Table 4 Univariate and multivariate analysis of PFS

Age(< / ≥ 65 years)

0.561(0.295–1.064)

0.077

Gender(Male/Female)

1.192(0.670–2.121)

0.551

Ecog(< 2/ ≥ 2)

1.005(0.397–2.546)

0.991

Tumor site(Multi-sides/Right colon /Left colon/Rectum)

0..941(0.692–1.281)

0.700

Histologic grade(Low grade/High grade)

1.350(0.718–2.537)

0.351

Number of metastatic sites(Single/Multiple)

1.445(0.814–2.564)

0.209

MMR Status(dMMR/pMMR)

4.070(0.553–29.943)

0.168

Primary tumor surgery(No/Yes)

0.438(0.243–0.790)

0.006*

0.523(0.280–0.974)

0.041*

Intestinal obstruction(No/Yes)

1.657(0.739–3.716)

0.221

Liver metastases(No/Yes)

2.058(1.132–3.742)

0.018*

1.677(0.890–3.157)

0.109

Lung metastases(No/Yes)

0.667(0.355–1.254)

0.208

Peritoneal metastasis(No/Yes)

1.813(0.840–3.915)

0.130

Distant lymph node metastases(No/Yes)

0.702(0.364–1.353)

0.291

First-line medication(Chemo/Chemo + targeted therapy)

0.734(0.413–1.304)

0.291