Comprehensive analyses of A 12-metabolism-associated gene signature and its connection with tumor metastases in clear cell renal cell carcinoma

Table 1 Univariate Cox regression analysis for overall survival

Gene ID	HR	CI	P
AK3	0.9868	0.98–0.9938	< 0.001
CHD9	0.9518	0.9332–0.9708	< 0.001
ENO2	1.0019	1.0009–1.0029	< 0.001
ENPP3	0.9987	0.998–0.9995	0.001
GALNT14	0.9971	0.9955–0.9987	< 0.001
GALNT7	1.0297	1.0116–1.048	0.001
GAPDH	1.0001	1–1.0001	0.002
GMPPA	1.0203	1.0091–1.0317	< 0.001
GUCY1A1	0.9918	0.9872–0.9964	< 0.001
HSD3B7	1.0016	1.0005–1.0027	0.003
HYI	1.0196	1.0087–1.0306	< 0.001
ITPKB	0.98	0.9696–0.9905	< 0.001
LPIN3	1.007	1.0032–1.0108	< 0.001
MAN1A2	0.9734	0.9599–0.987	< 0.001
METAP1	0.9691	0.9568–0.9817	< 0.001
NNMT	1.0002	1.0001–1.0004	0.004
PFKP	0.9985	0.9977–0.9993	< 0.001
PGK1	0.999	0.9985–0.9995	< 0.001
PLCB1	0.9601	0.9435–0.9771	< 0.001
PLIN2	0.9995	0.9993–0.9998	< 0.001
PLOD1	1.0014	1.0006–1.0022	0.001
PLOD2	1.0012	1.0007–1.0017	< 0.001
POMGNT2	0.9685	0.9493–0.9881	0.002
PTPRG	0.9708	0.9615–0.9802	< 0.001
RIMKLA	0.9596	0.9435–0.976	< 0.001
RPS15	1.0009	1.0003–1.0014	0.004
S100A10	1.0005	1.0002–1.0008	0.003
SMARCD3	1.028	1.0162–1.0399	< 0.001
SPTLC2	0.9858	0.9781–0.9936	< 0.001
TRIB3	1.0031	1.0018–1.0045	< 0.001
TYMS	0.9911	0.9851–0.9972	0.004

^aThe expression matrix and corresponding clinical information were derived from the TCGA-KIRC cohort
^bGenes involved in this univariate Cox regression analysis were derived from the red module of WGCNA analysis
^cP lower than 0.005 was set as thresholds
^dHazard ratio was estimated from Cox proportional hazard regression model
^eCI meant confidence interval of the estimated HR

ISSN: 1471-2407