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Table 3 Acceptable and unacceptable variation in dose

From: SAFESTEREO: phase II randomized trial to compare stereotactic radiosurgery with fractionated stereotactic radiosurgery for brain metastases

 

Per protocol dose

Acceptable variation

Unacceptable variation

PTV to be covered

99%

98% < V100% < 99%

V100% < 98%

Dmax OAR if volume

of OAR < 2 cm3

0.035 cm3

D0.035cm3 ≤ Dmax

D0.035cm3 > Dmax

Dmax OAR if volume

of OAR ≥ 2 cm3

2%

D2% ≤ Dmax

D2% > Dmax

  1. PTV Planning target volume, Dmax Maximum dose, OAR Organ at risk