From: Tumor–stroma ratio predicts prognosis and PD-L1 expression in hepatocellular carcinoma
Clinicopathologic variable | RFS | OS | ||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Univariate analysis | ||||
Gender (male vs. female) | 1.38 (0.28–6.81) | 0.69 | 2.04 (0.53–7.84) | 0.30 |
Age, years (> 60 vs. ≤ 60) | 1.02 (0.98–1.07) | 0.32 | 1.02 (0.98–1.06) | 0.40 |
Serum albumin, g/L (≤ 35 vs. > 35) | 1.03 (0.93–1.14) | 0.61 | 1.02 (0.94–1.10) | 0.68 |
Platelet,10^9/L (≤ 160 vs. > 160) | 0.997 (0.99–1.004) | 0.12 | 1.001 (0.996–1.01) | 0.63 |
ALT, U/L (≤ 50 vs. > 50) | 0.98 (0.981–1.007) | 0.35 | 0.994 (0.978–1.01) | 0.44 |
AST, U/L (≤ 40 vs. > 40) | 0.994 (0.99–1.03) | 0.29 | 1.004 (0.99–1.017) | 0.59 |
PT, s (≤ 13.2 vs. > 13.2) | 0.64 (0.40–1.02) | 0.06 | 0.82 (0.57–1.17) | 0.27 |
AFP, ng/mL (> 20 vs. ≤ 20) | 3.84 (0.81–18.14) | 0.09 | 1.11 (0.44–2.85) | 0.82 |
HBV (presence vs. absence) | 2.96 (0.36–24.37) | 0.31 | 1.78 (0.56–5.69) | 0.33 |
TSR (> high vs. ≤ low) | 1.16 (0.34–4.06) | 0.82 | 3.33 (1.03–10.73) | 0.04 |
BCLC stage (C vs. 0/A/B) | 1.78 (0.46–6.84) | 0.40 | 4.93 (1.35–18.02) | 0.02 |
TNM stage (II/III vs. I) | 4.75 (0.59–38.36) | 0.14 | 3.19 (0.86–11.87) | 0.08 |
Tumor number (multiple vs. single) | 1.44 (0.44–4.65) | 0.55 | 1.53 (0.54–4.36) | 0.42 |
Edmondson grade (III/IV vs. I/II) | 1.16 (0.34–3.98) | 0.82 | 1.21 (0.47–3.15) | 0.70 |
Tumor size, cm (> 5 vs. ≤ 5) | 1.13 (0.95–1.34) | 0.17 | 1.33 (1.13–1.58) | 0.01 |
Satellite nodules (presence vs. absence) | 1.27 (0.24–6.62) | 0.78 | 4.66 (0.56–38.6) | 0.15 |
Tumor encapsulation (none vs. complete) | 1.56 (0.51–4.79) | 0.44 | 1.04 (0.40–2.67) | 0.94 |
Liver cirrhosis (presence vs. absence) | 3.84 (0.81–18.14) | 0.09 | 1.41 (0.54–3.67) | 0.49 |
CTP (A vs. B) | 2.69 (0.32–22.28) | 0.36 | 6.57 (0.81–53.07) | 0.08 |
Multivariate analysis | ||||
PT, s (≤ 13.2 vs. > 13.2) | 0.91 (0.76–1.10) | 0.34 | NA | |
CTP (A vs. B) | NA | 1.11 (0.52–2.37) | 0.79 | |
AFP, ng/mL (> 20 vs. ≤ 20) | 1.29 (0.79–2.09) | 0.31 | 1.13 (0.67–1.94) | 0.63 |
Tumor size, cm (> 5 vs. ≤ 5) | 1.00 (0.92–1.08) | 0.35 | 1.05 (0.97–1.14) | 0.23 |
TSR (> high vs. ≤ low) | 10.06 (1.61–63.03) | 0.02 | 8.34 (1.18–59.48) | 0.03 |
BCLC (C vs. 0/A/B) | NA | 2.28 (1.08–4.82) | 0.31 | |
TNM (II/III vs. I) | 1.89 (0.92–3.88) | 0.81 | 1.01 (0.44–2.32) | 0.97 |
Liver cirrhosis (presence vs. absence) | 1.12 (0.68–1.83) | 0.65 | 1.14 (0.66–1.95) | 0.63 |