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Table 6 Univariate and multivariate logistic regression analysis for tumor response to neoadjuvant therapy

From: Effect of neoadjuvant chemotherapy combined with arterial chemoembolization on short-term clinical outcome of locally advanced gastric cancer

Patient characteristics

Univariate Analysis

Multivariate Analysis

OR

95% CI

P

OR

95% CI

P

Gender

      
 

Female

ref

     
 

Male

3.609

0.813–16.022

0.091

2.199

0.438–11.049

0.339

Age

      
 

<60 years

ref

     
 

≥ 60 years

1.744

0.71–4.284

0.225

   

BMI

      
 

<25 kg/m2

ref

     
 

≥ 25 kg/m2

1.966

0.71–5.445

0.194

   

Tumor location

  

0.988

   
 

Upper stomach

ref

     
 

Middle stomach

0.916

0.281–2.988

0.844

   
 

Lower stomach

0.945

0.344–2.593

0.913

   

Tumor size

      
 

<5.8 cm

ref

     
 

≥5.8 cm

0.824

0.339–2.004

0.67

   

Pre-treatment NLR

      
 

<2.86

ref

     
 

≥ 2.86

0.355

0.133–0.948

0.039

0.193

0.016–0.611

0.005

Pre-treatment PLR

      
 

<182

ref

     
 

≥ 182

0.137

0.039–0.478

0.002

0.077

0.018–0.333

0.001

CEA

      
 

<5.2ng/ml

ref

     
 

≥ 5.2ng/ml

1.628

0.657–4.035

0.292

   

CA19-9

      
 

<27U/ml

ref

     
 

≥ 27U/ml

0.624

0.219–1.773

0.376

   

Degree of differentiation

      
 

poor/mucinous

ref

     
 

moderate/well

0.994

0.409–2.417

0.989

   

HER-2

       
 

negative

ref

     
 

positive

2.756

0.352–21.561

0.334

   

Clinical T stage

  

0.907

   
 

T3

ref

     
 

T4a

0.854

0.309–2.357

0.76

   
 

T4b

1.154

0.208–6.413

0.87

   

Clinical N stage

  

0.062

  

0.064

 

N0

ref

  

ref

  
 

N1

0.208

0.048–0.905

0.036

0.445

0.069–2.875

0.395

 

N2

0.317

0.097–1.039

0.058

1.044

0.063–17.217

0.976

 

N3

0.88

0.248–3.128

0.843

5.391

0.303–95.933

0.251

Clinical TNM stage

      
 

II

ref

     
 

III

0.42

0.163–1.078

0.071

0.306

0.025–3.74

0.354

Chemotherapy regimen

      
 

DOS

ref

     
 

NPOS

1.156

0.461–2.896

0.757

   

Arterial chemoembolization

      
 

No

ref

     
 

Yes

3.84

1.359–10.853

0.011

3.766

1.177–12.054

0.025

Number of chemotherapy cycles

  

0.531

   
 

2

ref

     
 

3

0.541

0.186–1.579

0.261

   
 

4

0.806

0.215–3.024

0.749

   
  1. Abbreviations: BMI, Body mass index; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; CEA, Carcinoembryonic antigen; CA19-9, Carbohydrate antigen 19 − 9; NPOS, Nab-paclitaxel, oxaliplatin and S-1; DOS, Docetaxel, oxaliplatin and S-1