Table 2 Mendelian randomization estimates between phenotypes and ovarian cancer

Cigarettes per day

Overall ovarian cancer

Inverse-variance weighted

0.99 (0.90–1.08)

0.755

MR Egger

1.19 (1.01–1.40)

0.051

Weighted median

1.09 (0.95–1.24)

0.211

Weighted mode

1.11(0.97–1.27)

0.148

Simple mode

1.07 (0.80–1.43)

0.671

Smoking initiation

Overall ovarian cancer

Inverse-variance weighted

1.15 (1.02–1.29)

0.027

MR Egger

1.12 (0.61–2.05)

0.71

Weighted median

1.14 (0.96–1.35)

0.133

Weighted mode

1.17 (0.84–1.64)

0.349

Simple mode

1.20 (0.78–1.84)

0.41

Smoking cessation

Overall ovarian cancer

Inverse-variance weighted

0.95 (0.76–1.19)

0.665

MR Egger

1.00 (0.50–2.00)

0.991

Weighted median

0.97 (0.72–1.29)

0.814

Weighted mode

0.97 (0.68–1.38)

0.865

Simple mode

0.92 (0.60–1.40)

0.695

Alcohol consumption

Overall ovarian cancer

Inverse-variance weighted

0.79 (0.55–1.11)

0.175

MR Egger

0.66 (0.38–1.13)

0.136

Weighted median

0.74 (0.52–1.04)

0.081

Weighted mode

0.74 (0.53–1.05)

0.103

Simple mode

0.88 (0.39–1.96)

0.747

Coffee consumption

Overall ovarian cancer

Inverse-variance weighted

1.40 (1.02–1.93)

0.04

MR Egger

0.77 (0.40–1.50)

0.449

Weighted median

1.44 (0.87–2.41)

0.158

Weighted mode

1.47 (0.83–2.61)

0.2

Simple mode

1.77 (0.60–5.19)

0.308