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BMC Cancer

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosar...

    Authors: Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters and Janet M. Shipley

    Citation: BMC Cancer 2018 18:217

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  2. Content type: Research article

    Accumulating evidence suggest that autophagy plays a pivotal role in various anticancer therapies, including photodynamic therapy (PDT), acting as a pro-death or pro-survival mechanism in a context-dependent m...

    Authors: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab and Malgorzata Firczuk

    Citation: BMC Cancer 2018 18:210

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  3. Content type: Research article

    Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-a...

    Authors: Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira and Fabio Dall’Olio

    Citation: BMC Cancer 2018 18:198

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  4. Content type: Research article

    Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in sever...

    Authors: Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand and Uwe Knippschild

    Citation: BMC Cancer 2018 18:140

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  5. Content type: Debate

    The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential f...

    Authors: Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger and Sabine Grösch

    Citation: BMC Cancer 2018 18:153

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  6. Content type: Research article

    Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc...

    Authors: Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira and María Ana Duhagon

    Citation: BMC Cancer 2018 18:127

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  7. Content type: Research article

    Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers. Previous data indicates altered ER expressio...

    Authors: Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan and Syed Yousef Iftikhar

    Citation: BMC Cancer 2018 18:121

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  8. Content type: Research article

    Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited du...

    Authors: Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya and Mototsugu Oya

    Citation: BMC Cancer 2018 18:113

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  9. Content type: Technical advance

    The poor prognosis for glioblastoma patients is caused by the diffuse infiltrative growth pattern of the tumor. Therefore, the molecular and cellular processes underlying cell migration continue to be a major ...

    Authors: Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel and Heike Peterziel

    Citation: BMC Cancer 2018 18:103

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  10. Content type: Research article

    In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the cr...

    Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati and Sushanta K. Banerjee

    Citation: BMC Cancer 2018 18:99

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  11. Content type: Research article

    FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative rol...

    Authors: Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário and Humberto Miguel Garay-Malpartida

    Citation: BMC Cancer 2018 18:90

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  12. Content type: Research article

    One of the major challenges in soft tissue sarcomas is to identify factors that predict metastasis. AZGP1 is a potential biomarker of cancer progression, but its value in soft tissue sarcomas remains unknown. ...

    Authors: Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li and Jiafu Ji

    Citation: BMC Cancer 2018 18:89

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  13. Content type: Research article

    Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial–mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a i...

    Authors: San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:74

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  14. Content type: Research article

    RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not be...

    Authors: Jeffrey J. Heard, Ivy Phung, Mark I. Potes and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2018 18:69

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  15. Content type: Research article

    The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression...

    Authors: Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest and Deborah Bell-Pedersen

    Citation: BMC Cancer 2018 18:43

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  16. Content type: Research article

    Around the world, cervical cancer is the fourth most common cancer among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers and therapeutic approaches, resp...

    Authors: Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu and Qing H. Meng

    Citation: BMC Cancer 2018 18:61

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  17. Content type: Research article

    Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatmen...

    Authors: Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram and Gopal C. Kundu

    Citation: BMC Cancer 2018 18:52

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  18. Content type: Research article

    Moesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through transductional signals sent to actin filaments by glycoproteins, such as podopla...

    Authors: Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski and Denise Tostes Oliveira

    Citation: BMC Cancer 2018 18:53

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