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Table 2 ROC curve results based on FAR, FPR, NLR, PLR, LMR, PNI, FLR, and CA199 for distinguishing PC patients from HC in training set

From: Diagnostic value of combining preoperative inflammatory markers ratios with CA199 for patients with early-stage pancreatic cancer

Marker

AUC (95%CI)

P—value

cut-off

Sensitivity

Specificity

FAR

0.776(0.740–0.811)

< 0.0001

0.080

0.885

0.556

FPR

0.869(0.842–0.896)

< 0.0001

0.012

0.837

0.775

NLR

0.686(0.645–0.726)

< 0.0001

2.252

0.780

0.527

PLR

0.584(0.540–0.628)

0.0002

177.218

0.879

0.299

MLR

0.818(0.786–0.850)

< 0.0001

0.249

0.831

0.678

PNI

0.860(0.831–0.888)

< 0.0001

49.025

0.907

0.707

FLR

0.748(0.711–0.785)

< 0.0001

1.864

0.773

0.639

CA199

0.868(0.836–0.901)

< 0.0001

24.540

0.939

0.817

CA199 + FAR

0.942(0.924–0.960)

< 0.0001

-0.459

0.971

0.814

CA199 + FPR

0.964(0.951–0.977)

< 0.0001

-0.470

0.978

0.840

CA199 + MLR

0.940(0.921–0.960)

< 0.0001

0.371

0.946

0.870

CA199 + PNI

0.955(0.939–0.971)

< 0.0001

0.002

0.949

0.870

CA199 + FLR

0.917(0.893–0.940)

< 0.0001

-0.035

0.965

0.793

CA199 + FAR + FPR

0.964(0.951–0.978)

< 0.0001

-0.278

0.965

0.858

CA199 + FAR + FPR + FLR

0.964(0.951–0.978)

< 0.0001

-0.466

0.974

0.849

CA199 + FAR + FPR + MLR + PNI

0.976(0.965–0.988)

< 0.0001

-0.294

0.974

0.891

  1. Abbreviations: PC Pancreatic cancer, HC Heathy controls, ROC Receiver operating characteristic, AUC Area under the receiver operating characteristic curve, CI Confidence interval, FPR Fibrinogen-to-prealbumin ratio, FAR Fibrinogen-to-albumin ratio, NLR Neutrophil-to-lymphocyte ratio, PLR Platelets-to-lymphocyte ratio, MLR Monocytes-to-lymphocyte ratio, PNI Albumin + 5 × the lymphocyte count, FLR Fibrinogen-to-lymphocyte ratio