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Table 2 Multivariate analysis of prognostic factors for relapse-free survival in children with B-cell acute lymphoblastic leukemia

From: DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells

Variables

Relapse-free survival

 

Univariatea

P

Multivariateb

 

Hazard ratio (HR)

95% CI for HR

P

Lower

Upper

DNMT3A expression: Low (n = 21) vs. High (n = 75)

 < 0.001

36.824

3.746

362.033

0.002

Age(years): < 1 or ≥ 10 (n = 7) vs. 1 ~ 10 (n = 89)

0.375

0.000

0.000

 

0.988

WBC counts at diagnosis (× 109/L): ≥ 50 (n = 19) vs. < 50(n = 77)

0.16

1.042

0.21

5.178

0.96

MRD at day33: ≥ 10–3 (n = 11) vs. < 10–3 (n = 85)

0.172

0.969

0.098

9.525

0.978

Clinical risk:

0.053

    

 Intermediate-risk (n = 71) vs. Low-risk (n = 19)

 

1.757

0.198

15.624

0.613

 High-risk (6) vs. Low-risk (n = 19)

 

64.978

1.837

2298.197

0.022

  1. HR Indicates Hazard ratio, WBC White blood count, MRD Minimal residual disease
  2. aUnivariate analysis was performed by Kaplan–Meier Log-rank test
  3. bAll factors in the univariate analysis were selected in Cox regression of the multivariate analysis