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Biomarkers

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  1. This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myelom...

    Authors: Fan Zhou, Dongjiao Wang, Wei Wei, Haimin Chen, Haotian Shi, Nian Zhou, Lixia Wu and Rong Peng

    Citation: BMC Cancer 2020 20:40

    Content type: Research article

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  2. Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...

    Authors: Darina Kohoutova, Miroslava Forstlova, Paula Moravkova, Jiri Cyrany, Juraj Bosak, David Smajs, Stanislav Rejchrt and Jan Bures

    Citation: BMC Cancer 2020 20:39

    Content type: Research article

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  3. The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide...

    Authors: Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo and Yuanli Zhao

    Citation: BMC Cancer 2020 20:35

    Content type: Research article

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  4. High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine ...

    Authors: Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel and Ulrich Knigge

    Citation: BMC Cancer 2020 20:27

    Content type: Research article

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  5. The NEK serine/threonine protein kinases are involved in cell cycle checkpoints, DNA damage repair, and apoptosis. Alterations in these pathways are frequently associated with cell malignant cellular transform...

    Authors: Talita Diniz Melo-Hanchuk, Mariana Bonjiorno Martins, Lucas Leite Cunha, Fernando Augusto Soares, Laura Sterian Ward, José Vassallo and Jörg Kobarg

    Citation: BMC Cancer 2020 20:23

    Content type: Research article

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  6. Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy....

    Authors: Zuzana Cierna, Vera Miskovska, Jan Roska, Dana Jurkovicova, Lucia Borszekova Pulzova, Zuzana Sestakova, Lenka Hurbanova, Katarina Machalekova, Michal Chovanec, Katarina Rejlekova, Daniela Svetlovska, Katarina Kalavska, Karol Kajo, Pavel Babal, Jozef Mardiak, Thomas A. Ward…

    Citation: BMC Cancer 2020 20:17

    Content type: Research article

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  7. Hepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity is high. Tissue biopsy is an invasive operation and may in...

    Authors: Wene Wei, Mengshu Liu, Shufang Ning, Jing Wei, Jianhong Zhong, Jilin Li, Zhengmin Cai and Litu Zhang

    Citation: BMC Cancer 2020 20:6

    Content type: Research article

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  11. Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined perform...

    Authors: Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu and Xuelei Ma

    Citation: BMC Cancer 2019 19:1223

    Content type: Research article

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  12. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio

    Citation: BMC Cancer 2019 19:1216

    Content type: Research article

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  13. It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.

    Authors: Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang and Pei-Rong Ding

    Citation: BMC Cancer 2019 19:1210

    Content type: Research article

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  14. Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammato...

    Authors: Takumi Kishimoto, Nobukazu Fujimoto, Takeshi Ebara, Toyonori Omori, Tetsuya Oguri, Akio Niimi, Takako Yokoyama, Munehiro Kato, Ikuji Usami, Masayuki Nishio, Kosho Yoshikawa, Takeshi Tokuyama, Mouka Tamura, Yoshifumi Yokoyama, Ken Tsuboi, Yoichi Matsuo…

    Citation: BMC Cancer 2019 19:1204

    Content type: Research article

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  15. Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been ...

    Authors: Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung and Jae-Hoon Kim

    Citation: BMC Cancer 2019 19:1202

    Content type: Research article

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  16. To discover biomarker panels that could distinguish cancers (BC and RCC) from healthy controls (HCs) and bladder cancers (BC) from renal cell carcinoma (RCC), regardless of whether the patients have haematuria...

    Authors: Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang and Wei Sun

    Citation: BMC Cancer 2019 19:1195

    Content type: Research article

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  17. Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial therapeutic breakthrough has been made in the past few d...

    Authors: Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld…

    Citation: BMC Cancer 2019 19:1191

    Content type: Research article

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  18. Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses.

    Authors: Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh and Kung-Hao Liang

    Citation: BMC Cancer 2019 19:1190

    Content type: Research article

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  19. Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell inf...

    Authors: Xin Rui, Siliang Shao, Li Wang and Jiangyong Leng

    Citation: BMC Cancer 2019 19:1179

    Content type: Research article

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  20. Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used ...

    Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Piyali Sarkar, Shatakshee Chatterjee, Debashis Nath, Kshaunish Das and Srikanta Goswami

    Citation: BMC Cancer 2019 19:1175

    Content type: Research article

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  21. Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake ...

    Authors: Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu and Akihiko Saito

    Citation: BMC Cancer 2019 19:1170

    Content type: Research article

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  22. Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease that is involved in the invasiveness and progression of cancer. There is good evidence that uPA expression is a clinically re...

    Authors: Ming-Chao Tsai, Yi-Hao Yen, Kuo-Chin Chang, Chao-Hung Hung, Chien-Hung Chen, Ming-Tsung Lin and Tsung-Hui Hu

    Citation: BMC Cancer 2019 19:1169

    Content type: Research article

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  23. Circulating tumor cells (CTCs) are associated with breast cancer prognosis. Research is limited regarding the role of circulating cancer stem-like cells (cCSCs) considering the treatment response and survival ...

    Authors: Chun-Hui Lee, Jason Chia-Hsun Hsieh, Tyler Min-Hsien Wu, Ting-Shiuan Yeh, Hung-Ming Wang, Yung-Chan Lin, Jen-Shi Chen, Chia-Lin Lee, Wen-Kuan Huang, Tsung-Min Hung, Tzu-Tsen Yen, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Ching-Chih Hu and Pei-Hung Chang

    Citation: BMC Cancer 2019 19:1167

    Content type: Research article

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  25. Post-surgical staging is the mainstay of prognostic stratification for colorectal cancer (CRC). Here, we compare TNM staging to consensus molecular subtyping (CMS) and assess the value of subtyping in addition...

    Authors: Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson and Francis A. Frizelle

    Citation: BMC Cancer 2019 19:1155

    Content type: Research article

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  26. Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). ...

    Authors: Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan and Qinglian Wen

    Citation: BMC Cancer 2019 19:1134

    Content type: Research article

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  27. Operable breast cancer patients may experience late recurrences because of reactivation of dormant tumor cells within the bone marrow (BM). Identification of patients who would benefit from extended therapy is...

    Authors: Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen and Bjørnar Gilje

    Citation: BMC Cancer 2019 19:1131

    Content type: Research article

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  28. The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are ass...

    Authors: Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:1127

    Content type: Research article

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  29. Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

    Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang

    Citation: BMC Cancer 2019 19:1116

    Content type: Database

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  30. The aim was to investigate the prognostic value of MR apparent diffusion coefficients (ADC) using histogram analysis (HA) in predicting disease-free survival (DFS) of cervical cancer after chemo-radiation ther...

    Authors: Bo Zhao, Kun Cao, Xiao-Ting Li, Hai-Tao Zhu and Ying-Shi Sun

    Citation: BMC Cancer 2019 19:1115

    Content type: Research article

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  31. We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue micr...

    Authors: Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein and Jacek Pinski

    Citation: BMC Cancer 2019 19:1114

    Content type: Research article

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  32. Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. The presence of ctDNA in the blood is a result of biological pro...

    Authors: Leslie Calapre, Lydia Warburton, Michael Millward and Elin S. Gray

    Citation: BMC Cancer 2019 19:1109

    Content type: Case report

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  33. Recently, a growing number of studies have reported the coorelation between miR-155 and the diagnosis and prognosis of lung cancer, but results of these researches were still controversial due to insufficient ...

    Authors: Chuchu Shao, Fengming Yang, Zhiqiang Qin, Xinming Jing, Yongqian Shu and Hua Shen

    Citation: BMC Cancer 2019 19:1103

    Content type: Research article

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  34. The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratificati...

    Authors: Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni and Tanja Fehm

    Citation: BMC Cancer 2019 19:1101

    Content type: Research article

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  35. Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum ...

    Authors: Takahiro Maeda, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Kengo Kanayama, Susumu Maruta, Yuko Kusakabe, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Ryo Nakagawa…

    Citation: BMC Cancer 2019 19:1088

    Content type: Research article

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  36. SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far. Few patients with recurrent glioma have opportunity...

    Authors: Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng and Qichun Wei

    Citation: BMC Cancer 2019 19:1087

    Content type: Research article

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  37. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1085

    Content type: Research article

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  38. Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse lar...

    Authors: Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai and Shudao Xiong

    Citation: BMC Cancer 2019 19:1084

    Content type: Research article

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  39. Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF ...

    Authors: Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee and Ming-Hong Tai

    Citation: BMC Cancer 2019 19:1083

    Content type: Research article

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  40. To reveal roles of reactive oxygen species (ROS) status in chemotherapy resistance and to develop a ROS scoring system for prognosis prediction in ovarian cancer.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen

    Citation: BMC Cancer 2019 19:1061

    Content type: Research article

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  41. There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable pro...

    Authors: Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat and Andrey Bychkov

    Citation: BMC Cancer 2019 19:1050

    Content type: Research article

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  42. Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain controversial an...

    Authors: Yan-Li Li, Zhi-Hu Shi, Xian Wang, Kang-Sheng Gu and Zhi-Min Zhai

    Citation: BMC Cancer 2019 19:1049

    Content type: Research article

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  43. Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal therapeutic strategy still exists. This research was perfo...

    Authors: Chenjing Zhu, Otilia Menyhart, Balázs Győrffy and Xia He

    Citation: BMC Cancer 2019 19:1046

    Content type: Research article

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  44. The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pa...

    Authors: Chaohui Lisa Zhao, Kamaljeet Singh, Alexander S. Brodsky, Shaolei Lu, Theresa A. Graves, Mary Anne Fenton, Dongfang Yang, Ashlee Sturtevant, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1036

    Content type: Research article

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  45. The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using i...

    Authors: Yabing Cao, Kin Iong Chan, Gungli Xiao, Yanqun Chen, Xibin Qiu, Hu Hao, Sao Chi Mak and Tongyu Lin

    Citation: BMC Cancer 2019 19:1022

    Content type: Research article

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  46. Recent preclinical data suggest that androgen receptor (AR) signaling plays a significant role in subsets of breast cancer. Clinical trials testing AR-targeting therapies in breast cancer have been conducted. ...

    Authors: Toru Hanamura, Koichi Ohno, Shinya Hokibara, Hideki Murasawa, Toshitsugu Nakamura, Hidehiko Watanabe, Machiko Kaizuka, Shinji Sawano, Hiroshi Koyama and Ken-ichi Ito

    Citation: BMC Cancer 2019 19:1021

    Content type: Research article

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  47. Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical p...

    Authors: Sergei E. Titov, Mikhail K. Ivanov, Pavel S. Demenkov, Gevork A. Katanyan, Eugenia S. Kozorezova, Anastasia V. Malek, Yulia A. Veryaskina and Igor F. Zhimulev

    Citation: BMC Cancer 2019 19:1010

    Content type: Research article

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  48. An External Quality Assessment (EQA) program was developed to investigate the status of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 immunohistochemical (IHC) detection in breast cancer and to...

    Authors: Tianjie Pu, Ruohong Shui, Jie Shi, Zhiyong Liang, Wentao Yang, Hong Bu, Qin Li and Zhang Zhang

    Citation: BMC Cancer 2019 19:978

    Content type: Technical advance

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  49. Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors were associated with clinical benefit in patients with melanoma or lung cancer. In advanced gastric c...

    Authors: Ken Masuda, Hirokazu Shoji, Kengo Nagashima, Shun Yamamoto, Masashi Ishikawa, Hiroshi Imazeki, Masahiko Aoki, Takahiro Miyamoto, Hidekazu Hirano, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Atsuo Takashima, Ken Kato and Narikazu Boku

    Citation: BMC Cancer 2019 19:974

    Content type: Research article

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  50. Significant advances in the molecular profiling of gliomas, led the 2016 World Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers in glioma diagnosis: IDH mutations and ...

    Authors: Cheila Brito, Ana Azevedo, Susana Esteves, Ana Rita Marques, Carmo Martins, Ilda Costa, Manuela Mafra, José M. Bravo Marques, Lúcia Roque and Marta Pojo

    Citation: BMC Cancer 2019 19:968

    Content type: Research article

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