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Fig. 3 | BMC Cancer

Fig. 3

From: Comprehensive analyses of A 12-metabolism-associated gene signature and its connection with tumor metastases in clear cell renal cell carcinoma

Fig. 3

Construction of the MAPS and its prognostic value for ccRCC patients based on TCGA-KIRC cohort. A Distribution of LASSO coefficients of the 27 metabolism-associated genes in TCGA-KIRC cohort, and the generated coefficient distribution plots for the logarithmic (lambda) sequence to select the best parameter (lambda). B Forest plot demonstrating the multivariable Cox model results of 12 metabolism-associated signature genes using continuous TGCA-KIRC TPM data. C Distribution of the risk scores (the upper panel), distribution of prognostic status (the middle panel), and the expression of 12 genes in the MAPS in the TCGA-KIRC cohort (the lower panel). The relative expression of each gene from the MAPS was normalized into Z-score. D The Kaplan–Meier survival of the MAPS in the TCGA-KIRC cohort (log-rank test for statistics). E The time-dependent ROC curve of a prognostic model for predicting the 1-,3- and 5-year OS of ccRCC patients based on the TCGA-KIRC cohort. F The ROC curve of the MAPS for predicting the tumor progresses from stage T1 or T2 to stage T3 or T4, the emergence of lymph node metastases, and remote metastases based on the TCGA-KIRC cohort

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