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This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.
Research article
During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representin...
BMC Cancer 2017 17:546
Published on: 15 August 2017
Research article
Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this,...
BMC Cancer 2017 17:542
Published on: 14 August 2017
Research article
Real-time polymerase chain reaction (PCR) has become an increasingly important technique for gene expression profiling because it can provide insights into complex biological and pathological processes and be ...
BMC Cancer 2017 17:545
Published on: 14 August 2017
Research article
Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts p...
BMC Cancer 2017 17:539
Published on: 11 August 2017
Research article
Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alte...
BMC Cancer 2017 17:538
Published on: 10 August 2017
Research article
Insulin-like growth factors and insulin are important factors promoting cancer growth and metastasis. The molecules act through IGF1 (IGF1R) and insulin (InsR) receptors. Rhambodmyosarcomas (RMS) overproduce I...
BMC Cancer 2017 17:532
Published on: 9 August 2017
Case report
The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is parti...
BMC Cancer 2017 17:523
Published on: 5 August 2017
Research article
The biological phenomenon of cell fusion has been associated with cancer progression since it was determined that normal cell × tumor cell fusion-derived hybrid cells could exhibit novel properties, such as en...
BMC Cancer 2017 17:515
Published on: 2 August 2017
Technical advance
The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres. These different...
BMC Cancer 2017 17:516
Published on: 2 August 2017
Research article
Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.
BMC Cancer 2017 17:504
Published on: 26 July 2017
Research article
Germline mutations in genes encoding subunits of succinate dehydrogenase (SDH) are associated with the development of pheochromocytoma (PC) and/or paraganglioma (PGL). As assembly factors have been identified ...
BMC Cancer 2017 17:497
Published on: 24 July 2017
Research article
Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM als...
BMC Cancer 2017 17:492
Published on: 19 July 2017
Research article
Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, main...
BMC Cancer 2017 17:488
Published on: 17 July 2017
Research article
Mounting evidence has showed that Tumor-associated calcium signal transducer 2 (Trop2) is upregulated in various kinds of human cancers and plays important roles in tumorigenesis. However, the expression statu...
BMC Cancer 2017 17:486
Published on: 14 July 2017
Research article
The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple functions in vascular endothelial cell physiology and ...
BMC Cancer 2017 17:485
Published on: 14 July 2017
Research article
Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers, including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation. Additionally, loss ...
BMC Cancer 2017 17:473
Published on: 7 July 2017
Research article
Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour development. We previously documented an interaction betw...
BMC Cancer 2017 17:460
Published on: 1 July 2017
Research article
Dickkopf-4 (DKK4), a member of DKK family, appears to be a divergent protein. It remained multi-biological functions in carcinogenesis. The effect of DKK4 on the ovarian cancer cells remains unclear. This stud...
BMC Cancer 2017 17:455
Published on: 30 June 2017
Research article
Tongue cancer is still one of the leading causes of mortality around the world. Recently, the ubiquitin system has been established as a critical modulator of tumors. In order to find the oral cancer related E...
BMC Cancer 2017 17:452
Published on: 29 June 2017
Research article
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and is an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin is the most commonly ...
BMC Cancer 2017 17:449
Published on: 28 June 2017
