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Table 1 The results of cervical screening and GynTect® assay in cervical precancerous lesions and cervical cancer

From: Promoter hypermethylation analysis of host genes in cervical intraepithelial neoplasia and cervical cancers on histological cervical specimens

 

Histological groups

Total

P-value

CIN 1

CIN 2

CIN 3

Cervical Cancer

Cytology results(n)

     

0.000*

 Normal

42

40

17

17

116

 

  ≥ ASC-US

51

59

74

81

265

 

 Unknown

0

0

2

13

15

 

hrHPV results(n)

     

0.000*

 16 and/or 18

18

41

44

76

179

 

 Other 12 hrHPV

49

42

3

16

152

 

 Unknown

6

9

92

10

28

 

 All 14 type

73

92

 

102

359

 

GynTect® assay(n)

     

0.000*

 Positive

45

66

75

111

297

 

 Negative

48

33

18

0

99

 

 Score (Mean ± SD)

0.72 ± 0.28

0.87 ± 0.36

1.13 ± 0.32

1.30 ± 0.20

1.11 ± 0.35

0.000*

Score(n)

     

0.000*

  ≥ 1.1

3

15

42

87

147

 

  < 1.1

90

84

51

24

249

 
  1. CIN Cervical intraepithelial neoplasia, hrHPV High-risk human papillomavirus, hrHPV Positive refers to the presence of one or more of the following HPV types HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, SD Standard deviation, ASC-US Atypical squamous cells of undetermined significance, LSIL Low-grade squamous intraepithelial lesion, HSIL High-grade squamous intraepithelial lesion, GynTect® A diagnostic test of DNA methylation analysis of a methylation marker panel, the panel comprising six markers (ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671)
  2. *, P < 0.05