| Histological groups | Total | P-value |
---|
CIN 1 | CIN 2 | CIN 3 | Cervical Cancer |
---|
Cytology results(n) | | | | | | 0.000* |
Normal | 42 | 40 | 17 | 17 | 116 | |
≥ ASC-US | 51 | 59 | 74 | 81 | 265 | |
Unknown | 0 | 0 | 2 | 13 | 15 | |
hrHPV results(n) | | | | | | 0.000* |
16 and/or 18 | 18 | 41 | 44 | 76 | 179 | |
Other 12 hrHPV | 49 | 42 | 3 | 16 | 152 | |
Unknown | 6 | 9 | 92 | 10 | 28 | |
All 14 type | 73 | 92 | | 102 | 359 | |
GynTect® assay(n) | | | | | | 0.000* |
Positive | 45 | 66 | 75 | 111 | 297 | |
Negative | 48 | 33 | 18 | 0 | 99 | |
Score (Mean ± SD) | 0.72 ± 0.28 | 0.87 ± 0.36 | 1.13 ± 0.32 | 1.30 ± 0.20 | 1.11 ± 0.35 | 0.000* |
Score(n) | | | | | | 0.000* |
≥ 1.1 | 3 | 15 | 42 | 87 | 147 | |
< 1.1 | 90 | 84 | 51 | 24 | 249 | |
- CIN Cervical intraepithelial neoplasia, hrHPV High-risk human papillomavirus, hrHPV Positive refers to the presence of one or more of the following HPV types HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, SD Standard deviation, ASC-US Atypical squamous cells of undetermined significance, LSIL Low-grade squamous intraepithelial lesion, HSIL High-grade squamous intraepithelial lesion, GynTect® A diagnostic test of DNA methylation analysis of a methylation marker panel, the panel comprising six markers (ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671)
- *, P < 0.05