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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

    Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2019 19:1137

    Content type: Research article

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  2. Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4−), which fail to differentiate to pre-spermatogonia (POU...

    Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell

    Citation: BMC Cancer 2019 19:1124

    Content type: Research article

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  3. Osteosarcoma (OS) is a malignancy of the bone that has no clearly identified prognostic factors for diagnosis. In this study, we evaluated the regulatory role of long non-coding RNA (lncRNA) ANCR on the migrat...

    Authors: Bo Liu, Hongyan Zhao, Lili Zhang and Xuefeng Shi

    Citation: BMC Cancer 2019 19:1112

    Content type: Research article

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  4. Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often...

    Authors: Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri and Eric W.-F. Lam

    Citation: BMC Cancer 2019 19:1106

    Content type: Research article

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  5. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu

    Citation: BMC Cancer 2019 19:1094

    Content type: Research article

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  7. Conflicting results have been reported on the influence of carbohydrates in breast cancer.

    Authors: Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1076

    Content type: Research article

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  8. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen

    Citation: BMC Cancer 2019 19:1075

    Content type: Research article

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  9. DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional g...

    Authors: Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi and Yueying Wang

    Citation: BMC Cancer 2019 19:1072

    Content type: Research article

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  11. Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain succes...

    Authors: Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu and Liping Cao

    Citation: BMC Cancer 2019 19:1053

    Content type: Research article

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  13. The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly fo...

    Authors: Qing Zhang, Jian-He Liu, Jing-Li Liu, Chun-Ting Qi, Lei Yan, Yu Chen and Qiang Yu

    Citation: BMC Cancer 2019 19:1044

    Content type: Research article

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  15. Androgens, through their own receptor, play a protective role on breast tumor development and progression and counterbalance estrogen-dependent growth stimuli which are intimately linked to breast carcinogenesis.

    Authors: Francesca De Amicis, Chiara Chiodo, Catia Morelli, Ivan Casaburi, Stefania Marsico, Rosalinda Bruno, Diego Sisci, Sebastiano Andò and Marilena Lanzino

    Citation: BMC Cancer 2019 19:1038

    Content type: Research article

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  16. SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC.

    Authors: Zusen Wang, Yongxing Li, Shixiong Zhan, Lu Zhang, Shun Zhang, Qian Tang, Miaomiao Li, Zhen Tan, Shiguo Liu and Xiaoming Xing

    Citation: BMC Cancer 2019 19:1037

    Content type: Research article

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  17. β-arrestin-2(Arr2) functions as an anti-apoptotic factor and affects cell proliferation, but its downstream molecular pathway in endometrial carcinoma (EC) is still unclear. This study aimed to investigate the...

    Authors: Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun and Jianliu Wang

    Citation: BMC Cancer 2019 19:1035

    Content type: Research article

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  18. The lack of predictive biomarkers or test systems contributes to high failure rates of systemic therapy in metastasized colorectal carcinoma, accounting for a still unfavorable prognosis. Here, we present an e...

    Authors: Steve Z. Martin, Daniel C. Wagner, Nina Hörner, David Horst, Hauke Lang, Katrin E. Tagscherer and Wilfried Roth

    Citation: BMC Cancer 2019 19:1030

    Content type: Research article

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  19. Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression...

    Authors: Zahra Bolandghamat Pour, Mitra Nourbakhsh, Kazem Mousavizadeh, Zahra Madjd, Seyedeh Sara Ghorbanhosseini, Zohreh Abdolvahabi, Zahra Hesari and Samira Ezzati Mobasser

    Citation: BMC Cancer 2019 19:1027

    Content type: Research article

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  21. The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verify...

    Authors: Elisabetta Bassi, Paola Perucca, Isabella Guardamagna, Ennio Prosperi, Lucia A. Stivala and Ornella Cazzalini

    Citation: BMC Cancer 2019 19:1013

    Content type: Research article

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  22. High level of reactive oxygen species (ROS) has been detected in almost all cancers, which make it become one of the best-characterized phenotypes in cancers. Though ROS plays an important role in tumors, the ...

    Authors: Xiangcheng Qing, Deyao Shi, Xiao Lv, Baichuan Wang, Songfeng Chen and Zengwu Shao

    Citation: BMC Cancer 2019 19:997

    Content type: Research article

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  23. This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis.

    Authors: Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari and Gaurav Kaithwas

    Citation: BMC Cancer 2019 19:996

    Content type: Research article

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  24. Long non coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are not translated into proteins, but regulate the transcription of genes involved in different cellular processes, including c...

    Authors: Maria Barton, Julia Santucci-Pereira, Olivia G. Vaccaro, Theresa Nguyen, Yanrong Su and Jose Russo

    Citation: BMC Cancer 2019 19:994

    Content type: Research article

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  25. The glutathione S-transferases (GSTs) are a superfamily of phase II detoxifying enzymes that inactivates a wide variety of potential carcinogens through glutathione conjugation. Polymorphic changes in the GST gen...

    Authors: Nada Albarakati, Dareen Khayyat, Asharf Dallol, Jaudah Al-Maghrabi and Taoufik Nedjadi

    Citation: BMC Cancer 2019 19:991

    Content type: Research article

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  26. Nicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha...

    Authors: Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang and Yulan Yan

    Citation: BMC Cancer 2019 19:976

    Content type: Research article

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  27. Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis. The lack of in vitro model...

    Authors: P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito and G. P. Tonini

    Citation: BMC Cancer 2019 19:970

    Content type: Research article

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  28. Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the...

    Authors: Lei Li, Shuai Zhang, Hao Li and Haiyan Chou

    Citation: BMC Cancer 2019 19:963

    Content type: Research article

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  29. HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 o...

    Authors: Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho and Chun-Chia Cheng

    Citation: BMC Cancer 2019 19:959

    Content type: Research article

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  30. We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of ...

    Authors: Pascaline Nguemgo Kouam, Günther A. Rezniczek, Irenäus A. Adamietz and Helmut Bühler

    Citation: BMC Cancer 2019 19:958

    Content type: Research article

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  31. Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts. ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and...

    Authors: Ka-Kui Chan, Esther Shuk-Ying Wong, Ivy Tsz-Lo Wong, Claire Ling-Yang Cheung, Oscar Gee-Wan Wong, Hextan Yuen-Sheung Ngan and Annie Nga-Yin Cheung

    Citation: BMC Cancer 2019 19:953

    Content type: Research article

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  32. Transcription-coupled nucleotide excision repair (TC-NER) plays a prominent role in the removal of DNA adducts induced by platinum-based chemotherapy reagents. Cockayne syndrome protein B (CSB), the master sen...

    Authors: Zhenbang Yang, Chunling Liu, Hongjiao Wu, Yuning Xie, Hui Gao and Xuemei Zhang

    Citation: BMC Cancer 2019 19:948

    Content type: Research article

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  33. The Foxo3 gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene. Circ-Foxo3

    Authors: Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian and Zhao-Qun Deng

    Citation: BMC Cancer 2019 19:930

    Content type: Research article

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  34. Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing o...

    Authors: Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske and Ewelina Stoczynska-Fidelus

    Citation: BMC Cancer 2019 19:923

    Content type: Research article

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  35. A number of circular RNAs (circRNAs) have been identified in various cancer including F-box and WD repeat domain containing 7 (FBXW7) circular RNA (circ-FBXW7), which can suppress glioma cell growth. However, ...

    Authors: Haoran Lu, Baofu Yao, Xinyuan Wen and Baoqing Jia

    Citation: BMC Cancer 2019 19:918

    Content type: Research article

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  36. Interaction between cancer cells and fibroblasts mediated by extracellular matrix metalloproteinase inducer (emmprin, CD147) is important in the invasion and proliferation of cancer cells. However, the exact m...

    Authors: M. Aoki, K. Koga, M. Miyazaki, M. Hamasaki, N. Koshikawa, M. Oyama, H. Kozuka-Hata, M. Seiki, B. P. Toole and K. Nabeshima

    Citation: BMC Cancer 2019 19:912

    Content type: Research article

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  37. Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic options. Cell adhesion molecules play pivotal roles in the growth and progre...

    Authors: Qiong Jiang, Qing Xie, Chengliang Hu, Zhai Yang, Peizhi Huang, Huifan Shen, Melitta Schachner and Weijiang Zhao

    Citation: BMC Cancer 2019 19:911

    Content type: Research article

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  38. Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell–cell interactions and bind immunoglobulin-like lectins, causing inf...

    Authors: Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka and Ryuya Yamanaka

    Citation: BMC Cancer 2019 19:910

    Content type: Research article

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  39. Although the leucine zipper-EF-hand-containing transmembrane protein 1 (LETM1) is one of the mitochondrial inner membrane proteins that is involved in cancer prognosis in various tumors, LETM1 as a biomarker f...

    Authors: Longzhen Piao, Zhaoting Yang, Ying Feng, Chengye Zhang, Chunai Cui and Yanhua Xuan

    Citation: BMC Cancer 2019 19:898

    Content type: Research article

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  40. Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) in A549 cell...

    Authors: Liping Li, Songxin Yan, Hua Zhang, Min Zhang, Guofu Huang and Miaojuan Chen

    Citation: BMC Cancer 2019 19:894

    Content type: Research article

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  41. Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal cells. However, their clinical significance and biological functions in breast cancer remain unknown.

    Authors: Bin Xiao, Daxiang Chen, Quan Zhou, Jianfeng Hang, Weiyun Zhang, Zhenzhan Kuang, Zhaohui Sun and Linhai Li

    Citation: BMC Cancer 2019 19:891

    Content type: Research article

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  42. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic ce...

    Authors: Miao Lu, Daniel Hartmann, Rickmer Braren, Aayush Gupta, Baocai Wang, Yang Wang, Carolin Mogler, Zhangjun Cheng, Thomas Wirth, Helmut Friess, Jörg Kleeff, Norbert Hüser and Yoshiaki Sunami

    Citation: BMC Cancer 2019 19:887

    Content type: Research article

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  43. The ubiquitous expressed transcript (UXT) plays a key role in various tumors by regulating transcriptional activity of multiple transcription factors, including androgen receptor (AR). However, the role of UXT...

    Authors: Jin Zeng, Wei Xiang, Yucong Zhang, Chunhua Huang, Ke Chen and Zhiqiang Chen

    Citation: BMC Cancer 2019 19:874

    Content type: Research article

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  44. Metastasis of gastric cancer commonly manifests as a malignant effusion, which presents an alternative cell source for human epidermal growth factor receptor 2 (HER2) status identification. This study aimed to...

    Authors: Hongsik Kim, Seung-Myoung Son, Chang Gok Woo, Ok-Jun Lee, Dae Hoon Kim, Hyo Yung Yun, Jieun Yun, Hee Kyung Kim, Yaewon Yang and Hye Sook Han

    Citation: BMC Cancer 2019 19:834

    Content type: Research article

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  45. Lung cancer is the leading cause of cancer-related deaths worldwide. This study focuses on its most common form, Non-Small-Cell Lung Cancer (NSCLC). No cure exists for advanced NSCLC, and patient prognosis is ...

    Authors: Dania Movia, Despina Bazou and Adriele Prina-Mello

    Citation: BMC Cancer 2019 19:854

    Content type: Research article

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  46. Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is a great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2...

    Authors: Xiaoli Sheng, Yunxian Li, Yixuan Li, Wenlin Liu, Zhongming Lu, Jiandong Zhan, Mimi Xu, Liangsi Chen, Xiaoning Luo, Gang Cai and Siyi Zhang

    Citation: BMC Cancer 2019 19:840

    Content type: Research article

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  47. Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion ...

    Authors: Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma and Utpal Ghosh

    Citation: BMC Cancer 2019 19:829

    Content type: Research article

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  48. Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Rec...

    Authors: Hongbin Li, Xiaodong Jin, Bingtao Liu, Pengcheng Zhang, Weiqiang Chen and Qiang Li

    Citation: BMC Cancer 2019 19:826

    Content type: Research article

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  49. miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA in colorectal cancer (CRC). Although this microRNA is expressed in the early steps of...

    Authors: Lisa Perilli, Sofia Tessarollo, Laura Albertoni, Matteo Curtarello, Anna Pastò, Efrem Brunetti, Matteo Fassan, Massimo Rugge, Stefano Indraccolo, Alberto Amadori, Stefania Bortoluzzi and Paola Zanovello

    Citation: BMC Cancer 2019 19:821

    Content type: Research article

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  50. Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann

    Citation: BMC Cancer 2019 19:812

    Content type: Research article

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