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Biomarkers

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  1. Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expressi...

    Authors: Howard Yang, Hua Su, Nan Hu, Chaoyu Wang, Lemin Wang, Carol Giffen, Alisa M. Goldstein, Maxwell P. Lee and Philip R. Taylor

    Citation: BMC Cancer 2020 20:388

    Content type: Research article

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  2. Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-...

    Authors: Shuli Tang, Lin Lin, Jianan Cheng, Juan Zhao, Qijia Xuan, Jiayue Shao, Yang Zhou and Yanqiao Zhang

    Citation: BMC Cancer 2020 20:382

    Content type: Research article

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  3. Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on im...

    Authors: Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li and Kun Zhang

    Citation: BMC Cancer 2020 20:378

    Content type: Research article

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  4. The BRAFV600E gene encodes for the mutant BRAFV600E protein, which triggers downstream oncogenic signaling in thyroid cancer. Since most currently available methods have focused on detecting BRAFV600E mutations i...

    Authors: Tien Viet Tran, Kien Xuan Dang, Quynh Huong Pham, Ung Dinh Nguyen, Nhung Thi Trang Trinh, Luong Van Hoang, Son Anh Ho, Ba Van Nguyen, Duc Trong Nguyen, Dung Tuan Trinh, Dung Ngoc Tran, Arto Orpana, Ulf-Håkan Stenman, Jakob Stenman and Tho Huu Ho

    Citation: BMC Cancer 2020 20:368

    Content type: Research article

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  5. Correct identification of the EGFR c.2369C>T p.(Thr790Met) variant is key to decide on a targeted therapeutic strategy for patients with acquired EGFR TKI resistance in non-small cell lung cancer. The aim of this...

    Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Etienne Rouleau, Nils ’t Hart, Lukas Bubendorf, Kelly Dufraing, Céline Garrec, Paul Guéguen, Aude Lamy, Antonio Marchetti, Patrick Pauwels, Ales Ryska, Véronique Tack, Luigi Tornillo, Kaat Van Casteren, Jan H. von der Thüsen…

    Citation: BMC Cancer 2020 20:366

    Content type: Research article

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  6. The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been inv...

    Authors: Bin Li, Zheng Lu, Shengzheng Wang, Junqing Hou, Gang Xia, Heng Li, Bo Yin and Wei Lu

    Citation: BMC Cancer 2020 20:361

    Content type: Research article

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  7. The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth fact...

    Authors: Anne C. Chiang, Ancilla W. Fernandes, Melissa Pavilack, Jennifer W. Wu, François Laliberté, Mei Sheng Duh, Nabil Chehab and Janakiraman Subramanian

    Citation: BMC Cancer 2020 20:356

    Content type: Research article

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  8. ARID1A has been described as a tumor suppressor gene, participating in chromatin re-modeling, epithelial-mesenchymal-transition and many other cellular and molecular processes. It has been cited as a contribut...

    Authors: Mehran Erfani, Seyed Vahid Hosseini, Maral Mokhtari, Mozhdeh Zamani, Kamran Tahmasebi, Mahvash Alizadeh Naini, Alireza Taghavi, John M. Carethers, Minoru Koi, Hassan Brim, Pooneh Mokarram and Hassan Ashktorab

    Citation: BMC Cancer 2020 20:350

    Content type: Research article

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  9. Detection of programmed cell death ligand-1 (PD-L1) by immunohistochemistry (IHC) has been commonly used to predict the efficacy of treatment with PD-1/PD-L1 inhibitors. However, there is limited literature re...

    Authors: Yinying Zou, Liming Xu, Qiusu Tang, Qihan You, Xiaoling Wang, Wei Ding, Jing Zhao and Guoping Ren

    Citation: BMC Cancer 2020 20:344

    Content type: Research article

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  10. Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derive...

    Authors: Marjut Niinivirta, Maria Georganaki, Gunilla Enblad, Cecilia Lindskog, Anna Dimberg and Gustav J. Ullenhag

    Citation: BMC Cancer 2020 20:339

    Content type: Research article

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  11. Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death a...

    Authors: Annat Raiter, Julia Lipovetzki, Ido Lubin and Rinat Yerushalmi

    Citation: BMC Cancer 2020 20:333

    Content type: Research article

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  12. The gene encoding fibroblast growth factor receptor 1 (FGFR1) is emerging as a therapeutic and prognostic biomarker in various cancer types, including head and neck squamous cell carcinoma (SCC). Here, we investi...

    Authors: Eun Kyung Kim, Yoon Ah Cho, Yoon Woo Koh, Hyang Ae Shin, Byoung Chul Cho and Sun Och Yoon

    Citation: BMC Cancer 2020 20:348

    Content type: Research article

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  13. Sodium channels located in the dorsal root ganglion, particularly Nav1.7 and Nav1.8, encoded by SCN9A and SCN10A, respectively, act as molecular gatekeepers for pain detection. Our aim was to determine the associ...

    Authors: Yuko Tanabe, Seiji Shiraishi, Kenji Hashimoto, Kazutaka Ikeda, Daisuke Nishizawa, Junko Hasegawa, Akihiko Shimomura, Yukinori Ozaki, Nobuko Tamura, Mayu Yunokawa, Kan Yonemori, Toshimi Takano, Hidetaka Kawabata, Kenji Tamura, Yasuhiro Fujiwara and Chikako Shimizu

    Citation: BMC Cancer 2020 20:325

    Content type: Research article

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  14. Colon adenocarcinoma (COAD) is one of the most lethal cancers. It is particularly important to accurately predict prognosis and to provide individualized treatment. Several lines of evidence suggest that genet...

    Authors: Xueying Li, Weiming Yu, Chao Liang, Yuan Xu, Miaozun Zhang, Xiaoyun Ding and Xianlei Cai

    Citation: BMC Cancer 2020 20:305

    Content type: Research article

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  15. Although docetaxel-based chemohormonal therapy (CHT) is one of the standard treatments for castration-resistant prostate cancer (CRPC), pertinent biomarkers and precise mechanisms involved in the resistance fo...

    Authors: Yoshinori Matsuda, Shintaro Narita, Taketoshi Nara, Huang Mingguo, Hiromi Sato, Atsushi Koizumi, Sohei Kanda, Kazuyuki Numakura, Mitsuru Saito, Takamitsu Inoue, Yuko Hiroshima, Hiroshi Nanjo, Shigeru Satoh, Norihiko Tsuchiya and Tomonori Habuchi

    Citation: BMC Cancer 2020 20:302

    Content type: Research article

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  16. Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues is replicated in peripheral leukocytes. This study ai...

    Authors: Giselle M. Faria, Igor D. P. Soares, Marcela D’Alincourt Salazar, Marcia R. Amorim, Bruno L. Pessoa, Clovis O. da Fonseca and Thereza Quirico-Santos

    Citation: BMC Cancer 2020 20:294

    Content type: Research article

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  17. Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic drug resistance in AML. Studies rega...

    Authors: Sook-Kyoung Heo, Eui-Kyu Noh, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi and Jae-Cheol Jo

    Citation: BMC Cancer 2020 20:285

    Content type: Research article

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  18. The prevalence of programmed death-ligand 1 (PD-L1) and PD-L2 expression on tumor cells and tumor-infiltrating immune cells in primary central nervous system lymphoma (PCNSL) remains unclear. In the present st...

    Authors: Motomasa Furuse, Hiroko Kuwabara, Naokado Ikeda, Yasuhiko Hattori, Tomotsugu Ichikawa, Naoki Kagawa, Kenichiro Kikuta, Sho Tamai, Mitsutoshi Nakada, Toshihiko Wakabayashi, Masahiko Wanibuchi, Toshihiko Kuroiwa, Yoshinobu Hirose and Shin-Ichi Miyatake

    Citation: BMC Cancer 2020 20:277

    Content type: Research article

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  19. Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy ...

    Authors: Mercedes Delgado-García, Birgit Weynand, Lourdes Gómez-Izquierdo, María José Hernández, Ángela María Blanco, Mar Varela, Xavier Matias-Guiu, Ernest Nadal, Bélgica Márquez-Lobo, Ana Alarcão, Enrique de Álava and Michele Biscuola

    Citation: BMC Cancer 2020 20:275

    Content type: Research article

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  20. Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in cc...

    Authors: Ju-Yoon Yoon, Craig Gedye, Joshua Paterson and Laurie Ailles

    Citation: BMC Cancer 2020 20:272

    Content type: Research article

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  21. Lymphovascular invasion (LOI), a key pathological feature of head and neck squamous cell carcinoma (HNSCC), is predictive of poor survival; however, the associated clinical characteristics and underlying molec...

    Authors: Jian Zhang, Huaming Lin, Huali Jiang, Hualong Jiang, Tao Xie, Baiyao Wang, Xiaoting Huang, Jie Lin, Anan Xu, Rong Li, Jiexia Zhang and Yawei Yuan

    Citation: BMC Cancer 2020 20:266

    Content type: Research article

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  22. Chromodomain helicase DNA-binding protein 4 (CHD4) has been shown to contribute to DNA repair and cell cycle promotion; however, its roles in cancer initiation and progression remain largely unknown. This stud...

    Authors: Nuo Xu, Fanglei Liu, Shengdi Wu, Maosong Ye, Haiyan Ge, Meiling Zhang, Yuanlin Song, Lin Tong, Jian Zhou and Chunxue Bai

    Citation: BMC Cancer 2020 20:262

    Content type: Research article

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  23. No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).

    Authors: Kim Oren Gradel, Pedro Póvoa, Olav Sivertsen Garvik, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Ming Chen, Ram Benny Dessau, Jens Kjølseth Møller, John Eugenio Coia, Pernille Sanberg Ljungdalh, Annmarie Touborg Lassen and Henrik Frederiksen

    Citation: BMC Cancer 2020 20:249

    Content type: Research article

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  24. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. Despite the advances in radiation therap...

    Authors: Nasser Al-Rajhi, Hussein Soudy, Shoaib A. Ahmed, Tusneem Elhassan, Shamayel F. Mohammed, Hatim A. Khoja and Hazem Ghebeh

    Citation: BMC Cancer 2020 20:240

    Content type: Research article

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  25. Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigate...

    Authors: Hualin Song, Song Jin, Peng Xiang, Shuai Hu and Jie Jin

    Citation: BMC Cancer 2020 20:238

    Content type: Research article

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  26. The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated wi...

    Authors: Nianhua Ding, Juan Huang, Ningsha Li, Jiaqi Yuan, Shouman Wang and Zhi Xiao

    Citation: BMC Cancer 2020 20:235

    Content type: Research article

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  27. Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different p...

    Authors: Fabiana Pirani Carneiro, Rivadávio Fernandes Amorim, Marcos de Vasconcelos Carneiro, Tercia Maria Mendes Lousa de Castro, Leonora Maciel de Souza Vianna, Gustavo Henrique Soares Takano, Andersen Charles Daros, Isabela Peres, Selma Aparecida Souza Kuckelhaus and Andrea Barretto Motoyama

    Citation: BMC Cancer 2020 20:225

    Content type: Research article

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  28. Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging ca...

    Authors: Yosep Chong, Nishant Thakur, Kwang Yeol Paik, Eun Jung Lee and Chang Suk Kang

    Citation: BMC Cancer 2020 20:216

    Content type: Research article

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  29. Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer. Ubiquitin-specific protease (USP)44 has been reported to be involved in various cancers. We investigated the function, ro...

    Authors: Jiangqiao Zhou, Tianyu Wang, Tao Qiu, Zhongbao Chen, Xiaoxiong Ma, Long Zhang and Jilin Zou

    Citation: BMC Cancer 2020 20:214

    Content type: Research article

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  30. Tumor mutational burden (TMB) is a potential biomarker for immune checkpoint therapy and prognosis. The impact of TMB on clinical outcomes and the correlation coefficient between exome sequencing and targeted ...

    Authors: Lihong Wang, Jia Ge, Yang Lan, Yu Shi, Ying Luo, Yuhuan Tan, Mei Liang, Song Deng, Xia Zhang, Wenying Wang, Yaoyao Tan, Yuanyuan Xu and Tao Luo

    Citation: BMC Cancer 2020 20:213

    Content type: Research article

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  31. Inflammation-related parameters have been revealed to have prognostic value in multiple caners. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-l...

    Authors: Li-jian Xia, Wen Li, Jian-cheng Zhai, Chuan-wang Yan, Jing-bo Chen and Hui Yang

    Citation: BMC Cancer 2020 20:208

    Content type: Research article

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  32. The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the progno...

    Authors: Takaaki Oba, Kazuma Maeno, Daiya Takekoshi, Mayu Ono, Tokiko Ito, Toshiharu Kanai and Ken-ichi Ito

    Citation: BMC Cancer 2020 20:160

    Content type: Research article

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  33. Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CC...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun and Watcharin Loilome

    Citation: BMC Cancer 2020 20:154

    Content type: Research article

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  34. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequent...

    Authors: Danielle Pessôa-Pereira, Adriane Feijó Evangelista, Rhafaela Lima Causin, René Aloisio da Costa Vieira, Lucas Faria Abrahão-Machado, Iara Viana Vidigal Santana, Vinicius Duval da Silva, Karen Cristina Borba de Souza, Renato José de Oliveira-Silva, Gabriela Carvalho Fernandes, Rui Manuel Reis, Edenir Inêz Palmero and Márcia Maria Chiquitelli Marques

    Citation: BMC Cancer 2020 20:143

    Content type: Research article

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  35. The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for ...

    Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho and Joseph Taube

    Citation: BMC Cancer 2020 20:141

    Content type: Research article

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  36. To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay ...

    Authors: Shuang Ye, Xiaohua Sun, Bin Kang, Fei Wu, Zhong Zheng, Libing Xiang, Mylène Lesénéchal, Fabienne Heskia, Ji Liang and Huijuan Yang

    Citation: BMC Cancer 2020 20:138

    Content type: Research article

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  37. In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitiv...

    Authors: Cherylle Goebel, Christopher L. Louden, Robert Mckenna Jr, Osita Onugha, Andrew Wachtel and Thomas Long

    Citation: BMC Cancer 2020 20:137

    Content type: Research article

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  38. Microvascular invasion (MVI) is an independent risk factor for poor prognosis in hepatocellular carcinoma (HCC). However, there is still a lack of preoperative markers to predict MVI in HCC. This study intends...

    Authors: Hongxing Zhang, Yu Zhou, Yicheng Li, Wanying Qin, Yunhua Zi, Yulan Liu, Xiaoying Qiu, Hongyuan Xu, Weijia Liao and Zhaoquan Huang

    Citation: BMC Cancer 2020 20:132

    Content type: Research article

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  39. Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile...

    Authors: Shuang Zhang, Takeo Minaguchi, Chenyang Xu, Nan Qi, Hiroya Itagaki, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Hiroyuki Ochi and Toyomi Satoh

    Citation: BMC Cancer 2020 20:127

    Content type: Research article

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  40. Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for mo...

    Authors: Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Silva dos Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim…

    Citation: BMC Cancer 2020 20:119

    Content type: Research article

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  41. Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-associated deaths and a majority of its histological type is manifested as serous ovarian cancer (SOC). In this study, we investigat...

    Authors: Yijing He, Ting Li, Jue Liu, Qiong Ou and Junlin Zhou

    Citation: BMC Cancer 2020 20:116

    Content type: Research article

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  42. The HER2 extracellular domain shed in blood (HER2ECD) is reported to rise and fall in parallel with HER2+ breast cancer behavior. In this study, we evaluated the clinical relevance of plasma HER2ECD values in pat...

    Authors: Serenella Eppenberger-Castori, Dirk Klingbiel, Thomas Ruhstaller, Daniel Dietrich, Daniel Alexander Rufle, Karin Rothgiesser, Olivia Pagani and Beat Thürlimann

    Citation: BMC Cancer 2020 20:114

    Content type: Research article

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  43. Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of cir...

    Authors: Jian Zheng, Xiong Ye, Yanan Liu, Yuxia Zhao, Mudan He and Hui Xiao

    Citation: BMC Cancer 2020 20:106

    Content type: Research article

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  44. Recent studies indicate the benefit of treatment with osimertinib over that with conventional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for untreated EGFR-mutated non-small cell lun...

    Authors: Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai and Keisuke Tomii

    Citation: BMC Cancer 2020 20:104

    Content type: Research article

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  45. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto

    Citation: BMC Cancer 2020 20:103

    Content type: Research article

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  46. Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent nee...

    Authors: Yan Su, Lijun Wang, Chiyi Jiang, Zhixia Yue, Hongjun Fan, Huimin Hong, Chao Duan, Mei Jin, Dawei Zhang, Lihua Qiu, Xianfeng Cheng, Zhong Xu and Xiaoli Ma

    Citation: BMC Cancer 2020 20:102

    Content type: Research article

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  47. Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT s...

    Authors: César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde…

    Citation: BMC Cancer 2020 20:99

    Content type: Research article

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