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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy...

    Authors: Christian Linke, Markus Wösle and Anja Harder

    Citation: BMC Cancer 2020 20:896

    Content type: Research article

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  2. Increased fucosylation is associated with the chemoresistance phenotype. Meanwhile, fucosyltransferase IV (FUT4) amounts are frequently elevated in lung cancer and may be related to increased chemoresistance.

    Authors: Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong and Jianping Pan

    Citation: BMC Cancer 2020 20:895

    Content type: Research article

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  3. We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mecha...

    Authors: Tingting Yao, Xueling Weng, Yao Yao, Chunxian Huang, Jing Li, Yongpai Peng, Rongchun Lin and Zhongqiu Lin

    Citation: BMC Cancer 2020 20:891

    Content type: Research article

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  4. Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most commo...

    Authors: Divya Bakshi, Ashna Nagpal, Varun Sharma, Indu Sharma, Ruchi Shah, Bhanu Sharma, Amrita Bhat, Sonali Verma, Gh. Rasool Bhat, Deepak Abrol, Rahul Sharma, Samantha Vaishnavi and Rakesh Kumar

    Citation: BMC Cancer 2020 20:861

    Content type: Research article

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  5. Excision Repair Cross-Complementation group 6-like (ERCC6L) has been shown to exhibit carcinogenic effect in several malignant tumors. However, the function and molecular mechanism of the ERCC6L in hepatocellu...

    Authors: Han Chen, Hengxiao Wang, Xiqiao Yu, Shuping Zhou, Yueying Zhang, Zhaopeng Wang, Shuhong Huang and Zhaoxia Wang

    Citation: BMC Cancer 2020 20:853

    Content type: Research article

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  6. Genomic instability is a hallmark of cancer. The G1 checkpoint allows cells to repair damaged DNA that may lead to genomic instability. The high-risk human papillomavirus (HPV) E7 gene can abrogate the G1 chec...

    Authors: Yunying Zhou, Fengyan Pei, Mingyu Ji, Fang Zhang, Yingshuo Sun, Qianqian Zhao, Xiao Wang, Yatian Hong, Juanjuan Tian, Yunshan Wang and Jason J. Chen

    Citation: BMC Cancer 2020 20:840

    Content type: Research article

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  8. N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathologic...

    Authors: Kumar Saurabh, Parag P. Shah, Mark A. Doll, Leah J. Siskind and Levi J. Beverly

    Citation: BMC Cancer 2020 20:824

    Content type: Research article

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  9. Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. However, the molecular mechanisms underlying th...

    Authors: Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada and Satoru Sasagawa

    Citation: BMC Cancer 2020 20:802

    Content type: Research article

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  10. Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contr...

    Authors: Martin Paré, Cédric Y. Darini, Xi Yao, Bérengère Chignon-Sicard, Samah Rekima, Simon Lachambre, Virginie Virolle, Adriana Aguilar-Mahecha, Mark Basik, Christian Dani and Annie Ladoux

    Citation: BMC Cancer 2020 20:784

    Content type: Research article

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  11. Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer c...

    Authors: Xinxin Du, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Yuanguang Meng and Vladimir Isachenko

    Citation: BMC Cancer 2020 20:753

    Content type: Research article

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  12. The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an incr...

    Authors: Zaid H. Maayah, Shingo Takahara, Abrar S. Alam, Mourad Ferdaoussi, Gopinath Sutendra, Ayman O. S. El-Kadi, John R. Mackey, Edith Pituskin, D. Ian Paterson and Jason R. B. Dyck

    Citation: BMC Cancer 2020 20:751

    Content type: Research article

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  13. Accumulating evidence has revealed the critical role of long non-coding RNAs (lncRNAs) in cellular processes during tumor progression. As documented in cancer-related literatures, LINC00992 expression is assoc...

    Authors: Jianheng Chen, Xiaodong Liu, Kunbin Ke, Jianan Zou, Zhan Gao, Tomonori Habuchi and Xuezhen Yang

    Citation: BMC Cancer 2020 20:749

    Content type: Research article

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  14. The deubiquitinating (DUB) enzyme ubiquitin-specific protease 18 (USP18), also known as UBP43, is an ubiquitin-specific protease linked to several human malignancies. However, USP18’s underlying function in hu...

    Authors: Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du and Huifen Chen

    Citation: BMC Cancer 2020 20:741

    Content type: Research article

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  15. Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and micro...

    Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick and Shulin Li

    Citation: BMC Cancer 2020 20:715

    Content type: Research article

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  16. Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the on...

    Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger and Tilman D. Rachner

    Citation: BMC Cancer 2020 20:703

    Content type: Research article

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  17. Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-...

    Authors: Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao and Zhongliang Zheng

    Citation: BMC Cancer 2020 20:665

    Content type: Research article

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  18. IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, ...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Kenny Misael Calvillo-Rodriguez, Karla Maria Alvarez-Valadez, Ashanti C. Uscanga-Palomeque, Reyes S. Tamez-Guerra and Cristina Rodríguez-Padilla

    Citation: BMC Cancer 2020 20:647

    Content type: Research article

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  19. Breast cancer is one of the most common tumors for women globally. Various miRNAs have been reported to play a crucial role in breast cancer, however the clinical significance of miR-1908-3p in breast cancer r...

    Authors: Youzhi Zhu, Qingshui Wang, Yun Xia, Xiaoxue Xiong, Shuyun Weng, Huizhen Ni, Yan Ye, Ling Chen, Junyu Lin, Yajuan Chen, Haitao Niu, Xiangjin Chen and Yao Lin

    Citation: BMC Cancer 2020 20:644

    Content type: Research article

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  20. The skeleton is the first and most common distant metastatic site for breast cancer. Such metastases complicate cancer management, inducing considerable morbidities and decreasing patient survival. Osteomimeti...

    Authors: L. Absil, F. Journé, D. Larsimont, J. J. Body, L. Tafforeau and D. Nonclercq

    Citation: BMC Cancer 2020 20:640

    Content type: Research article

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  21. Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and...

    Authors: Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou and Tao Ren

    Citation: BMC Cancer 2020 20:634

    Content type: Research article

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  22. Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of o...

    Authors: Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen and Jianjiang Zhao

    Citation: BMC Cancer 2020 20:632

    Content type: Research article

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  23. Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and m...

    Authors: Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam and Claire H. Seedhouse

    Citation: BMC Cancer 2020 20:629

    Content type: Research article

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  24. Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. miR...

    Authors: Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani and Kamran Ghaedi

    Citation: BMC Cancer 2020 20:621

    Content type: Research article

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  25. Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/22...

    Authors: Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu, Yuan Li, Lixiao Zhen, Qian Zhao, Yuefan Guo, Zhaohui Wang, Evelyne Bischof and Zuoren Yu

    Citation: BMC Cancer 2020 20:627

    Content type: Research article

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  26. The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes ...

    Authors: Baili Xia, Lijun Hou, Huan Kang, Wenhui Chang, Yi Liu, Yanli Zhang and Yi Ding

    Citation: BMC Cancer 2020 20:626

    Content type: Research article

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  27. The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...

    Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen

    Citation: BMC Cancer 2020 20:552

    Content type: Research article

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  28. Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as...

    Authors: Marcela García, Maria Belen Palma, Jerome Verine, Santiago Miriuka, Ana M. Inda, Ana L. Errecalde, François Desgrandchamps, Edgardo D. Carosella and Diana Tronik-Le Roux

    Citation: BMC Cancer 2020 20:624

    Content type: Research article

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  29. We assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclop...

    Authors: Ka-Won Kang, Seung-Jin Lee, Ji Hye Kim, Byung-Hyun Lee, Seok Jin Kim, Yong Park and Byung Soo Kim

    Citation: BMC Cancer 2020 20:619

    Content type: Research article

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  30. The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearran...

    Authors: Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski…

    Citation: BMC Cancer 2020 20:612

    Content type: Research article

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  31. A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a ...

    Authors: Pierre-Antoine Bissey, Mona Teng, Jacqueline H. Law, Wei Shi, Jeff P. Bruce, Valentin Petit, Sai W. Tsao, Kenneth W. Yip and Fei-Fei Liu

    Citation: BMC Cancer 2020 20:597

    Content type: Research article

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  32. As a natural alkaloid product isolated from Sophora alopecuroides. L, Sophoridine reshapes gastric cancer immune microenvironment via inhibiting chemotaxis and M2 polarization of tumor-associated macrophages (TAM...

    Authors: Zhiyang Peng, Qing Guan, Jianfei Luo, Wenhong Deng, Jiasheng Liu, Ruicheng Yan and Weixing Wang

    Citation: BMC Cancer 2020 20:582

    Content type: Research article

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  33. The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit ...

    Authors: Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung and Jeong Eun Lee

    Citation: BMC Cancer 2020 20:571

    Content type: Research article

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  34. Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...

    Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek and Ido Wolf

    Citation: BMC Cancer 2020 20:531

    Content type: Research article

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  35. Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparagina...

    Authors: Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka and Julia Starkova

    Citation: BMC Cancer 2020 20:526

    Content type: Research article

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  36. microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported in various human cancers, its role in GC remains obscure.

    Authors: Qin Hui Sun, Zong Xiu Yin, Zhi Li, Shu Bo Tian, Hong Chang Wang, Fang Xu Zhang, Le Ping Li, Chun Ning Zheng and Shuai Kong

    Citation: BMC Cancer 2020 20:522

    Content type: Research article

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  37. Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...

    Authors: Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto, Tomoyuki Miyamoto, Kohta Ebisui, Shinichi Toyooka and Aiji Ohtsuka

    Citation: BMC Cancer 2020 20:521

    Content type: Research article

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  38. Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the proges...

    Authors: Rayna Rosati, Kailey Oppat, Yanfang Huang, Seongho Kim and Manohar Ratnam

    Citation: BMC Cancer 2020 20:512

    Content type: Research article

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  39. The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. ...

    Authors: Joon Won Yoon, Marilyn Lamm, Christopher Chandler, Philip Iannaccone and David Walterhouse

    Citation: BMC Cancer 2020 20:511

    Content type: Research article

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  40. Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitr...

    Authors: K. J. Norberg, X. Liu, C. Fernández Moro, C. Strell, S. Nania, M. Blümel, A. Balboni, B. Bozóky, R. L. Heuchel and J. M. Löhr

    Citation: BMC Cancer 2020 20:475

    Content type: Research article

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  41. Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) on...

    Authors: José Ignácio Gonzalez Solari, Eduardo Filippi-Chiela, Emily Salles Pilar, Vitória Nunes, Esteban Alberto Gonzalez, Fabrício Figueiró, Cristiano Feijó Andrade and Fábio Klamt

    Citation: BMC Cancer 2020 20:474

    Content type: Research article

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  42. Acute myeloid leukemia (AML) is a common hematopoietic malignancy that has a high relapse rate, and the number of regulatory T cells (Tregs) in AML patients is significantly increased. The aim of this study wa...

    Authors: Yuling Wan, Congxiao Zhang, Yingxi Xu, Min Wang, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Yingchang Mi, Ying Wang and Jianxiang Wang

    Citation: BMC Cancer 2020 20:472

    Content type: Research article

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  43. Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...

    Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills…

    Citation: BMC Cancer 2020 20:469

    Content type: Research article

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  44. The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin–dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OV...

    Authors: Hideaki Tsuyoshi, Makoto Orisaka, Yuko Fujita, Meshach Asare-Werehene, Benjamin K. Tsang and Yoshio Yoshida

    Citation: BMC Cancer 2020 20:467

    Content type: Research article

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  45. Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion...

    Authors: Sera Selina Fahlbusch, Silvia Keil, Jörg T. Epplen, Kurt S. Zänker and Thomas Dittmar

    Citation: BMC Cancer 2020 20:446

    Content type: Research article

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  47. α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The late...

    Authors: Christine Moore, Victoria E. Palau, Rashid Mahboob, Janet Lightner, William Stone and Koyamangalath Krishnan

    Citation: BMC Cancer 2020 20:428

    Content type: Research article

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  48. Colon cancer is one of the most commonly diagnosed types of cancer with surgical resection of the tumor being the primary choice of treatment. However, the surgical stress response induced during treatment may...

    Authors: Johanne Davidsen, Stine Bull Jessen, Sara Kehlet Watt, Sylvester Larsen, Katja Dahlgaard, Tove Kirkegaard, Ismail Gögenur and Jesper T. Troelsen

    Citation: BMC Cancer 2020 20:426

    Content type: Research article

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  49. Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor biology. Cell cultures can serve as an excellent p...

    Authors: L. Ehlen, J. Arndt, D. Treue, P. Bischoff, F. N. Loch, E. M. Hahn, K. Kotsch, F. Klauschen, K. Beyer, G. A. Margonis, M. E. Kreis and C. Kamphues

    Citation: BMC Cancer 2020 20:417

    Content type: Research article

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