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Biomarkers

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  1. Content type: Research article

    Ovarian cancer is the main cause of gynecological cancer-associated death. However, 5-year survival rates differ dramatically between the five main ovarian carcinoma histotypes. Therefore, we need to have a be...

    Authors: Hanna Engqvist, Toshima Z. Parris, Anikó Kovács, Szilárd Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson and Khalil Helou

    Citation: BMC Cancer 2019 19:928

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  2. Content type: Research article

    This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels i...

    Authors: Xue-Song Sun, Yu-Jing Liang, Sai-Lan Liu, Qiu-Yan Chen, Shan-Shan Guo, Yue-Feng Wen, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Xiao-Yun Li, Jin-Jie Yan, Lin-Quan Tang and Hai-Qiang Mai

    Citation: BMC Cancer 2019 19:908

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  3. Content type: Study protocol

    Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal ca...

    Authors: Alessandro Ottaiano, Stefania Scala, Nicola Normanno, Maria Napolitano, Monica Capozzi, Anna Maria Rachiglio, Cristin Roma, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Carmela Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Salvatore Tafuto…

    Citation: BMC Cancer 2019 19:899

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  4. Content type: Research article

    We evaluated the clinical efficacy and prognosis of muscle-invasive bladder cancer according to the basal/squamous-like (BASQ) classification system based on immunohistochemical staining [CK5/6(+), CK14(+), GA...

    Authors: Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon and Ja Hyeon Ku

    Citation: BMC Cancer 2019 19:897

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  5. Content type: Research article

    Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...

    Authors: Jasmine A. McQuerry, David F. Jenkins, Susan E. Yost, Yuqing Zhang, Daniel Schmolze, W. Evan Johnson, Yuan Yuan and Andrea H. Bild

    Citation: BMC Cancer 2019 19:881

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  6. Content type: Research article

    Breast cancer is the most common malignancy in women, and neoadjuvant chemotherapy has been recommended to the patients with locally advanced breast cancer as the initial treatments. Long non-coding RNA (lncRN...

    Authors: Battseren Bayarmaa, Ziping Wu, Jing Peng, Yan Wang, Shuguang Xu, Tingting Yan, Wenjin Yin, Jinsong Lu and Liheng Zhou

    Citation: BMC Cancer 2019 19:877

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  7. Content type: Research article

    Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around the world. We previously demonstrated that eIF3b could promote the progression of ESCC. The exact mechani...

    Authors: Fengkai Xu, Shu Zhang, Zhonghe Liu, Jie Gu, Yin Li, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Di Ge and Chunlai Lu

    Citation: BMC Cancer 2019 19:875

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  8. Content type: Research article

    This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy.

    Authors: Haiyan Zhu, Xuejiao Tao, Lulu Zhou, Bo Sheng, Xuejie Zhu and Xueqiong Zhu

    Citation: BMC Cancer 2019 19:865

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  9. Content type: Research article

    Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play cri...

    Authors: Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma and Ming Liu

    Citation: BMC Cancer 2019 19:851

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  10. Content type: Research article

    Recent studies reported that blood-based microRNAs (miRNAs) could detect cancers and predict prognosis have opened a new field of utilizing circulating miRNAs as cancer biomarkers. In this pilot study, we cond...

    Authors: Lirong Wu, Kexiao Zheng, Cheng Yan, Xuan Pan, Yatian Liu, Juying Liu, Feijiang Wang, Wenjie Guo, Xia He, Jiong Li and Ye Shen

    Citation: BMC Cancer 2019 19:843

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  11. Content type: Research article

    Metastasis is responsible for the majority of deaths in a variety of cancer types, including breast cancer. Although several factors or biomarkers have been identified to predict the outcome of patients with b...

    Authors: Liang Zeng, Xiyun Deng, Jingmin Zhong, Li Yuan, Xiaojun Tao, Sai Zhang, Yong Zeng, Guangchun He, Pingping Tan and Yongguang Tao

    Citation: BMC Cancer 2019 19:831

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  12. Content type: Research article

    The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the...

    Authors: Fatima Qadir, Anand Lalli, Huma Habib Dar, Sungjae Hwang, Hebah Aldehlawi, Hong Ma, Haiyan Dai, Ahmad Waseem and Muy-Teck Teh

    Citation: BMC Cancer 2019 19:830

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  13. Content type: Research article

    Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphoc...

    Authors: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary and Loic Ysebaert

    Citation: BMC Cancer 2019 19:809

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  14. Content type: Research article

    Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases...

    Authors: Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa and Michèle J. Hoffmann

    Citation: BMC Cancer 2019 19:806

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  15. Content type: Research article

    Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development. The Hippo/YAP pathway is commonly disr...

    Authors: Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho and Min-Kyung Yeo

    Citation: BMC Cancer 2019 19:804

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  16. Content type: Research article

    To validate the utility of the chemokine ligand 12 (CXCL12) as prognostic marker in patients with localized and metastatic germ cell tumors (GCT).

    Authors: Christian Daniel Fankhauser, Lisa Roth, Nico Christian Grossmann, Benedikt Kranzbühler, Daniel Eberli, Tullio Sulser, Holger Moch, Peter-Karl Bode, Joerg Beyer and Thomas Hermanns

    Citation: BMC Cancer 2019 19:802

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  17. Content type: Research article

    Histology is a traditional way to classify subtypes of thymoma, because of low cost and convenience. Yet, due to the diverse morphology of thymoma, this method increases the complexity of histopathologic class...

    Authors: Liang-Chuan Lai, Qiang-Ling Sun, Yu-An Chen, Yi-Wen Hsiao, Tzu-Pin Lu, Mong-Hsun Tsai, Lei Zhu, Eric Y. Chuang and Wentao Fang

    Citation: BMC Cancer 2019 19:796

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  18. Content type: Research article

    Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit formation of breast-cancer-derived experimental lu...

    Authors: Rossano Lattanzio, Manuela Iezzi, Gianluca Sala, Nicola Tinari, Marco Falasca, Saverio Alberti, Simonetta Buglioni, Marcella Mottolese, Letizia Perracchio, Pier Giorgio Natali and Mauro Piantelli

    Citation: BMC Cancer 2019 19:747

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  19. Content type: Research article

    Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to r...

    Authors: Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang

    Citation: BMC Cancer 2019 19:743

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  20. Content type: Research article

    The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that ...

    Authors: Dijana Djureinovic, Victor Pontén, Per Landelius, Sahar Al Sayegh, Kai Kappert, Masood Kamali-Moghaddam, Patrick Micke and Elisabeth Ståhle

    Citation: BMC Cancer 2019 19:741

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  21. Content type: Research article

    Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cle...

    Authors: Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: BMC Cancer 2019 19:732

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  22. Content type: Research article

    Local or distant relapse is the key event for the overall survival of early-stage breast cancer after initial surgery. A small subset of breast cancer cells, which share similar properties with normal stem cel...

    Authors: Yan Qiu, Liya Wang, Xiaorong Zhong, Li Li, Fei Chen, Lin Xiao, Fangyu Liu, Bo Fu, Hong Zheng, Feng Ye and Hong Bu

    Citation: BMC Cancer 2019 19:729

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  23. Content type: Research article

    One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de ...

    Authors: Timo Gemoll, Elena Miroll, Oliver Klein, Annette Lischka, Murat Eravci, Christoph Thorns and Jens K. Habermann

    Citation: BMC Cancer 2019 19:710

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  24. Content type: Research article

    In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern...

    Authors: Weiwei Gong, Yueyang Liu, Christof Seidl, Eleftherios P. Diamandis, Marion Kiechle, Enken Drecoll, Matthias Kotzsch, Viktor Magdolen and Julia Dorn

    Citation: BMC Cancer 2019 19:696

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  25. Content type: Research article

    It is important to identify biomarkers associated with BRCA mutation in women with early breast cancer (BC) to improve early identification of mutation carriers. Thus, in this study, we examined the protein expre...

    Authors: Sabine Danzinger, Yen Yen Tan, Margaretha Rudas, Marie-Theres Kastner, Sigrid Weingartshofer, Daniela Muhr and Christian F. Singer

    Citation: BMC Cancer 2019 19:695

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  26. Content type: Research article

    Current evidence suggests that patients with Luminal A early breast cancer can skip chemotherapy or extended endocrine therapy, but immunohistochemistry-based biomarker analysis for St Gallen subtyping may not...

    Authors: Mark Laible, Kerstin Hartmann, Claudia Gürtler, Tobias Anzeneder, Ralph Wirtz, Stephan Weber, Thomas Keller, Ugur Sahin, Martin Rees and Annette Ramaswamy

    Citation: BMC Cancer 2019 19:694

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  27. Content type: Research article

    The protease uPA and its inhibitor PAI-1 play major roles in hemostasis and are also involved in cancer progression. This is mainly caused by their ability to degrade extracellular matrix-facilitating tumor ce...

    Authors: Bruno Märkl, Martin Kazik, Nadia Harbeck, Elzbieta Jakubowicz, Reinhard Hoffmann, Thomas Jung, Dieter Steinfeld, Gerhard Schenkirsch, Günter Schlimok and Daniel Oruzio

    Citation: BMC Cancer 2019 19:692

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  28. Content type: Research article

    Prognostication of patients with colorectal cancer (CRC) currently relies on tumor-node-metastasis (TNM) staging but clinical outcomes of patients of the same histoclinical stage are heterogeneous. It is there...

    Authors: Tung H. Ng, Kathy W. Y. Sham, Chuan M. Xie, Simon S. M. Ng, Ka F. To, Joanna H. M. Tong, Wing Y. Z. Liu, Lin Zhang, Matthew T. V. Chan, William K. K. Wu and Christopher H. K. Cheng

    Citation: BMC Cancer 2019 19:649

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  29. Content type: Research article

    Investigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach...

    Authors: Christian Hunnicke Petersen, Badar Mahmood, Christoffer Badsted, Tina Dahlby, Hanne Borger Rasmussen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Cancer 2019 19:643

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  30. Content type: Research article

    Delivering widespread BRCA testing to patients with ovarian cancer has been suggested by several scientists, recommended by professional societies and solicited by patients organizations. However, based on the...

    Authors: A. V. Paradiso, M. Digennaro, M. Patruno, S. De Summa, S. Tommasi and I. Berindan-Neagoe

    Citation: BMC Cancer 2019 19:641

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  31. Content type: Research article

    Noninvasive biomarkers are urgently needed for optimal management of nonalcoholic fatty liver disease (NAFLD) for the prevention of disease progression into nonalcoholic steatohepatitis (NASH) and hepatocellul...

    Authors: Naohiko Nakamura, Etsuro Hatano, Kohta Iguchi, Motohiko Sato, Hiroaki Kawaguchi, Iwao Ohtsu, Takaki Sakurai, Nobuhiro Aizawa, Hiroko Iijima, Shuhei Nishiguchi, Takuya Tomono, Yukihiro Okuda, Seidai Wada, Satoru Seo, Kojiro Taura, Shinji Uemoto…

    Citation: BMC Cancer 2019 19:621

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  32. Content type: Research article

    Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance...

    Authors: Fiona M. Walter, Matthew J. Thompson, Ian Wellwood, Gary A. Abel, William Hamilton, Margaret Johnson, Georgios Lyratzopoulos, Michael P. Messenger, Richard D. Neal, Greg Rubin, Hardeep Singh, Anne Spencer, Stephen Sutton, Peter Vedsted and Jon D. Emery

    Citation: BMC Cancer 2019 19:586

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  33. Content type: Research article

    Distant metastases frequently occur in gastroenteropancreatic neuroendocrine tumors. If hepatic surgery is not feasible, patients are treated with somatostatin analogs. However, the underlying mechanisms of ac...

    Authors: Florian Bösch, Alexandr V. Bazhin, Sabine Heublein, Katharina Brüwer, Thomas Knösel, Florian P. Reiter, Christoph J. Auernhammer, Markus O. Guba, Christine Spitzweg, Jens Werner and Martin K. Angele

    Citation: BMC Cancer 2019 19:575

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  34. Content type: Research article

    The aberrant expression of N-glycolyl GM3 ganglioside (NeuGcGM3) in patients with sarcomas was reevaluated by assessing the relation of this molecule with some clinicopathological features and overall survival...

    Authors: Daniel Pilco-Janeta, Myriam De la Cruz Puebla, Jorge Soriano, Marta Osorio, Iraida Caballero, Adanays Calvo Pérez, Laynes Savon, Natalia Cremades, Rancés Blanco and Adriana Carr

    Citation: BMC Cancer 2019 19:556

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  35. Content type: Research article

    Triple negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Nomograms predicting outcomes of TNBC are needed for risk management.

    Authors: Yaping Yang, Ying Wang, Heran Deng, Cui Tan, Qian Li, Zhanghai He, Wei Wei, Enxiang Zhou, Qiang Liu and Jieqiong Liu

    Citation: BMC Cancer 2019 19:541

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  36. Content type: Research article

    FBXO11, a member of the F-box protein family, regulates the cell-cycle by promoting the degradation of Bcl-6 and p53. This protein has been implicated in the progression of several cancers, including renal cel...

    Authors: Bo Fan, Wei Wang, Xianping Zhang, Min Sun, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Qun Wang, Na Yu and Xiancheng Li

    Citation: BMC Cancer 2019 19:534

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  37. Content type: Research article

    Growing evidence has indicated that tumor biomarkers, including cytokeratin 19 fragment antigen 21–1 (Cyfra21–1), carbohydrate antigen 19–9 (CA19–9), carbohydrate antigen 72–4 (CA72–4), carcinoembryonic antige...

    Authors: Yuchong Yang, Xuanzhang Huang, Likun Zhou, Ting Deng, Tao Ning, Rui Liu, Le Zhang, Ming Bai, Haiyang Zhang, Hongli Li and Yi Ba

    Citation: BMC Cancer 2019 19:526

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  38. Content type: Research article

    Radiation therapy is a standard form of treating non-small cell lung cancer, however, local recurrence is a major issue with this type of treatment. A better understanding of the metabolic response to radiatio...

    Authors: Samantha J. Van Nest, Leah M. Nicholson, Nils Pavey, Mathew N. Hindi, Alexandre G. Brolo, Andrew Jirasek and Julian J. Lum

    Citation: BMC Cancer 2019 19:474

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  39. Content type: Research article

    The application of circulating, cell-free, methylated Septin9 (mSEPT9) DNA in screening and recurrence monitoring is highly promising. CpG island methylator phenotype (CIMP) is associated with microsatellite inst...

    Authors: Jie Sun, Fei Fei, Mingqing Zhang, Yuwei Li, Xipeng Zhang, Siwei Zhu and Shiwu Zhang

    Citation: BMC Cancer 2019 19:450

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  40. Content type: Research article

    Matrix metalloproteinase 19 (MMP19) is a member of zinc-dependent endopeptidases, which have been involved in various physiological and pathological processes. Its expression has been demonstrated in some type...

    Authors: Zaiping Chen, Guiyang Wu, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Xiongwen Zhu and Chongshan Wu

    Citation: BMC Cancer 2019 19:448

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  41. Content type: Research article

    Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast...

    Authors: Zongbi Yi, Fei Ma, Binliang Liu, Xiuwen Guan, Lixi Li, Chunxiao Li, Haili Qian and Binghe Xu

    Citation: BMC Cancer 2019 19:442

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  42. Content type: Research article

    Breast cancer is the leading cause of cancer related death in women, with metastasis the principle cause of mortality. New non-invasive prognostic markers are needed for the early detection of metastasis, faci...

    Authors: Peter McAnena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown and Michael J. Kerin

    Citation: BMC Cancer 2019 19:436

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