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Biomarkers

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  1. Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy ...

    Authors: Mercedes Delgado-García, Birgit Weynand, Lourdes Gómez-Izquierdo, María José Hernández, Ángela María Blanco, Mar Varela, Xavier Matias-Guiu, Ernest Nadal, Bélgica Márquez-Lobo, Ana Alarcão, Enrique de Álava and Michele Biscuola

    Citation: BMC Cancer 2020 20:275

    Content type: Research article

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  2. Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in cc...

    Authors: Ju-Yoon Yoon, Craig Gedye, Joshua Paterson and Laurie Ailles

    Citation: BMC Cancer 2020 20:272

    Content type: Research article

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  3. Lymphovascular invasion (LOI), a key pathological feature of head and neck squamous cell carcinoma (HNSCC), is predictive of poor survival; however, the associated clinical characteristics and underlying molec...

    Authors: Jian Zhang, Huaming Lin, Huali Jiang, Hualong Jiang, Tao Xie, Baiyao Wang, Xiaoting Huang, Jie Lin, Anan Xu, Rong Li, Jiexia Zhang and Yawei Yuan

    Citation: BMC Cancer 2020 20:266

    Content type: Research article

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  4. Chromodomain helicase DNA-binding protein 4 (CHD4) has been shown to contribute to DNA repair and cell cycle promotion; however, its roles in cancer initiation and progression remain largely unknown. This stud...

    Authors: Nuo Xu, Fanglei Liu, Shengdi Wu, Maosong Ye, Haiyan Ge, Meiling Zhang, Yuanlin Song, Lin Tong, Jian Zhou and Chunxue Bai

    Citation: BMC Cancer 2020 20:262

    Content type: Research article

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  5. No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).

    Authors: Kim Oren Gradel, Pedro Póvoa, Olav Sivertsen Garvik, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Ming Chen, Ram Benny Dessau, Jens Kjølseth Møller, John Eugenio Coia, Pernille Sanberg Ljungdalh, Annmarie Touborg Lassen and Henrik Frederiksen

    Citation: BMC Cancer 2020 20:249

    Content type: Research article

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  6. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. Despite the advances in radiation therap...

    Authors: Nasser Al-Rajhi, Hussein Soudy, Shoaib A. Ahmed, Tusneem Elhassan, Shamayel F. Mohammed, Hatim A. Khoja and Hazem Ghebeh

    Citation: BMC Cancer 2020 20:240

    Content type: Research article

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  7. Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigate...

    Authors: Hualin Song, Song Jin, Peng Xiang, Shuai Hu and Jie Jin

    Citation: BMC Cancer 2020 20:238

    Content type: Research article

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  8. The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated wi...

    Authors: Nianhua Ding, Juan Huang, Ningsha Li, Jiaqi Yuan, Shouman Wang and Zhi Xiao

    Citation: BMC Cancer 2020 20:235

    Content type: Research article

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  9. Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different p...

    Authors: Fabiana Pirani Carneiro, Rivadávio Fernandes Amorim, Marcos de Vasconcelos Carneiro, Tercia Maria Mendes Lousa de Castro, Leonora Maciel de Souza Vianna, Gustavo Henrique Soares Takano, Andersen Charles Daros, Isabela Peres, Selma Aparecida Souza Kuckelhaus and Andrea Barretto Motoyama

    Citation: BMC Cancer 2020 20:225

    Content type: Research article

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  10. Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging ca...

    Authors: Yosep Chong, Nishant Thakur, Kwang Yeol Paik, Eun Jung Lee and Chang Suk Kang

    Citation: BMC Cancer 2020 20:216

    Content type: Research article

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  11. Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer. Ubiquitin-specific protease (USP)44 has been reported to be involved in various cancers. We investigated the function, ro...

    Authors: Jiangqiao Zhou, Tianyu Wang, Tao Qiu, Zhongbao Chen, Xiaoxiong Ma, Long Zhang and Jilin Zou

    Citation: BMC Cancer 2020 20:214

    Content type: Research article

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  12. Tumor mutational burden (TMB) is a potential biomarker for immune checkpoint therapy and prognosis. The impact of TMB on clinical outcomes and the correlation coefficient between exome sequencing and targeted ...

    Authors: Lihong Wang, Jia Ge, Yang Lan, Yu Shi, Ying Luo, Yuhuan Tan, Mei Liang, Song Deng, Xia Zhang, Wenying Wang, Yaoyao Tan, Yuanyuan Xu and Tao Luo

    Citation: BMC Cancer 2020 20:213

    Content type: Research article

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  13. Inflammation-related parameters have been revealed to have prognostic value in multiple caners. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-l...

    Authors: Li-jian Xia, Wen Li, Jian-cheng Zhai, Chuan-wang Yan, Jing-bo Chen and Hui Yang

    Citation: BMC Cancer 2020 20:208

    Content type: Research article

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  14. The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the progno...

    Authors: Takaaki Oba, Kazuma Maeno, Daiya Takekoshi, Mayu Ono, Tokiko Ito, Toshiharu Kanai and Ken-ichi Ito

    Citation: BMC Cancer 2020 20:160

    Content type: Research article

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  15. Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CC...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun and Watcharin Loilome

    Citation: BMC Cancer 2020 20:154

    Content type: Research article

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  16. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequent...

    Authors: Danielle Pessôa-Pereira, Adriane Feijó Evangelista, Rhafaela Lima Causin, René Aloisio da Costa Vieira, Lucas Faria Abrahão-Machado, Iara Viana Vidigal Santana, Vinicius Duval da Silva, Karen Cristina Borba de Souza, Renato José de Oliveira-Silva, Gabriela Carvalho Fernandes, Rui Manuel Reis, Edenir Inêz Palmero and Márcia Maria Chiquitelli Marques

    Citation: BMC Cancer 2020 20:143

    Content type: Research article

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  17. The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for ...

    Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho and Joseph Taube

    Citation: BMC Cancer 2020 20:141

    Content type: Research article

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  18. To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay ...

    Authors: Shuang Ye, Xiaohua Sun, Bin Kang, Fei Wu, Zhong Zheng, Libing Xiang, Mylène Lesénéchal, Fabienne Heskia, Ji Liang and Huijuan Yang

    Citation: BMC Cancer 2020 20:138

    Content type: Research article

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  19. In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitiv...

    Authors: Cherylle Goebel, Christopher L. Louden, Robert Mckenna Jr, Osita Onugha, Andrew Wachtel and Thomas Long

    Citation: BMC Cancer 2020 20:137

    Content type: Research article

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  20. Microvascular invasion (MVI) is an independent risk factor for poor prognosis in hepatocellular carcinoma (HCC). However, there is still a lack of preoperative markers to predict MVI in HCC. This study intends...

    Authors: Hongxing Zhang, Yu Zhou, Yicheng Li, Wanying Qin, Yunhua Zi, Yulan Liu, Xiaoying Qiu, Hongyuan Xu, Weijia Liao and Zhaoquan Huang

    Citation: BMC Cancer 2020 20:132

    Content type: Research article

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  21. Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile...

    Authors: Shuang Zhang, Takeo Minaguchi, Chenyang Xu, Nan Qi, Hiroya Itagaki, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Hiroyuki Ochi and Toyomi Satoh

    Citation: BMC Cancer 2020 20:127

    Content type: Research article

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  22. Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for mo...

    Authors: Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Silva dos Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim…

    Citation: BMC Cancer 2020 20:119

    Content type: Research article

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  23. Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-associated deaths and a majority of its histological type is manifested as serous ovarian cancer (SOC). In this study, we investigat...

    Authors: Yijing He, Ting Li, Jue Liu, Qiong Ou and Junlin Zhou

    Citation: BMC Cancer 2020 20:116

    Content type: Research article

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  24. The HER2 extracellular domain shed in blood (HER2ECD) is reported to rise and fall in parallel with HER2+ breast cancer behavior. In this study, we evaluated the clinical relevance of plasma HER2ECD values in pat...

    Authors: Serenella Eppenberger-Castori, Dirk Klingbiel, Thomas Ruhstaller, Daniel Dietrich, Daniel Alexander Rufle, Karin Rothgiesser, Olivia Pagani and Beat Thürlimann

    Citation: BMC Cancer 2020 20:114

    Content type: Research article

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  25. Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of cir...

    Authors: Jian Zheng, Xiong Ye, Yanan Liu, Yuxia Zhao, Mudan He and Hui Xiao

    Citation: BMC Cancer 2020 20:106

    Content type: Research article

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  26. Recent studies indicate the benefit of treatment with osimertinib over that with conventional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for untreated EGFR-mutated non-small cell lun...

    Authors: Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai and Keisuke Tomii

    Citation: BMC Cancer 2020 20:104

    Content type: Research article

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  27. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto

    Citation: BMC Cancer 2020 20:103

    Content type: Research article

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  28. Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent nee...

    Authors: Yan Su, Lijun Wang, Chiyi Jiang, Zhixia Yue, Hongjun Fan, Huimin Hong, Chao Duan, Mei Jin, Dawei Zhang, Lihua Qiu, Xianfeng Cheng, Zhong Xu and Xiaoli Ma

    Citation: BMC Cancer 2020 20:102

    Content type: Research article

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  29. Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT s...

    Authors: César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde…

    Citation: BMC Cancer 2020 20:99

    Content type: Research article

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  30. Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association...

    Authors: Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng and Yunpeng Hua

    Citation: BMC Cancer 2020 20:95

    Content type: Research article

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  31. Interrogation of site-specific CpG methylation in circulating tumor DNAs (ctDNAs) has been employed in a number of studies for early detection of breast cancer (BrCa). In many of these studies, the markers wer...

    Authors: Manny D. Bacolod, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Aashiq H. Mirza, Alexander Swistel, Steven A. Soper and Francis Barany

    Citation: BMC Cancer 2020 20:85

    Content type: Research article

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  32. Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar ...

    Authors: Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra…

    Citation: BMC Cancer 2020 20:83

    Content type: Research article

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  33. Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease. This PDAC scenario urges ...

    Authors: Palloma Porto Almeida, Cristina Padre Cardoso and Leandro Martins de Freitas

    Citation: BMC Cancer 2020 20:82

    Content type: Software

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  34. Recently, accumulating evidence has suggested that the aberrant expression of SNHG6 exists in a variety of tumors and has a correlation with poor clinical outcomes across cancer patients. Considering the incon...

    Authors: Si Zhao, Hanlong Zhu, Ruonan Jiao, Xueru Wu, Guozhong Ji and Xiuhua Zhang

    Citation: BMC Cancer 2020 20:77

    Content type: Research article

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  35. Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final...

    Authors: Peng Liu, Lingming Kong, Keke Liang, Yunhao Wu, Haoyi Jin, Bing Song and Xiaodong Tan

    Citation: BMC Cancer 2020 20:45

    Content type: Research article

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  36. This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myelom...

    Authors: Fan Zhou, Dongjiao Wang, Wei Wei, Haimin Chen, Haotian Shi, Nian Zhou, Lixia Wu and Rong Peng

    Citation: BMC Cancer 2020 20:40

    Content type: Research article

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  37. Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...

    Authors: Darina Kohoutova, Miroslava Forstlova, Paula Moravkova, Jiri Cyrany, Juraj Bosak, David Smajs, Stanislav Rejchrt and Jan Bures

    Citation: BMC Cancer 2020 20:39

    Content type: Research article

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  38. The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide...

    Authors: Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo and Yuanli Zhao

    Citation: BMC Cancer 2020 20:35

    Content type: Research article

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  39. High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine ...

    Authors: Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel and Ulrich Knigge

    Citation: BMC Cancer 2020 20:27

    Content type: Research article

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  40. The NEK serine/threonine protein kinases are involved in cell cycle checkpoints, DNA damage repair, and apoptosis. Alterations in these pathways are frequently associated with cell malignant cellular transform...

    Authors: Talita Diniz Melo-Hanchuk, Mariana Bonjiorno Martins, Lucas Leite Cunha, Fernando Augusto Soares, Laura Sterian Ward, José Vassallo and Jörg Kobarg

    Citation: BMC Cancer 2020 20:23

    Content type: Research article

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  41. Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy....

    Authors: Zuzana Cierna, Vera Miskovska, Jan Roska, Dana Jurkovicova, Lucia Borszekova Pulzova, Zuzana Sestakova, Lenka Hurbanova, Katarina Machalekova, Michal Chovanec, Katarina Rejlekova, Daniela Svetlovska, Katarina Kalavska, Karol Kajo, Pavel Babal, Jozef Mardiak, Thomas A. Ward…

    Citation: BMC Cancer 2020 20:17

    Content type: Research article

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  42. Hepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity is high. Tissue biopsy is an invasive operation and may in...

    Authors: Wene Wei, Mengshu Liu, Shufang Ning, Jing Wei, Jianhong Zhong, Jilin Li, Zhengmin Cai and Litu Zhang

    Citation: BMC Cancer 2020 20:6

    Content type: Research article

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  43. Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined perform...

    Authors: Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu and Xuelei Ma

    Citation: BMC Cancer 2019 19:1223

    Content type: Research article

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  44. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio

    Citation: BMC Cancer 2019 19:1216

    Content type: Research article

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  45. It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.

    Authors: Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang and Pei-Rong Ding

    Citation: BMC Cancer 2019 19:1210

    Content type: Research article

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