Fig. 4
From: CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer
Chemokine CCL19 has strong chemotactic activity on Treg cells. (A) Relative CCL19 mRNA expression in 32 pairs of cancerous and noncancerous tissues from gastric cancer patients in TCGA database. (B-C) Immunofluorescence staining showed that the percentage of CCL19 + cells were positively correlated with the percentage of FOXP3 + cells in gastric cancer tissues. (D-E) Transwell experiment showed that the number of migrated CD8 + T cells was slightly increased in supernatant containing chemokine CCL19. (F-G) Transwell experiment showed that the number of migrated Treg cells was remarkably increased in supernatant containing chemokine CCL19. (H) Survival analysis of gastric cancer patients in TCGA database demonstrated that the patients with high CCL19 expression had worse overall survival than those with low CCL19 expression. Values are mean ± s.d., *P < 0.05 (Student’s t-test)