Table 3 Univariate analysis of potential factors associated with PFS and OS [Median (Q25, Q75)]

Gender

0.769

0.381

2.584

0.108

 Male

192(69.1%)

6.0(5.16,6.85)

25.0(22.25,27.75)

 Female

86(30.9%)

6.0(4.18,7.82)

26.00(20.88,31.12)

Age

0.899

0.343

1.881

0.170

 < 60

109(39.2%)

6.0(5.28,6.72)

26.0(22.96,29.05)

 ≥ 60

169(60.8%)

6.0(4.84,7.16)

23.0(19.26,26.74)

Smoking status

0.065

0.799

1.598

0.206

 Minimal/never

116(41.7%)

6.0(4.76,7.24)

25.0(20.25,29.75)

 Current/former

162(58.3%)

6.0(4.96,7.04)

25.0(22.16,27.84)

ECOG-PS

1.615

0.204

5.642

0.018

 0/1

160(57.6%)

6.0(4.97,7.03)

27.0(24.68,29.32)

 2

118(42.4%)

6.0(4.94,7.06)

22.0(19.76,24.24)

Histology subtype

0.646

0.724

1.730

0.421

 Squamous

113(40.6%)

6.0(4.85,7.15)

25.0(22.48,27.52)

 Adenocarcinoma

133(47.8%)

6.0(4.67,7.33)

25.0(20.72,29.28)

 others

32(11.5%)

6.0(4.63,7.38)

26.0(15.7,36.26)

TNM staging

6.549

0.010

12.981

0.000

 III

102(36.7%)

6.0(5.24,6.76)

27.0(23.35,30.65)

 IV

176(63.3%)

6.0(4.76,7.24)

23.0(20.23,25.77)

Chemotherapy regimens

1.156

0.885

1.419

0.841

 DP

32(11.5%)

5.0(1.67,8.33)

20.0(14.46,25.54)

 GP

97(34.9%)

6.0(4.79,7.21)

26.0(22.08,29.92)

 NP

37(13.3%)

7.0(4.02,9.98)

23.0(15.87,30.13)

 PC

83(29.9%)

6.0(5.01,6.99)

25.0(20.71,29.29)

 TP

29(10.4%)

5.0(3.49,6.51)

26.0(19.87,32.13)

CEA

3.240

0.072

2.163

0.141

 Normal

123(44.2%)

6.0(5.06,6.94)

25.0(22.02,27.98)

 High

155(55.8%)

6.0(4.54,7.46)

26.0(22.39,29.61)

CYF

3.147

0.076

1.105

0.293

 Normal

76(27.3%)

6.0(4.88,7.13)

25.0(21.92,28.08)

 High

202(72.7%)

6.0(4.97,7.03)

25.0(22.08,27.93)

NSE

0.945

0.331

1.406

0.236

 Normal

153(55.0%)

6.0(4.99,7.01)

23.0(20.49,25.51)

 High

125(45.0%)

6.0(4.71,7.29)

26.0(22.07,29.93)

SII

9.309

0.002

25.937

0.000

 < 984.72

140(50%)

7(5.45,8.54)

30.0(27.25,32.75)

 ≥ 984.72

138(50%)

5(4.26,5.74)

18.0(15.58,20.42)

PNI

13.631

0.000

48.178

0.000

 ≥ 48.95

129(46%)

7.0(5.81,8.19)

31.0(27.69,34.31)

 < 48.95

149(54%)

5.0(4.15,5.86)

18.0(15.51,20.49)

CONUT score

62.912

0.000

78.963

0.000

 < 3

164(59.0%)

8.0(5.72,10.28)

30.0(27.58,32.42)

 ≥ 3

114(41.1%)

4.0(3.13,4.87)

16.0(14.17,17.83)