Table 3 Uni- and multivariate analyses for RFS in IASLC grade 2–3 patients (N = 473)

Sex (male)

1.036 (0.685–1.566)

0.866

0.606 (0.324–1.135)

0.606

Age

1.077 (1.050–1.105)

< 0.001

1.079 (1.051–1.107)

< 0.001

Smoking status (current or ex-)

1.628 (1.062–2.496)

0.025

1.516 (0.965–2.380)

0.071

Surgical procedure (wedge resection)

1.774 (0.984–3.199)

0.057

1.346 (0.718–2.524)

0.354

Pathological invasive size (mm)

1.051 (1.033–1.071)

< 0.001

1.031 (1.009–1.053)

0.005

IASLC grade (grade 3)

2.171 (1.397–3.374)

< 0.001

1.210 (0.733–1.997)

0.456

Pleural invasion (positive)

3.799 (2.491–5.793)

< 0.001

2.784 (1.714–4.520)

< 0.001

Lymphovascular invasion (positive)

2.712 (1.797–4.092)

< 0.001

1.996 (1.227–3.245)

0.005

Intrapulmonary metastasis (positive)

3.644 (1.678–7.914)

0.001

3.845 (1.702–8.687)

0.001

EGFR/KRAS mutation (positive)

1.553 (1.004–2.402)

0.048

2.007 (1.265–3.183)

0.003