Table 2 Association between clinicopathological characteristics with the p53 staining in hypopharyngeal squamous cell carcinoma patients

Age (years)

 ≤60

26

27

4

5

22

22

 >60

22

22

1

5

21

17

Smoking

 No

14

11

1

1

13

10

 Yes

34

38

4

9

30

29

Drinking

 No

16

16

1

0

15

16

 Yes

32

33

4

10

27

23

Tumor site

 Pyriform sinus

40

44

4

8

36

36

 Not pyriform sinus

8

5

1

2

7

3

cT stage

 T1-2

26

21

3

3

23

18

 T3-4

22

28

2

7

20

21

cN stage

 N0

9

6

0

2

9

4

 N1-3

39

43

5

8

34

35

Clinical stage

 I+II

3

2

0

1

3

1

 III+IV

45

47

5

9

40

38

pT stage

 T1-2

25

16

3

1

22

15

 T3-4

23

33

2

9

21

24

pN stage

 N0

3

8

0

3

3

5

 N1-3

45

41

5

7

40

34

Pathological stage

 I+II+III

10

14

0

0

10

14

 IV

38

35

5

10

33

25

Tumor differentiation

 Well+ well-moderately

3

6

0

1

3

5

 Moderately+ Moderately-poorly

45

43

5

9

40

34

Surgical margin status

 ≥0.5 cm

26

23

3

6

23

17

 <0.5 cm

22

26

2

4

20

24

Tumor size (cm)

 ≤3.5

33

26

2

2

31

24

 >3.5

15

23

3

8

12

15

Lymph nodal fusion

 No

37

35

3

6

34

29

 Yes

11

14

2

4

9

10

Metastatic lymph node size (cm)

 ≤3

32

31

3

5

29

26

 >3

16

18

2

5

14

13

Cervical nodal necrosis

 No

26

27

0

5

26

22

 Yes

22

22

5

5

17

17

Lymphovascular invasion

 No

43

45

4

10

39

35

 Yes

5

4

1

0

4

4

Extracapsular spread

 No

39

35

3

6

36

29

 Yes

9

14

2

4

7

10

Fixation of hemilarynx

 No

25

22

4

8

21

14

 Yes

23

27

1

2

22

25

Thyroid gland invasion

 No

45

49

5

15

40

34

 Yes

3

0

0

0

3

0

Laryngeal invasion

 No

21

19

3

4

18

15

 Yes

27

30

2

6

25

24