From: Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence
Character | Training set | Â | Â | Validation set | ||
---|---|---|---|---|---|---|
Distant metastasis | HR (95% CI) | P-value | Distant metastasis | |||
no | yes | no | yes | |||
Age (mean ± SD, years) | 47.1 (9.75) | 46.3 (10.0) | 0.984 (0.949–1.02) | 0.395 | 48.9 (9.46) | 48.3 (14.8) |
Family history of BC | ||||||
 Yes | 4 (4.60%) | 1 (3.33%) | 0.985 (0.235–4.13) | 0.983 | 2 (5.41%) | 1 (8.33%) |
 No | 83 (95.40%) | 29 (96.67%) | 35 (94.59%) | 11 (91.67%) | ||
Breast-feeding histories | ||||||
 Yes | 75 (86.21%) | 26 (86.67%) | 0.505 (0.216–1.18) | 0.113 | 33 (89.19%) | 8 (66.67%) |
 No | 12 (13.79%) | 4 (13.33%) | 4 (10.81%) | 4 (33.33%) | ||
Abortion | ||||||
 Yes | 52 (59.77%) | 18 (60.00%) | 0.623 (0.303–1.28) | 0.200 | 24 (64.86%) | 3 (25.00%) |
 No | 35 (40.23%) | 12 (40.00%) | 13 (35.14%) | 9 (75.00%) | ||
Reproductive history | ||||||
 Yes | 84 (96.55%) | 28 (93.33%) | 0.463 (0.162–1.33) | 0.152 | 34 (91.89%) | 9 (75.00%) |
 No | 3 (3.45%) | 2 (6.67%) | 3 (8.11%) | 3 (25.00%) | ||
Menstrual status | ||||||
 Menstruate | 56 (64.37%) | 20 (66.67%) | 0.845 (0.396–1.81) | 0.665 | 22 (59.46%) | 6 (50.00%) |
 Menopause | 31 (35.63%) | 10 (33.33%) | 15 (40.54%) | 6 (50.00%) | ||
Age of menarche | 14.4 (1.69) | 14.2 (1.69) | 0.802 (0.635–1.01) | 0.063 | 14.9 (1.79) | 14.3 (2.38) |
Lymph node metastasis | ||||||
 Have | 26 (29.89%) | 19 (63.33%) | 4.9 (2.29–10.5) |  < 0.001 | 4 (10.81%) | 7 (58.33%) |
 None | 61 (70.11%) | 11 (36.67%) | 33 (89.19%) | 5 (41.67%) | ||
molecular subtyping | ||||||
 1 | 9 (10.34%) | 3 (10.00%) | 1.08 (0.706–1.66) | 0.718 | 4 (10.81%) | 0 (0.00%) |
 2 | 61 (70.11%) | 14 (46.67%) | 24 (64.86%) | 7 (58.33%) | ||
 3 | 4 (4.60%) | 6 (20.00%) | 2 (5.41%) | 2 (16.67%) | ||
 4 | 13 (14.94%) | 7 (23.33%) | 7 (18.92%) | 3 (25.00%) | ||
ER | ||||||
 Positive | 70 (80.46%) | 14 (46.67%) | 0.456 (0.221–0.939) | 0.033 | 28 (75.68%) | 7 (58.33%) |
 Negative | 17 (19.54%) | 16 (53.33%) | 9 (24.32%) | 5 (41.67%) | ||
PR | ||||||
 Positive | 69 (79.31%) | 13 (43.33%) | 0.482 (0.234–0.993) | 0.048 | 26 (70.27%) | 7 (58.33%) |
 Negative | 18 (20.69%) | 17 (56.67%) | 11 (29.73%) | 5 (41.67%) | ||
HER2 status | ||||||
 Positive | 57 | 16 | 1.6 (1.02–2.5) | 0.041 | 27 | 7 |
 Negative | 30 | 14 | 10 | 5 | ||
Ki-67 | ||||||
 Positive | 77 (88.51%) | 26 (86.67%) | 0.996 (0.981–1.01) | 0.603 | 32 (86.49%) | 11 (91.67%) |
 Negative | 10 (11.49%) | 4 (13.33%) | 5 (13.51%) | 1 (8.33%) | ||
TPSA | ||||||
 Positive | 8 (9.20%) | 4 (13.33%) | 0.596 (0.142–2.5) | 0.479 | 5 (13.51%) | 2 (16.67%) |
 Negative | 79 (90.80%) | 26 (86.67%) | 32 (86.49%) | 10 (83.33%) | ||
CA153 | ||||||
 Positive | 0 (0.00%) | 5 (16.67%) | 5.49 (2.09–14.4) |  < 0.001 | 1 (2.70%) | 3 (25.00%) |
 Negative | 87 (100.00%) | 25 (83.33%) | 36 (97.30%) | 9 (75.00%) | ||
CEA | ||||||
 Positive | 1 (1.15%) | 4 (13.33%) | 5.52 (2.1–14.5) | 0.004 | 0 (0.00%) | 3 (25.00%) |
 Negative | 86 (98.85%) | 26 (86.67%) | 37 (100.00%) | 9 (75.00%) | ||
CA125 | ||||||
 Positive | 7 (8.05%) | 4 (13.33%) | 1.77 (0.616–5.07) | 0.290 | 1 (2.70%) | 2 (16.67%) |
 Negative | 80 (91.95%) | 26 (86.67%) | 36 (97.30%) | 10 (83.33%) | ||
Operation | ||||||
 No surgery | 0 (0.00%) | 3 (10.00%) | 1.02 (0.503–2.05) | 0.965 | 0 (0.00%) | 2 (16.67%) |
 Conserving | 40 (45.98%) | 6 (20.00%) | 15 (40.54%) | 3 (25.00%) | ||
 Radical | 47 (54.02%) | 21 (70.00%) | 22 (59.46%) | 7 (58.33%) | ||
Endocrinotherapy | ||||||
 Yes | 11 (12.64%) | 0 (0.00%) | 1.31e-08 (0-Inf) | 0.997 | 1 (2.70%) | 0 (0.00%) |
 No | 76 (87.36%) | 30 (100.00%) | 36 (97.30%) | 12 (100.00%) | ||
Radiotherapy | ||||||
 Yes | 14 (16.09%) | 8 (26.67%) | 2.42 (1.08–5.45) | 0.033 | 3 (8.11%) | 3 (25.00%) |
 No | 73 (83.91%) | 22 (73.33%) | 34 (91.89%) | 9 (75.00%) | ||
Chemotherapy | ||||||
 Yes | 78 (89.66%) | 30 (100.00%) | 3.02 (0.411–22.2) | 0.277 | 35 (94.59%) | 11 (91.67%) |
 No | 9 (10.34%) | 0 (0.00%) | 2 (5.41%) | 1 (8.33%) | ||
RadScore (mean ± SD) | -2.77 (0.56) | -1.66 (0.44) | 20 (8.27–48.2) |  < 0.001 | -2.60 (0.74) | -2.23 (0.60) |