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Biomarkers

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  1. Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (...

    Authors: Shaozheng Chen and Kejun Li

    Citation: BMC Cancer 2020 20:924

    Content type: Research article

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  2. It is a well-known fact show that the risk of developing endometrial cancer (type 1 EC) is strongly associated with obesity. In this study, selected markers, such as obesity, insulin resistance, angiogenesis a...

    Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Robert Terlikowski, Anna Sienkiewicz, Maciej Kinalski and Slawomir J. Terlikowski

    Citation: BMC Cancer 2020 20:921

    Content type: Research article

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  3. Inflammatory cytokine markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte ratio, and platelet-to-lymphocyte ratio, play important roles as prognostic markers in several solid malig...

    Authors: Takashi Kawahara, Masashi Kato, Kenichi Tabata, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Hideyasu Tsumura, Masatsugu Iwamura, Hiroji Uemura and Yasuhide Miyoshi

    Citation: BMC Cancer 2020 20:919

    Content type: Research article

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  4. Identification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation an...

    Authors: Chunmei Fan, Jinpeng Wang, Yanyan Tang, Shanshan Zhang, Fang Xiong, Can Guo, Yanhong Zhou, Zheng Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong

    Citation: BMC Cancer 2020 20:917

    Content type: Research article

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  6. Various parameters have been considered for predicting survival in pancreatic ductal adenocarcinoma. Information about western population is missing. The aim of this study is to assess the association between ...

    Authors: Mar Achalandabaso Boira, Marcello Di Martino, Carlos Gordillo, Magdalena Adrados and Elena Martín-Pérez

    Citation: BMC Cancer 2020 20:909

    Content type: Research article

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  7. Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

    Authors: Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim

    Citation: BMC Cancer 2020 20:907

    Content type: Research article

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  9. There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions...

    Authors: Huy Gia Vuong, Thu Quynh Nguyen, Tam N. M. Ngo, Hoang Cong Nguyen, Kar-Ming Fung and Ian F. Dunn

    Citation: BMC Cancer 2020 20:897

    Content type: Research article

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  10. Extremity liposarcoma represents 25% of extremity soft tissue sarcoma and has a better prognosis than liposarcoma occurring in other anatomic sites. The purpose of this study was to develop two nomograms for p...

    Authors: Lin Ye, Chuan Hu, Cailin Wang, Weiyang Yu, Feijun Liu and Zhenzhong Chen

    Citation: BMC Cancer 2020 20:889

    Content type: Research article

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  11. There is growing evidence that pseudogenes may serve as prognostic biomarkers in several cancers. The present study was designed to develop and validate an accurate and robust pseudogene pairs-based signature ...

    Authors: Yajuan Du and Ying Gao

    Citation: BMC Cancer 2020 20:887

    Content type: Research article

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  12. The nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) is a long non-coding RNA aberrantly expressed in human malignancies. We aimed to analyze available data to evaluate the correlation betwee...

    Authors: Chenghao Zhang, Xiaolei Ren, Zhongyue Liu and Chao Tu

    Citation: BMC Cancer 2020 20:879

    Content type: Research article

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  13. Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with TNBC could help guide treatment. Extensive evidence demonstrates that an...

    Authors: Yu-Chen Cai, Hang Yang, Ke-Feng Wang, Tan-Huan Chen, Wen-Qi Jiang and Yan-Xia Shi

    Citation: BMC Cancer 2020 20:878

    Content type: Research article

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  14. BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting ...

    Authors: Shixu Fang, Zhou Liu, Qiang Guo, Cheng Chen, Xixian Ke and Gang Xu

    Citation: BMC Cancer 2020 20:870

    Content type: Research article

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  15. Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon rec...

    Authors: Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho and Humberto Dellê

    Citation: BMC Cancer 2020 20:869

    Content type: Research article

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  16. An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristi...

    Authors: Xiao Jin, Lu Dai, Yilan Ma, Jiayan Wang, Haihao Yan, Ye Jin, Xiaojuan Zhu and Zheng Liu

    Citation: BMC Cancer 2020 20:866

    Content type: Research article

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  18. Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear.

    Authors: Wenxing Su, Yi Guan, Biao Huang, Juanjuan Wang, Yuqian Wei, Ying Zhao, Qingqing Jiao, Jiang Ji, Daojiang Yu and Longjiang Xu

    Citation: BMC Cancer 2020 20:863

    Content type: Research article

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  19. Gastric/gastroesophageal junction (GEJ) adenocarcinomas are heterogeneous, comprising four molecularly distinct subtypes, namely EBV-positive, microsatellite instability (MSI), chromosomal instability (CIN) an...

    Authors: Ju-Yoon Yoon, Christine Brezden-Masley and Catherine J. Streutker

    Citation: BMC Cancer 2020 20:860

    Content type: Research article

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  20. Cell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell struc...

    Authors: Alhadi Almangush, Antti A. Mäkitie, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Tuula Salo and Ilmo Leivo

    Citation: BMC Cancer 2020 20:843

    Content type: Research article

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  21. To investigate the differences in plasma metabolomic characteristics between pathological complete response (pCR) and non-pCR patients and identify biomarker candidates for predicting the response to neoadjuva...

    Authors: Yaowen Zhang, Jianpo Wang, Ningtao Dai, Peng Han, Jian Li, Jiangman Zhao, Weilan Yuan, Jiahuan Zhou and Fuyou Zhou

    Citation: BMC Cancer 2020 20:835

    Content type: Research article

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  22. Role of tumor markers in gall bladder carcinoma (GBC) is not well established. We evaluated the prognostic value of carbohydrate antigen 19–9 (CA19–9) and carcinoma embryonic antigen (CEA) in patients with GBC.

    Authors: Ashish Sachan, Sundeep Singh Saluja, Phani Kumar Nekarakanti, Nimisha, Bhawna Mahajan, Hirdaya H. Nag and Pramod K. Mishra

    Citation: BMC Cancer 2020 20:826

    Content type: Research article

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  23. Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a c...

    Authors: Hayoung Choi, Yousang Ko and Chang Youl Lee

    Citation: BMC Cancer 2020 20:825

    Content type: Research article

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  24. Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning...

    Authors: Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen Lopez, Imelda Tenggara, Jeffry P. Simko, Terence W. Friedlander, Patricia S. Li, Pamela L. Paris, Peter R. Carroll and John S. Witte

    Citation: BMC Cancer 2020 20:820

    Content type: Research article

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  25. Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development...

    Authors: Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang

    Citation: BMC Cancer 2020 20:815

    Content type: Research article

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  26. Tumor microenvironment (TME) plays an important role in malignant tumors. Our study aimed to investigate the effect of the TME and related genes in osteosarcoma patients.

    Authors: Chuan Hu, Chuan Liu, Shaoqi Tian, Yuanhe Wang, Rui Shen, Huili Rao, Jianyi Li, Xu Yang, Bo Chen and Lin Ye

    Citation: BMC Cancer 2020 20:814

    Content type: Research article

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  27. To improve the postoperative prognosis of patients with lung cancer, predicting the recurrence high-risk patients is needed for the efficient application of adjuvant chemotherapy. However, predicting lung canc...

    Authors: Yusuke Takanashi, Kazuhito Funai, Shumpei Sato, Akikazu Kawase, Hong Tao, Yutaka Takahashi, Haruhiko Sugimura, Mitsutoshi Setou, Tomoaki Kahyo and Norihiko Shiiya

    Citation: BMC Cancer 2020 20:800

    Content type: Research article

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  28. Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We...

    Authors: Xiu-Ping Tu, Hao Li, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang and Shao-Hua Chen

    Citation: BMC Cancer 2020 20:794

    Content type: Research article

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  29. The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the o...

    Authors: Junyu Zhao, Jing Wen, Shengnan Wang, Jinming Yao, Lin Liao and Jianjun Dong

    Citation: BMC Cancer 2020 20:788

    Content type: Research article

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  30. SOCS1 and SOCS3 genes are considered tumor suppressors in hepatocellular carcinoma (HCC) due to frequent epigenetic repression. Consistent with this notion, mice lacking SOCS1 or SOCS3 show increased susceptibili...

    Authors: Md Gulam Musawwir Khan, Amit Ghosh, Bhavesh Variya, Madanraj Appiya Santharam, Awais Ullah Ihsan, Sheela Ramanathan and Subburaj Ilangumaran

    Citation: BMC Cancer 2020 20:774

    Content type: Research article

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  31. Immunosenescence biomarkers and peripheral blood parameters are evaluated separately as possible predictive markers of immunotherapy. Here, we illustrate the use of a causal inference model to identify predict...

    Authors: Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Tania Crombet, Wim Van der Elst, Ariel Alonso, Geert Molenberghs and Agustin Lage

    Citation: BMC Cancer 2020 20:772

    Content type: Research article

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  32. Autophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been propose...

    Authors: Xingxing Huo, Jian Qi, Kaiquan Huang, Su Bu, Wei Yao, Ying Chen and Jinfu Nie

    Citation: BMC Cancer 2020 20:771

    Content type: Research article

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  33. Sphingosine-1-phosphate receptor (S1PR1) is involved in vascular development, a key process in tumorigenesis. This study aimed to evaluate its roles in tumor development and prognosis.

    Authors: Limei Zhong, Linling Xie, Zhiyong Yang, Lijuan Li, Shaohua Song, Donglin Cao and Yufeng Liu

    Citation: BMC Cancer 2020 20:766

    Content type: Research article

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  34. Anti-Androgen Receptor (AR) therapy holds promise for a subset of AR expressing triple-negative breast cancer (TNBC) patients. However, current AR assays are suboptimal in detecting the dynamic range of AR exp...

    Authors: Sindhu Govindan, Mallikarjuna Siraganahalli Eswaraiah, Chetana Basavaraj, Manjula Adinarayan, Satish Sankaran and Manjiri Bakre

    Citation: BMC Cancer 2020 20:745

    Content type: Research article

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  35. Cancer cells induce the infiltration of various immune cells that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We there...

    Authors: Jie Wang, Shu Tian, Ji Sun, Jiahao Zhang, Lan Lin and Chunyan Hu

    Citation: BMC Cancer 2020 20:731

    Content type: Research article

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  36. Better biomarkers for assessing risk of relapse in stage I testicular germ cell tumor patients are needed, to complement classical histopathological variables. We aimed to assess the prognostic value of previo...

    Authors: João Lobo, Ad J. M. Gillis, Annette van den Berg and Leendert H. J. Looijenga

    Citation: BMC Cancer 2020 20:728

    Content type: Research article

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  37. The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. Ho...

    Authors: Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon and Thibaud Valentin

    Citation: BMC Cancer 2020 20:716

    Content type: Study protocol

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  38. A number of studies have reported hyperprogressive disease (HPD) in non-small cell lung cancer (NSCLC) after treatment with immune checkpoint inhibitor (ICI). This study aimed to summarize the incidence and su...

    Authors: Yan Chen, Junjie Hu, Fangfang Bu, Haiping Zhang, Ke Fei and Peng Zhang

    Citation: BMC Cancer 2020 20:707

    Content type: Research article

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  39. The insulin-like growth factor 1 receptor (IGF1R) is suspected to be involved in colorectal carcinogenesis and has been associated with worse survival in colorectal cancer (CRC). We hypothesized that the alleg...

    Authors: Steffen M. Heckl, Marie Pellinghaus, Hans-Michael Behrens, Sandra Krüger, Stefan Schreiber and Christoph Röcken

    Citation: BMC Cancer 2020 20:704

    Content type: Research article

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  40. In this study, we examined the differential associations of various proinflammatory and anti-inflammatory cytokines with depression severity from the development of breast cancer to subsequent chemotherapy tre...

    Authors: Bor-Show Tzang, Vincent Chin-Hung Chen, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Hsing-Ying Ho, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng and Yi-Lung Chen

    Citation: BMC Cancer 2020 20:686

    Content type: Research article

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  41. Long intergenic non-coding RNA 00511 (LINC00511) is highly expressed in diverse cancers and has a correlation with poor clinical outcomes for cancer patients. In view of contradictory data among published data...

    Authors: Yannick Luther Agbana, Manzama-Esso Abi, Yueli Ni, Guohang Xiong, Jing Chen, Fang Yun, Zihan Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang and Yuechun Zhu

    Citation: BMC Cancer 2020 20:682

    Content type: Research article

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  42. Breast cancer clinical management requires the assessment of hormone receptors (estrogen (ER) and progesterone receptor (PR)), human epidermal growth factor receptor 2 (HER2) and cellular proliferation index K...

    Authors: Laura Rey-Vargas, Juan Carlos Mejía-Henao, María Carolina Sanabria-Salas and Silvia J. Serrano-Gomez

    Citation: BMC Cancer 2020 20:675

    Content type: Research article

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  45. As one of the most common cancers with high mortality in the world, we are still facing a huge challenge in the prevention and treatment of colon cancer. With the rapid development of high throughput technolog...

    Authors: Fuyan Hu, Qing Wang, Zhiyuan Yang, Zeng Zhang and Xiaoping Liu

    Citation: BMC Cancer 2020 20:668

    Content type: Research article

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  46. Recent studies have highlighted the important role of long non-coding RNA SNHG16 in various human cancers. Here, we conducted a meta-analysis to investigate the effect of SNHG16 expression on clinicopathologic...

    Authors: Ruonan Jiao, Wei Jiang, Xin Wei, Mengpei Zhang, Si Zhao and Guangming Huang

    Citation: BMC Cancer 2020 20:662

    Content type: Research article

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  47. Expression of matrix metalloproteases 2, 9 and 14 (MMP-2, MMP-9, MMP-14), tissue inhibitors of metalloprotease 1 and 2 (TIMP-1, TIMP-2) and vascular endothelial growth factor A (VEGF-A) is involved in tumor in...

    Authors: Jordana Maria Azevedo Martins, Silvia Helena Rabelo-Santos, Maria Cristina do Amaral Westin and Luiz Carlos Zeferino

    Citation: BMC Cancer 2020 20:660

    Content type: Research article

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  48. Sentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the sa...

    Authors: Yilin Shao, Xin Liu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhiguo Luo and Xichun Hu

    Citation: BMC Cancer 2020 20:639

    Content type: Research article

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  49. Several studies have investigated the associations between the podocalyxin-like protein (PODXL) expression quantity or locations and cancers survival, but the results were far from conclusive. Therefore, we pr...

    Authors: Siying He, Wenjie Du, Menglan Li, Ming Yan and Fang Zheng

    Citation: BMC Cancer 2020 20:620

    Content type: Research article

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  50. Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT ant...

    Authors: Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda and Hiroshi Shiku

    Citation: BMC Cancer 2020 20:606

    Content type: Research article

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BMC Cancer

ISSN: 1471-2407

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