Fig. 1From: CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growthCYD0281 binds to the Bcl-2 BH4 domain to induce the exposure of the BH3 domain. A The chemical structure of CYD0281. B Structural modeling of CYD0281 docked in the BH4 domain binding pocket of Bcl-2 protein. C The exposure of the BH3 domain of recombinant Bcl-2 protein was analyzed by immunoprecipitation followed by Western blot analysis. DMSO and BDA-366 were used as negative and positive control respectively. D Quantification of BH3 domain exposed Bcl2, n = 3. Significant effect compared to the DMSO group: *P < 0.05Back to article page