Skip to main content

Advertisement

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

Page 1 of 24

  1. Content type: Research article

    The Foxo3 gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene. Circ-Foxo3

    Authors: Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian and Zhao-Qun Deng

    Citation: BMC Cancer 2019 19:930

    Published on:

  2. Content type: Research article

    Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing o...

    Authors: Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske and Ewelina Stoczynska-Fidelus

    Citation: BMC Cancer 2019 19:923

    Published on:

  3. Content type: Research article

    A number of circular RNAs (circRNAs) have been identified in various cancer including F-box and WD repeat domain containing 7 (FBXW7) circular RNA (circ-FBXW7), which can suppress glioma cell growth. However, ...

    Authors: Haoran Lu, Baofu Yao, Xinyuan Wen and Baoqing Jia

    Citation: BMC Cancer 2019 19:918

    Published on:

  4. Content type: Research article

    Interaction between cancer cells and fibroblasts mediated by extracellular matrix metalloproteinase inducer (emmprin, CD147) is important in the invasion and proliferation of cancer cells. However, the exact m...

    Authors: M. Aoki, K. Koga, M. Miyazaki, M. Hamasaki, N. Koshikawa, M. Oyama, H. Kozuka-Hata, M. Seiki, B. P. Toole and K. Nabeshima

    Citation: BMC Cancer 2019 19:912

    Published on:

  5. Content type: Research article

    Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic options. Cell adhesion molecules play pivotal roles in the growth and progre...

    Authors: Qiong Jiang, Qing Xie, Chengliang Hu, Zhai Yang, Peizhi Huang, Huifan Shen, Melitta Schachner and Weijiang Zhao

    Citation: BMC Cancer 2019 19:911

    Published on:

  6. Content type: Research article

    Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell–cell interactions and bind immunoglobulin-like lectins, causing inf...

    Authors: Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka and Ryuya Yamanaka

    Citation: BMC Cancer 2019 19:910

    Published on:

  7. Content type: Research article

    Although the leucine zipper-EF-hand-containing transmembrane protein 1 (LETM1) is one of the mitochondrial inner membrane proteins that is involved in cancer prognosis in various tumors, LETM1 as a biomarker f...

    Authors: Longzhen Piao, Zhaoting Yang, Ying Feng, Chengye Zhang, Chunai Cui and Yanhua Xuan

    Citation: BMC Cancer 2019 19:898

    Published on:

  8. Content type: Research article

    Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) in A549 cell...

    Authors: Liping Li, Songxin Yan, Hua Zhang, Min Zhang, Guofu Huang and Miaojuan Chen

    Citation: BMC Cancer 2019 19:894

    Published on:

  9. Content type: Research article

    Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal cells. However, their clinical significance and biological functions in breast cancer remain unknown.

    Authors: Bin Xiao, Daxiang Chen, Quan Zhou, Jianfeng Hang, Weiyun Zhang, Zhenzhan Kuang, Zhaohui Sun and Linhai Li

    Citation: BMC Cancer 2019 19:891

    Published on:

  10. Content type: Research article

    Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic ce...

    Authors: Miao Lu, Daniel Hartmann, Rickmer Braren, Aayush Gupta, Baocai Wang, Yang Wang, Carolin Mogler, Zhangjun Cheng, Thomas Wirth, Helmut Friess, Jörg Kleeff, Norbert Hüser and Yoshiaki Sunami

    Citation: BMC Cancer 2019 19:887

    Published on:

  11. Content type: Research article

    The ubiquitous expressed transcript (UXT) plays a key role in various tumors by regulating transcriptional activity of multiple transcription factors, including androgen receptor (AR). However, the role of UXT...

    Authors: Jin Zeng, Wei Xiang, Yucong Zhang, Chunhua Huang, Ke Chen and Zhiqiang Chen

    Citation: BMC Cancer 2019 19:874

    Published on:

  12. Content type: Research article

    Metastasis of gastric cancer commonly manifests as a malignant effusion, which presents an alternative cell source for human epidermal growth factor receptor 2 (HER2) status identification. This study aimed to...

    Authors: Hongsik Kim, Seung-Myoung Son, Chang Gok Woo, Ok-Jun Lee, Dae Hoon Kim, Hyo Yung Yun, Jieun Yun, Hee Kyung Kim, Yaewon Yang and Hye Sook Han

    Citation: BMC Cancer 2019 19:834

    Published on:

  13. Content type: Research article

    Lung cancer is the leading cause of cancer-related deaths worldwide. This study focuses on its most common form, Non-Small-Cell Lung Cancer (NSCLC). No cure exists for advanced NSCLC, and patient prognosis is ...

    Authors: Dania Movia, Despina Bazou and Adriele Prina-Mello

    Citation: BMC Cancer 2019 19:854

    Published on:

  14. Content type: Research article

    Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is a great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2...

    Authors: Xiaoli Sheng, Yunxian Li, Yixuan Li, Wenlin Liu, Zhongming Lu, Jiandong Zhan, Mimi Xu, Liangsi Chen, Xiaoning Luo, Gang Cai and Siyi Zhang

    Citation: BMC Cancer 2019 19:840

    Published on:

  15. Content type: Research article

    Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion ...

    Authors: Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma and Utpal Ghosh

    Citation: BMC Cancer 2019 19:829

    Published on:

  16. Content type: Research article

    Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Rec...

    Authors: Hongbin Li, Xiaodong Jin, Bingtao Liu, Pengcheng Zhang, Weiqiang Chen and Qiang Li

    Citation: BMC Cancer 2019 19:826

    Published on:

  17. Content type: Research article

    miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA in colorectal cancer (CRC). Although this microRNA is expressed in the early steps of...

    Authors: Lisa Perilli, Sofia Tessarollo, Laura Albertoni, Matteo Curtarello, Anna Pastò, Efrem Brunetti, Matteo Fassan, Massimo Rugge, Stefano Indraccolo, Alberto Amadori, Stefania Bortoluzzi and Paola Zanovello

    Citation: BMC Cancer 2019 19:821

    Published on:

  18. Content type: Research article

    Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann

    Citation: BMC Cancer 2019 19:812

    Published on:

  19. Content type: Research article

    Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of G...

    Authors: Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R. Broaddus, Ji Yeon Ahn, Jeong Mook Lim and Jae-Wook Jeong

    Citation: BMC Cancer 2019 19:810

    Published on:

  20. Content type: Research article

    Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermine...

    Authors: Yin-Hsun Feng, Yu-Chu Su, Shuo-Fu Lin, Pey-Ru Lin, Chao-Liang Wu, Chao-Ling Tung, Chien-Feng Li, Gia-Shing Shieh and Ai-Li Shiau

    Citation: BMC Cancer 2019 19:791

    Published on:

  21. Content type: Research article

    Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curativ...

    Authors: Becky A. S. Bibby, Cecelia S. Miranda, John V. Reynolds, Christopher J. Cawthorne and Stephen G. Maher

    Citation: BMC Cancer 2019 19:784

    Published on:

  22. Content type: Research article

    Lung cancer in young patients is rare and has unique clinicopathological features. However, the molecular features of lung cancer in these patients are unclear. In this study, we aimed to describe the molecula...

    Authors: Zhen Chen, Xiao Teng, Jing Zhang, Ke Huang, Qian Shen, He Cao, Huisong Luo, Yanting Yuan and Xiaodong Teng

    Citation: BMC Cancer 2019 19:777

    Published on:

  23. Content type: Research article

    The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a ...

    Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee and Jeung-Whan Han

    Citation: BMC Cancer 2019 19:773

    Published on:

  24. Content type: Research article

    Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical application...

    Authors: Carla Pereira Gomes, Sandrina Nóbrega-Pereira, Beatriz Domingues-Silva, Kenny Rebelo, Catarina Alves-Vale, Sérgio Pires Marinho, Tânia Carvalho, Sérgio Dias and Bruno Bernardes de Jesus

    Citation: BMC Cancer 2019 19:771

    Published on:

  25. Content type: Research article

    The role of sphere-forming culture in enriching subpopulations with stem-cell properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its value in enriching cancer stem cells (C...

    Authors: Xiao-Lu Ma, Yun-Fan Sun, Bei-Li Wang, Min-Na Shen, Yan Zhou, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Ya Cao, Bai-shen Pan, Jian Zhou, Jia Fan, Wei Guo and Xin-Rong Yang

    Citation: BMC Cancer 2019 19:760

    Published on:

  26. Content type: Research article

    Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and su...

    Authors: Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh and Anna-Mart Engelbrecht

    Citation: BMC Cancer 2019 19:757

    Published on:

  28. Content type: Research article

    Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...

    Authors: Lucía Barreno, Sara Cáceres, Ángela Alonso-Diez, Ana Vicente-Montaña, María Luisa García, Mónica Clemente, Juan Carlos Illera and Laura Peña

    Citation: BMC Cancer 2019 19:750

    Published on:

  29. Content type: Research article

    Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progres...

    Authors: Jia-Wei Mei, Zi-Yi Yang, Hong-Gang Xiang, Runfa Bao, Yuan-Yuan Ye, Tai Ren, Xue-Feng Wang and Yi-Jun Shu

    Citation: BMC Cancer 2019 19:740

    Published on:

  30. Content type: Research article

    Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer.

    Authors: Hui Wang, Zheqiong Tan, Hui Hu, Hongzhou Liu, Tangwei Wu, Chao Zheng, Xiuling Wang, Zhenzhao Luo, Jing Wang, Shuiyi Liu, Zhongxin Lu and Jiancheng Tu

    Citation: BMC Cancer 2019 19:738

    Published on:

  31. Content type: Research article

    SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research...

    Authors: Hairu Yu, Jiayi Sun, Congxuan Zhao, Haotian Wang, Yeqiu Liu, Jiajia Xiong, Jing Chang, Mixue Wang, Wenhui Wang, Dongman Ye, Hongyan Zhou and Tao Yu

    Citation: BMC Cancer 2019 19:736

    Published on:

  32. Content type: Research article

    Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). However, whether there is a crosstalk b...

    Authors: Qiang Zhou, Wei Zhang, Zhongfeng Wang and Songyang Liu

    Citation: BMC Cancer 2019 19:731

    Published on:

  33. Content type: Research article

    Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the m...

    Authors: José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre and María de Jesús Ibarra-Sánchez

    Citation: BMC Cancer 2019 19:728

    Published on:

  34. Content type: Research article

    Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.

    Authors: Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson and Matthew G. Vander Heiden

    Citation: BMC Cancer 2019 19:723

    Published on:

  35. Content type: Research article

    Tongue squamous cell carcinoma (TSCC) is a special type of oral cancer. Cervical lymph node relapse may occur in a large percentage of TSCC patients, which usually indicates poor prognosis. In this cohort stud...

    Authors: Kailiu Wu, Junshui Wei, Zhengwu Liu, Binbin Yu, Xi Yang, Chunye Zhang, Ahmed Abdelrehem, Chenping Zhang and Siyi Li

    Citation: BMC Cancer 2019 19:714

    Published on:

  36. Content type: Research article

    Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC pro...

    Authors: Lui Ng, Virginia Kwan, Ariel Chow, Thomas Chung-Cheung Yau, Ronnie Tung-Ping Poon, Roberta Pang and Wai-Lun Law

    Citation: BMC Cancer 2019 19:713

    Published on:

  37. Content type: Research article

    Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expr...

    Authors: M.C. Casey, A. Prakash, E. Holian, A. McGuire, O. Kalinina, A. Shalaby, C. Curran, M. Webber, G. Callagy, E. Bourke, M. J. Kerin and J. A. Brown

    Citation: BMC Cancer 2019 19:712

    Published on:

  38. Content type: Research article

    Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clini...

    Authors: Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng and Haozhe Piao

    Citation: BMC Cancer 2019 19:706

    Published on:

  40. Content type: Research article

    Thyroid cancer is the most common endocrinology cancer that its incidence has increased in recent decades. miRNAs are new biomarkers in recent studies in the diagnosis and follow-up of these patients.

    Authors: Mahsa Rezaei, Amir Mahdi Khamaneh, Nosratollah Zarghami, Armin Vosoughi and Shahriar Hashemzadeh

    Citation: BMC Cancer 2019 19:690

    Published on:

  41. Content type: Research article

    Re-capture of the differences between tumor and normal tissues observed at the patient level in cell cultures and animal models is critical for applications of these cancer-related differences. The epithelial-...

    Authors: Jing Song, Wenqing Wang, Yingyan Wang, Yongxin Qin, Yingzi Wang, Jian Zhou, Xuelian Wang, Yi Zhang and Qi Wang

    Citation: BMC Cancer 2019 19:680

    Published on:

  42. Content type: Research article

    Although the prognosis of chronic myeloid leukemia (CML) has dramatically improved, the pathogenesis of CML remains elusive. Studies have shown that sustained phosphorylation of AKT1 plays a crucial role in th...

    Authors: Xiaorong Liu, Huirong Mai, Hanfang Jiang, Zhihao Xing, Dong Peng, Yuan Kong, Chunqing Zhu and Yunsheng Chen

    Citation: BMC Cancer 2019 19:679

    Published on:

  43. Content type: Research article

    In epithelial cells, tyrosine kinases induce tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which is responsible for the epithelial-mesenchymal transition (EMT). However, the precise me...

    Authors: Yunfeng Zhang, Liangzhang Sun, Xiao Gao, Aining Guo, Yan Diao and Yang Zhao

    Citation: BMC Cancer 2019 19:670

    Published on:

  44. Content type: Research article

    Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of whi...

    Authors: Ana Martín-Pardillos, Ángeles Valls Chiva, Gemma Bande Vargas, Pablo Hurtado Blanco, Roberto Piñeiro Cid, Pedro J. Guijarro, Stefan Hümmer, Eva Bejar Serrano, Aitor Rodriguez-Casanova, Ángel Diaz-Lagares, Josep Castellvi, Samuel Miravet-Verde, Luis Serrano, María Lluch-Senar, Víctor Sebastian, Ana Bribian…

    Citation: BMC Cancer 2019 19:666

    Published on:

  45. Content type: Research article

    Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However,...

    Authors: Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf and Mirle Schemionek

    Citation: BMC Cancer 2019 19:658

    Published on:

  46. Content type: Research article

    Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it i...

    Authors: Yingjie Chen, Zhipeng Yang, Yingxue Wang, Juandong Wang and Chuanxin Wang

    Citation: BMC Cancer 2019 19:651

    Published on:

  47. Content type: Research article

    DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA plo...

    Authors: Jing Xu, Ruolin Zhu, Lulu Fan, Shangqing Ge, Wei Wei, Xiaoqiu Li, Liangshan Da, Zhenya Jia, Zhiyan Zhao, Jie Ning, Jie Da, Wanren Peng, Kangsheng Gu and Guoping Sun

    Citation: BMC Cancer 2019 19:650

    Published on:

  48. Content type: Research article

    Recently, long non-coding RNAs (lncRNAs) were considered as important gene expression regulators involving various biological processes. In this study, we explored the role of lncRNAs in the pathogenesis of ra...

    Authors: Ju-Mei Zhou, Rong Liang, Su-Yu Zhu, Hui Wang, Min Zou, Wei-Jing Zou and Shao-Lin Nie

    Citation: BMC Cancer 2019 19:647

    Published on:

  49. Content type: Research article

    Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...

    Authors: Bin Liu, Xiaojie Huang, Yifang Li, Weiguo Liao, Mingyi Li, Yi Liu, Rongrong He, Du Feng, Runzhi Zhu and Hiroshi Kurihara

    Citation: BMC Cancer 2019 19:645

    Published on:

  50. Content type: Research article

    Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...

    Authors: Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung and Wei-Qun Ding

    Citation: BMC Cancer 2019 19:642

    Published on:

Submit manuscript

Follow

Advertisement

BMC Cancer

ISSN: 1471-2407

Contact us