Fig. 2

Identification and functional annotation of lncRNAs associated with genomic instability in PAAD patients. A Heatmap of top 20 genomic instability-related lncRNAs with the most significant upregulated and downregulated lncRNAs. B Based on 189 lncRNAs associated with genomic instability, unsupervised clustering was performed in 178 PAAD patients. The blue cluster on the right represents the GS-like group, and the red cluster on the left represents the GU-like group. C Somatic cumulative mutations in the GU-like group are significantly higher compared with those in the GS-like group. D The expression level of UBQLN4 in GU-like group was significantly higher than that in GS-like group. E Based on Pearson correlation coefficient, we constructed a network of genomic instability-related lncRNAs and their co-expressed genes. Blue circle represents lncRNA, and red circle represents mRNA. F-G The GO and KEGG functions of lncRNA co-expressed mRNAs were analyzed