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Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Majority of neuroblastoma patients develop metastatic disease at diagnosis and their prognosis is poor with current therapeutic approach. Major challenges are how to tackle the mechanisms responsible for tumor...

    Authors: Jiao-Le Yu, Shing Chan, Marcus Kwong-Lam Fung and Godfrey Chi-Fung Chan

    Citation: BMC Cancer 2021 21:393

    Content type: Research article

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  2. The 37 kDa/67 kDa laminin receptor (LRP/LR) is involved in several tumourigenic-promoting processes including cellular viability maintenance and apoptotic evasion. Thus, the aim of this study was to assess the...

    Authors: Leila Vania, Gavin Morris, Eloise Ferreira and Stefan F. T. Weiss

    Citation: BMC Cancer 2021 21:392

    Content type: Research article

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  3. An important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomar...

    Authors: Zhao Liu, Jiaxin Liu, Ruimiao Liu, Man Xue, Weifan Zhang, Xinhui Zhao, Jiang Zhu and Peng Xia

    Citation: BMC Cancer 2021 21:367

    Content type: Research article

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  4. The long non-coding (lnc) RNA activated by small nucleolar RNA host gene 16 (SNHG16), which has been reported to play a vital role in a number of different types of cancer, is a novel lncRNA. However, followin...

    Authors: Xiao Xiao, Ge Jiang, Shengtao Zhang, Shuo Hu, Yunshan Fan, Gang Li, Haiyang Yu and Shisheng He

    Citation: BMC Cancer 2021 21:355

    Content type: Research article

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  5. Immunotherapy has been recently established as a new direction for the treatment of colorectal cancer (CRC), a gastrointestinal cancer. In this investigation, we aimed to expound how the posttranscriptional re...

    Authors: Shiquan Li, Guoqiang Yan, Meng Yue and Lei Wang

    Citation: BMC Cancer 2021 21:349

    Content type: Research article

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  6. Icaritin, an active ingredient of the Chinese herb Epimedium, plays an anti-tumor role in liver cancer by inhibiting the proliferation of hepatocellular cells and promoting their apoptosis. In China, phase II ...

    Authors: Hui Li, Yujuan Liu, Wei Jiang, Junhui Xue, Yuning Cheng, Jiyin Wang, Ruixiang Yang and Xiaowei Zhang

    Citation: BMC Cancer 2021 21:318

    Content type: Research article

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  7. Forkhead transcription factors control cell growth in multiple cancer types. Foxd1 is essential for kidney development and mitochondrial metabolism, but its significance in renal cell carcinoma (ccRCC) has not be...

    Authors: Kyle H. Bond, Jennifer L. Fetting, Christine W. Lary, Ivette F. Emery and Leif Oxburgh

    Citation: BMC Cancer 2021 21:312

    Content type: Research article

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  8. Chromosomal inversions involving anaplastic lymphoma kinase (ALK) and echinoderm microtubule associated protein like 4 (EML4) generate a fusion protein EML4-ALK in non-small cell lung cancer (NSCLC). The understa...

    Authors: Akihiko Miyanaga, Masaru Matsumoto, Jessica A. Beck, Izumi Horikawa, Takahiro Oike, Hirokazu Okayama, Hiromi Tanaka, Sandra S. Burkett, Ana I. Robles, Mohammed Khan, Delphine Lissa, Masahiro Seike, Akihiko Gemma, Hiroyuki Mano and Curtis C. Harris

    Citation: BMC Cancer 2021 21:310

    Content type: Research article

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  9. Circular RNAs (circRNAs) feature prominently in tumor progression. However, the biological function and molecular mechanism of circ_0003266 in colorectal cancer (CRC) require further investigation.

    Authors: Caihong Wen, Xiaoqing Feng, Honggang Yuan, Yong Gong and Guangsheng Wang

    Citation: BMC Cancer 2021 21:284

    Content type: Research article

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  10. Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell dy...

    Authors: Lucía Benítez, Lucas Barberis, Luciano Vellón and Carlos A. Condat

    Citation: BMC Cancer 2021 21:276

    Content type: Research article

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  11. Dysregulated miRNAs are involved in carcinogenesis of the breast and may be used as prognostic biomarkers and therapeutic targets during the cancer process. The purpose of this study was to explore the effect ...

    Authors: Bo Lin, Chunhua Liu, Enyi Shi, Qiu Jin, Wenhui Zhao, Juan Wang and Runyuan Ji

    Citation: BMC Cancer 2021 21:275

    Content type: Research article

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  12. Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their Wo...

    Authors: Waseem Masalha, Karam Daka, Jakob Woerner, Nils Pompe, Stefan Weber, Daniel Delev, Marie T. Krüger, Oliver Schnell, Jürgen Beck, Dieter Henrik Heiland and Juergen Grauvogel

    Citation: BMC Cancer 2021 21:211

    Content type: Research article

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  13. The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy of CD19+ B-cell malignancies has opened a new and useful way for the treatment of malignant tumors. Nonetheless, there are stil...

    Authors: Zhitao Ying, Ting He, Xiaopei Wang, Wen Zheng, Ningjing Lin, Meifeng Tu, Yan Xie, Lingyan Ping, Chen Zhang, Weiping Liu, Lijuan Deng, Meng Wu, Feier Feng, Xin Leng, Tingting Du, Feifei Qi…

    Citation: BMC Cancer 2021 21:198

    Content type: Research article

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  14. Activation of autophagy flux contributed to resistance of breast cancer (BC) cells to current chemotherapeutic drugs, which seriously limited their therapeutic efficacy and facilitated BC recurrence in clinic....

    Authors: Libo Yu, Qingtao Shi, Yan Jin, Zhixin Liu, Jiaxin Li and Wenzhou Sun

    Citation: BMC Cancer 2021 21:195

    Content type: Research article

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  15. Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT famil...

    Authors: Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang…

    Citation: BMC Cancer 2021 21:180

    Content type: Research article

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  16. Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms b...

    Authors: Jing Guo, Kiyotoshi Satoh, Sho Tabata, Masaru Mori, Masaru Tomita and Tomoyoshi Soga

    Citation: BMC Cancer 2021 21:174

    Content type: Research article

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  17. Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island. Human and animal studies have shown that colib...

    Authors: Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt and Manuela M. Santos

    Citation: BMC Cancer 2021 21:172

    Content type: Research article

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  18. Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the mo...

    Authors: Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang and Jinquan Cui

    Citation: BMC Cancer 2021 21:163

    Content type: Research article

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  19. Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior...

    Authors: Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata and Kiyoko Kato

    Citation: BMC Cancer 2021 21:156

    Content type: Research article

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  20. p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC). Extracel...

    Authors: Eid S. Alshammari, Amjad A. Aljagthmi, Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia and Weiwen Long

    Citation: BMC Cancer 2021 21:155

    Content type: Research article

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  21. Cholangiocarcinoma is a common malignant tumor of digestive system. LncRNA metallothionein 1 J, pseudogene (MT1JP) has been reported to play tumor-suppressing roles in multiple cancers. However, its effect on ...

    Authors: Wei Zhao, Jing Zhao, Xiao Guo, Yujie Feng, Bingyuan Zhang and Lantian Tian

    Citation: BMC Cancer 2021 21:142

    Content type: Research article

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  22. Prostate cancers frequently metastasize to bone, where the best microenvironment for distant colonization is provided. Since osteotropic metastasis of prostate cancer is a critical determinant of patients’ sur...

    Authors: Bongjun Kim, Suhan Jung, Haemin Kim, Jun-Oh Kwon, Min-Kyoung Song, Min Kyung Kim, Hyung Joon Kim and Hong-Hee Kim

    Citation: BMC Cancer 2021 21:137

    Content type: Research article

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  23. The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy.

    Authors: Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley and Peter R. Shepherd

    Citation: BMC Cancer 2021 21:136

    Content type: Research article

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  24. Prostate cancer is one of the most common malignant cancers with the second highest global rate of mortality in men. During the early stages of disease progression, tumour growth is local and androgen-dependen...

    Authors: Kristen A. Marcellus, Tara E. Crawford Parks, Shekoufeh Almasi and Bernard J. Jasmin

    Citation: BMC Cancer 2021 21:120

    Content type: Research article

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  25. Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin.

    Authors: Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer and Virna D. Leaner

    Citation: BMC Cancer 2021 21:106

    Content type: Research article

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  26. Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor ...

    Authors: Atene Ito, Shunsuke Kagawa, Shuichi Sakamoto, Kazuya Kuwada, Hiroki Kajioka, Masashi Yoshimoto, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa and Toshiyoshi Fujiwara

    Citation: BMC Cancer 2021 21:102

    Content type: Research article

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  27. Long intergenic non-coding RNAs (lincRNAs) are capable of regulating several tumours, while competitive endogenous RNA (ceRNA) networks are of great significance in revealing the biological mechanism of tumour...

    Authors: Guangdong Liu, Danian Liu, Jingjing Huang, Jianxin Li, Chuang Wang, Guangyao Liu, Shiqiang Ge and Haidong Gong

    Citation: BMC Cancer 2021 21:98

    Content type: Research article

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  28. Recent years, survival rates of human with high-risk acute myeloid leukaemia (AML) have not raised substantially. This research aimed to investigate the role of 4′-O-Methylbroussochalcone B, for the treatment ...

    Authors: Ziying Liu, Changshui Wang, Yali Wang, Lei Wang, Yueyuan Zhang and Genquan Yan

    Citation: BMC Cancer 2021 21:91

    Content type: Research article

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  29. Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to ...

    Authors: Jonathan Guihurt Santiago, Neikelyn Burgos-Tirado, Daniella Dorta Lafontaine, José C. Mendoza Sierra, Roberto Herrera Camacho, Clara M. Vecchini Rodríguez, Vanessa Morales-Tirado and Jacqueline Flores-Otero

    Citation: BMC Cancer 2021 21:53

    Content type: Research article

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  30. Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r...

    Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida

    Citation: BMC Cancer 2021 21:48

    Content type: Research article

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  31. lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has b...

    Authors: Gwan Woo Ku, Yujin Kang, Seong-Lan Yu, Joonghoon Park, Sejin Park, In Beom Jeong, Min Woong Kang, Ji Woong Son and Jaeku Kang

    Citation: BMC Cancer 2021 21:44

    Content type: Research article

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  32. Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG)...

    Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu and He Huang

    Citation: BMC Cancer 2021 21:36

    Content type: Research article

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  33. Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extr...

    Authors: Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang and Zhi-Hui Deng

    Citation: BMC Cancer 2021 21:33

    Content type: Research article

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  34. Aberrant expression of P-cadherin has been reported in various cancers, and has been attracting attention as a target for cancer treatment. Ovarian cancer, the leading cause of death among gynecologic malignan...

    Authors: Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku and Hiroshi Fujiwara

    Citation: BMC Cancer 2021 21:32

    Content type: Research article

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  35. The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth ...

    Authors: Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang and Ming Shi

    Citation: BMC Cancer 2021 21:24

    Content type: Research article

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  36. MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aim...

    Authors: Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia and Hong Zhang

    Citation: BMC Cancer 2021 21:2

    Content type: Research article

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  37. Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vasc...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:1215

    Content type: Research article

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  38. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer and John R. Henley

    Citation: BMC Cancer 2020 20:1213

    Content type: Research article

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  39. The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. ...

    Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma and P. M. A. Sloot

    Citation: BMC Cancer 2020 20:1201

    Content type: Research article

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  40. Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggests that targeting circular RNAs (circRNAs) is an effective strategy to increase cisplatin-...

    Authors: Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang and Xiaojiang Sun

    Citation: BMC Cancer 2020 20:1190

    Content type: Research article

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  41. Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, epidermal growth factor recep...

    Authors: Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu and Jun Chen

    Citation: BMC Cancer 2020 20:1189

    Content type: Research article

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  42. Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. H...

    Authors: Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom and Jung-Ae Kim

    Citation: BMC Cancer 2020 20:1180

    Content type: Research article

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  43. Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    Authors: A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider and C. Gorzelanny

    Citation: BMC Cancer 2020 20:1178

    Content type: Research article

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  44. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

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  45. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

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