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Table 1 Characteristics of Discovery and Validation cohorts

From: Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma

 

Discovery cohort

Validation cohort

PwHCC (N = 55)

Healthy

participants (N = 55)

PwHCC (N = 54)

Healthy

participants (N = 55)

N (%)

N (%)

N (%)

N (%)

Gendera

 Female

8 (14.5)

32 (58.2)

16 (29.6)

29 (54.7)

 Male

47 (85.5)

23 (41.8)

38 (70.4)

24 (45.3)

Ageb

 Median

58

42

60

40

 Min

24

25

33

26

 Max

87

81

77

67

Stage

 I

9 (16.4)

NA

All patients were confirmed to have non-metastatic HCC

NA

 II

29 (52.7)

NA

NA

 III

3 (5.5)

NA

NA

 NA

14 (25.5)

NA

NA

Risk factor

 HBV

43 (78.2)

NA

32

NA

 HCV

3 (5.5)

NA

10

 

 HBV/HCV

1 (1.8)

NA

1

 

 No

6 (10.9)

NA

7

 

 Not detected

2 (3.6)

NA

3

 
  1. a Chi-square values of ratio of female to male: Discovery cohort, p = 5.146e-06; Validation cohort, p = 0.015
  2. b Wilcoxon signed rank test for ages: Discovery cohort, p = 2.444e−06; Validation cohort, p = 4.223e−10