Table 16 Analysis of the risk factors independently associated with cardiotoxicity (based on biochemical analysis)

Age (Years) Reference; Age < 50 years

 50—59

0.55

0.27—1.11

0.095

0.70

0.35—1.38

0.302

 60—79

1.46

0.73—2.92

0.280

1.32

0.66—2.64

0.425

BMI (kg/m²) Reference; Normal

 Overweight

2.60

1.34—5.04

0.005**

1.19

0.63—2.28

0.593

 Obese

4.06

1.76—9.40

0.001**

2.04

0.93—4.51

0.077

Nottingham grade of cancer

 Reference; Grade I

  Grade II

1.06

0.45—2.52

0.885

1.27

0.56—2.90

0.566

  Grade III

2.88

1.17—7.09

0.022*

1.79

0.75—4.30

0.190

Cumulative dose of anthracycline ≥ 350 mg/m²

7.28

3.81—13.84

0.001**

2.09

1.18—3.70

0.014*

Treatment with doxorubicin

1.16

0.57—2.38

0.685

0.78

0.39—1.58

0.498

Diabetes mellitus

1.02

0.58—1.82

0.933

1.09

0.62—1.92

0.772

Dyslipidaemia

0.79

0.43—1.44

0.445

1.00

0.55—1.79

0.991

Trastuzumab

0.77

0.25—2.40

0.659

0.86

0.29—2.57

0.781

Radiation

12.93

1.68—99.60

0.014*

3.07

0.96—9.79

0.057