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Table 1 List of abbreviations

From: ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling – a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial

Abbreviation

Definition

BRAF

B-Raf proto-oncogene, serine/threonine kinase

CA-125

Cancer antigene 125

CI

Confidence interval

CR

Complete response

CTCAE

Common Terminology Criteria for Adverse Events

ctDNA

circulating tumor DNA

EGFR

Epidermal growth factor receptor

EMA

European Medicines Agency

ERBB2

erb-b2 receptor tyrosine kinase 2

FDA

Food and Drug Administration

FFPE

Formalin fixed paraffin embedded

GCIG

Gynecological Cancer InterGroup

GCP

Good Clinical Practice

GOF

Gain of function

IMP

Investigational medical product

IMWG

International Myeloma Working Group

IV

Intravenous

KIT

Mast/stem cell growth factor receptor Kitq

LVEF

Left ventricle ejection fraction

MET

Hepatocyte growth factor receptor

DN-MTB

Danish National Molecular Tumor Board

OS

Overall survival

PCWG3

Prostate Cancer Working Group 3

PD

Progressive disease

PFS

Progression free survival

PR

Partial response

PSA

Prostate specific antigene

RANO

Response Assessment in Neuro-oncology Criteria

RECIST

Response Evaluation Criteria in Solid Tumours

SD

Stable disease

TIA

Transient ischemic attack

TMB

Tumor Mutational Burden

WES

Whole exome sequencing

WGS

Whole genome sequencing