Table 7 Analysis of the risk factors independently associated with cardiotoxicity (based on electrocardiography (ECG) analysis)

Age (Years) Reference; < 50 years

 50—59

1.43

0.73–2.83

0.299

1.70

0.75–3.82

0.201

 60—79

2.84

1.39–5.80

0.004**

3.40

1.26–9.14

0.015*

BMI (kg/m²) Reference; normal

 Overweight

0.67

0.34–1.32

0.254

1.23

0.50–2.98

0.654

 Obese

0.76

0.31–1.84

0.545

1.20

0.37–3.85

0.765

Nottingham grade of cancer

 Reference; Grade I

  Grade II

1.31

0.58–2.97

0.521

1.87

0.74–4.73

0.185

  Grade III

1.39

0.58–3.33

0.458

1.87

0.82–6.50

0.111

Treatment with doxorubicin

1.07

0.45–2.54

0.876

0.79

0.38–1.64

0.526

Cumulative dose of anthracycline

 ≥ 350 mg/m²

2.00

0.99–4.03

0.049*

2.14

1.16–3.96

0.014*

Diabetes mellitus

1.04

0.59–1.82

0.850

1.81

0.85–3.85

0.121

Dyslipidaemia

1.08

0.60–1.94

0.799

1.06

0.50–2.22

0.886

Trastuzumab

0.59

0.13–2.75

0.480

0.57

0.15–2.11

0.379

Chest wall irradiation

0.93

0.77–1.11

0.434

1.18

0.93–1.50

0.176