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Fig. 2 | BMC Cancer

Fig. 2

From: Evaluating the prognostic significance of p53 and TP53 mutations in HPV-negative hypopharyngeal carcinoma patients: a 5-year follow-up retrospective study

Fig. 2

Patterns of p53 protein expression and prognostic significance of p53 protein and TP53 gene in HPV(-) advanced HPSCC patients (A) Complete absence or low expression (<50% of the tumour cells) of staining in the tumour. B Uniform strong nuclear staining in at least 50% of the tumour cells. Scale bar: 100 μm. Kaplan-Meier estimates of (C) OS and (D) RFS among the 39 HPSCC patients with HPV(-)/p53high (of whom 12 died) and the 43 HPSCC patients with HPV(-)/p53low (of whom 18 died). The mean OS and RFS among patients with HPV(-)/p53high were 44.46 and 41.33 years, as compared with 39.86 and 35.63 years among patients with HPV(-)/p53low. p=0.2771 for OS, p=0.3715 for RFS (Log-rank test). Eleven patients did not undergo IHC staining due to sample reasons. E Kaplan-Meier curves shows outcome significance of TP53 gene expression among 522 head and neck cancer (HR=0.97, p=0.632). F Kaplan-Meier curves shows outcome significance of TP53 gene expression among 98 HPV(+) head and neck cancer (HR=0.65, p=0.0157). G Kaplan-Meier curves shows outcome significance of TP53 gene expression among 422 HPV(-) head and neck cancer (HR=1.04, p=0.555). Data available from Gene_Outcome module in TIMER2.0 (http://timer.cistrome.org/)

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