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Table 3 Results of multivariate weighted Cox regression

From: The influence of socioeconomic aspects and hospital case volume on survival in colorectal cancer in Saxony, Germany

 

Colon cancer (C18)

Rectal cancer (C19/C20)

 

Hazard Ratio

(95% CI)

p

Hazard Ratio

(95% CI)

p

Sex

    

 Male

Reference

 

Reference

 

 Female

0.89 (0.84; 0.94)

< 0.001

0.85 (0.78; 0.92)

< 0.001

Age

    

 ≤ 70 years

Reference

 

Reference

 

 > 70 years

1.91 (1.79; 2.03)

< 0.001

2.12 (1.95; 2.30)

< 0.001

Localization 1

    

 Colon right-sided

Reference

 

-

 

 Colon left-sided

0.92 (0.86; 0.97)

< 0.001

-

 

 Colon others

1.13 (0.84; 1.53)

0.410

-

 

 Rectosigmoid junction

-

 

Reference

 

 Rectum

-

 

1.01 (0.61; 1.68)

0.969

UICC tumor stage

    

 I

Reference

 

Reference

 

 II

1.51 (1.37; 1.67)

< 0.001

1.60 (1.39; 1.85)

< 0.001

 III

2.98 (2.68; 3.31)

< 0.001

1.89 (1.64; 2.16)

< 0.001

 IV

10.81 (9.65; 12.11)

< 0.001

7.30 (6.24; 8.53)

< 0.001

Surgical approach

    

 Open

Reference

 

Reference

 

 Laparoscopic

0.76 (0.68; 0.83)

< 0.001

0.87 (0.78; 0.98)

< 0.01

 Conversion

0.94 (0.73; 1.21)

0.632

1.09 (0.92; 1.28)

0.318

 Others/n. a.

0.96 (0.89; 1.04)

0.288

1.05 (0.94; 1.17)

0.383

Urgency of surgery

    

 Elective surgery

Reference

 

Reference

 

 Emergency surgery

1.78 (1.62; 1.95)

< 0.001

2.14 (1.68; 2.74)

< 0.001

 Unknown/missing

1.06 (0.99; 1.14)

0.887

0.96 (0.88; 1.06)

0.424

Resected lymph nodes

    

 < 12

Reference

 

Reference

 

 12+

0.78 (0.70; 0.87)

< 0.001

1.05 (0.93; 1.19)

0.412

Adjuvant chemotherapy

    

 no

Reference

 

Reference

 

 yes

0.49 (0.46; 0.53)

< 0.001

0.64 (0.58; 0.70)

< 0.001

Hospital case volume 2

    

 Low

Reference

 

Reference

 

 High

0.97 (0.91; 1.03)

0.303

0.89 (0.82; 0.97)

< 0.01

Year of surgery

    

 2010–2013

Reference

 

Reference

 

 2014–2017

0.97 (0.90; 1.03)

0.334

0.89 (0.81; 0.98)

< 0.01

 2018–2020

1.06 (0.97; 1.16)

0.233

0.83 (0.72; 0.95)

< 0.001

GISD

    

 1 – low

Reference

 

Reference

 

 2 – mid-low

1.18 (1.08; 1.30)

< 0.001

1.36 (1.19; 1.55)

< 0.001

 3 – mid

1.18 (1.07; 1.29)

< 0.001

1.34 (1.18; 1.53)

< 0.001

 4- mid-high

1.22 (1.12; 1.33)

< 0.001

1.18 (1.03; 1.34)

< 0.01

 5 - high

1.06 (0.96; 1.18)

0.240

1.04 (0.90; 1.21)

0.573

  1. 1 Colon right-sided: C18.0, C18.2-C18.4, Colon left-sided: C18.5-C18.7, Colon others: C18.8-C18.9.
  2. 2 C18: low < 30 surgeries/year, high ≥ 30 surgeries/year. C19/20: low < 20 surgeries/year, high ≥ 20 surgeries/year.
  3. Abbreviations: CI, Confidence interval; GISD, German Index of Socioeconomic Deprivation; UICC Union for International Cancer Control.
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BMC Cancer

ISSN: 1471-2407

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