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Table 3 GO enrichment annotations for the WCGNA gene network associated with the Tumor Contour trait, notable for increased telomerase activity and down regulation of TGF-β. Some of these biological processes have been independently described in the literatures, including TGF-β induced telomerase-dependent pancreatic tumor cell cycle arrest [23] and TGF-β receptor mediated telomerase inhibition and telomere shortening associated with cellular senescence [24]. Further, the reciprocal relationship between telomerase activity and TGF-β activity are consistent with reports in the literature

From: Construction of a radiogenomic association map of pancreatic ductal adenocarcinoma

GO term

Description

P value

FDR q-value

Enrichment

GO:0003720

telomerase activity

3.50E-04

8.17E-01

68.17

GO:0003964

RNA-directed DNA polymerase activity

3.50E-04

1.00E+00

68.17

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

6.05E-04

1.00E+00

10.36

GO:1903845

negative regulation of cellular response to transforming growth factor beta stimulus

6.96E-04

1.00E+00

9.98