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Table 2 Univariate and multivariate analyses of prognostic factors in NPC

From: Cytoplasmic poly(A)-binding protein 1 (PABPC1) is a prognostic biomarker to predict survival in nasopharyngeal carcinoma regardless of chemoradiotherapy

Variable

Univariate analysis

Multivariable analysis

OS

DFS

OS

DFS

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age, <55 vs. ≥55

5.151 (2.423-10.950)

<0.001**

2.752 (1.484-5.105)

0.001**

3.399 (1.438-8.030)

0.005**

1.703 (0.840-3.453)

0.140

Gender, male vs. female

0.637 (0.292-1.391)

0.258

0.699 (0.345-1.415)

0.319

0.340 (0.147-0.786)

0.012*

0.422 (0.198-0.902)

0.026*

T stage, T1-2 vs. T3-4

1.378 (0.729-2.606)

0.323

1.387 (0.767-2.508)

0.279

1.864 (0.867-3.017)

0.111

1.125 (0.550-2.301)

0.747

N stage, N0 vs. N1-3

1.000 (0.440-2.271)

0.999

0.739 (0.365-1.496)

0.401

0.933 (0.289-3.017)

0.908

0.391 (0.144-1.063)

0.066

Clinical stage, I-II vs. III-IV

1.652 (0.690-3.954)

0.259

1.692 (0.753-3.798)

0.203

2.653 (0.616-11.428)

0.190

7.125 (1.809-28.068)

0.005**

p53 expression, low vs. high

1.105 (0.486-2.513)

0.811

1052 (0.489-2.264)

0.897

0.978 (0.399-2.401)

0.962

1.036 (0.440-2.441)

0.935

Ki-67 expression, low vs. high

0.900 (0.469-1.730)

0.753

0.699 (0.374-1.307)

0.262

0.710 (0.338-1.491)

0.365

0.676 (0.334-1.369)

0.277

EBER expression, low vs. high

1.166 (0.455-2.992)

0.749

1.307 (0.513-3.325)

0.575

0.742 (0.268-2.054)

0.565

0.892 (0.330-2.410)

0.821

PABPC1 expression, low vs. high

6.788 (2.837-16.244)

<0.001**

3.889 (1.964-7.702)

<0.001**

5.376 (2.110-13.694)

<0.001**

3.311 (1.580-6.940)

0.002**

Treatment, no vs. yes

0.137 (0.071-0.262)

<0.001**

0.176 (0.097-0.319)

<0.001**

0.097 (0.043-0.215)

<0.001**

0.092 (0.043-0.197)

<0.001**

Drugs, Docetaxel vs. Paclitaxel

0.473 (0.153-1.463)

0.194

0.894 (0.342-2.338)

0.820

0.841 (0.228-3.099)

0.794

1.768 (0.586-5.332)

0.312

Combination, Paclitaxel + PABPC1 low-expression vs. other regimens

7.305 (0.941-56.716)

0.057

1.542 (0.546-4.351)

0.414

4.117 (0.394-43.028)

0.237

1.112 (0.231-5.350)

0.895

  1. NPC Nasopharyngeal carcinoma, HR Hazard ratio, CI Confidence interval, OS Overall survival, DFS Disease-free survival
  2. * and **, P value < 0.05 and 0.01 were used to determine whether differences were statistically significant between the two compared groups.