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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Content type: Research article

    Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells...

    Authors: Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui and Zhuo Chen

    Citation: BMC Cancer 2019 19:247

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  2. Content type: Research article

    Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologi...

    Authors: Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou and Qi Song

    Citation: BMC Cancer 2019 19:240

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  3. Content type: Research article

    Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr

    Citation: BMC Cancer 2019 19:234

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  5. Content type: Research article

    Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. AL...

    Authors: Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng and Claudio Luchini

    Citation: BMC Cancer 2019 19:232

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  6. Content type: Research article

    This study aimed to determine whether the enhancer of the rudimentary homolog (ERH) gene regulates cell migration and invasion in human bladder urothelial carcinoma (BUC) T24 cells and the underlying mechanism.

    Authors: Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han and Conghui Han

    Citation: BMC Cancer 2019 19:225

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  7. Content type: Research article

    Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX...

    Authors: Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao and Kai-qun Ren

    Citation: BMC Cancer 2019 19:224

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  8. Content type: Research article

    Previous studies have demonstrated that β2-microglobulin (β2M) promotes the growth and survival of a variety of cancer cells and has different regulatory effects on the expression of Bcl-2 and HER2 in HER2− breas...

    Authors: Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu and Xiaowen Lian

    Citation: BMC Cancer 2019 19:223

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  9. Content type: Research article

    The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The ...

    Authors: Qi Chen, Yueqin Liu, Xiao-lan Zhu, Fan Feng, Hui Yang and Wenlin Xu

    Citation: BMC Cancer 2019 19:211

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  10. Content type: Research article

    The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomi...

    Authors: Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas and Jaunius Urbonavičius

    Citation: BMC Cancer 2019 19:197

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  11. Content type: Review

    Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based stud...

    Authors: Peter L. Labib, George Goodchild and Stephen P. Pereira

    Citation: BMC Cancer 2019 19:185

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  12. Content type: Research article

    VEGF/VEGFR2 pathway is the central therapeutic target in anti-angiogenic treatment in multiple cancers. However, little work has been carried out concerning the pro-malignancy functions of VEGFR2 that are inde...

    Authors: Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou and Min Jiang

    Citation: BMC Cancer 2019 19:183

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  13. Content type: Research article

    Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following...

    Authors: Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews and Christopher Bradley

    Citation: BMC Cancer 2019 19:179

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  14. Content type: Research article

    Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits osteoclastogenesis. Emerging evidence suggests that ZA has anti-tumor and anti-metastatic properties for breast cancer cells. In a mouse mod...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen and Tsun-Mei Lin

    Citation: BMC Cancer 2019 19:176

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  15. Content type: Research article

    Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) ...

    Authors: Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu and Xipeng Wang

    Citation: BMC Cancer 2019 19:171

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  16. Content type: Research article

    Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utiliz...

    Authors: Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha and Patrick E. Chappell

    Citation: BMC Cancer 2019 19:158

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  17. Content type: Research article

    Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical impor...

    Authors: Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton and Sebastian G. B. Furness

    Citation: BMC Cancer 2019 19:157

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  18. Content type: Research article

    Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells)....

    Authors: Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu

    Citation: BMC Cancer 2019 19:153

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  19. Content type: Research article

    A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...

    Authors: Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim

    Citation: BMC Cancer 2019 19:148

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  20. Content type: Research article

    Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...

    Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc

    Citation: BMC Cancer 2019 19:137

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  21. Content type: Research article

    Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a...

    Authors: Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir

    Citation: BMC Cancer 2019 19:135

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  22. Content type: Research article

    Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The...

    Authors: Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid and Fabian D. Mairinger

    Citation: BMC Cancer 2019 19:108

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  24. Content type: Research article

    In this report we examine candidate pathways perturbed by Compound Kushen Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to alter the gene expression patterns of multiple p...

    Authors: Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang and David L. Adelson

    Citation: BMC Cancer 2019 19:103

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  25. Content type: Research article

    Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and pro...

    Authors: Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma and Jian Lu

    Citation: BMC Cancer 2019 19:94

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  27. Content type: Research article

    Podoplanin (PDPN) is a mucin-type transmembrane glycoprotein specific to the lymphatic system. PDPN expression has been found in various human tumors and is considered to be a marker of cancer. We had previous...

    Authors: Justyna Sikorska, Damian Gaweł, Hanna Domek, Magdalena Rudzińska and Barbara Czarnocka

    Citation: BMC Cancer 2019 19:85

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  29. Content type: Research article

    BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expressi...

    Authors: Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson and Kiven Erique Lukong

    Citation: BMC Cancer 2019 19:78

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  30. Content type: Research article

    Invasive micropapillary carcinoma (IMPC) of the breast is characterized by its unique morphology and frequent nodal metastasis. However, the mechanism for development of this unique subtype has not been clearl...

    Authors: Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi and Takuya Moriya

    Citation: BMC Cancer 2019 19:76

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  31. Content type: Research article

    Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (C...

    Authors: Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda and Olivia Fromigué

    Citation: BMC Cancer 2019 19:62

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  32. Content type: Case report

    Philadelphia (Ph) chromosome results from the reciprocal translocation t(9;22)(q34.1;q11.2) and is diagnostic for chronic myeloid leukemia (CML). However, this translocation is also found in acute lymphoid leu...

    Authors: Monica Piedimonte, Tiziana Ottone, Valentina Alfonso, Antonella Ferrari, Esmeralda Conte, Mariadomenica Divona, Maria Paola Bianchi, Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Alessia Campagna, Laura Cicconi, Giulia Galassi, Sabrina Pelliccia, Annapaola Leporace, Francesco Lo Coco…

    Citation: BMC Cancer 2019 19:50

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  33. Content type: Research article

    The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a p...

    Authors: Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber and Simone Muenst

    Citation: BMC Cancer 2019 19:41

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  37. Content type: Research article

    We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on...

    Authors: Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee and Dae Seog Heo

    Citation: BMC Cancer 2019 19:19

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  38. Content type: Research article

    Gastric cancer (GC) is a common malignant disease worldwide. Aberrant miRNAs expression contributes to malignant cells behaviour, and in preclinical research, miRNA targeting has shown potential for improving ...

    Authors: Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu and Jianlin Ren

    Citation: BMC Cancer 2019 19:14

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  39. Content type: Research article

    Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ap...

    Authors: Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland and Anders Molven

    Citation: BMC Cancer 2019 19:11

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  40. Content type: Research article

    Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estroge...

    Authors: Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park and Eui-Ju Hong

    Citation: BMC Cancer 2019 19:6

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  41. Content type: Research article

    MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Ther...

    Authors: Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang and Xingsheng Yang

    Citation: BMC Cancer 2018 18:1294

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  42. Content type: Research article

    Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear...

    Authors: Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang and Huanzhou Xue

    Citation: BMC Cancer 2018 18:1286

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  43. Content type: Research article

    Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such...

    Authors: Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright and Mark D. Temple

    Citation: BMC Cancer 2018 18:1284

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  44. Content type: Research article

    Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic o...

    Authors: Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi and Rakesh K. Singh

    Citation: BMC Cancer 2018 18:1283

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  45. Content type: Research article

    Breast cancer is the most common malignancy in women affecting one out of eight females throughout their lives. Autotaxin (ATX) is upregulated in breast cancer which results in increased lysophosphatidic acid ...

    Authors: Rafael Schmid, Katharina Wolf, Jan W. Robering, Selina Strauß, Pamela L. Strissel, Reiner Strick, Matthias Rübner, Peter A. Fasching, Raymund E. Horch, Andreas E. Kremer, Anja M. Boos and Annika Weigand

    Citation: BMC Cancer 2018 18:1273

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  46. Content type: Research article

    We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the p...

    Authors: Yi Xu, Xiaoyu Yang, Di Gao, Liu Yang, Keith Miskimins and Steven Y. Qian

    Citation: BMC Cancer 2018 18:1268

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  47. Content type: Research article

    Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration. The aim of this study was to determine the effects of leptin on the antioxidant response in th...

    Authors: Sinda Mahbouli, Jérémie Talvas, Audrey der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson and Adrien Rossary

    Citation: BMC Cancer 2018 18:1264

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  48. Content type: Research article

    Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions. GR...

    Authors: Christopher N. Cultrara, Stephen D. Kozuch, Poornema Ramasundaram, Claudia J. Heller, Sunil Shah, Adah E. Beck, David Sabatino and Jenny Zilberberg

    Citation: BMC Cancer 2018 18:1263

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  49. Content type: Research article

    FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating...

    Authors: Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola and Ratna Chakrabarti

    Citation: BMC Cancer 2018 18:1257

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  50. Content type: Research article

    The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is character...

    Authors: Taoufik Nedjadi, Anthony Evans, Adnan Sheikh, Lawrence Barerra, Suliman Al-Ghamdi, Lucy Oldfield, W. Greenhalf, John P. Neoptolemos and Eithne Costello

    Citation: BMC Cancer 2018 18:1255

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