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The prognostic role of palliative gastrectomy in advanced gastric cancer: a systematic review and meta-analysis

BMC Cancer volume 24, Article number: 1096 (2024) Cite this article

Abstract

Background

The effectiveness of palliative gastrectomy for advanced GC remains a topic of debate. This study sought to establish whether palliative gastrectomy has an impact on prolonging survival.

Methods

We carried out systematic searches in PubMed, Cochrane Library, Web of Science, and the EMBASE databases from database inception to July 2023 to gather studies that examined the connection between palliative gastrectomy and the prognosis of advanced GC. The study employed overall survival as the primary outcome, with the hazard ratio serving as the selected parameter to gauge the association. Subgroup analyses were performed to delve into potential differences within the included studies, categorizing them by study region and sample size in order to examine possible sources of heterogeneity. The stability of individual studies was assessed through sensitivity analysis. The analysis included 20 articles, encompassing a total of 23,061 patients.

Results

According to the meta-analysis results, patients who underwent palliative gastrectomy exhibited a noteworthy enhancement in overall survival (HR: 1.49; 95% CI: 1.12–1.99; P = 0.006) in comparison to those who did not receive this procedure. There was no association between the type of surgery and the length of hospital stay, as revealed by the analysis (HR = -0.02; 95% CI: -0.84–0.81; P = 0.970).

Conclusions

Based on this meta-analysis, patients with advanced gastric cancer who underwent palliative gastrectomy may experience an extended survival duration without a significant prolongation of their hospitalization.

Peer Review reports

Background

Even with substantial advancements in diagnosis, experimental research, and therapeutic approaches, GC remains responsible for more than 6.8% of global cancer-related mortality and retains its position as the fifth key cause of cancer-related mortality, following female breast [1, 2]. Yet, recent years have seen significant progress in new treatment modalities and chemotherapy, leading to improved overall survival rates among GC patients with untreatable factors, as compared to those undergoing solely supportive treatment [3,4,5]. Timely diagnosis leads to improved long-term outcomes in cases of early GC, but when it comes to advanced GC with incurable factors, the outlook is less hopeful [6, 7]. Peritoneal dissemination, distant lymph node metastases, liver dissemination, lung metastases, and the presence of a significantly large primary tumor are the factors that classify patients with advanced gastric cancer as incurable [8]. Thus, palliative approaches remain essential for gastric cancer patients, particularly those in advanced stages [9].

In accordance with the guidelines from the National Comprehensive Cancer Network (NCCN), the use of gastric resections is advised primarily for symptom palliation, such as the management of uncontrollable bleeding orobstruction, in patients with incurable disease [10]. The guidelines established by the Japanese Gastric Cancer Association (JGCA) propose that patients diagnosed with metastases, yet not experiencing significant symptoms, may be eligible for treatment involving gastrectomy [11]. While surgical resection is generally deemed the most appropriate approach for treating GC, there remains ongoing debate concerning its application in cases of GC with incurable factors. Moreover, the guidelines established by the JGCA propose that patients diagnosed with oligometastatic disease may be eligible for weakly recommended surgical treatment following chemotherapy. Through palliative gastric resection, symptoms such as bleeding and obstruction can be alleviated and oral food intake can be restored [12, 13]. According to several research studies, gastric resection has been associated with potential advantages in terms of survival, symptom relief, and the enhancement of quality of life [13,14,15,16,17]. Conversely, a number of additional studies have noted that survival following palliative gastrectomy was linked to notable morbidity, extended hospitalizations, and diminished quality of life [18, 19]. It was recommended to consider gastrectomy only in cases characterized by severe complications, such as organ perforation or tumor bleeding [20, 21]. This study focuses specifically on palliative gastrectomy, which involves the surgical removal of part or all of the stomach for symptom relief in incurable cases, as opposed to other palliative surgeries that may not involve gastric resection.

Several review studies have explored palliative gastrectomy in patients with advanced, incurable GC. It is not difficult to find that the industry is increasingly clear about the therapeutic intent of palliative gastrectomy in patients with advanced, incurable GC and the positive impact on their survival outcomes. [22, 23] Given the timeliness of previous published studies and significant quality issues in some of the included trials, meta-analyses incorporating the latest findings are necessary to further identify the most appropriate surgical treatment strategies and patient populations. Therefore, we conducted this meta-analysis to assess the clinical relevance of palliative gastrectomy on overall survival for patients diagnosed with incurable advanced gastric cancer, paying particular attention to the criteria for patient selection and the choice of treatment strategy.

Methods

This study is registered on the PROSPERO with the registration number: CRD42023454278.

Systematic search strategy

A comprehensive and sensitive search strategy was created to include literature published from database inception to July 2023, ensuring a comprehensive coverage of relevant material. Electronic databases such as PubMed, Cochrane Library, Web of Science, and the EMBASE were employed in the comprehensive search process. Keywords such as “palliative gastrectomy,” “stomach neoplasm” and “gastric cancer,” were integrated into the search strategy. The search strategy was adapted for each database’s specific syntax and indexing terms while maintaining the core concepts of palliative gastrectomy and advanced gastric cancer. Two independent reviewers (Luo and Xu) were responsible for the article search process. In instances of discordance, they engaged in comprehensive discussions to achieve a consensus resolution. Titles and abstracts from studies considered potentially relevant were collected and incorporated into management software (EndNote®).

Inclusion and exclusion criteria

Inclusion criteria: (1) Population: In this analysis, all the studies were comparative studies, specifically addressing patients with incurable advanced gastric cancer (GC). The core focus of these studies was the comparison between patients who received palliative gastrectomy and those who did not. In this context, advanced GC was explicitly defined using the TNM classification criteria, which encompassed T1–4N3M0, T4N1–3 M0, and any T or N with an M1 tumor designation [24, 25] The present study considered articles that included patients diagnosed with GC with metastasis, even if they did not utilize the TNM staging system. To ensure only incurable cases were included, we carefully reviewed the full texts of studies to confirm that patients had M1 or locally advanced disease deemed unresectable. Studies that did not clearly differentiate between potentially curable and incurable cases were excluded. (2) Intervention: effect of palliative surgery on prognosis in patients with advanced GC. We defined palliative gastrectomy as surgical removal of part or all of the stomach in patients with known incurable disease. Studies that did not clearly distinguish between curative-intent and palliative gastrectomies were excluded. (3) Outcome: overall survival, survival curves, median survival time and hazard ratio (HR), were included in the study to provide a comprehensive assessment of the data. (4) Study design: retrospective, cross-sectional, case-controlled, prospective studies, and randomized controlled trials (RCTs). Exclusion criteria: (1) In this study, only published studies that had undergone peer review and were available in journals were included. The exclusion criteria encompassed the exclusion of conference abstracts, reviews, protocols, letters, comments, articles lacking full-text, and any data that could not be obtained from the authors. (2) In instances where multiple investigations were conducted simultaneously by the same team, this study made the selection to include either the most recent publication or the article with the most extensive dataset. Additionally, any pertinent supplemental data were incorporated as needed.

Data extraction and quality assessment of the included literature

Two researchers conducted the data collection and analysis, utilizing predefined tables with categories that encompassed authorship, publication date, geographical origin, study period, sample size, median survival duration, overall survival, and hospitalization duration. In instances where HR for overall survival were absent in the articles, the analysis utilized Engauge Digitizer 4.1 software to extract and compute HRs from the survival curves. Data extraction was undertaken by the first reviewer (Jiang), and the accuracy of the extracted data was verified through a thorough review performed by the second reviewer (Zheng).

The assessment of study quality in this meta-analysis was performed based on the Newcastle-Ottawa Quality Assessment Scale (NOS), ensuring rigorous evaluation of the included studies. For cohort studies, the NOS evaluated the quality of each study with regard to three domains: participant selection, comparability of groups, and the outcome of interest. The scoring system utilized in the NOS spans from 0 to 9, with studies that received scores surpassing 6 being deemed of high quality [26].

Study outcomes

The primary outcomes were median survival in the two groups and the potential association of palliative gastrectomy for gastric cancer with overall survival. Secondary outcomes included length of hospitalization; post-operative complications and in-hospital mortality. Length of hospitalization analysis excluded patients with hospital mortality. Post-operative complications, as outlined in this study, comprised incidents that could be either surgically related or non-surgically related in origin. Hospital mortality, as defined in this study, encompassed deaths occurring either during the hospital stay or within 30 days following admission.

Statistical analysis

The Tierney et al. method was utilized to calculate HRs and their corresponding 95%CIs based on the available data, in order to investigate potential associations with overall survival in the two study groups [27]. Length of hospitalization was compared based on the difference in mean and standard deviation of post-treatment length of stay between the control and intervention groups. The random-effect model was employed in this study to calculate the aggregated results for various study characteristics. The estimation of hospital stay for continuous outcomes involved the calculation of the standardized mean difference (SMD) along with a 95% confidence interval (CI). The overall effect size was determined using Cohen’s categories, which included the delineation of effect sizes into three categories: small (0.2–0.5), moderate (0.5–0.8), and large (> 0.8).

The assessment of statistical heterogeneity among the studies involved the use of Cochran’s Q test and the I2 statistic for quantitative evaluation, along with forest plots for visual examination. Heterogeneity was categorized as follows: 0–40%, considered not important; 30–60%, characterized as low heterogeneity; 50–90%, denoted moderate heterogeneity; and 75–100%, indicative of high heterogeneity. In cases where statistical heterogeneity was observed, subgroup analysis was performed to investigate the origin of heterogeneity. This analysis was based on two factors: the study area (China or non-China) and the sample size of studies (< 100 vs. ≥100). To gauge the possibility of publication bias, the research conducted visual screening of the Begg’s funnel plot and performed Begg’s test as an analytical tool to evaluate the presence or absence of publication bias. To enhance the reliability of our findings, a sensitivity analysis was carried out. The study implemented sensitivity analysis to assess the potential effect of individual studies on the overall results. This was accomplished by sequentially excluding one study at a time from the pooled analysis. The significance level for effect sizes in this research was defined at a P value of 0.05.

The statistical analysis in this study was carried out using Stata SE version 15.1 (Stata Corp, College Station, TX, USA). Reporting in this study was guided by the PRISMA Checklist.

Results

The included literature and methodological quality

From the initial literature search, a total of 3,571 articles were collected, with 605 originating from PubMed, 2,104 from Web of Science, 643 from Embase, and 219 from the Cochrane Library. After removing duplicate studies and filtering out non-relevant articles via the evaluation of article titles and abstracts, 116 studies that held promise for relevance underwent an in-depth review. In accordance with the pre-defined inclusion and exclusion criteria, this study encompassed a total of 20 studies, which collectively involved 23,061 patients diagnosed with advanced gastric cancer [15, 20, 28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46] Fig. 1 provides a visual representation of the literature search flow. The studies included in this analysis were published over a span of 18 years, from 2003 to 2021. All the articles considered in this study were observational trials, with a patient population of 5,431 individuals who underwent palliative gastrectomy and 17,630 individuals who did not undergo palliative surgery. The details regarding the characteristics of the studies and the results of the methodological quality assessment are presented in Table 1.

Fig. 1
figure 1

Flow diagram of study selection

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Table 1 Characteristic of the included studies
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The primary outcomes

Median survival

Nine of the included articles presented data related to median survival times. The calculated weighted average of the median survival time in the palliative gastrectomy group was 13.91 months (95% CI: 10.84–16.99), as illustrated in Fig. 2A; and within the non-gastrectomy group, the weighted mean of the median survival time was calculated to be 7.42 months (95% CI: 4.63–10.21), as depicted in Fig. 2B.

Fig. 2
figure 2

Forest plots show the association between palliative gastrectomy (A) non-gastrectomy (B) and overall survival

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Overall survival

The 20 studies explored the association between palliative gastrectomy and OS outcomes. The prevailing results across the studies consistently pointed to the benefit of palliative gastrectomy in enhancing long-term survival for patients afflicted with incurable gastric cancer. The statistical significance of between-study heterogeneity was investigated, and the HR for overall survival was determined to be 1.49 (95% CI: 1.12–1.99; p = 0.006). The presence of significant heterogeneity (P < 0.001, I2 = 94.4%) was observed, and this is visually represented in Fig. 3.

Fig. 3
figure 3

Forest plots show the association between palliative gastrectomy and overall survival outcomes

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The secondary outcomes

Length of hospital stay

A total of six studies participated in the length of hospital stay analysis of the relationship between palliative gastrectomy and non-resection procedure. The results showed that the length of hospital stay was not related to the type of surgery (HR =-0.02, 95% CI: -0.84–0.81, P = 0.970), and the heterogeneity across the studies was significant (P < 0.001, I2 = 97.3%; Fig. 4).

Fig. 4
figure 4

Forest plots show the length of hospital stay between palliative gastrectomy and non-resection procedure

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Post-operative complications

Nine studies reported data on the incidence of postoperative complications in patients undergoing palliative surgery and non-gastrectomy. Palliative gastrectomy was linked to a rise in overall complications when compared to non-gastrectomy surgery (OR = 1.96; 95% CI: 1.02–3.75; p = 0.042). Furthermore, there was significant heterogeneity observed across the studies (P < 0.001, I2 = 76.0%; as depicted in Fig. 5).

Fig. 5
figure 5

Forest plots show the post-operative complications in patients undergoing palliative gastrectomy and non-resection procedure

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In-hospital mortality

Data on in-hospital mortality, specifically comparing patients who underwent palliative surgery to those who did not, were reported in five studies. The analysis indicated that palliative surgery did not result in a statistically significant increase in in-hospital mortality when compared to non-gastrectomy surgery (OR = 1.29; 95% CI: 0.77–2.16; p = 0.337). Remarkably, there was no significant heterogeneity observed among the included studies (P = 0.907, I2 = 0.0%), as depicted in Fig. 6.

Fig. 6
figure 6

Forest plots show the in-hospital mortality comparing patients undergoing palliative surgery compared to non-gastrectomy

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Meta regression analysis

Taking the effect size as the dependent variable, and year of publication, time period, country, number of people, and intervention method of the control group as the independent variables, Meta-regression analysis was conducted, and it was found that these variables did not significantly affect the effect size, and the specific results are shown in Table 2.

Table 2 Meta-regression for the association of palliative gastrectomy and the hazard ratio for overall survival
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Subgroup analysis

To investigate the likely causes of heterogeneity in the combined HR for overall survival, we carried out subgroup analyses by dividing eligible studies into subgroups based on study area (China vs. non-China) and sample size (< 100 vs. ≥100). The heterogeneity among the studies ceased to exist when they were categorized into two subgroups based on sample size. With regard to sample size, palliative gastrectomy was significantly correlated with longer OS (HR: 1.86; 95%CI:1.40–2.48; I2 = 0.0%; P < 0.001) in<100 compared with ≥ 100 (HR:1.49; 95%CI: 1.05–1.95; I2 = 95.0%; P = 0.022) (Fig. 7A). The subgroup analysis based on study area did not result in a significant modification of the prognostic impact of palliative gastrectomy on overall survival. However, it’s noteworthy that significant heterogeneity persisted across the studies, as shown in Fig. 7B.

Fig. 7
figure 7

Forest plots show the association between palliative gastrectomy and overall survival stratified by the sample size (A) and studied area (B)

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Sensitivity analysis and publication bias

Sensitivity analyses were then performed as part of the study. The sensitivity analyses involved the stepwise removal of a single study from the meta-analysis in order to reveal the influence of each individual dataset on the aggregated HR. The results from the sensitivity analyses conducted in this study demonstrated that the exclusion of any individual study had no notable effect on the meta-analytic outcomes. This underscores the robust nature of the results, as visually represented in Fig. 8. The results from the Begg’s funnel plot demonstrated considerable asymmetry for all the included studies, which is visually represented in Fig. 9. It’s noteworthy that, despite the visual asymmetry in the Begg’s funnel plot, the quantitative assessment using Begg’s test indicated the absence of statistically significant publication bias in the studies reporting overall survival (P = 0.347).

Fig. 8
figure 8

Sensitivity analysis examining the influence of individual studies on pooled results

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Fig. 9
figure 9

The Begg’s funnel plot for all included studies

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Discussion

Over the course of the last 30 years, there have been transformations in the metastasis, recurrence, and survival characteristics of gastric cancer patients, accompanied by a decrease in the worldwide incidence of the disease. This trend has been accelerated by the implementation of strategies to combat Helicobacter pylori [47], advancements in standardized surgical techniques and supplementary tools, and enhancements in the overall quality of life across various societies, among other factors [48]. Nevertheless, patients diagnosed with GC are often already in an advanced stage. Recent advancements in chemotherapy protocols have led to enhanced survival rates among gastric cancer patients with incurable factors. Despite this, there is still a debate surrounding the suitability of palliative resection for patients diagnosed with advanced GC [49]. Hence, our study stands as the pioneering effort to conduct a meta-analysis on palliative resection in patients diagnosed with incurable advanced gastric cancer. The data revealed a discernible trend that implied palliative gastrectomy could be associated with enhanced survival in patients with advanced GC in an incurable state. Patients who undergo palliative gastrectomy experience hospital stays of similar duration to those who opt for non-resection procedures.

Almost all the articles in this study employed median survival time as the measure for evaluating the effect. Consequently, the overall survival rates derived from each article were considered suitable for examination within the scope of this study. In spite of notable heterogeneity, the results of this study still pointed towards an improvement in overall survival rates associated with palliative gastrectomy, reflecting an HR of 1.49 (95% CI 1.12–1.99).

The comprehensive meta-analysis by Cowling et al. provides important context for interpreting our results [50]. While they found improved 1-year survival with palliative gastrectomy, the benefits became less clear over time. This underscores the importance of considering both short-term and long-term outcomes when evaluating the role of palliative gastrectomy. Their observation of increased complications with palliative resections aligns with our findings of higher complication rates, emphasizing the need to carefully weigh potential benefits against risks. Three of other relevant systematic review and meta-analysis offers additional support for our findings [22, 23, 51]. Among these researches, Zheng et al.‘s observation that palliative gastrectomy plus chemotherapy improved overall survival compared to non-resection surgery plus chemotherapy is consistent with our results. However, their study also highlighted the potential benefits of specific surgical approaches, such as D1 + and D2 lymphadenectomy, which were not specifically addressed in our analysis. This suggests an area for future research to refine patient selection and surgical techniques for optimal outcomes. Morever, while affirming that palliative gastrectomy prolongs survival period, Sun et al. highlighted its superior performance in patients with stage M1 GCs [23].

While our results support the potential benefit of palliative gastrectomy, they also highlight the persistent challenges in this field. As noted by Lasithiotakis et al., the heterogeneity of patients with advanced gastric cancer makes it difficult to draw definitive conclusions about the universal applicability of palliative gastrectomy [52]. Our subgroup analyses, particularly the differences observed between studies from China and other regions, underscore the need for careful consideration of patient and tumor characteristics when deciding on treatment approaches.

The value of palliative gastrectomy for incurable patients depends on whether it improves survival and quality of life. In clinical practice, the benefits of surgery must be weighed against the risks and costs before a treatment decision is made. It’s important to note that the decision for palliative gastrectomy was typically made either upfront based on preoperative staging or intraoperatively upon discovering unresectable disease. The specific decision-making process varied among studies and was not always clearly reported. Quality of life is an important factor in assessing the effect of resection, but it is rarely mentioned in the articles included in the analysis. As we have limited data from retrospective trials and therefore cannot determine quality of life and costs, current evidence cannot elucidate potential clinical benefit or harm. However, Chang [30] used length of hospital stay as a parameter to evaluate quality of life. Our pooled results on length of hospital stay suggest that palliative gastrectomy may not reduce quality of life. Despite this, the question of whether palliative gastrectomy has an impact on quality of life continues to be a matter of contention, highlighting the requirement for future research.

In multiple Asian nations, early diagnosis and prevention strategies are rigorously executed [53], yielding a greater proportion of early-stage tumor diagnoses and improved prognostic outcomes for individuals with gastric cancer when compared to their European and Western counterparts. Discrepancies in the outcomes could be attributed to variances in geographical regions. Among the articles included in this study, nine were contributed by China, while the remaining eleven were from sources outside of China. Subgroup analyses were performed by region to investigate whether regional differences had an influence on the analysis. According to our results, the potential benefit of palliative gastrectomy on survival was more prominent in China, while the dataset exhibited noticeable heterogeneity. Before arriving at a definitive conclusion, it is essential to gather additional data from non-Chinese sources for comparison with the existing Chinese data.

It’s important to note that there are certain limitations in our study. First, while our meta-analysis included studies from various institutions, including large database studies like those using SEER data, it’s important to note that many of the included studies were single-institution retrospective analyses. This mix of study types contributes to the heterogeneity observed in our results. It’s important to note that the second limitation of our study lies in the fact that the decision to opt for either palliative gastrectomy or non-resection procedures was based on a case-by-case assessment conducted by the surgical team. The third limitation is related to the fact that we did not have access to data on performance status, quality of life metrics, or detailed information about the chemotherapy regimen. The observed heterogeneity in the included studies was largely attributed to disparities in study design as well as variations in treatment modalities, such as single-agent versus combination chemotherapy regimens and chemotherapy with or without non-resection surgery. Fourth, our analysis of hospital stay length has limitations. Patients who received outpatient treatments like chemotherapy were not captured in this metric. This could potentially skew the results and should be considered when interpreting the findings. Finally, future research endeavors may find it worthwhile to explore the possibility of surgical resection following chemotherapy as a strategy to enhance the survival of patients with advanced GC. Substantial emphasis should be placed on conducting high-quality multicenter clinical RCTs in the future to meticulously examine the influence of gastrectomy on overall survival (OS).

Finally, it should be acknowledged that this study does not encompass data on long-term complications, morbidity, and the quality of life of patients in the aftermath of gastrectomy. It is vital to recognize that, for a subset of patients, these considerations play a pivotal role in their treatment decisions. Hence, future studies on this topic should prioritize a more robust investigation of these elements.

Conclusions

The results of this meta-analysis demonstrate that palliative gastrectomy confers a statistically significant survival advantage for individuals diagnosed with incurable advanced GC, while not imposing a substantial increase in the duration of hospitalization. However, further validation of the survival advantages linked to palliative gastrectomy in advanced GC patients necessitates the execution of prospective trials and RCTs.

Data availability

All data generated or analysed during this study are included in this article.

Abbreviations

NCCN:

National comprehensive cancer network

JGCA:

Japanese gastric cancer association

RCTs:

Randomized controlled trials

NOS:

Newcastle-Ottawa quality assessment scale

SMD:

Standardized mean difference

CI:

Confidence interval

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Acknowledgements

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Funding

This research was funded by Impact and significance of different digestive tract reconstruction methods on pancreatic exocrine function after laparoscopic early proximal gastric cancer resection (Grant number: 2022KY1429). The funders had no role in study design, data collection and analysis, decision to pub-lish, or preparation of the manuscript.

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  1. Department of Gastrointestinal Abdominal Hernia Surgery, Lishui Municipal Central Hospital, Lishui, 323000, Zhejiang, China

    Desheng Luo, Hongtao Xu, Chuan Jiang, Jingjing Zheng, Dan Wu, Laizhen Tou, Haifeng Que & Zheng Sun

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  1. Desheng Luo
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Contributions

Conceptualization, LDS, XHT; methodology, LDS, XHT; formal analysis, LDS, WD, TLZ; investigation, JC, ZJJ; data curation, QHF, SZ; writing—original draft preparation, LDS, XHT; writing—review and editing, LDS, XHT. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Desheng Luo or Hongtao Xu.

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Luo, D., Xu, H., Jiang, C. et al. The prognostic role of palliative gastrectomy in advanced gastric cancer: a systematic review and meta-analysis. BMC Cancer 24, 1096 (2024). https://doi.org/10.1186/s12885-024-12860-z

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BMC Cancer

ISSN: 1471-2407

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