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Biomarkers

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting. 

Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies" (J Clin Oncol 23:9067, 2005) and "Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): An Abridged Explanation and Elaboration" (J Natl Cancer Inst . 2018 Aug 1;110(8):803-811.). 

They should report biomarkers that have a clear biologic relevance to a particular tumor type and be validated in at least one independent validation cohort and with biological validation in vitro or in vivo. Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation will not be considered at BMC Cancer.

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  1. Cervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer patient survival. However, there is no relevant study on the relations...

    Authors: Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li and Xiaojian Yan

    Citation: BMC Cancer 2020 20:1133

    Content type: Research article

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  2. The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...

    Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege…

    Citation: BMC Cancer 2020 20:1130

    Content type: Research article

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  3. Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this ...

    Authors: Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier and Takahisa Furuta

    Citation: BMC Cancer 2020 20:1123

    Content type: Research article

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  4. Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urin...

    Authors: Wen Liu, Zhankun Wang, Shuai Liu, Yu Yao, Yong Liu and Guiming Zhang

    Citation: BMC Cancer 2020 20:1113

    Content type: Research article

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  5. Identifying the mutation status of KRAS is important for optimizing treatment in patients with colorectal cancer (CRC). The aim of this study was to investigate the predictive value of haematological parameter...

    Authors: Yinghao Cao, Junnan Gu, Lizhao Yan, Shenghe Deng, Fuwei Mao, Wentai Cai, Hang Li, Xinghua Liu, Jiliang Wang, Ke Wu and Kailin Cai

    Citation: BMC Cancer 2020 20:1099

    Content type: Research article

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  6. Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive a...

    Authors: Mouadh Barbirou, Henok G. Woldu, Ikram Sghaier, Sinda A. Bedoui, Amina Mokrani, Radhia Aami, Amel Mezlini, Besma Yacoubi-Loueslati, Peter J. Tonellato and Balkiss Bouhaouala-Zahar

    Citation: BMC Cancer 2020 20:1086

    Content type: Research article

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  7. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported ...

    Authors: Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai and Ze Yang

    Citation: BMC Cancer 2020 20:1071

    Content type: Research article

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  8. Extensive research has revealed that genes play a pivotal role in tumor development and growth. However, the underlying involvement of gene expression in gastric carcinoma (GC) remains to be investigated further.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren

    Citation: BMC Cancer 2020 20:1062

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1141

  9. Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma that is highly aggressive where one-third of the patients relapse despite effective treatment. Interaction between the lymphoma cells and the non...

    Authors: Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain and Dipti Talaulikar

    Citation: BMC Cancer 2020 20:1061

    Content type: Research article

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  10. Measurement of serum human epidermal growth factor receptor-2 (HER-2/neu) levels might play an essential role as a diagnostic/screening marker for the early selection of therapeutic approaches and predict prognos...

    Authors: Amir Shamshirian, Amir Reza Aref, George W. Yip, Majid Ebrahimi Warkiani, Keyvan Heydari, Sajad Razavi Bazaz, Zeinab Hamzehgardeshi, Danial Shamshirian, Mahmood Moosazadeh and Reza Alizadeh-Navaei

    Citation: BMC Cancer 2020 20:1049

    Content type: Research article

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  11. Lung adenocarcinoma (LUAD) remains a crucial factor endangering human health. Gene-based clinical predictions could be of great help for cancer intervention strategies. Here, we tried to build a gene-based sur...

    Authors: Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han and Tao Jiang

    Citation: BMC Cancer 2020 20:1046

    Content type: Research article

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  12. OCT-1 gene is a member of the POU-homeodomain family of transcriptional regulators of B-lymphocyte differentiation by controlling expression of B-cell specific genes. BCL-2 gene is a potent inhibitor of apoptosis...

    Authors: Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa and Juliana Pereira

    Citation: BMC Cancer 2020 20:1041

    Content type: Research article

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  13. High-grade serous ovarian cancer (HGSOC) is a fatal form of ovarian cancer. Previous studies indicated some potential biomarkers for clinical evaluation of HGSOC prognosis. However, there is a lack of systemat...

    Authors: Min Li, Xue Cheng, Rong Rong, Yan Gao, Xiuwu Tang and Youguo Chen

    Citation: BMC Cancer 2020 20:1032

    Content type: Research article

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  14. Globally, endometrial cancer is the fourth most common malignant tumor in women and the number of women being diagnosed is increasing. Tumor progression is strongly related to the cell survival-promoting funct...

    Authors: Jun Zhang, Ziwei Wang, Rong Zhao, Lanfen An, Xing Zhou, Yingchao Zhao and Hongbo Wang

    Citation: BMC Cancer 2020 20:1030

    Content type: Research article

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  15. Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this ...

    Authors: Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez and José Luis Bello López

    Citation: BMC Cancer 2020 20:1017

    Content type: Research article

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  16. The positive response and the clinical usefulness of 14 serum antibodies in patients with esophageal squamous cell carcinoma (ESCC) were examined in this study. The Cancer Genome Atlas (TCGA) was used to inves...

    Authors: Isamu Hoshino, Yoshihiro Nabeya, Nobuhiro Takiguchi, Hisashi Gunji, Fumitaka Ishige, Yosuke Iwatate, Akiko Kuwajima, Fumiaki Shiratori, Rei Okada and Hideaki Shimada

    Citation: BMC Cancer 2020 20:1007

    Content type: Research article

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  17. An increasing number of studies have reported circular RNAs (circRNAs) as new potential biomarkers for the prognosis of gliomas. However, the overall prognostic value of circRNAs for glioma remains unclear. Th...

    Authors: Xiangqian Ding, Luyao Yang, Xin Geng, Yanghong Zou, Zhigang Wang, Yao Li, Renli Qi, Wei Wang, Jinghui Li and Hualin Yu

    Citation: BMC Cancer 2020 20:1005

    Content type: Research article

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  18. Increasing studies indicated that microRNA-203 (miR-203) may play an important part in the prognosis of CRC. Nevertheless, the prognostic and influential mechanism of miR-203 expression in CRC remains to be in...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Shang Cai, Zhengyang Feng, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: BMC Cancer 2020 20:1003

    Content type: Research article

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  19. MCM5 is a protein involved in DNA replication, facilitating cell proliferation. In normal epithelium MCM5 expression is restricted to the cells in the basal proliferative compartments, however in the presence ...

    Authors: J. Stockley, R. Akhand, A. Kennedy, C. Nyberg, E. J. Crosbie and R. J. Edmondson

    Citation: BMC Cancer 2020 20:1000

    Content type: Research article

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  20. Cervical cancer is the second-most common gynecological cancer, early screening plays a key role in the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Sustained E7 protein expression is t...

    Authors: Linghua Kong, Xiaoping Xiao, Huiping Lou, Pengfei Liu, Shuhui Song, Moudu Liu, Tao Xu, Ying Zhang, Caijuan Li, Ruoli Guan, Yan Li, Xin Yu, Haiyuan Liu, Qingbo Fan, Honghui Shi and Lan Zhu

    Citation: BMC Cancer 2020 20:999

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1027

  21. The BRCA mutation (BRCAm) in males has been reported to confer a higher risk for the development of various tumors. However, little is known about its clinicopathologic features and prognostic implications.

    Authors: Peng Sun, Yue Li, Xue Chao, Jibin Li, Rongzhen Luo, Mei Li and Jiehua He

    Citation: BMC Cancer 2020 20:994

    Content type: Research article

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  22. Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The a...

    Authors: Mingxuan Li, Jiwei Bai, Shuai Wang, Yixuan Zhai, Shuheng Zhang, Chuzhong Li, Jiang Du and Yazhuo Zhang

    Citation: BMC Cancer 2020 20:988

    Content type: Research article

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  23. In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-S...

    Authors: Yin-Zhe An, Eunae Cho, Junqi Ling and Xianglan Zhang

    Citation: BMC Cancer 2020 20:987

    Content type: Research article

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  24. Serum lipids were reported to be the prognostic factors of various cancers, but their prognostic value in malignant biliary tumor (MBT) patients remains unclear. Thus we aim to assess and compare prognosis val...

    Authors: Lejia Sun, Xin Ji, Dongyue Wang, Ai Guan, Yao Xiao, Haifeng Xu, Shunda Du, Yiyao Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang and Yilei Mao

    Citation: BMC Cancer 2020 20:980

    Content type: Research article

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  25. lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is sti...

    Authors: Jigao Feng, Yibin Ouyang, Dedong Xu, Qinglong He, Dayuan Liu, Xudong Fan, Pengxiang Xu and Yehe Mo

    Citation: BMC Cancer 2020 20:976

    Content type: Research article

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  26. Hepatocellular carcinoma (HCC) is the leading cause of primary liver cancers. Surveillance of individuals at specific risk of developing HCC, early diagnostic markers, and new therapeutic approaches are essent...

    Authors: Veronica Bazzani, Arianna Barchiesi, Dorota Radecka, Riccardo Pravisani, Antonio Guadagno, Carla Di Loreto, Umberto Baccarani and Carlo Vascotto

    Citation: BMC Cancer 2020 20:969

    Content type: Research article

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  27. After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structura...

    Authors: N. Oosterom, M. Fiocco, R. Q. H. Kloos, I. M. van der Sluis, R. Pieters, B. D. van Zelst, D. E. C. Smith, M. M. van den Heuvel-Eibrink, R. de Jonge and S. G. Heil

    Citation: BMC Cancer 2020 20:940

    Content type: Research article

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  28. Glioma is a deadly and immunosuppressive brain tumour. Complement C1r subcomponent like (C1RL), a prognostic biomarker in several kinds of tumours, has attracted increasing attention from oncologists. However, th...

    Authors: Junyou Wang, Luqing Tong, Gaojun Lin, Hui Wang, Liang Zhang and Xuejun Yang

    Citation: BMC Cancer 2020 20:931

    Content type: Research article

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  29. Role of biomarkers for promotion of tumor proliferation (BPTPs) and for promotion of apoptosis (BPAs) in thymic malignant tumors is still unclear. The purpose of this study was to evaluate the relationship bet...

    Authors: Huilan Zeng, Weilin Yang, Bo Xu, Jianyong Zou, Chunhua Su, Beilong Zhong, Haoshuai Zhu and Zhenguang Chen

    Citation: BMC Cancer 2020 20:928

    Content type: Research article

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  30. Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (...

    Authors: Shaozheng Chen and Kejun Li

    Citation: BMC Cancer 2020 20:924

    Content type: Research article

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  31. It is a well-known fact show that the risk of developing endometrial cancer (type 1 EC) is strongly associated with obesity. In this study, selected markers, such as obesity, insulin resistance, angiogenesis a...

    Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Robert Terlikowski, Anna Sienkiewicz, Maciej Kinalski and Slawomir J. Terlikowski

    Citation: BMC Cancer 2020 20:921

    Content type: Research article

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  32. Inflammatory cytokine markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte ratio, and platelet-to-lymphocyte ratio, play important roles as prognostic markers in several solid malig...

    Authors: Takashi Kawahara, Masashi Kato, Kenichi Tabata, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Hideyasu Tsumura, Masatsugu Iwamura, Hiroji Uemura and Yasuhide Miyoshi

    Citation: BMC Cancer 2020 20:919

    Content type: Research article

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  33. Identification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation an...

    Authors: Chunmei Fan, Jinpeng Wang, Yanyan Tang, Shanshan Zhang, Fang Xiong, Can Guo, Yanhong Zhou, Zheng Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong

    Citation: BMC Cancer 2020 20:917

    Content type: Research article

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  34. Various parameters have been considered for predicting survival in pancreatic ductal adenocarcinoma. Information about western population is missing. The aim of this study is to assess the association between ...

    Authors: Mar Achalandabaso Boira, Marcello Di Martino, Carlos Gordillo, Magdalena Adrados and Elena Martín-Pérez

    Citation: BMC Cancer 2020 20:909

    Content type: Research article

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  35. Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

    Authors: Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim

    Citation: BMC Cancer 2020 20:907

    Content type: Research article

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  36. There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions...

    Authors: Huy Gia Vuong, Thu Quynh Nguyen, Tam N. M. Ngo, Hoang Cong Nguyen, Kar-Ming Fung and Ian F. Dunn

    Citation: BMC Cancer 2020 20:897

    Content type: Research article

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  37. Extremity liposarcoma represents 25% of extremity soft tissue sarcoma and has a better prognosis than liposarcoma occurring in other anatomic sites. The purpose of this study was to develop two nomograms for p...

    Authors: Lin Ye, Chuan Hu, Cailin Wang, Weiyang Yu, Feijun Liu and Zhenzhong Chen

    Citation: BMC Cancer 2020 20:889

    Content type: Research article

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  38. There is growing evidence that pseudogenes may serve as prognostic biomarkers in several cancers. The present study was designed to develop and validate an accurate and robust pseudogene pairs-based signature ...

    Authors: Yajuan Du and Ying Gao

    Citation: BMC Cancer 2020 20:887

    Content type: Research article

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  39. The nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) is a long non-coding RNA aberrantly expressed in human malignancies. We aimed to analyze available data to evaluate the correlation betwee...

    Authors: Chenghao Zhang, Xiaolei Ren, Zhongyue Liu and Chao Tu

    Citation: BMC Cancer 2020 20:879

    Content type: Research article

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  40. Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with TNBC could help guide treatment. Extensive evidence demonstrates that an...

    Authors: Yu-Chen Cai, Hang Yang, Ke-Feng Wang, Tan-Huan Chen, Wen-Qi Jiang and Yan-Xia Shi

    Citation: BMC Cancer 2020 20:878

    Content type: Research article

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  41. BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting ...

    Authors: Shixu Fang, Zhou Liu, Qiang Guo, Cheng Chen, Xixian Ke and Gang Xu

    Citation: BMC Cancer 2020 20:870

    Content type: Research article

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  42. Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon rec...

    Authors: Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho and Humberto Dellê

    Citation: BMC Cancer 2020 20:869

    Content type: Research article

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  43. An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristi...

    Authors: Xiao Jin, Lu Dai, Yilan Ma, Jiayan Wang, Haihao Yan, Ye Jin, Xiaojuan Zhu and Zheng Liu

    Citation: BMC Cancer 2020 20:866

    Content type: Research article

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