:838

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  2. Content type: Research article

    Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and meta...

    Authors: Thao N. D. Pham, Bethany E. Perez White, Huiping Zhao, Fariborz Mortazavi and Debra A. Tonetti

    Citation: BMC Cancer 2017 17:832

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  3. Content type: Research article

    Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells...

    Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi and Aike Li

    Citation: BMC Cancer 2017 17:813

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  4. Content type: Research article

    Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cel...

    Authors: Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar and Mohamed Boudjelal

    Citation: BMC Cancer 2017 17:803

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  5. Content type: Research article

    As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can b...

    Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi and Jianxiang Wang

    Citation: BMC Cancer 2017 17:795

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  6. Content type: Research article

    Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human di...

    Authors: Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, Sebastian Meister, Marieta Toma, Ralf Wiedemuth, Achim Temme, Vladimir Novotny, Manfred P. Wirth, Michael Bachmann, Jens Pietzsch and Susanne Fuessel

    Citation: BMC Cancer 2017 17:790

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  7. Content type: Research article

    Retinoblastoma (Rb), the most common childhood intraocular malignant tumor, is reported to have cancer stem cells (CSCs) similar to other tumors. Our previous investigation in primary tumors identified the sma...

    Authors: Rohini M. Nair, Murali MS. Balla, Imran Khan, Ravi Kiran Reddy Kalathur, Paturu Kondaiah and Geeta K. Vemuganti

    Citation: BMC Cancer 2017 17:779

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  8. Content type: Research article

    The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 wa...

    Authors: Rodrigo Fernandes da Silva, Daniela Maira Cardozo, Gisele Olinto Libanio Rodrigues, Caroline Natânia de Souza-Araújo, Natacha Azussa Migita, Liliana Aparecida Lucci de Angelo Andrade, Sophie Derchain, José Andrés Yunes and Fernando Guimarães

    Citation: BMC Cancer 2017 17:756

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  9. Content type: Research article

    Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigati...

    Authors: Jie Li, Yuanhui Lai, Jieyi Ma, Yue Liu, Jiong Bi, Longjuan Zhang, Lianzhou Chen, Chen Yao, Weiming Lv, Guangqi Chang, Shenming Wang, Mao Ouyang and Wenjian Wang

    Citation: BMC Cancer 2017 17:745

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  10. Content type: Research article

    Altered expression of receptor tyrosine kinases (RTKs) is a major driver of growth and metastasis of cancers. Recepteur d’origine nantais (RON) receptor is a single-pass transmembrane RTK aberrantly expressed ...

    Authors: Soundararajan Krishnaswamy, Abdul Khader Mohammed, Gyanendra Tripathi, Majed S. Alokail and Nasser M. Al-Daghri

    Citation: BMC Cancer 2017 17:738

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  11. Content type: Research article

    Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer ...

    Authors: Tingting Wang, Xufang Chen, Weiwei Qiao, Lijun Kong, Daqing Sun and Zunling Li

    Citation: BMC Cancer 2017 17:719

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  12. Content type: Research article

    Widely established targeted therapies directed at triple negative breast cancer (TNBC) are missing. Classical chemotherapy remains the systemic treatment option. Cisplatin has been tested in TNBC but bears the...

    Authors: Katharina Gohr, Alexandra Hamacher, Laura H. Engelke and Matthias U. Kassack

    Citation: BMC Cancer 2017 17:711

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  13. Content type: Technical advance

    Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set...

    Authors: Henriette L. Lanz, Anthony Saleh, Bart Kramer, Junmei Cairns, Chee Ping Ng, Jia Yu, Sebastiaan J. Trietsch, Thomas Hankemeier, Jos Joore, Paul Vulto, Richard Weinshilboum and Liewei Wang

    Citation: BMC Cancer 2017 17:709

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  14. Content type: Research article

    PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin f...

    Authors: Heli Repo, Natalia Gurvits, Eliisa Löyttyniemi, Marjukka Nykänen, Minnamaija Lintunen, Henna Karra, Samu Kurki, Teijo Kuopio, Kati Talvinen, Mirva Söderström and Pauliina Kronqvist

    Citation: BMC Cancer 2017 17:705

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  15. Content type: Research article

    Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) ...

    Authors: Silje Haukali Omland, Erika Elgstrand Wettergren, Tobias Mourier, Anders Johannes Hansen, Maria Asplund, Sarah Mollerup and Robert Robert

    Citation: BMC Cancer 2017 17:675

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  16. Content type: Research article

    Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a ...

    Authors: Samantha S. Dykes, Joshua J. Steffan and James A. Cardelli

    Citation: BMC Cancer 2017 17:672

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  17. Content type: Research article

    Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated...

    Authors: Shanyang He, Bing Liao, Yalan Deng, Chang Su, Jiuling Tuo, Jun Liu, Shuzhong Yao and Lin Xu

    Citation: BMC Cancer 2017 17:673

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  18. Content type: Research article

    Slug is a transcription factor that activates the epithelial–mesenchymal transition (EMT) process in cancer progression. The aim of our study was to evaluate the clinical significance ...

    Authors: Han Hee Lee, Sung Hak Lee, Kyo Young Song, Sae Jung Na, Joo Hyun O, Jae Myung Park, Eun Sun Jung, Myung-Gyu Choi and Cho Hyun Park

    Citation: BMC Cancer 2017 17:670

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