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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and micro...

    Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick and Shulin Li

    Citation: BMC Cancer 2020 20:715

    Content type: Research article

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  2. Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the on...

    Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger and Tilman D. Rachner

    Citation: BMC Cancer 2020 20:703

    Content type: Research article

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  3. Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-...

    Authors: Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao and Zhongliang Zheng

    Citation: BMC Cancer 2020 20:665

    Content type: Research article

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  4. IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, ...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Kenny Misael Calvillo-Rodriguez, Karla Maria Alvarez-Valadez, Ashanti C. Uscanga-Palomeque, Reyes S. Tamez-Guerra and Cristina Rodríguez-Padilla

    Citation: BMC Cancer 2020 20:647

    Content type: Research article

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  5. Breast cancer is one of the most common tumors for women globally. Various miRNAs have been reported to play a crucial role in breast cancer, however the clinical significance of miR-1908-3p in breast cancer r...

    Authors: Youzhi Zhu, Qingshui Wang, Yun Xia, Xiaoxue Xiong, Shuyun Weng, Huizhen Ni, Yan Ye, Ling Chen, Junyu Lin, Yajuan Chen, Haitao Niu, Xiangjin Chen and Yao Lin

    Citation: BMC Cancer 2020 20:644

    Content type: Research article

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  6. The skeleton is the first and most common distant metastatic site for breast cancer. Such metastases complicate cancer management, inducing considerable morbidities and decreasing patient survival. Osteomimeti...

    Authors: L. Absil, F. Journé, D. Larsimont, J. J. Body, L. Tafforeau and D. Nonclercq

    Citation: BMC Cancer 2020 20:640

    Content type: Research article

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  7. Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and...

    Authors: Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou and Tao Ren

    Citation: BMC Cancer 2020 20:634

    Content type: Research article

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  8. Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of o...

    Authors: Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen and Jianjiang Zhao

    Citation: BMC Cancer 2020 20:632

    Content type: Research article

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  9. Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and m...

    Authors: Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam and Claire H. Seedhouse

    Citation: BMC Cancer 2020 20:629

    Content type: Research article

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  10. Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. miR...

    Authors: Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani and Kamran Ghaedi

    Citation: BMC Cancer 2020 20:621

    Content type: Research article

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  11. Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/22...

    Authors: Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu, Yuan Li, Lixiao Zhen, Qian Zhao, Yuefan Guo, Zhaohui Wang, Evelyne Bischof and Zuoren Yu

    Citation: BMC Cancer 2020 20:627

    Content type: Research article

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  12. The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes ...

    Authors: Baili Xia, Lijun Hou, Huan Kang, Wenhui Chang, Yi Liu, Yanli Zhang and Yi Ding

    Citation: BMC Cancer 2020 20:626

    Content type: Research article

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  13. The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...

    Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen

    Citation: BMC Cancer 2020 20:552

    Content type: Research article

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  14. Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as...

    Authors: Marcela García, Maria Belen Palma, Jerome Verine, Santiago Miriuka, Ana M. Inda, Ana L. Errecalde, François Desgrandchamps, Edgardo D. Carosella and Diana Tronik-Le Roux

    Citation: BMC Cancer 2020 20:624

    Content type: Research article

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  15. We assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclop...

    Authors: Ka-Won Kang, Seung-Jin Lee, Ji Hye Kim, Byung-Hyun Lee, Seok Jin Kim, Yong Park and Byung Soo Kim

    Citation: BMC Cancer 2020 20:619

    Content type: Research article

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  16. The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearran...

    Authors: Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski…

    Citation: BMC Cancer 2020 20:612

    Content type: Research article

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  17. A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a ...

    Authors: Pierre-Antoine Bissey, Mona Teng, Jacqueline H. Law, Wei Shi, Jeff P. Bruce, Valentin Petit, Sai W. Tsao, Kenneth W. Yip and Fei-Fei Liu

    Citation: BMC Cancer 2020 20:597

    Content type: Research article

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  18. As a natural alkaloid product isolated from Sophora alopecuroides. L, Sophoridine reshapes gastric cancer immune microenvironment via inhibiting chemotaxis and M2 polarization of tumor-associated macrophages (TAM...

    Authors: Zhiyang Peng, Qing Guan, Jianfei Luo, Wenhong Deng, Jiasheng Liu, Ruicheng Yan and Weixing Wang

    Citation: BMC Cancer 2020 20:582

    Content type: Research article

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  19. The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit ...

    Authors: Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung and Jeong Eun Lee

    Citation: BMC Cancer 2020 20:571

    Content type: Research article

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  20. Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...

    Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek and Ido Wolf

    Citation: BMC Cancer 2020 20:531

    Content type: Research article

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  21. Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparagina...

    Authors: Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka and Julia Starkova

    Citation: BMC Cancer 2020 20:526

    Content type: Research article

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  22. microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported in various human cancers, its role in GC remains obscure.

    Authors: Qin Hui Sun, Zong Xiu Yin, Zhi Li, Shu Bo Tian, Hong Chang Wang, Fang Xu Zhang, Le Ping Li, Chun Ning Zheng and Shuai Kong

    Citation: BMC Cancer 2020 20:522

    Content type: Research article

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  23. Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...

    Authors: Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto, Tomoyuki Miyamoto, Kohta Ebisui, Shinichi Toyooka and Aiji Ohtsuka

    Citation: BMC Cancer 2020 20:521

    Content type: Research article

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  24. Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the proges...

    Authors: Rayna Rosati, Kailey Oppat, Yanfang Huang, Seongho Kim and Manohar Ratnam

    Citation: BMC Cancer 2020 20:512

    Content type: Research article

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  25. The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. ...

    Authors: Joon Won Yoon, Marilyn Lamm, Christopher Chandler, Philip Iannaccone and David Walterhouse

    Citation: BMC Cancer 2020 20:511

    Content type: Research article

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  26. Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitr...

    Authors: K. J. Norberg, X. Liu, C. Fernández Moro, C. Strell, S. Nania, M. Blümel, A. Balboni, B. Bozóky, R. L. Heuchel and J. M. Löhr

    Citation: BMC Cancer 2020 20:475

    Content type: Research article

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  27. Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) on...

    Authors: José Ignácio Gonzalez Solari, Eduardo Filippi-Chiela, Emily Salles Pilar, Vitória Nunes, Esteban Alberto Gonzalez, Fabrício Figueiró, Cristiano Feijó Andrade and Fábio Klamt

    Citation: BMC Cancer 2020 20:474

    Content type: Research article

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  28. Acute myeloid leukemia (AML) is a common hematopoietic malignancy that has a high relapse rate, and the number of regulatory T cells (Tregs) in AML patients is significantly increased. The aim of this study wa...

    Authors: Yuling Wan, Congxiao Zhang, Yingxi Xu, Min Wang, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Yingchang Mi, Ying Wang and Jianxiang Wang

    Citation: BMC Cancer 2020 20:472

    Content type: Research article

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  29. Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...

    Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills…

    Citation: BMC Cancer 2020 20:469

    Content type: Research article

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  30. The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin–dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OV...

    Authors: Hideaki Tsuyoshi, Makoto Orisaka, Yuko Fujita, Meshach Asare-Werehene, Benjamin K. Tsang and Yoshio Yoshida

    Citation: BMC Cancer 2020 20:467

    Content type: Research article

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  31. Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion...

    Authors: Sera Selina Fahlbusch, Silvia Keil, Jörg T. Epplen, Kurt S. Zänker and Thomas Dittmar

    Citation: BMC Cancer 2020 20:446

    Content type: Research article

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  32. α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The late...

    Authors: Christine Moore, Victoria E. Palau, Rashid Mahboob, Janet Lightner, William Stone and Koyamangalath Krishnan

    Citation: BMC Cancer 2020 20:428

    Content type: Research article

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  33. Colon cancer is one of the most commonly diagnosed types of cancer with surgical resection of the tumor being the primary choice of treatment. However, the surgical stress response induced during treatment may...

    Authors: Johanne Davidsen, Stine Bull Jessen, Sara Kehlet Watt, Sylvester Larsen, Katja Dahlgaard, Tove Kirkegaard, Ismail Gögenur and Jesper T. Troelsen

    Citation: BMC Cancer 2020 20:426

    Content type: Research article

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  34. Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor biology. Cell cultures can serve as an excellent p...

    Authors: L. Ehlen, J. Arndt, D. Treue, P. Bischoff, F. N. Loch, E. M. Hahn, K. Kotsch, F. Klauschen, K. Beyer, G. A. Margonis, M. E. Kreis and C. Kamphues

    Citation: BMC Cancer 2020 20:417

    Content type: Research article

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  35. Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER), cytokeratin 5/6 positivity and basal-like features of breast c...

    Authors: Nina Gran Egeland, Kristin Jonsdottir, Miriam Ragle Aure, Kristine Sahlberg, Vessela N. Kristensen, Deirdre Cronin-Fenton, Ivar Skaland, Einar Gudlaugsson, Jan P. A. Baak and Emiel A. M. Janssen

    Citation: BMC Cancer 2020 20:377

    Content type: Research article

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  36. The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast ca...

    Authors: So-Hyun Yoon, Hoe Suk Kim, Ryong Nam Kim, So-Youn Jung, Bok Sil Hong, Eun Ji Kang, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh and Wonshik Han

    Citation: BMC Cancer 2020 20:375

    Content type: Research article

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  37. The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet i...

    Authors: Shika Hanif Malgundkar, Ikram Burney, Mansour Al Moundhri, Moza Al Kalbani, Ritu Lakhtakia, Aikou Okamoto and Yahya Tamimi

    Citation: BMC Cancer 2020 20:374

    Content type: Research article

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  38. Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets H...

    Authors: Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed, Tessa Davis, Thomas E. Yankeelov and Anna G. Sorace

    Citation: BMC Cancer 2020 20:359

    Content type: Research article

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  39. Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathw...

    Authors: K. Harpelunde Poulsen, J. E. Nielsen, B. Grønkær Toft, U. N. Joensen, L. J. Rasmussen, M. Blomberg Jensen, R. T. Mitchell, A. Juul, E. Rajpert-De Meyts and A. Jørgensen

    Citation: BMC Cancer 2020 20:349

    Content type: Research article

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  40. The enrichment of cancer stem cell-like cells (CSCs) has been considered to be responsible for tumor progression after an initial response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ...

    Authors: Wenxiu Yao, Liyang Wang, Huan Huang, Xin Li, Pinjia Wang, Kun Mi, Jia Cheng, Huifen Liu, Cuirong Gu, Lingxiao Huang and Jianming Huang

    Citation: BMC Cancer 2020 20:315

    Content type: Research article

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  41. Persistent infection with high-risk Human Papillomavirus (HPVs) is associated with the development of cervical cancer. The transforming capacity of these viruses relies on the cooperative action of the E6 and ...

    Authors: María Paula Dizanzo, Federico Marziali, Clarisse Brunet Avalos, Marina Bugnon Valdano, Santiago Leiva, Ana Laura Cavatorta and Daniela Gardiol

    Citation: BMC Cancer 2020 20:293

    Content type: Research article

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  42. Solute Carrier Family 6 Member 1 (SLC6A1) has been identified as a cancer-promoting gene in various human cancers, such as clear cell renal cell carcinoma and ovarian cancer. However, its roles in prostate can...

    Authors: Chaojiang Chen, Zhiduan Cai, Yangjia Zhuo, Ming Xi, Zhuoyuan Lin, Funeng Jiang, Zezhen Liu, Yueping Wan, Yu Zheng, Jianxin Li, Xing Zhou, Jianguo Zhu and Weide Zhong

    Citation: BMC Cancer 2020 20:289

    Content type: Research article

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  43. Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for the majority of the skin-cancer-related deaths. Despite great development and evolution have been made in surgery, ra...

    Authors: Fei Liu, Lanting Hu, Yi Pei, Ke Zheng, Wei Wang, Shenglong Li, Enduo Qiu, Guanning Shang, Jiaming Zhang and Xiaojing Zhang

    Citation: BMC Cancer 2020 20:258

    Content type: Research article

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  44. This study was designed to investigate the clinicopathologic features of pulmonary blastomatoid carcinosarcoma and explore the genomic profiles of epithelial and mesenchymal components in this tumor.

    Authors: Jikai Zhao, Chan Xiang, Ruiying Zhao, Ping Guo, Jingjing Zheng, Han Han-Zhang, Keke Yu, Jie Zhang and Yuchen Han

    Citation: BMC Cancer 2020 20:248

    Content type: Research article

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