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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Recent years, survival rates of human with high-risk acute myeloid leukaemia (AML) have not raised substantially. This research aimed to investigate the role of 4′-O-Methylbroussochalcone B, for the treatment ...

    Authors: Ziying Liu, Changshui Wang, Yali Wang, Lei Wang, Yueyuan Zhang and Genquan Yan

    Citation: BMC Cancer 2021 21:91

    Content type: Research article

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  2. Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to ...

    Authors: Jonathan Guihurt Santiago, Neikelyn Burgos-Tirado, Daniella Dorta Lafontaine, José C. Mendoza Sierra, Roberto Herrera Camacho, Clara M. Vecchini Rodríguez, Vanessa Morales-Tirado and Jacqueline Flores-Otero

    Citation: BMC Cancer 2021 21:53

    Content type: Research article

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  3. Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r...

    Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida

    Citation: BMC Cancer 2021 21:48

    Content type: Research article

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  4. lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has b...

    Authors: Gwan Woo Ku, Yujin Kang, Seong-Lan Yu, Joonghoon Park, Sejin Park, In Beom Jeong, Min Woong Kang, Ji Woong Son and Jaeku Kang

    Citation: BMC Cancer 2021 21:44

    Content type: Research article

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  5. Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG)...

    Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu and He Huang

    Citation: BMC Cancer 2021 21:36

    Content type: Research article

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  6. Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extr...

    Authors: Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang and Zhi-Hui Deng

    Citation: BMC Cancer 2021 21:33

    Content type: Research article

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  7. Aberrant expression of P-cadherin has been reported in various cancers, and has been attracting attention as a target for cancer treatment. Ovarian cancer, the leading cause of death among gynecologic malignan...

    Authors: Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku and Hiroshi Fujiwara

    Citation: BMC Cancer 2021 21:32

    Content type: Research article

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  8. The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth ...

    Authors: Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang and Ming Shi

    Citation: BMC Cancer 2021 21:24

    Content type: Research article

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  9. MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aim...

    Authors: Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia and Hong Zhang

    Citation: BMC Cancer 2021 21:2

    Content type: Research article

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  10. Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vasc...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:1215

    Content type: Research article

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  11. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer and John R. Henley

    Citation: BMC Cancer 2020 20:1213

    Content type: Research article

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  12. The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. ...

    Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma and P. M. A. Sloot

    Citation: BMC Cancer 2020 20:1201

    Content type: Research article

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  13. Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggests that targeting circular RNAs (circRNAs) is an effective strategy to increase cisplatin-...

    Authors: Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang and Xiaojiang Sun

    Citation: BMC Cancer 2020 20:1190

    Content type: Research article

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  14. Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, epidermal growth factor recep...

    Authors: Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu and Jun Chen

    Citation: BMC Cancer 2020 20:1189

    Content type: Research article

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  15. Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. H...

    Authors: Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom and Jung-Ae Kim

    Citation: BMC Cancer 2020 20:1180

    Content type: Research article

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  16. Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    Authors: A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider and C. Gorzelanny

    Citation: BMC Cancer 2020 20:1178

    Content type: Research article

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  17. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

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  18. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

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  19. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang

    Citation: BMC Cancer 2020 20:1152

    Content type: Research article

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  20. All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated i...

    Authors: Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov and Dora Visnjic

    Citation: BMC Cancer 2020 20:1090

    Content type: Research article

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  21. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson

    Citation: BMC Cancer 2020 20:1085

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1196

  22. Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide ...

    Authors: Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez and Susana del Toro-Arreola

    Citation: BMC Cancer 2020 20:1083

    Content type: Research article

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  23. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to...

    Authors: Alexander Ring, Pushpinder Kaur and Julie E. Lang

    Citation: BMC Cancer 2020 20:1076

    Content type: Research article

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  24. Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. How...

    Authors: Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He and Chengfeng Wang

    Citation: BMC Cancer 2020 20:1065

    Content type: Research article

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  25. Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechan...

    Authors: Tao Na, Kehua Zhang and Bao-Zhu Yuan

    Citation: BMC Cancer 2020 20:1064

    Content type: Research article

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  26. This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and p...

    Authors: Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang and Xiaoping Chen

    Citation: BMC Cancer 2020 20:1047

    Content type: Research article

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  27. Breast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The ...

    Authors: Changran Wei and Xiangqi Li

    Citation: BMC Cancer 2020 20:1042

    Content type: Research article

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  28. Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are inco...

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber

    Citation: BMC Cancer 2020 20:1039

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1127

  29. Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elu...

    Authors: Jianbing Liu, Yunfeng Li, Xihua Chen, Xiangbo Xu, Haoqi Zhao, Shufang Wang, Jianqing Hao, Bin He, Shuyan Liu and Jiedong Wang

    Citation: BMC Cancer 2020 20:1029

    Content type: Research article

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  30. Prostate cancer (PCa) is one of the most common types of cancer in men. In the course of the development and progression of this disease, abnormal expression of miR-203 is usually accompanied. However, its rol...

    Authors: Yang Meng, Xiaoyan Hu, Shasha Li, Xinyi Zeng, Lei Qiu, Mingtian Wei, Ziqing Wang and Junhong Han

    Citation: BMC Cancer 2020 20:1028

    Content type: Research article

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  31. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo

    Citation: BMC Cancer 2020 20:1019

    Content type: Research article

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  32. Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be us...

    Authors: Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh

    Citation: BMC Cancer 2020 20:1016

    Content type: Technical advance

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  33. Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are c...

    Authors: Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski and Pamela K. Kreeger

    Citation: BMC Cancer 2020 20:1008

    Content type: Research article

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  34. Triple-negative breast cancer (TNBC), in part because of the high metastasis rate, is one of the most prevalent causes of malignancy-related mortality globally. Ubiquitin specific peptidase 6 N-terminal like (...

    Authors: Teng Ma, Huaidong Liu, Yan Liu, Tingting Liu, Hui Wang, Fulu Qiao, Lu Song and Lin Zhang

    Citation: BMC Cancer 2020 20:998

    Content type: Research article

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  35. Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success. The present study examined enhanced anti-apo...

    Authors: Rie Nishi, Hiroko Shigemi, Eiju Negoro, Miyuki Okura, Naoko Hosono and Takahiro Yamauchi

    Citation: BMC Cancer 2020 20:984

    Content type: Research article

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  36. The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determ...

    Authors: Ruth M. Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed

    Citation: BMC Cancer 2020 20:960

    Content type: Research article

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  37. Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel thera...

    Authors: Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li and Liming Zhao

    Citation: BMC Cancer 2020 20:957

    Content type: Research article

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  38. Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast can...

    Authors: Liqin Xia, Feng Li, Jun Qiu, Zhongming Feng, Zihan Xu, Zhengtang Chen and Jianguo Sun

    Citation: BMC Cancer 2020 20:949

    Content type: Research article

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  39. Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor ...

    Authors: Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto and Takuya Moriya

    Citation: BMC Cancer 2020 20:944

    Content type: Research article

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  40. Several studies have demonstrated autophagy was involved in the process of esophageal adenocarcinoma (EAC). The aim of this study was to explore autophagy-related genes (ARGs) correlated with overall survival ...

    Authors: Lei Zhu, Lin Dong, Minghao Feng, Fugui Yang, Wenhao Jiang, Zhiyuan Huang, Fabing Liu, Lingwei Wang, Guangxue Wang and Qinchuan Li

    Citation: BMC Cancer 2020 20:943

    Content type: Research article

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  41. Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of...

    Authors: Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter and Angie Rizzino

    Citation: BMC Cancer 2020 20:941

    Content type: Research article

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  42. Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) ce...

    Authors: Mayumi Fujita, Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa and David A. Wink

    Citation: BMC Cancer 2020 20:929

    Content type: Research article

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  43. Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy...

    Authors: Christian Linke, Markus Wösle and Anja Harder

    Citation: BMC Cancer 2020 20:896

    Content type: Research article

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  44. Increased fucosylation is associated with the chemoresistance phenotype. Meanwhile, fucosyltransferase IV (FUT4) amounts are frequently elevated in lung cancer and may be related to increased chemoresistance.

    Authors: Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong and Jianping Pan

    Citation: BMC Cancer 2020 20:895

    Content type: Research article

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  45. We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mecha...

    Authors: Tingting Yao, Xueling Weng, Yao Yao, Chunxian Huang, Jing Li, Yongpai Peng, Rongchun Lin and Zhongqiu Lin

    Citation: BMC Cancer 2020 20:891

    Content type: Research article

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  46. Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most commo...

    Authors: Divya Bakshi, Ashna Nagpal, Varun Sharma, Indu Sharma, Ruchi Shah, Bhanu Sharma, Amrita Bhat, Sonali Verma, Gh. Rasool Bhat, Deepak Abrol, Rahul Sharma, Samantha Vaishnavi and Rakesh Kumar

    Citation: BMC Cancer 2020 20:861

    Content type: Research article

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