Table 9 Univariate and multivariate analyses model analyzed predictors of successful conversion in 809 patients.
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | |
Age (years, < 65 vs ≥65) | 0.629(0.213~1.86) | 0.402 | ||
Sex (female vs male) | 0.95(0.281~3.212) | 0.935 | ||
ECOG PS (0~2 vs 3~4) | 0.049(0.022~1.229) | 0.769 | ||
BCLC staging (A~B vs C~D) | 1.134(0.435~2.953) | 0.797 | ||
Child-Pugh classification (A~B vs C) | 0.384(0.051~2.883) | 0.838 | ||
Number of tumors (solitary vs multiple) | 0.391(0.166~0.921) | 0.032 | 0.738(0.278~1.956) | 0.541 |
Tumor size (cm, ≤10 vs >10) | 3.077(1.296~7.302) | 0.011 | 2.484(0.892~6.92) | 0.082 |
AFP(ng/ml,≤400 vs >400) | 2.122(0.796~5.653) | 0.133 | 2.099(0.766~5.751) | 0.15 |
HBV (no vs yes) | 0.451(0.16~1.268) | 0.131 | 0.63(0.218~1.815) | 0.63 |
ALT (u/L,≤40 vs >40) | 0.704(0.264~1.876) | 0.483 | ||
AST(u/L, ≤35 vs >35) | 2.375(0.687~8.204) | 0.172 | 2.132(0.575~7.905) | 0.257 |
Bilirubin(umol/L, ≤35 vs >35) | 0.042(0~29.086) | 0.342 | ||
Albumin (g/L, ≤35 vs >35) | 0.94(0.272~3.248) | 0.922 | ||
Liver cirrhosis (no vs yes) | 0.165(0.06~0.454) | <0.001 | 0.291(0.098~0.869) | 0.027 |
PVTT (no vs yes) | 1.18(0.489~2.85) | 0.713 | ||
HVTT (no vs yes) | 2.501(0.58~10.782) | 0.219 | ||
IVCTT (no vs yes) | 0.045(0~93.26) | 0.425 | ||
Ascites (no vs yes) | 0.229(0.053~0.987) | 0.048 | 0.259(0.056~1.206) | 0.085 |
Intrahepatic metastasis (no vs yes) | 0.301(0.04~2.25) | 0.242 | ||
Extrahepatic metastasis (no vs yes) | 0.148(0.054~0.993) | 0.063 | 0.181(0.024~1.378) | 0.099 |
lymphatic metastasis (no vs yes) | 0.672(0.252~2.012) | 0.478 | ||
Treatment (LR+TKI/anti-PD-1 vs LR+TKI+anti-PD-1) | 1.71(0.584~5.002) | 0.328 | ||