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Biomarkers

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  1. The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratificati...

    Authors: Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni and Tanja Fehm

    Citation: BMC Cancer 2019 19:1101

    Content type: Research article

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  2. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1085

    Content type: Research article

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  3. Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse lar...

    Authors: Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai and Shudao Xiong

    Citation: BMC Cancer 2019 19:1084

    Content type: Research article

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  4. Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF ...

    Authors: Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee and Ming-Hong Tai

    Citation: BMC Cancer 2019 19:1083

    Content type: Research article

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  5. To reveal roles of reactive oxygen species (ROS) status in chemotherapy resistance and to develop a ROS scoring system for prognosis prediction in ovarian cancer.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen

    Citation: BMC Cancer 2019 19:1061

    Content type: Research article

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  6. There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable pro...

    Authors: Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat and Andrey Bychkov

    Citation: BMC Cancer 2019 19:1050

    Content type: Research article

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  7. Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain controversial an...

    Authors: Yan-Li Li, Zhi-Hu Shi, Xian Wang, Kang-Sheng Gu and Zhi-Min Zhai

    Citation: BMC Cancer 2019 19:1049

    Content type: Research article

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  8. Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal therapeutic strategy still exists. This research was perfo...

    Authors: Chenjing Zhu, Otilia Menyhart, Balázs Győrffy and Xia He

    Citation: BMC Cancer 2019 19:1046

    Content type: Research article

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  9. The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pa...

    Authors: Chaohui Lisa Zhao, Kamaljeet Singh, Alexander S. Brodsky, Shaolei Lu, Theresa A. Graves, Mary Anne Fenton, Dongfang Yang, Ashlee Sturtevant, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1036

    Content type: Research article

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  10. The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using i...

    Authors: Yabing Cao, Kin Iong Chan, Gungli Xiao, Yanqun Chen, Xibin Qiu, Hu Hao, Sao Chi Mak and Tongyu Lin

    Citation: BMC Cancer 2019 19:1022

    Content type: Research article

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  11. Recent preclinical data suggest that androgen receptor (AR) signaling plays a significant role in subsets of breast cancer. Clinical trials testing AR-targeting therapies in breast cancer have been conducted. ...

    Authors: Toru Hanamura, Koichi Ohno, Shinya Hokibara, Hideki Murasawa, Toshitsugu Nakamura, Hidehiko Watanabe, Machiko Kaizuka, Shinji Sawano, Hiroshi Koyama and Ken-ichi Ito

    Citation: BMC Cancer 2019 19:1021

    Content type: Research article

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  12. Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical p...

    Authors: Sergei E. Titov, Mikhail K. Ivanov, Pavel S. Demenkov, Gevork A. Katanyan, Eugenia S. Kozorezova, Anastasia V. Malek, Yulia A. Veryaskina and Igor F. Zhimulev

    Citation: BMC Cancer 2019 19:1010

    Content type: Research article

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  13. An External Quality Assessment (EQA) program was developed to investigate the status of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 immunohistochemical (IHC) detection in breast cancer and to...

    Authors: Tianjie Pu, Ruohong Shui, Jie Shi, Zhiyong Liang, Wentao Yang, Hong Bu, Qin Li and Zhang Zhang

    Citation: BMC Cancer 2019 19:978

    Content type: Technical advance

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  14. Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors were associated with clinical benefit in patients with melanoma or lung cancer. In advanced gastric c...

    Authors: Ken Masuda, Hirokazu Shoji, Kengo Nagashima, Shun Yamamoto, Masashi Ishikawa, Hiroshi Imazeki, Masahiko Aoki, Takahiro Miyamoto, Hidekazu Hirano, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Atsuo Takashima, Ken Kato and Narikazu Boku

    Citation: BMC Cancer 2019 19:974

    Content type: Research article

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  15. Significant advances in the molecular profiling of gliomas, led the 2016 World Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers in glioma diagnosis: IDH mutations and ...

    Authors: Cheila Brito, Ana Azevedo, Susana Esteves, Ana Rita Marques, Carmo Martins, Ilda Costa, Manuela Mafra, José M. Bravo Marques, Lúcia Roque and Marta Pojo

    Citation: BMC Cancer 2019 19:968

    Content type: Research article

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  16. Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties.

    Authors: Sören A. Weidemann, Charlotte Sauer, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Guido Sauter, Cosima Göbel, Patrick Lebok, David Dum, Christoph Fraune…

    Citation: BMC Cancer 2019 19:944

    Content type: Research article

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  17. Prognostic assessment is crucial for optimal treatment. The aim of our study was to investigate the potential impact of estrogen receptor-α (ER-α) and progesterone receptor (PR) on the prognosis of colorectal ...

    Authors: Shu-Biao Ye, Yi-Kan Cheng, Lin Zhang, Xue-Ping Wang, Lei Wang and Ping Lan

    Citation: BMC Cancer 2019 19:933

    Content type: Research article

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  18. Ovarian cancer is the main cause of gynecological cancer-associated death. However, 5-year survival rates differ dramatically between the five main ovarian carcinoma histotypes. Therefore, we need to have a be...

    Authors: Hanna Engqvist, Toshima Z. Parris, Anikó Kovács, Szilárd Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson and Khalil Helou

    Citation: BMC Cancer 2019 19:928

    Content type: Research article

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  19. This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels i...

    Authors: Xue-Song Sun, Yu-Jing Liang, Sai-Lan Liu, Qiu-Yan Chen, Shan-Shan Guo, Yue-Feng Wen, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Xiao-Yun Li, Jin-Jie Yan, Lin-Quan Tang and Hai-Qiang Mai

    Citation: BMC Cancer 2019 19:908

    Content type: Research article

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  20. Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal ca...

    Authors: Alessandro Ottaiano, Stefania Scala, Nicola Normanno, Maria Napolitano, Monica Capozzi, Anna Maria Rachiglio, Cristin Roma, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Carmela Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Salvatore Tafuto…

    Citation: BMC Cancer 2019 19:899

    Content type: Study protocol

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  21. We evaluated the clinical efficacy and prognosis of muscle-invasive bladder cancer according to the basal/squamous-like (BASQ) classification system based on immunohistochemical staining [CK5/6(+), CK14(+), GA...

    Authors: Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon and Ja Hyeon Ku

    Citation: BMC Cancer 2019 19:897

    Content type: Research article

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  22. Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...

    Authors: Jasmine A. McQuerry, David F. Jenkins, Susan E. Yost, Yuqing Zhang, Daniel Schmolze, W. Evan Johnson, Yuan Yuan and Andrea H. Bild

    Citation: BMC Cancer 2019 19:881

    Content type: Research article

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  23. Breast cancer is the most common malignancy in women, and neoadjuvant chemotherapy has been recommended to the patients with locally advanced breast cancer as the initial treatments. Long non-coding RNA (lncRN...

    Authors: Battseren Bayarmaa, Ziping Wu, Jing Peng, Yan Wang, Shuguang Xu, Tingting Yan, Wenjin Yin, Jinsong Lu and Liheng Zhou

    Citation: BMC Cancer 2019 19:877

    Content type: Research article

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  24. Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around the world. We previously demonstrated that eIF3b could promote the progression of ESCC. The exact mechani...

    Authors: Fengkai Xu, Shu Zhang, Zhonghe Liu, Jie Gu, Yin Li, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Di Ge and Chunlai Lu

    Citation: BMC Cancer 2019 19:875

    Content type: Research article

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  25. This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy.

    Authors: Haiyan Zhu, Xuejiao Tao, Lulu Zhou, Bo Sheng, Xuejie Zhu and Xueqiong Zhu

    Citation: BMC Cancer 2019 19:865

    Content type: Research article

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  26. Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play cri...

    Authors: Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma and Ming Liu

    Citation: BMC Cancer 2019 19:851

    Content type: Research article

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  27. Recent studies reported that blood-based microRNAs (miRNAs) could detect cancers and predict prognosis have opened a new field of utilizing circulating miRNAs as cancer biomarkers. In this pilot study, we cond...

    Authors: Lirong Wu, Kexiao Zheng, Cheng Yan, Xuan Pan, Yatian Liu, Juying Liu, Feijiang Wang, Wenjie Guo, Xia He, Jiong Li and Ye Shen

    Citation: BMC Cancer 2019 19:843

    Content type: Research article

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  28. Metastasis is responsible for the majority of deaths in a variety of cancer types, including breast cancer. Although several factors or biomarkers have been identified to predict the outcome of patients with b...

    Authors: Liang Zeng, Xiyun Deng, Jingmin Zhong, Li Yuan, Xiaojun Tao, Sai Zhang, Yong Zeng, Guangchun He, Pingping Tan and Yongguang Tao

    Citation: BMC Cancer 2019 19:831

    Content type: Research article

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  29. The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the...

    Authors: Fatima Qadir, Anand Lalli, Huma Habib Dar, Sungjae Hwang, Hebah Aldehlawi, Hong Ma, Haiyan Dai, Ahmad Waseem and Muy-Teck Teh

    Citation: BMC Cancer 2019 19:830

    Content type: Research article

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  30. Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphoc...

    Authors: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary and Loic Ysebaert

    Citation: BMC Cancer 2019 19:809

    Content type: Research article

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  31. Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases...

    Authors: Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa and Michèle J. Hoffmann

    Citation: BMC Cancer 2019 19:806

    Content type: Research article

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  32. Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development. The Hippo/YAP pathway is commonly disr...

    Authors: Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho and Min-Kyung Yeo

    Citation: BMC Cancer 2019 19:804

    Content type: Research article

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  33. To validate the utility of the chemokine ligand 12 (CXCL12) as prognostic marker in patients with localized and metastatic germ cell tumors (GCT).

    Authors: Christian Daniel Fankhauser, Lisa Roth, Nico Christian Grossmann, Benedikt Kranzbühler, Daniel Eberli, Tullio Sulser, Holger Moch, Peter-Karl Bode, Joerg Beyer and Thomas Hermanns

    Citation: BMC Cancer 2019 19:802

    Content type: Research article

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  34. Histology is a traditional way to classify subtypes of thymoma, because of low cost and convenience. Yet, due to the diverse morphology of thymoma, this method increases the complexity of histopathologic class...

    Authors: Liang-Chuan Lai, Qiang-Ling Sun, Yu-An Chen, Yi-Wen Hsiao, Tzu-Pin Lu, Mong-Hsun Tsai, Lei Zhu, Eric Y. Chuang and Wentao Fang

    Citation: BMC Cancer 2019 19:796

    Content type: Research article

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  35. Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit formation of breast-cancer-derived experimental lu...

    Authors: Rossano Lattanzio, Manuela Iezzi, Gianluca Sala, Nicola Tinari, Marco Falasca, Saverio Alberti, Simonetta Buglioni, Marcella Mottolese, Letizia Perracchio, Pier Giorgio Natali and Mauro Piantelli

    Citation: BMC Cancer 2019 19:747

    Content type: Research article

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  36. Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to r...

    Authors: Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang

    Citation: BMC Cancer 2019 19:743

    Content type: Research article

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  37. The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that ...

    Authors: Dijana Djureinovic, Victor Pontén, Per Landelius, Sahar Al Sayegh, Kai Kappert, Masood Kamali-Moghaddam, Patrick Micke and Elisabeth Ståhle

    Citation: BMC Cancer 2019 19:741

    Content type: Research article

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  38. Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cle...

    Authors: Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: BMC Cancer 2019 19:732

    Content type: Research article

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  39. Local or distant relapse is the key event for the overall survival of early-stage breast cancer after initial surgery. A small subset of breast cancer cells, which share similar properties with normal stem cel...

    Authors: Yan Qiu, Liya Wang, Xiaorong Zhong, Li Li, Fei Chen, Lin Xiao, Fangyu Liu, Bo Fu, Hong Zheng, Feng Ye and Hong Bu

    Citation: BMC Cancer 2019 19:729

    Content type: Research article

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  40. One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de ...

    Authors: Timo Gemoll, Elena Miroll, Oliver Klein, Annette Lischka, Murat Eravci, Christoph Thorns and Jens K. Habermann

    Citation: BMC Cancer 2019 19:710

    Content type: Research article

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  41. In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern...

    Authors: Weiwei Gong, Yueyang Liu, Christof Seidl, Eleftherios P. Diamandis, Marion Kiechle, Enken Drecoll, Matthias Kotzsch, Viktor Magdolen and Julia Dorn

    Citation: BMC Cancer 2019 19:696

    Content type: Research article

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  42. It is important to identify biomarkers associated with BRCA mutation in women with early breast cancer (BC) to improve early identification of mutation carriers. Thus, in this study, we examined the protein expre...

    Authors: Sabine Danzinger, Yen Yen Tan, Margaretha Rudas, Marie-Theres Kastner, Sigrid Weingartshofer, Daniela Muhr and Christian F. Singer

    Citation: BMC Cancer 2019 19:695

    Content type: Research article

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  43. Current evidence suggests that patients with Luminal A early breast cancer can skip chemotherapy or extended endocrine therapy, but immunohistochemistry-based biomarker analysis for St Gallen subtyping may not...

    Authors: Mark Laible, Kerstin Hartmann, Claudia Gürtler, Tobias Anzeneder, Ralph Wirtz, Stephan Weber, Thomas Keller, Ugur Sahin, Martin Rees and Annette Ramaswamy

    Citation: BMC Cancer 2019 19:694

    Content type: Research article

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  44. The protease uPA and its inhibitor PAI-1 play major roles in hemostasis and are also involved in cancer progression. This is mainly caused by their ability to degrade extracellular matrix-facilitating tumor ce...

    Authors: Bruno Märkl, Martin Kazik, Nadia Harbeck, Elzbieta Jakubowicz, Reinhard Hoffmann, Thomas Jung, Dieter Steinfeld, Gerhard Schenkirsch, Günter Schlimok and Daniel Oruzio

    Citation: BMC Cancer 2019 19:692

    Content type: Research article

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