Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages

Fig. 3

sVEGFR1 down-regulates PD-L1 but promoted sPD-L1 expression on GBM-educated macrophages. (a) Typical flow-cytometry results of VEGFR1 surface expression on macrophages derived from circulating monocytes of a healthy control or a GBM patient. (b) sVEGFR1 levels in the supernatant of monocytes or their derived macrophages from healthy controls (n = 6) and GBM patients (n = 6). ** P < 0.01. n.s. not significant. (c) PD-L1 on healthy control or GBM monocyte-derived macrophages (both n = 6), treated with sVEGFR1. * P < 0.05, ** P < 0.01, control vs. sVEGFR1. (d) sPD-L1 levels in the supernatant of healthy control or GBM monocyte-derived macrophages (both n = 6), activated by LPS (100ng/mL). * P < 0.05. (e) sPD-L1 levels in the supernatant of healthy control or GBM monocyte-derived macrophages (both n = 6), treated with sVEGFR1 and LPS. * P < 0.05, ** P < 0.01, control vs. sVEGFR1. P values are achieved by t-test. GEMs, GBM-educated macrophages

Back to article page