| Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
Sex (male) | 1.036 (0.685–1.566) | 0.866 | 0.606 (0.324–1.135) | 0.606 |
Age | 1.077 (1.050–1.105) | < 0.001 | 1.079 (1.051–1.107) | < 0.001 |
Smoking status (current or ex-) | 1.628 (1.062–2.496) | 0.025 | 1.516 (0.965–2.380) | 0.071 |
Surgical procedure (wedge resection) | 1.774 (0.984–3.199) | 0.057 | 1.346 (0.718–2.524) | 0.354 |
Pathological invasive size (mm) | 1.051 (1.033–1.071) | < 0.001 | 1.031 (1.009–1.053) | 0.005 |
IASLC grade (grade 3) | 2.171 (1.397–3.374) | < 0.001 | 1.210 (0.733–1.997) | 0.456 |
Pleural invasion (positive) | 3.799 (2.491–5.793) | < 0.001 | 2.784 (1.714–4.520) | < 0.001 |
Lymphovascular invasion (positive) | 2.712 (1.797–4.092) | < 0.001 | 1.996 (1.227–3.245) | 0.005 |
Intrapulmonary metastasis (positive) | 3.644 (1.678–7.914) | 0.001 | 3.845 (1.702–8.687) | 0.001 |
EGFR/KRAS mutation (positive) | 1.553 (1.004–2.402) | 0.048 | 2.007 (1.265–3.183) | 0.003 |