Skip to main content

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

Page 1 of 27

  1. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

    Published on:

  2. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

    Published on:

  3. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang

    Citation: BMC Cancer 2020 20:1152

    Content type: Research article

    Published on:

  4. The objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research. Folate receptor is expressed on a wide variety of cancers and certain immune cells.

    Authors: Cari A. Didion and Walter A. Henne

    Citation: BMC Cancer 2020 20:1109

    Content type: Research article

    Published on:

  5. All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated i...

    Authors: Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov and Dora Visnjic

    Citation: BMC Cancer 2020 20:1090

    Content type: Research article

    Published on:

  6. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...

    Authors: Schiavone Giovanna, Epistolio Samantha, Martin Vittoria, Molinari Francesca, Barizzi Jessica, Mazzucchelli Luca, Frattini Milo and Wannesson Luciano

    Citation: BMC Cancer 2020 20:1085

    Content type: Research article

    Published on:

  7. Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide ...

    Authors: Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez and Susana del Toro-Arreola

    Citation: BMC Cancer 2020 20:1083

    Content type: Research article

    Published on:

  8. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to...

    Authors: Alexander Ring, Pushpinder Kaur and Julie E. Lang

    Citation: BMC Cancer 2020 20:1076

    Content type: Research article

    Published on:

  9. Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. How...

    Authors: Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He and Chengfeng Wang

    Citation: BMC Cancer 2020 20:1065

    Content type: Research article

    Published on:

  10. Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechan...

    Authors: Tao Na, Kehua Zhang and Bao-Zhu Yuan

    Citation: BMC Cancer 2020 20:1064

    Content type: Research article

    Published on:

  11. This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and p...

    Authors: Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang and Xiaoping Chen

    Citation: BMC Cancer 2020 20:1047

    Content type: Research article

    Published on:

  12. Breast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The ...

    Authors: Changran Wei and Xiangqi Li

    Citation: BMC Cancer 2020 20:1042

    Content type: Research article

    Published on:

  13. Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are inco...

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber

    Citation: BMC Cancer 2020 20:1039

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:1127

  14. Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elu...

    Authors: Jianbing Liu, Yunfeng Li, Xihua Chen, Xiangbo Xu, Haoqi Zhao, Shufang Wang, Jianqing Hao, Bin He, Shuyan Liu and Jiedong Wang

    Citation: BMC Cancer 2020 20:1029

    Content type: Research article

    Published on:

  15. Prostate cancer (PCa) is one of the most common types of cancer in men. In the course of the development and progression of this disease, abnormal expression of miR-203 is usually accompanied. However, its rol...

    Authors: Yang Meng, Xiaoyan Hu, Shasha Li, Xinyi Zeng, Lei Qiu, Mingtian Wei, Ziqing Wang and Junhong Han

    Citation: BMC Cancer 2020 20:1028

    Content type: Research article

    Published on:

  16. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo

    Citation: BMC Cancer 2020 20:1019

    Content type: Research article

    Published on:

  17. Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be us...

    Authors: Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh

    Citation: BMC Cancer 2020 20:1016

    Content type: Technical advance

    Published on:

  18. Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are c...

    Authors: Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski and Pamela K. Kreeger

    Citation: BMC Cancer 2020 20:1008

    Content type: Research article

    Published on:

  19. Triple-negative breast cancer (TNBC), in part because of the high metastasis rate, is one of the most prevalent causes of malignancy-related mortality globally. Ubiquitin specific peptidase 6 N-terminal like (...

    Authors: Teng Ma, Huaidong Liu, Yan Liu, Tingting Liu, Hui Wang, Fulu Qiao, Lu Song and Lin Zhang

    Citation: BMC Cancer 2020 20:998

    Content type: Research article

    Published on:

  20. Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success. The present study examined enhanced anti-apo...

    Authors: Rie Nishi, Hiroko Shigemi, Eiju Negoro, Miyuki Okura, Naoko Hosono and Takahiro Yamauchi

    Citation: BMC Cancer 2020 20:984

    Content type: Research article

    Published on:

  21. The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determ...

    Authors: Ruth M. Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed

    Citation: BMC Cancer 2020 20:960

    Content type: Research article

    Published on:

  22. Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel thera...

    Authors: Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li and Liming Zhao

    Citation: BMC Cancer 2020 20:957

    Content type: Research article

    Published on:

  23. Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast can...

    Authors: Liqin Xia, Feng Li, Jun Qiu, Zhongming Feng, Zihan Xu, Zhengtang Chen and Jianguo Sun

    Citation: BMC Cancer 2020 20:949

    Content type: Research article

    Published on:

  24. Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor ...

    Authors: Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto and Takuya Moriya

    Citation: BMC Cancer 2020 20:944

    Content type: Research article

    Published on:

  25. Several studies have demonstrated autophagy was involved in the process of esophageal adenocarcinoma (EAC). The aim of this study was to explore autophagy-related genes (ARGs) correlated with overall survival ...

    Authors: Lei Zhu, Lin Dong, Minghao Feng, Fugui Yang, Wenhao Jiang, Zhiyuan Huang, Fabing Liu, Lingwei Wang, Guangxue Wang and Qinchuan Li

    Citation: BMC Cancer 2020 20:943

    Content type: Research article

    Published on:

  26. Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of...

    Authors: Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter and Angie Rizzino

    Citation: BMC Cancer 2020 20:941

    Content type: Research article

    Published on:

  27. Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) ce...

    Authors: Mayumi Fujita, Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa and David A. Wink

    Citation: BMC Cancer 2020 20:929

    Content type: Research article

    Published on:

  28. Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy...

    Authors: Christian Linke, Markus Wösle and Anja Harder

    Citation: BMC Cancer 2020 20:896

    Content type: Research article

    Published on:

  29. Increased fucosylation is associated with the chemoresistance phenotype. Meanwhile, fucosyltransferase IV (FUT4) amounts are frequently elevated in lung cancer and may be related to increased chemoresistance.

    Authors: Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong and Jianping Pan

    Citation: BMC Cancer 2020 20:895

    Content type: Research article

    Published on:

  30. We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mecha...

    Authors: Tingting Yao, Xueling Weng, Yao Yao, Chunxian Huang, Jing Li, Yongpai Peng, Rongchun Lin and Zhongqiu Lin

    Citation: BMC Cancer 2020 20:891

    Content type: Research article

    Published on:

  31. Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most commo...

    Authors: Divya Bakshi, Ashna Nagpal, Varun Sharma, Indu Sharma, Ruchi Shah, Bhanu Sharma, Amrita Bhat, Sonali Verma, Gh. Rasool Bhat, Deepak Abrol, Rahul Sharma, Samantha Vaishnavi and Rakesh Kumar

    Citation: BMC Cancer 2020 20:861

    Content type: Research article

    Published on:

  32. Excision Repair Cross-Complementation group 6-like (ERCC6L) has been shown to exhibit carcinogenic effect in several malignant tumors. However, the function and molecular mechanism of the ERCC6L in hepatocellu...

    Authors: Han Chen, Hengxiao Wang, Xiqiao Yu, Shuping Zhou, Yueying Zhang, Zhaopeng Wang, Shuhong Huang and Zhaoxia Wang

    Citation: BMC Cancer 2020 20:853

    Content type: Research article

    Published on:

  33. Genomic instability is a hallmark of cancer. The G1 checkpoint allows cells to repair damaged DNA that may lead to genomic instability. The high-risk human papillomavirus (HPV) E7 gene can abrogate the G1 chec...

    Authors: Yunying Zhou, Fengyan Pei, Mingyu Ji, Fang Zhang, Yingshuo Sun, Qianqian Zhao, Xiao Wang, Yatian Hong, Juanjuan Tian, Yunshan Wang and Jason J. Chen

    Citation: BMC Cancer 2020 20:840

    Content type: Research article

    Published on:

  34. N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathologic...

    Authors: Kumar Saurabh, Parag P. Shah, Mark A. Doll, Leah J. Siskind and Levi J. Beverly

    Citation: BMC Cancer 2020 20:824

    Content type: Research article

    Published on:

  35. Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. However, the molecular mechanisms underlying th...

    Authors: Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada and Satoru Sasagawa

    Citation: BMC Cancer 2020 20:802

    Content type: Research article

    Published on:

  36. Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contr...

    Authors: Martin Paré, Cédric Y. Darini, Xi Yao, Bérengère Chignon-Sicard, Samah Rekima, Simon Lachambre, Virginie Virolle, Adriana Aguilar-Mahecha, Mark Basik, Christian Dani and Annie Ladoux

    Citation: BMC Cancer 2020 20:784

    Content type: Research article

    Published on:

  37. Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer c...

    Authors: Xinxin Du, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Yuanguang Meng and Vladimir Isachenko

    Citation: BMC Cancer 2020 20:753

    Content type: Research article

    Published on:

  38. The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an incr...

    Authors: Zaid H. Maayah, Shingo Takahara, Abrar S. Alam, Mourad Ferdaoussi, Gopinath Sutendra, Ayman O. S. El-Kadi, John R. Mackey, Edith Pituskin, D. Ian Paterson and Jason R. B. Dyck

    Citation: BMC Cancer 2020 20:751

    Content type: Research article

    Published on:

  39. Accumulating evidence has revealed the critical role of long non-coding RNAs (lncRNAs) in cellular processes during tumor progression. As documented in cancer-related literatures, LINC00992 expression is assoc...

    Authors: Jianheng Chen, Xiaodong Liu, Kunbin Ke, Jianan Zou, Zhan Gao, Tomonori Habuchi and Xuezhen Yang

    Citation: BMC Cancer 2020 20:749

    Content type: Research article

    Published on:

  40. The deubiquitinating (DUB) enzyme ubiquitin-specific protease 18 (USP18), also known as UBP43, is an ubiquitin-specific protease linked to several human malignancies. However, USP18’s underlying function in hu...

    Authors: Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du and Huifen Chen

    Citation: BMC Cancer 2020 20:741

    Content type: Research article

    Published on:

  41. Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and micro...

    Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick and Shulin Li

    Citation: BMC Cancer 2020 20:715

    Content type: Research article

    Published on:

  42. Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the on...

    Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger and Tilman D. Rachner

    Citation: BMC Cancer 2020 20:703

    Content type: Research article

    Published on:

  43. Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-...

    Authors: Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao and Zhongliang Zheng

    Citation: BMC Cancer 2020 20:665

    Content type: Research article

    Published on:

  44. IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, ...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Kenny Misael Calvillo-Rodriguez, Karla Maria Alvarez-Valadez, Ashanti C. Uscanga-Palomeque, Reyes S. Tamez-Guerra and Cristina Rodríguez-Padilla

    Citation: BMC Cancer 2020 20:647

    Content type: Research article

    Published on:

  45. Breast cancer is one of the most common tumors for women globally. Various miRNAs have been reported to play a crucial role in breast cancer, however the clinical significance of miR-1908-3p in breast cancer r...

    Authors: Youzhi Zhu, Qingshui Wang, Yun Xia, Xiaoxue Xiong, Shuyun Weng, Huizhen Ni, Yan Ye, Ling Chen, Junyu Lin, Yajuan Chen, Haitao Niu, Xiangjin Chen and Yao Lin

    Citation: BMC Cancer 2020 20:644

    Content type: Research article

    Published on:

  46. The skeleton is the first and most common distant metastatic site for breast cancer. Such metastases complicate cancer management, inducing considerable morbidities and decreasing patient survival. Osteomimeti...

    Authors: L. Absil, F. Journé, D. Larsimont, J. J. Body, L. Tafforeau and D. Nonclercq

    Citation: BMC Cancer 2020 20:640

    Content type: Research article

    Published on:

  47. Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and...

    Authors: Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou and Tao Ren

    Citation: BMC Cancer 2020 20:634

    Content type: Research article

    Published on:

  48. Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of o...

    Authors: Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen and Jianjiang Zhao

    Citation: BMC Cancer 2020 20:632

    Content type: Research article

    Published on: