Fig. 4

Bubble plots of meta-regression regarding the HR of ASCT compared with No-ASCT for PFS and OS, according to the characteristics of the enrolled patients. 1: PFS; 2: OS; A: number of patients; B: median or mean age; C: ISS III; D: high-risk genetics; E: median follow-up; F: male; G: enrollment periods ≥ 2012; ASCT, autologous stem-cell transplantation; ISS, international Staging System; HR, hazard ratio; PFS, progression-free survival; OS, overall survival; * statistical significance