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Fig. 7 | BMC Cancer

Fig. 7

From: Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies

Fig. 7

Immunostaining of N-cadherin in human testicular biopsy specimens. (A) In the seminiferous tubule with normal spermatogenesis, the brown signal of the reaction can be mainly seen in the cytoplasm of Sertoli cells (white arrowheads), which surround different germ cells, but also the cell boundaries between adjacent Sertoli and germ cells are in parts clearly stained (arrows). (B) Tubules harboring germ cell neoplasia in situ also show distinct staining of the cytoplasm of Sertoli cells (white arrowheads), which are displaced to the center of the tubule. The basally located degenerated germ cells display staining of the cell membranes (arrows). (C) The membranes of adjacent seminoma cells show a positive signal (arrows), while Sertoli cells cannot be found anymore. Negative controls (inserts) do not show any reaction. Scale bars = 20 μm (A–C), 50 μm (inserts)

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BMC Cancer

ISSN: 1471-2407

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