Table 3 Comparison of electrocardiographic (ECG) parameters at four time points

PR interval (ms)

141.6 (139.0, 144.3)

141.6 (139.0, 144.3)

143.3 (140.6, 146.0)

149.5 (146.8, 152.2)

QRS duration (ms)

99.6 (96.5, 102.7)

103.8 (100.7, 106.9)

110.4 (107.3, 113.5)

113.3 (110.2, 116.4)

QTc interval (ms)

434.6 (432.1, 437.1)

438.7 (436.2, 441.2)

445.0 (442.5, 447.5)

448.0 (445.5, 450.5)

Mean difference (95% CI)

FTP I—Baseline

FTP II—Baseline

FTP III—Baseline

FTP II—FTP I

FTP III—FTP I

FTP III—FTP II

PR interval (ms)

0.0 (-4.9, 4.9)

1.6 (-3.3, 6.6)

7.9*** (2.9, 12.8)

1.6 (-3.3, 6.6)

7.9*** (2.9, 12.8)

6.2** (1.3, 11.2)

QRS duration (ms)

4.2 (-1.5, 9.9)

10.8*** (5.1, 16.5)

13.7*** (8.0, 19.4)

6.6* (0.9, 12.4)

9.5*** (3.8, 15.2)

2.9 (-2.9, 8.6)

QTc interval (ms)

4.1 (-0.5, 8.7)

10.4*** (5.8, 15.0)

13.4*** (8.7, 18.0)

6.3** (1.7, 10.9)

9.3*** (4.7, 13.9)

3.0 (-1.7, 7.6)