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Table 4 Univariable and multivariable analyses for RFS in the training cohort

From: A novel preoperative inflammation score system established for postoperative prognosis predicting of intrahepatic cholangiocarcinoma

 

Univariable

Multivariable

Variables

HR

95%CI

P value

HR

95%CI

P value

Age, year

0.997

0.986–1.008

0.586

   

Sex, male vs. female

0.938

0.745–1.180

0.583

   

Hepatolithiasis, yes vs. no

0.995

0.675–1.467

0.980

   

Diabetes, yes vs. no

0.770

0.479–1.240

0.283

   

HBsAg (+), yes vs. no

0.859

0.688–1.071

0.177

   

Anti-HCV, yes vs. no

0.313

0.078–1.257

0.101

   

Child-Pugh grade, B vs. A

0.754

0.374–1.523

0.432

   

TBIL, mg/dL

1.001

0.997–1.004

0.655

   

ALT, IU/L

0.999

0.996–1.001

0.335

   

AST, IU/L

1.000

0.998–1.001

0.656

   

GGT, IU/L

1.000

0.999–1.001

0.070

   

HgB, g/L

0.994

0.988-1.000

0.049

   

PT, second

1.036

0.940–1.141

0.479

   

ALB, g/L

0.986

0.959–1.013

0.311

   

PLT, ×109/L

1.002

1.000-1.003

0.037

   

WBC, ×109/L

1.064

1.010–1.122

0.019

   

AFP, µg/L

1.001

0.999–1.002

0.151

   

CEA, µg/L

1.000

0.999–1.001

0.110

   

CA19-9, IU/mL

1.001

1.0006–1.0012

< 0.001

1.001

1.000-1.008

0.011

Perioperative transfusion, yes vs. no

1.152

0.857–1.548

0.348

   

Anatomic resection, yes vs. no

1.289

0.966–1.720

0.085

   

Major resection, yes vs. no

1.299

1.017–1.658

0.036

   

Resection margin < 10 mm, yes vs. no

1.439

0.987–2.096

0.057

   

Cirrhosis, yes vs. no

0.788

0.596–1.043

0.096

   

Tumor diameter, cm

1.117

1.079–1.158

< 0.001

1.059

1.015–1.105

0.008

Multiple tumors, yes vs. no

1.039

0.637–1.694

0.879

   

Satellite nodules, yes vs. no

1.970

1.557–2.494

< 0.001

1.419

1.098–1.834

0.007

Tumor capsule, yes vs. no

0.750

0.568–0.989

0.042

   

Tumor differentiation,

high vs. median vs. low

1.019

0.662–1.569

0.93

   

Adjacent tissue invasion, yes vs. no

1.810

1.160–2.825

0.009

   

MVI, yes vs. no

1.955

1.400–2.730

< 0.001

1.664

1.182–2.342

0.003

LNM, yes vs. no

1.998

1.511–2.643

< 0.001

1.406

1.040–1.901

0.027

IFS, high vs. median vs. low

1.857

1.603–2.153

< 0.001

1.572

1.322–1.87

< 0.001

  1. Abbreviations: HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; TBIL, total bilirubin; ALB, albumin; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; PT, prothrombin time; PLT, platelet; AFP, alpha-fetoprotein; CEA, carcinoembryonic antigen; CA19-9, carbonhydrateantigen19-9; MVI, microvascular invasion; LNM, lymph node metastasis; IFS, inflammation score
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BMC Cancer

ISSN: 1471-2407

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