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Fig. 4 | BMC Cancer

Fig. 4

From: CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

Fig. 4

CYD0281 inhibits angiogenesis in a concentration-dependent manner in chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. A Representative images of the growth of blood vessel branches and vascular network in chick embryo CAM model at 48 h of incubation. B Quantification of microvessel density (MVD). C Angiogenesis assay in chick embryo YSM model at 24 h of incubation. D Quantification of relative MVD/DMSO group in YSM models. Significant effect compared to DMSO group (B) and between the groups (D): *P < 0.05, **P < 0.01, and ***P < 0.001. Scale bars: 500 μm (A) and 200 μm (C)

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