Fig. 9

Infiltration of immune cells and drug susceptibility analyses of the MAPS. A Comparison of chemokines which are important for the recruitment, differentiation, and activation of macrophages in TIME, and chemokine receptors that promote Tregs cell migration to the TIME between the high- and low-risk subgroups based on the TCGA-KIRC cohort. The gene-level transcription estimates were shown in a form of log2 (TPM + 1). B Comparison of drug sensitivity of sunitinib, sorafenib, pazopanib, and rapamycin between the high- and low-risk subgroups of the MAPS. C Comparison of the expression of PD-1, CTLA4, CD27, CD28, LAG3, TNFRSF18, and TNFSF14 between the high- and low-risk subgroups of the MAPS. The gene-level transcription estimates were shown in a form of log2 (TPM + 1). D Comparison of the immunotherapy score from ImmuCell AI algorithm between the high-risk subgroup and low-risk subgroup of the MAPS. E Comparison of the dysfunction score from the TIDE algorithm between the high-risk subgroup and the low-risk subgroup of the MAPS. P was calculated the via two-tailed Mann–Whitney test (A, B, C, and D) and student’s t-test (E). For all the panels, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, "ns" means no significance