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Biomarkers

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  1. Recent studies indicate the benefit of treatment with osimertinib over that with conventional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for untreated EGFR-mutated non-small cell lun...

    Authors: Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai and Keisuke Tomii

    Citation: BMC Cancer 2020 20:104

    Content type: Research article

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  2. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto

    Citation: BMC Cancer 2020 20:103

    Content type: Research article

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  3. Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT s...

    Authors: César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde…

    Citation: BMC Cancer 2020 20:99

    Content type: Research article

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  4. Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association...

    Authors: Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng and Yunpeng Hua

    Citation: BMC Cancer 2020 20:95

    Content type: Research article

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  5. Interrogation of site-specific CpG methylation in circulating tumor DNAs (ctDNAs) has been employed in a number of studies for early detection of breast cancer (BrCa). In many of these studies, the markers wer...

    Authors: Manny D. Bacolod, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Aashiq H. Mirza, Alexander Swistel, Steven A. Soper and Francis Barany

    Citation: BMC Cancer 2020 20:85

    Content type: Research article

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  6. Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar ...

    Authors: Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra…

    Citation: BMC Cancer 2020 20:83

    Content type: Research article

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  7. Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease. This PDAC scenario urges ...

    Authors: Palloma Porto Almeida, Cristina Padre Cardoso and Leandro Martins de Freitas

    Citation: BMC Cancer 2020 20:82

    Content type: Software

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  8. Recently, accumulating evidence has suggested that the aberrant expression of SNHG6 exists in a variety of tumors and has a correlation with poor clinical outcomes across cancer patients. Considering the incon...

    Authors: Si Zhao, Hanlong Zhu, Ruonan Jiao, Xueru Wu, Guozhong Ji and Xiuhua Zhang

    Citation: BMC Cancer 2020 20:77

    Content type: Research article

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  9. Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final...

    Authors: Peng Liu, Lingming Kong, Keke Liang, Yunhao Wu, Haoyi Jin, Bing Song and Xiaodong Tan

    Citation: BMC Cancer 2020 20:45

    Content type: Research article

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  10. This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myelom...

    Authors: Fan Zhou, Dongjiao Wang, Wei Wei, Haimin Chen, Haotian Shi, Nian Zhou, Lixia Wu and Rong Peng

    Citation: BMC Cancer 2020 20:40

    Content type: Research article

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  11. Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...

    Authors: Darina Kohoutova, Miroslava Forstlova, Paula Moravkova, Jiri Cyrany, Juraj Bosak, David Smajs, Stanislav Rejchrt and Jan Bures

    Citation: BMC Cancer 2020 20:39

    Content type: Research article

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  12. The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide...

    Authors: Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo and Yuanli Zhao

    Citation: BMC Cancer 2020 20:35

    Content type: Research article

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  13. High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine ...

    Authors: Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel and Ulrich Knigge

    Citation: BMC Cancer 2020 20:27

    Content type: Research article

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  14. The NEK serine/threonine protein kinases are involved in cell cycle checkpoints, DNA damage repair, and apoptosis. Alterations in these pathways are frequently associated with cell malignant cellular transform...

    Authors: Talita Diniz Melo-Hanchuk, Mariana Bonjiorno Martins, Lucas Leite Cunha, Fernando Augusto Soares, Laura Sterian Ward, José Vassallo and Jörg Kobarg

    Citation: BMC Cancer 2020 20:23

    Content type: Research article

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  15. Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy....

    Authors: Zuzana Cierna, Vera Miskovska, Jan Roska, Dana Jurkovicova, Lucia Borszekova Pulzova, Zuzana Sestakova, Lenka Hurbanova, Katarina Machalekova, Michal Chovanec, Katarina Rejlekova, Daniela Svetlovska, Katarina Kalavska, Karol Kajo, Pavel Babal, Jozef Mardiak, Thomas A. Ward…

    Citation: BMC Cancer 2020 20:17

    Content type: Research article

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  16. Hepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity is high. Tissue biopsy is an invasive operation and may in...

    Authors: Wene Wei, Mengshu Liu, Shufang Ning, Jing Wei, Jianhong Zhong, Jilin Li, Zhengmin Cai and Litu Zhang

    Citation: BMC Cancer 2020 20:6

    Content type: Research article

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  17. Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined perform...

    Authors: Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu and Xuelei Ma

    Citation: BMC Cancer 2019 19:1223

    Content type: Research article

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  18. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio

    Citation: BMC Cancer 2019 19:1216

    Content type: Research article

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  19. It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.

    Authors: Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang and Pei-Rong Ding

    Citation: BMC Cancer 2019 19:1210

    Content type: Research article

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  20. Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammato...

    Authors: Takumi Kishimoto, Nobukazu Fujimoto, Takeshi Ebara, Toyonori Omori, Tetsuya Oguri, Akio Niimi, Takako Yokoyama, Munehiro Kato, Ikuji Usami, Masayuki Nishio, Kosho Yoshikawa, Takeshi Tokuyama, Mouka Tamura, Yoshifumi Yokoyama, Ken Tsuboi, Yoichi Matsuo…

    Citation: BMC Cancer 2019 19:1204

    Content type: Research article

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  21. Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been ...

    Authors: Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung and Jae-Hoon Kim

    Citation: BMC Cancer 2019 19:1202

    Content type: Research article

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  22. To discover biomarker panels that could distinguish cancers (BC and RCC) from healthy controls (HCs) and bladder cancers (BC) from renal cell carcinoma (RCC), regardless of whether the patients have haematuria...

    Authors: Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang and Wei Sun

    Citation: BMC Cancer 2019 19:1195

    Content type: Research article

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  23. Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial therapeutic breakthrough has been made in the past few d...

    Authors: Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld…

    Citation: BMC Cancer 2019 19:1191

    Content type: Research article

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  24. Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses.

    Authors: Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh and Kung-Hao Liang

    Citation: BMC Cancer 2019 19:1190

    Content type: Research article

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  25. Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell inf...

    Authors: Xin Rui, Siliang Shao, Li Wang and Jiangyong Leng

    Citation: BMC Cancer 2019 19:1179

    Content type: Research article

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  26. Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used ...

    Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Piyali Sarkar, Shatakshee Chatterjee, Debashis Nath, Kshaunish Das and Srikanta Goswami

    Citation: BMC Cancer 2019 19:1175

    Content type: Research article

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  27. Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake ...

    Authors: Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu and Akihiko Saito

    Citation: BMC Cancer 2019 19:1170

    Content type: Research article

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  28. Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease that is involved in the invasiveness and progression of cancer. There is good evidence that uPA expression is a clinically re...

    Authors: Ming-Chao Tsai, Yi-Hao Yen, Kuo-Chin Chang, Chao-Hung Hung, Chien-Hung Chen, Ming-Tsung Lin and Tsung-Hui Hu

    Citation: BMC Cancer 2019 19:1169

    Content type: Research article

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  29. Circulating tumor cells (CTCs) are associated with breast cancer prognosis. Research is limited regarding the role of circulating cancer stem-like cells (cCSCs) considering the treatment response and survival ...

    Authors: Chun-Hui Lee, Jason Chia-Hsun Hsieh, Tyler Min-Hsien Wu, Ting-Shiuan Yeh, Hung-Ming Wang, Yung-Chan Lin, Jen-Shi Chen, Chia-Lin Lee, Wen-Kuan Huang, Tsung-Min Hung, Tzu-Tsen Yen, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Ching-Chih Hu and Pei-Hung Chang

    Citation: BMC Cancer 2019 19:1167

    Content type: Research article

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  30. Post-surgical staging is the mainstay of prognostic stratification for colorectal cancer (CRC). Here, we compare TNM staging to consensus molecular subtyping (CMS) and assess the value of subtyping in addition...

    Authors: Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson and Francis A. Frizelle

    Citation: BMC Cancer 2019 19:1155

    Content type: Research article

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  31. Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). ...

    Authors: Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan and Qinglian Wen

    Citation: BMC Cancer 2019 19:1134

    Content type: Research article

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  32. Operable breast cancer patients may experience late recurrences because of reactivation of dormant tumor cells within the bone marrow (BM). Identification of patients who would benefit from extended therapy is...

    Authors: Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen and Bjørnar Gilje

    Citation: BMC Cancer 2019 19:1131

    Content type: Research article

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  33. The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are ass...

    Authors: Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:1127

    Content type: Research article

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  34. Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

    Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang

    Citation: BMC Cancer 2019 19:1116

    Content type: Database

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  35. The aim was to investigate the prognostic value of MR apparent diffusion coefficients (ADC) using histogram analysis (HA) in predicting disease-free survival (DFS) of cervical cancer after chemo-radiation ther...

    Authors: Bo Zhao, Kun Cao, Xiao-Ting Li, Hai-Tao Zhu and Ying-Shi Sun

    Citation: BMC Cancer 2019 19:1115

    Content type: Research article

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  36. We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue micr...

    Authors: Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein and Jacek Pinski

    Citation: BMC Cancer 2019 19:1114

    Content type: Research article

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  37. Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. The presence of ctDNA in the blood is a result of biological pro...

    Authors: Leslie Calapre, Lydia Warburton, Michael Millward and Elin S. Gray

    Citation: BMC Cancer 2019 19:1109

    Content type: Case report

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  38. Recently, a growing number of studies have reported the coorelation between miR-155 and the diagnosis and prognosis of lung cancer, but results of these researches were still controversial due to insufficient ...

    Authors: Chuchu Shao, Fengming Yang, Zhiqiang Qin, Xinming Jing, Yongqian Shu and Hua Shen

    Citation: BMC Cancer 2019 19:1103

    Content type: Research article

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  39. The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratificati...

    Authors: Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni and Tanja Fehm

    Citation: BMC Cancer 2019 19:1101

    Content type: Research article

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  40. Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum ...

    Authors: Takahiro Maeda, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Kengo Kanayama, Susumu Maruta, Yuko Kusakabe, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Ryo Nakagawa…

    Citation: BMC Cancer 2019 19:1088

    Content type: Research article

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  41. SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far. Few patients with recurrent glioma have opportunity...

    Authors: Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng and Qichun Wei

    Citation: BMC Cancer 2019 19:1087

    Content type: Research article

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  42. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1085

    Content type: Research article

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  43. Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse lar...

    Authors: Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai and Shudao Xiong

    Citation: BMC Cancer 2019 19:1084

    Content type: Research article

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  44. Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF ...

    Authors: Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee and Ming-Hong Tai

    Citation: BMC Cancer 2019 19:1083

    Content type: Research article

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  45. To reveal roles of reactive oxygen species (ROS) status in chemotherapy resistance and to develop a ROS scoring system for prognosis prediction in ovarian cancer.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen

    Citation: BMC Cancer 2019 19:1061

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:210