Fig. 2

CDH1 mRNA is either upregulated or remains unchanged in tumor subtypes and major stages of most carcinoma tissues. The levels of CDH1 mRNA were significantly upregulated in all breast cancer subtypes luminal B (T = 194), luminal A (T = 415), HER2 (T = 66), and basal-like (T = 135) compared to the normal tissues (N = 291) (A) and in all colon cancer subtypes: MSS (T = 175), MSI-L (T = 48) and MSI-H (T = 48) compared to the normal tissues (N = 349) (B). C, CDH1 mRNA levels remain unchanged in the four subtypes of head/neck carcinoma subtypes: mesenchymal (T = 75), classical (T = 49), basal (T = 87), and atypical (T = 67) compared to the normal tissues (N = 44). D, CDH1 mRNA is significantly upregulated in iCluster 1 (T = 53) but remains unchanged in iCluster 2 (T = 55) and iCluster 3 (T = 63) of liver carcinoma compared to the normal tissues (N = 160). Grey, normal; red, carcinoma in (A)-(D). The levels of CDH1 mRNA are not significantly different across the major stages of breast carcinoma (p-value = 0.265) (E) but are significantly downregulated when ovarian carcinoma progresses from stage 2 to stage 3 (p-value = 0.015) (F). *, p < 0.05, **, p < 0.01