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Table 2 Adverse events of grade 3 and higher

From: Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours

Adverse event

Grade 3

Grade 4

Grade 5

Acute kidney injury

1

  

AP increaseda

2

  

 Anaemia

2

  

 Anorexia

1

  

 ASAT increased

1

  

 Bile duct stenosis

1

  

 Cholangitis

2

  

 Chronic kidney disease

1

  

CK increaseda

1

  

Dyspnoeaa

1

  

 Fatigue

1

  

Gastric perforationa

1

  

 Gastro intestinal haemorrhage

1

  

 Gastrointestinal abdominal pain

2

  

GGT increaseda

1

1

 

 Hypertension

1

  

 Hypophosphatemia

1

  

 Ileus

2

  

WBCC decreaseda

1

  

 Pneumothorax left

1

  

Thromboembolic eventa

2

  

 Urinary tract infection

1

  
  1. All the adverse events of grade 3 or higher. For each adverse event, the number of patients is displayed in whom it was reported at grade 3, 4 or 5 as the highest grade
  2. Abbreviations: AP alkaline phosphatase, ASAT aspartate aminotransferase, CK creatinine phosphokinase, GGT, gamma-glutamyl transpeptidase, WBCC white blood cell count
  3. aFor the adverse events in bold, the relation to the treatment was scored as either ‘possible’, ‘probable’ or ‘definite’