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Biomarkers

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  1. This study was aimed to explore the predictive ability of tumor infiltrating neutrophil (TIN) in patients with breast cancer treated with neoadjuvant chemotherapy (NACT). Furthermore, the significance of TIN’s...

    Authors: Sheng-Kai Geng, Shao-Mei Fu, Shi-Hong Ma, Yi-Peng Fu and Hong-Wei Zhang

    Citation: BMC Cancer 2021 21:68

    Content type: Research article

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  2. The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. Our aim is to explore the expression of NNMT in ovarian cancer and to assess its association with patient prognosis and t...

    Authors: Jun Li, Huiran Yue, Hailin Yu, Xin Lu and Xiaohong Xue

    Citation: BMC Cancer 2021 21:67

    Content type: Research article

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  3. We evaluated the prognostic potential of tumor 18F-fluorodeoxyglucose (FDG) uptake derived from positron emission tomography (PET) and known inflammatory hematological markers, both individually and in combinatio...

    Authors: Kewei Zhao, Chunsheng Wang, Fang Shi, Yong Huang, Li Ma, Minghuan Li and Yipeng Song

    Citation: BMC Cancer 2021 21:66

    Content type: Research article

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  4. Autophagy-related genes (ARGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of ARGs and their clinical significance i...

    Authors: Yuanhe Wang, Jianyi Li, Cheng Shao, Xiaojie Tang, Yukun Du, Tongshuai Xu, Zheng Zhao, Huiqiang Hu, Yingyi Sheng, Chuan Hu and Yongming Xi

    Citation: BMC Cancer 2021 21:58

    Content type: Research article

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  5. Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal ana...

    Authors: Saskia Hussung, Dilara Akhoundova, Julian Hipp, Marie Follo, Rhena F. U. Klar, Ulrike Philipp, Florian Scherer, Nikolas von Bubnoff, Justus Duyster, Melanie Boerries, Uwe Wittel and Ralph M. Fritsch

    Citation: BMC Cancer 2021 21:49

    Content type: Research article

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  6. To improve the efficiency of early diagnosis systems for cervical cancer, the use of cellular and viral markers for identifying precancerous lesions with a greater probability to progress to cancer has been pr...

    Authors: Oscar Del Moral-Hernández, Daniel Hernández-Sotelo, Luz del Carmen Alarcón-Romero, Miguel Angel Mendoza-Catalán, Eugenia Flores-Alfaro, Yaneth Castro-Coronel, Julio Ortiz-Ortiz, Marco Antonio Leyva-Vázquez, Carlos Ortuño-Pineda, Wendy Castro-Mora and Berenice Illades-Aguiar

    Citation: BMC Cancer 2021 21:39

    Content type: Research article

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  7. Endometrial cancer (EC) is one of the most common gynecological malignancies worldwide. However, the molecular mechanisms and the prognostic prediction for EC patients remain unclear.

    Authors: Jinhui Liu, Pinping Jiang, Xucheng Chen, Yujie Shen, Guoliang Cui, Ziyan Ma, Shaojie Zhao and Yan Zhang

    Citation: BMC Cancer 2021 21:29

    Content type: Research article

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  8. Contradictory and limited data are available about the presentation and outcomes of patients with RET-fusion positive metastatic NSCLC as compared to patients without RET fusions. This observational study utilizi...

    Authors: Lisa M. Hess, Yimei Han, Yajun Emily Zhu, Naleen Raj Bhandari and Anthony Sireci

    Citation: BMC Cancer 2021 21:28

    Content type: Research article

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  9. Clear cell renal cell carcinoma is susceptible to ferroptosis, and immunotherapy is recently recommended as a priority for the initial treatment of metastatic clear cell renal carcinoma. Increased ferroptosis ...

    Authors: Yanhua Mou, Jinchun Wu, Yao Zhang, Omar Abdihamid, Chaojun Duan and Bin Li

    Citation: BMC Cancer 2021 21:18

    Content type: Research article

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  10. Autophagy is a highly conserved homeostatic process in the human body that is responsible for the elimination of aggregated proteins and damaged organelles. Several autophagy-related genes (ARGs) contribute to...

    Authors: Lei Wu, Wen Quan, Guojun Yue, Qiong Luo, Dongxu Peng, Ying Pan and Guihai Zhang

    Citation: BMC Cancer 2021 21:15

    Content type: Research article

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  11. Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) regulate alternative splicing events of various pre-mRNAs. Some of these targets play a role in cancer-associated processes, including cytoskeleto...

    Authors: Morton Freytag, Martina Kluth, Elena Bady, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Hans Heinzer, Doris Höflmayer, Sören Weidemann, Ria Uhlig, Hartwig Huland, Markus Graefen, Christian Bernreuther, Corinna Wittmer, Maria Christina Tsourlakis, Sarah Minner, David Dum…

    Citation: BMC Cancer 2020 20:1220

    Content type: Research article

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  12. Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can b...

    Authors: Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner and Edward B. Brown

    Citation: BMC Cancer 2020 20:1217

    Content type: Research article

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  13. We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis.

    Authors: Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Han Shin Lee, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong and Young-Tae Ju

    Citation: BMC Cancer 2020 20:1206

    Content type: Research article

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  14. Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immu...

    Authors: Shibai Yan, Juntao Fang, Yongcai Chen, Yong Xie, Siyou Zhang, Xiaohui Zhu and Feng Fang

    Citation: BMC Cancer 2020 20:1205

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2021 21:55

  15. Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates worldwide. Alcohol dehydrogenases (ADHs) are huge family of dehydrogenase enzymes and associated with the prognosis of var...

    Authors: Xiangye Liu, Tingting Li, Delong Kong, Hongjuan You, Fanyun Kong and Renxian Tang

    Citation: BMC Cancer 2020 20:1204

    Content type: Research article

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  16. Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive...

    Authors: Lavanya Lokhande, Venera Kuci Emruli, Arne Kolstad, Martin Hutchings, Riikka Räty, Mats Jerkeman and Sara Ek

    Citation: BMC Cancer 2020 20:1202

    Content type: Research article

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  17. Streptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic efficacy is relatively low in GI-NETs. Therefore, it has become pivotal ...

    Authors: Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno and Hironobu Sasano

    Citation: BMC Cancer 2020 20:1195

    Content type: Research article

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  18. It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeas...

    Authors: Hideaki Kinugasa, Sakiko Hiraoka, Kazuhiro Nouso, Shumpei Yamamoto, Mami Hirai, Hiroyuki Terasawa, Eriko Yasutomi, Shohei Oka, Masayasu Ohmori, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Keita Harada, Takehiro Tanaka and Hiroyuki Okada

    Citation: BMC Cancer 2020 20:1188

    Content type: Research article

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  19. MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, highly expressed in diverse cancers and was involved in cancer molecular pathogenesis. However, its deliverance profil...

    Authors: Chensheng Qiu, Weiliang Su, Nana Shen, Xiaoying Qi, Xiaolin Wu, Kai Wang, Lin Li, Zhu Guo, Hao Tao, Guanrong Wang, Bohua Chen and Hongfei Xiang

    Citation: BMC Cancer 2020 20:1187

    Content type: Research article

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  20. Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immuno...

    Authors: Javed Akhtar, Ratna Priya, Vaishali Jain, Puja Sakhuja, Anil Kumar Agarwal, Surbhi Goyal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar and Poonam Gautam

    Citation: BMC Cancer 2020 20:1175

    Content type: Research article

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  21. An increasing number of studies have focused on the association between leptin, adiponectin levels and the risk as well as the prognosis of hepatocellular carcinoma. However, the reported results are conflicting.

    Authors: Lilong Zhang, Qihang Yuan, Man Li, Dongqi Chai, Wenhong Deng and Weixing Wang

    Citation: BMC Cancer 2020 20:1167

    Content type: Research article

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  22. Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involve...

    Authors: Xiao-Han Cui, Shu-Yi Hu, Chun-Fu Zhu and Xi-Hu Qin

    Citation: BMC Cancer 2020 20:1160

    Content type: Research article

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  23. Whether tumour-infiltrating lymphocytes (TILs) play different roles in different molecular subtypes of breast cancer remains unknown. Additionally, their prognostic and predictive value in different molecular ...

    Authors: Zhao-hua Gao, Cun-xin Li, Ming Liu and Jia-yuan Jiang

    Citation: BMC Cancer 2020 20:1150

    Content type: Research article

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  24. Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.

    Authors: Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin and Jian Zhang

    Citation: BMC Cancer 2020 20:1143

    Content type: Research article

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  25. Hepatocellular carcinoma (HCC) is among the deadliest forms of cancer. While RNA-binding proteins (RBPs) have been shown to be key regulators of oncogenesis and tumor progression, their dysregulation in the co...

    Authors: Min Wang, Shan Huang, Zefeng Chen, Zhiwei Han, Kezhi Li, Chuang Chen, Guobin Wu and Yinnong Zhao

    Citation: BMC Cancer 2020 20:1136

    Content type: Research article

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  26. The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in ...

    Authors: Zizhen Zhang, Sheng Zheng, Yifeng Lin, Jiawei Sun, Ning Ding, Jingyu Chen, Jing Zhong, Liuhong Shi and Meng Xue

    Citation: BMC Cancer 2020 20:1135

    Content type: Research article

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  27. Cervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer patient survival. However, there is no relevant study on the relations...

    Authors: Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li and Xiaojian Yan

    Citation: BMC Cancer 2020 20:1133

    Content type: Research article

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  28. The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...

    Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege…

    Citation: BMC Cancer 2020 20:1130

    Content type: Research article

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  29. Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this ...

    Authors: Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier and Takahisa Furuta

    Citation: BMC Cancer 2020 20:1123

    Content type: Research article

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  30. Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urin...

    Authors: Wen Liu, Zhankun Wang, Shuai Liu, Yu Yao, Yong Liu and Guiming Zhang

    Citation: BMC Cancer 2020 20:1113

    Content type: Research article

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  31. Identifying the mutation status of KRAS is important for optimizing treatment in patients with colorectal cancer (CRC). The aim of this study was to investigate the predictive value of haematological parameter...

    Authors: Yinghao Cao, Junnan Gu, Lizhao Yan, Shenghe Deng, Fuwei Mao, Wentai Cai, Hang Li, Xinghua Liu, Jiliang Wang, Ke Wu and Kailin Cai

    Citation: BMC Cancer 2020 20:1099

    Content type: Research article

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  32. Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive a...

    Authors: Mouadh Barbirou, Henok G. Woldu, Ikram Sghaier, Sinda A. Bedoui, Amina Mokrani, Radhia Aami, Amel Mezlini, Besma Yacoubi-Loueslati, Peter J. Tonellato and Balkiss Bouhaouala-Zahar

    Citation: BMC Cancer 2020 20:1086

    Content type: Research article

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  33. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported ...

    Authors: Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai and Ze Yang

    Citation: BMC Cancer 2020 20:1071

    Content type: Research article

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  34. Extensive research has revealed that genes play a pivotal role in tumor development and growth. However, the underlying involvement of gene expression in gastric carcinoma (GC) remains to be investigated further.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren

    Citation: BMC Cancer 2020 20:1062

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1141

  35. Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma that is highly aggressive where one-third of the patients relapse despite effective treatment. Interaction between the lymphoma cells and the non...

    Authors: Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain and Dipti Talaulikar

    Citation: BMC Cancer 2020 20:1061

    Content type: Research article

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  36. Measurement of serum human epidermal growth factor receptor-2 (HER-2/neu) levels might play an essential role as a diagnostic/screening marker for the early selection of therapeutic approaches and predict prognos...

    Authors: Amir Shamshirian, Amir Reza Aref, George W. Yip, Majid Ebrahimi Warkiani, Keyvan Heydari, Sajad Razavi Bazaz, Zeinab Hamzehgardeshi, Danial Shamshirian, Mahmood Moosazadeh and Reza Alizadeh-Navaei

    Citation: BMC Cancer 2020 20:1049

    Content type: Research article

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  37. Lung adenocarcinoma (LUAD) remains a crucial factor endangering human health. Gene-based clinical predictions could be of great help for cancer intervention strategies. Here, we tried to build a gene-based sur...

    Authors: Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han and Tao Jiang

    Citation: BMC Cancer 2020 20:1046

    Content type: Research article

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  38. OCT-1 gene is a member of the POU-homeodomain family of transcriptional regulators of B-lymphocyte differentiation by controlling expression of B-cell specific genes. BCL-2 gene is a potent inhibitor of apoptosis...

    Authors: Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa and Juliana Pereira

    Citation: BMC Cancer 2020 20:1041

    Content type: Research article

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  39. High-grade serous ovarian cancer (HGSOC) is a fatal form of ovarian cancer. Previous studies indicated some potential biomarkers for clinical evaluation of HGSOC prognosis. However, there is a lack of systemat...

    Authors: Min Li, Xue Cheng, Rong Rong, Yan Gao, Xiuwu Tang and Youguo Chen

    Citation: BMC Cancer 2020 20:1032

    Content type: Research article

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  40. Globally, endometrial cancer is the fourth most common malignant tumor in women and the number of women being diagnosed is increasing. Tumor progression is strongly related to the cell survival-promoting funct...

    Authors: Jun Zhang, Ziwei Wang, Rong Zhao, Lanfen An, Xing Zhou, Yingchao Zhao and Hongbo Wang

    Citation: BMC Cancer 2020 20:1030

    Content type: Research article

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  41. Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this ...

    Authors: Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez and José Luis Bello López

    Citation: BMC Cancer 2020 20:1017

    Content type: Research article

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