Fig. 7
From: LncRNA-PVT1 was identified as a key regulator for TMZ resistance and STAT-related pathway in glioma
Knockdown of PVT1 inhibits cell proliferation and TMZ resistance in vitro. (A) qRT-PCR analysis of the knockdown efficiency of siRNA#1 and siRNA#4 in U87 and LN229; (B) Transwell assay of U87 and LN229 cell lines treated with PVT1 siRNA#4 or NC. (C) The wound-healing assays were performed to assess the effect of PVT1 knockdown on cell migration. (D) Knockdown of PVT1 increased the sensitivity of chemotherapy in TMZ-resistant U87 and LN229 cells. E, The protein level of JAK3 and STAT3 in U87 and LN229 cells were decreased after PVT1 knockdown