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Biomarkers

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  1. Several studies have investigated the associations between the podocalyxin-like protein (PODXL) expression quantity or locations and cancers survival, but the results were far from conclusive. Therefore, we pr...

    Authors: Siying He, Wenjie Du, Menglan Li, Ming Yan and Fang Zheng

    Citation: BMC Cancer 2020 20:620

    Content type: Research article

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  2. Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT ant...

    Authors: Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda and Hiroshi Shiku

    Citation: BMC Cancer 2020 20:606

    Content type: Research article

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  3. Esophageal squamous cell carcinoma (ESCC) is a common malignant carcinoma of digestive system with high mortality. RAB, member RAS oncogene family like 6 (RABL6), a member of the RAS subfamily, has been reported ...

    Authors: Yanfen Feng, Shumei Yan, Yuhua Huang, Qitao Huang, Fang Wang and Yiyan Lei

    Citation: BMC Cancer 2020 20:602

    Content type: Research article

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  4. Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Masatsune Shibutani, Tsutomu Takashima, Hisakazu Fujita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:598

    Content type: Research article

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  5. Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer ...

    Authors: Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yan Lin, Liangrui Zhou and Qiang Sun

    Citation: BMC Cancer 2020 20:584

    Content type: Research article

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  6. Esophageal carcinoma (EC) is the seventh-most prevalent tumor in the world, which is still one of the primary causes of tumor-related death. Identifying noteworthy biomarkers for EC is particularly significant...

    Authors: Yiding Li, Guiling Wu, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Yujie Zhang, Jinqiang Liu, Liu Hong and Daiming Fan

    Citation: BMC Cancer 2020 20:581

    Content type: Research article

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  7. Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carc...

    Authors: Mohammad Ali Zolfaghari, Abbas Karimi, Elham Kalantari, Alireza Korourian, Alireza Ghanadan, Kambiz Kamyab, Nafiseh Esmaili, Amir Nader Emami Razavi and Zahra Madjd

    Citation: BMC Cancer 2020 20:567

    Content type: Research article

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  8. The prognosis is very poor for lung cancer patients with bone metastasis. Unfortunately, a suitable method has yet to become available for the early diagnosis of bone metastasis in lung cancer patients. The pr...

    Authors: Xiaoyan Teng, Lirong Wei, Liming Han, Daliu Min and Yuzhen Du

    Citation: BMC Cancer 2020 20:562

    Content type: Research article

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  9. A prognostic model combining biomarkers of metaphase-anaphase transition of the cell cycle was developed for invasive breast cancer. The prognostic value and clinical applicability of the model was evaluated i...

    Authors: Heli Repo, Eliisa Löyttyniemi, Samu Kurki, Lila Kallio, Teijo Kuopio, Kati Talvinen and Pauliina Kronqvist

    Citation: BMC Cancer 2020 20:558

    Content type: Research article

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  10. Prostate cancer (PC), a common malignant tumor, is the second-leading cause of cancer death among American men. Its successful treatment greatly relies on the early diagnose. Engrailed-2 (EN2) has been confirm...

    Authors: Qi Li, Yibo Shi, Rigai Sa, Jun Hao, Jinhao Hu, Mulun Xiao, Chaoliang Wang, Liang Yan, Baoping Qiao and Guoxun Chen

    Citation: BMC Cancer 2020 20:555

    Content type: Research article

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  11. Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and Group 4 patients have a higher incidence of metastatic disease, especially involving the neuroaxis. At p...

    Authors: Sharon Y. Y. Low, Nurfahanah Bte Syed Sulaiman, Enrica E. K. Tan, Lee Ping Ng, Chik Hong Kuick, Kenneth T. E. Chang, Phua Hwee Tang, Ru Xin Wong, Wen Shen Looi, David C. Y. Low and Wan Tew Seow

    Citation: BMC Cancer 2020 20:554

    Content type: Research article

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  12. Unresectable esophageal cancer harbors high mortality despite chemoradiotherapy. Better patient selection for more personalized management may result in better treatment outcomes. We presume the ratio of maxim...

    Authors: Po-Jui Chen, Wing-Keen Yap, Yu-Chuan Chang, Chen-Kan Tseng, Yin-Kai Chao, Jason Chia-Hsun Hsieh, Ping-Ching Pai, Ching-Hsin Lee, Chan-Keng Yang, Albert Tsung-Ying Ho and Tsung-Min Hung

    Citation: BMC Cancer 2020 20:545

    Content type: Research article

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  13. Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreat...

    Authors: Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen and Zhen Chen

    Citation: BMC Cancer 2020 20:541

    Content type: Research article

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  14. Expression of forkhead box P3 (FOXP3), a key regulator of T-cell function, in the tumor immune microenvironment is related to survival in classic Hodgkin lymphoma (CHL). Vitamin D receptor (VDR), a transcripti...

    Authors: Gaurav K. Gupta, Tanupriya Agrawal and Monika Pilichowska

    Citation: BMC Cancer 2020 20:535

    Content type: Research article

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  15. Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRI...

    Authors: Guoliang Xiao, Qiuxi Yang, Ziwei Bao, Haixia Mao, Yi Zhang and Shibu Lin

    Citation: BMC Cancer 2020 20:525

    Content type: Research article

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  16. Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targete...

    Authors: Thomas J. W. Klein Nulent, Matthijs H. Valstar, Laura A. Smit, Ludwig E. Smeele, Nicolaas P. A. Zuithoff, Bart de Keizer, Remco de Bree, Robert J. J. van Es and Stefan M. Willems

    Citation: BMC Cancer 2020 20:519

    Content type: Research article

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  17. Although many studies have identified several inflammation-based and/or nutritional markers with prognostic value for patients with various types of cancer, the optimal markers and cut-off values for these mar...

    Authors: Takahiro Toyokawa, Kazuya Muguruma, Mami Yoshii, Tatsuro Tamura, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Shigeru Lee, Masakazu Yashiro and Masaichi Ohira

    Citation: BMC Cancer 2020 20:517

    Content type: Research article

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  18. Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biop...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:513

    Content type: Research article

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  19. Recent studies have extensively investigated the roles of miR-106 in colorectal cancer (CRC). However, the associations and molecular mechanism underlying the roles of miR-106 in CRC remain unclear. We aimed t...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Ming Cheng, Yaqun Zhu and Bo Xu

    Citation: BMC Cancer 2020 20:506

    Content type: Research article

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  20. Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification.

    Authors: Matthew P. Humphries, Stephanie G. Craig, Rafal Kacprzyk, Natalie C. Fisher, Victoria Bingham, Stephen McQuaid, Graeme I. Murray, Damian McManus, Richard C. Turkington, Jacqueline James and Manuel Salto-Tellez

    Citation: BMC Cancer 2020 20:500

    Content type: Research article

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  21. Bone metastasis (BM) is one of the common sites of hepatocellular carcinoma (HCC), and the prognosis of BM patients is worse than patients without it. Our study aimed to identify predictors and prognostic fact...

    Authors: Chuan Hu, Jiaxin Yang, Zhangheng Huang, Chuan Liu, Yijun Lin, Yuexin Tong, Zhiyi Fan, Bo Chen, Cailin Wang and Cheng-Liang Zhao

    Citation: BMC Cancer 2020 20:494

    Content type: Research article

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  22. Prostate MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present ana...

    Authors: Hans-Jonas Meyer, Andreas Wienke and Alexey Surov

    Citation: BMC Cancer 2020 20:482

    Content type: Research article

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  23. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) copy number alterations and unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, LRIG1 loss was recently s...

    Authors: Mahmood Faraz, Andreas Tellström, Christina Edwinsdotter Ardnor, Kjell Grankvist, Lukasz Huminiecki, Björn Tavelin, Roger Henriksson, Håkan Hedman and Ingrid Ljuslinder

    Citation: BMC Cancer 2020 20:459

    Content type: Research article

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  24. After neoadjuvant chemotherapy of breast cancer pathologic complete response (pCR) indicates a favorable prognosis. Among non-selected patients, pCR is, however, achieved in only 10–30%. Early evaluation of tu...

    Authors: Bernhard Tribukait

    Citation: BMC Cancer 2020 20:440

    Content type: Research article

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  25. Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic ...

    Authors: Ilona Dudka, Elin Thysell, Kristina Lundquist, Henrik Antti, Diego Iglesias-Gato, Amilcar Flores-Morales, Anders Bergh, Pernilla Wikström and Gerhard Gröbner

    Citation: BMC Cancer 2020 20:437

    Content type: Research article

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  26. The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.

    Authors: Toshiaki Iwase, Kenichi Harano, Hiroko Masuda, Kumiko Kida, Kenneth R. Hess, Ying Wang, Luc Dirix, Steven J. Van Laere, Anthony Lucci, Savitri Krishnamurthy, Wendy A. Woodward, Rachel M. Layman, François Bertucci and Naoto T. Ueno

    Citation: BMC Cancer 2020 20:430

    Content type: Research article

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  27. Enhancer of zeste homolog 2 (EZH2) is considered an important driver of tumor development and progression by its histone modifying capabilities. Inhibition of EZH2 activity is thought to be a potent treatment ...

    Authors: Chidimma Agatha Akpa, Karsten Kleo, Elisabeth Oker, Nancy Tomaszewski, Clemens Messerschmidt, Cristina López, Rabea Wagener, Kathrin Oehl-Huber, Katja Dettmer, Anne Schoeler, Dido Lenze, Peter J. Oefner, Dieter Beule, Reiner Siebert, David Capper, Lora Dimitrova…

    Citation: BMC Cancer 2020 20:427

    Content type: Research article

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  28. PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate th...

    Authors: Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha and Andrew R. Green

    Citation: BMC Cancer 2020 20:425

    Content type: Research article

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  29. The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamo...

    Authors: Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou and Tiejun Yin

    Citation: BMC Cancer 2020 20:424

    Content type: Research article

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  30. Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigat...

    Authors: Chiao-En Wu, Wen-Chi Chou, Chia-Hsun Hsieh, John Wen-Cheng Chang, Cheng-Yu Lin, Chun-Nan Yeh and Jen-Shi Chen

    Citation: BMC Cancer 2020 20:422

    Content type: Research article

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  31. It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic va...

    Authors: Qiliang Peng, Peifeng Zhao, Yi Shen, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: BMC Cancer 2020 20:420

    Content type: Research article

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  32. Anaemia is highly prevalent in gastric cancer (GC) patients. The role of initial haemoglobin levels in predicting the prognosis of GC patients treated by chemotherapy has not been well determined. Our present ...

    Authors: Wen-Huan Li, Ji-Yu Zhang, Wen-Hui Liu and Xian-Xian Chen

    Citation: BMC Cancer 2020 20:414

    Content type: Research article

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  33. Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to imp...

    Authors: Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner and Sabine Merkelbach-Bruse

    Citation: BMC Cancer 2020 20:408

    Content type: Research article

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  34. Thyroid Hurthle cell carcinoma (HCC) is a rare disease with high risk of invasion and metastasis and poor prognosis. The clinical characteristics, prognosis and treatment of HCC are still controversial, and cl...

    Authors: Xingtong Zhou, Zhibo Zheng, Chuyan Chen, Bangbo Zhao, Hongtao Cao, Tianhao Li, Xudong Liu, Weibin Wang and Yongning Li

    Citation: BMC Cancer 2020 20:407

    Content type: Research article

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  35. Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previo...

    Authors: Eric T. Miller, Sungyong You, Radu M. Cadaneanu, Minhyung Kim, Junhee Yoon, Sandy T. Liu, Xinmin Li, Lorna Kwan, Jennelle Hodge, Michael J. Quist, Catherine S. Grasso, Michael S. Lewis, Beatrice S. Knudsen, Michael R. Freeman and Isla P. Garraway

    Citation: BMC Cancer 2020 20:398

    Content type: Research article

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  36. Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expressi...

    Authors: Howard Yang, Hua Su, Nan Hu, Chaoyu Wang, Lemin Wang, Carol Giffen, Alisa M. Goldstein, Maxwell P. Lee and Philip R. Taylor

    Citation: BMC Cancer 2020 20:388

    Content type: Research article

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  37. Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-...

    Authors: Shuli Tang, Lin Lin, Jianan Cheng, Juan Zhao, Qijia Xuan, Jiayue Shao, Yang Zhou and Yanqiao Zhang

    Citation: BMC Cancer 2020 20:382

    Content type: Research article

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  38. Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on im...

    Authors: Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li and Kun Zhang

    Citation: BMC Cancer 2020 20:378

    Content type: Research article

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  39. The BRAFV600E gene encodes for the mutant BRAFV600E protein, which triggers downstream oncogenic signaling in thyroid cancer. Since most currently available methods have focused on detecting BRAFV600E mutations i...

    Authors: Tien Viet Tran, Kien Xuan Dang, Quynh Huong Pham, Ung Dinh Nguyen, Nhung Thi Trang Trinh, Luong Van Hoang, Son Anh Ho, Ba Van Nguyen, Duc Trong Nguyen, Dung Tuan Trinh, Dung Ngoc Tran, Arto Orpana, Ulf-Håkan Stenman, Jakob Stenman and Tho Huu Ho

    Citation: BMC Cancer 2020 20:368

    Content type: Research article

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  40. Correct identification of the EGFR c.2369C>T p.(Thr790Met) variant is key to decide on a targeted therapeutic strategy for patients with acquired EGFR TKI resistance in non-small cell lung cancer. The aim of this...

    Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Etienne Rouleau, Nils ’t Hart, Lukas Bubendorf, Kelly Dufraing, Céline Garrec, Paul Guéguen, Aude Lamy, Antonio Marchetti, Patrick Pauwels, Ales Ryska, Véronique Tack, Luigi Tornillo, Kaat Van Casteren, Jan H. von der Thüsen…

    Citation: BMC Cancer 2020 20:366

    Content type: Research article

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  41. The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been inv...

    Authors: Bin Li, Zheng Lu, Shengzheng Wang, Junqing Hou, Gang Xia, Heng Li, Bo Yin and Wei Lu

    Citation: BMC Cancer 2020 20:361

    Content type: Research article

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  42. The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth fact...

    Authors: Anne C. Chiang, Ancilla W. Fernandes, Melissa Pavilack, Jennifer W. Wu, François Laliberté, Mei Sheng Duh, Nabil Chehab and Janakiraman Subramanian

    Citation: BMC Cancer 2020 20:356

    Content type: Research article

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  43. ARID1A has been described as a tumor suppressor gene, participating in chromatin re-modeling, epithelial-mesenchymal-transition and many other cellular and molecular processes. It has been cited as a contribut...

    Authors: Mehran Erfani, Seyed Vahid Hosseini, Maral Mokhtari, Mozhdeh Zamani, Kamran Tahmasebi, Mahvash Alizadeh Naini, Alireza Taghavi, John M. Carethers, Minoru Koi, Hassan Brim, Pooneh Mokarram and Hassan Ashktorab

    Citation: BMC Cancer 2020 20:350

    Content type: Research article

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  44. Detection of programmed cell death ligand-1 (PD-L1) by immunohistochemistry (IHC) has been commonly used to predict the efficacy of treatment with PD-1/PD-L1 inhibitors. However, there is limited literature re...

    Authors: Yinying Zou, Liming Xu, Qiusu Tang, Qihan You, Xiaoling Wang, Wei Ding, Jing Zhao and Guoping Ren

    Citation: BMC Cancer 2020 20:344

    Content type: Research article

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  45. Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derive...

    Authors: Marjut Niinivirta, Maria Georganaki, Gunilla Enblad, Cecilia Lindskog, Anna Dimberg and Gustav J. Ullenhag

    Citation: BMC Cancer 2020 20:339

    Content type: Research article

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  46. Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death a...

    Authors: Annat Raiter, Julia Lipovetzki, Ido Lubin and Rinat Yerushalmi

    Citation: BMC Cancer 2020 20:333

    Content type: Research article

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