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Table 1 Clinicopathologic and histologic features of double primary mutant GISTs

From: Clinicopathological and mutational characteristics of primary double mutant gastrointestinal stromal tumor: a single center study with review of the literature

Case

Age

Gender

Clinical Presentation

Site

Size

(Maximum Diameter)

Mitosis

(50/HPF)

NIH Risk Classification

AJCC stage

Cell type (histologic subtype)

Treatment

Follow-up Information

1

63

M

hematochezia

rectum

6 cm

5

High

II

Mixed(hypercellular spindle + hypercellular epithelioid)

excision and imatinib(400 mg)

NED at 61 mo

2

69

M

asymptomatic

ileum

5.5 cm

4

High

II

Mixed(sclerosing spindle + sclerosing epithelioid )

excision and imatinib(400 mg)

NED at 45 mo

3

63

F

asymptomatic

stomach

5.2 cm

2

Moderate

IB

Mixed(sclerosing spindle + sclerosing and dyscohesive epithelioid)

excision and imatinib(200 mg)

NED at 43 mo

4

83

M

abdominal mass

jejunum

21.3 cm

10

High

IIIB

Mixed(hypercellular spindle + hypercellular epithelioid )

excision and imatinib(400 mg)

NED at 39 mo

5

62

M

abdominal pain

duodenum

7 cm

8

High

IIIB

Mixed(sclerosing spindle + dyscohesive and sclerosing epithelioid)

excision and imatinib(400 mg)

NED at 22 mo

6

70

M

asymptomatic

stomach

6 cm

2

Moderate

IB

Mixed(sclerosing spindle + dyscohesive epithelioid)

excision

NED at 21 mo

7

57

F

abdominal pain

jejunum

5.4 cm

2

High

II

Mixed(sclerosing spindle + sclerosing and dyscohesive epithelioid)

excision

NED at 12 mo

8

64

M

abdominal mass

retroperitoneum

10.5 cm

2

High

IIIA

Mixed(hypercellular and palisade-vacuolated spindle + epithelioid)

excision and imatinib(600 mg)

NED at 10 mo

  1. Abbreviations: HPF, high power field; M, male; F, female; NED, no evidence of disease;