Fig. 3

Distribution and prognostic significance of TP53 mutation in HPV(-) advanced HPSCC (A) Distribution of exon 5, 6 and 8 mutations of TP53. Kaplan-Meier estimates of (B) OS and (C) RFS among the 51 HPSCC patients with HPV(-)/TP53^wt (of whom 18 died) and the 39 HPSCC patients with HPV(-)/TP53^mut (of whom 17 died). The mean OS and RFS among patients with HPV(-)/TP53^wt were 41.10 and 36.78 years, as compared with 41.95 and 38.33 years among patients with HPV(-)/TP53^mut. p=0.5798 for OS, p=0.6264 for RFS (Log-rank test). Three patients did not undergo TP53 mutation detection due to sample reasons. wt, wild type; mut, mutation. OS (D-F) and RFS (G-I) of each exon among the HPV(-)HPSCC patients. E, exon