Fig. 2

Effects on metastatic load in the lungs. a Relative changes in % of GFP + cells in lungs; a parabolic (quadratic) trend with the nadir at the group treated with excision of primary tumor and nonenriched ε-PCL implant (R² = 71.13%, ΔAIC = 14.65, ER≈1.52·10³, p = 0.0002-*). b Proportion (%) of GFP + cells in lungs of mice on log₂ scale; the Gaussian distribution was used to model data from groups that were treated with primary tumor excision only (μ = 0.33 ± 0.005, σ = 0.09 ± 0.01, R² = 99%) and primary tumor excision with nonenriched implant (μ = 0.22 ± 0.02, σ = 0.13 ± 0.04, R² = 90%), while the data from mice treated with excision of primary and VEGF enriched implant was modeled with exponential distribution (β = 0.7 ± 0.06, R² = 94%). Legend: ε-PCL, eta polycaprolactone; μ, arithmetic mean; σ, standard deviation; β, scale parameter of the exponential distribution which equals arithmetic mean and standard deviation; standard error is used as a measure of uncertainty of an estimate