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Table 7 Log-rank univariate OS and PFS analysis of 64 patients with lung cancer

From: Circulating tumor cells (CTCs) and hTERT gene expression in CTCs for radiotherapy effect with lung cancer

Factor

mOS (95%CI)

P

mPFS (95%CI)

P

Age (years)

 

0.365

 

0.289

 ≤ 60

40.230 (34.731–45.729)

14.900 (3.498–26.302)

 >60

—

14.340 (10.084–18.596)

Gender

 

0.999

 

0.339

 female

42.930 (—)

10.630 (1.580–19.680)

 male

40.230 (34.778–45.682)

14.900 (5.947–23.853)

Histology

 

0.219

 

0.002*

 SCC

37.930 (37.249–38.611)

14.500 (1.271–27.729)

 ADC

42.930 (21.276–64.584)

21.470 (8.098–34.842)

 SCA

26.000 (—)

5.500 (0.000-11.233)

TNM Stage

 

0.017*

 

0.001*

 I/II

43.470 (—)

28.270 (25.892–30.648)

 III/IV

37.930 (18.560–57.300)

12.870 (8.561–17.179)

Smoking

 

0.876

 

0.584

 Yes

42.930 (—)

14.830 (0.323–29.337)

 No

40.230 (34.663–45.797)

14.900 (9.193–20.607)

ECOG

 

0.040*

 

0.000*

 ≤ 1

—

27.500 (22.864–32.136)

 > 1

37.930 (10.296–65.564)

11.233 (7.834–14.632)

Tumor Size (cm)

 

0.092

 

0.002*

 ≤ 4

42.930 (38.301–47.559)

24.000 (8.021–39.979)

 >4

37.630 (4.625–70.635)

10.630 (7.219–14.041)

TCTCs of Pre-RT (n)

 

0.023*

 

0.003*

 ≤ 13

40.230 (20.293–60.167)

27.470 (20.882–34.058)

 >13

37.630 (13.424–61.836)

11.700 (7.229–16.171)

TCTCs of Post-RT (n)

 

0.173

 

0.001*

 ≤ 4

42.930 (37.675–48.185)

27.500 (18.045–36.955)

 >4

37.630 (1.823–73.437)

10.100 (6.287–13.913)

ECTCs of Pre-RT (n)

 

0.144

 

0.233

 ≤ 2

43.470 (—)

24.000 (10.728–37.272)

 >2

37.930 (23.548–52.312)

14.000 (10.912–17.088)

ECECs of Post-RT (n)

 

0.099

 

0.033*

 = 0

42.930 (33.760–52.100)

27.470 (14.189–40.751)

 >0

40.230 (16.614–63.846)

10.467 (6.818–14.115)

EMCTCs of Pre-RT (n)

 

0.002*

 

0.035*

 ≤ 6

47.400 (35.847–58.953)

24.000 (7.346–40.654)

 >6

37.630 (9.675–65.585)

12.500 (3.665–21.335)

EMCTCs of Post-RT (n)

 

0.516

 

0.030*

 ≤ 2

40.230 (25.837–54.623)

26.500 (12.373–40.627)

 >2

37.930 (32.652–43.208)

10.630 (6.384–14.876)

hTERT (+) TCTCs (n) of Pre-RT

 

0.106

 

0.520

 ≤ 5

40.230 (14.691–65.769)

22.500 (8.698–36.302)

 >5

37.930 (32.248–43.612)

14.000 (9.452–18.548)

hTERT (+) EMCTCs (n) of Pre-RT

 

0.046*

 

0.206

 ≤ 3

40.230 (20.207–60.253)

24.000 (8.407–39.593)

 >3

37.930 (12.235–63.625)

14.340 (9.603–19.077)

hTERT (+) ECTCs (n) of Pre-RT

 

0.515

 

0.462

 = 0

43.470 (—)

23.46 (9.444–37.490)

 >0

40.230 (36.355–44.105)

14.340 (13.036–15.644)

  1. Notes:*P < 0.05.
  2. Abbreviations: CI, confidence index; OS, overall survival; PFS, progression-free survival; SCC, squamous cell carcinoma; ECTCs, epithelial circulating tumor cells; EMCTCs, epithelial–mesenchymal circulating tumor cells; MCTCs, mesenchymal circulating tumor cells; TCTCs, total CTCs; Pre-RT, Pre-radiotherapy; Post-RT, Post-radiotherapy
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BMC Cancer

ISSN: 1471-2407

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