Drug | Acceptable Genomic Alterationsab | Excluded Genomic Alterationsc |
---|---|---|
Alectinib | EML4-ALK fusions or mutations, ROS1 fusions | None |
Atezolizumab | MSI high | None |
POLE mutations: R150X, P286R, P286H, S297F, Y298fs, F367S, V411L, L424V, P436R, V437M, S459F, R573L, E597K, R665W, L698fs, R762W, R793C, K1008N, T1052M, R1111Q, L1235I, V1368M, R1519C, P1547S, R1826W, R1879C, Y1889C, S1892N, A1967V, A2213V, A2243T | ||
POLD1 mutations: W79L, P112fs, A930fs, N247I, R352C, Q461H, S478N, A864T, E1105D | ||
TMB ≥10 mut/mb | ||
Avelumab | MSI high | None |
POLE mutations: R150X, P286R, P286H, S297F, Y298fs, F367S, V411L, L424V, P436R, V437M, S459F, R573L, E597K, R665W, L698fs, R762W, R793C, K1008N, T1052M, R1111Q, L1235I, V1368M, R1519C, P1547S, R1826W, R1879C, Y1889C, S1892N, A1967V, A2213V, A2243T | ||
POLD1 mutations: W79L, P112fs, A930fs, N247I, R352C, Q461H, S478N, A864T, E1105D | ||
TMB ≥10 mut/mb | ||
Axitinib | VEGFR1 (FLT1), VEGFR2 (KDR), VEGFR3 (FLT-4) GOF mutations, amplification, or overexpression | None |
Erlotinib | EGFR exon 19 deletions in the region E746-E759 EGFR mutations: E709A/G/K, E884K, G719A/C/S, S768I, L858R, L861Q, L833V | Any of the following EGFR mutations: L747S, T790M, or T854A Exon 20 insertions |
Niraparib | Germline or somatic BRCA1/BRCA2 inactivating mutations ATM/ATR mutations or deletions HRD positive d | None |
Pemigatinib | Mutations in PDGFRA, PDGFRB, or PCM1-JAK2 fusions. FGF/FGFR amplifications, mutation and fusions | None |
Trastuzumab plus Pertuzumab | ERBB2 amplification, overexpression, or mutations: G309A, G309E, S310F, D769H, D769Y, L755S, V777L, V842I, E321G, R896C ERBB2 P780insertions ERBB2 deletions in the region L755–T759 | None |
Trastuzumab emtansine | ERBB2 amplification, or overexpression, or presence of any activating ERBB2 mutations | None |
Vemurafenib plus Cobimetinib | BRAF V600E/D/K/R mutations | Any mutations in MAP 2 K1, MAP 2 K2, MEK1, MEK2, NRAS |
Vismodegib | PTCH1 deletion or inactivating mutations | SMO mutations: D473G/H/Y, W535L GLI2 amplification |